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公开(公告)号：US08664212B2
公开(公告)日：2014-03-04
申请号：US13557804
申请日：2012-07-25
Applicant: Shaomeng Wang , Yuefeng Peng , Haiying Sun , Qian Cai , Zaneta Nikolovska-Coleska , Jianfeng Lu , Su Qiu
Inventor： Shaomeng Wang , Yuefeng Peng , Haiying Sun , Qian Cai , Zaneta Nikolovska-Coleska , Jianfeng Lu , Su Qiu
IPC: A61K31/33 , C07D245/04 , C07D487/02
CPC classification number: G01N33/5011 , C07D487/04
Abstract: The invention relates to diazo bicyclic mimetics of Smac which function as inhibitors of Inhibitor of Apoptosis Proteins. The invention also relates to the use of these mimetics for inducing apoptotic cell death and for sensitizing cells to inducers of apoptosis.
Abstract translation: 本发明涉及作为细胞凋亡蛋白抑制剂抑制剂的Smac的重氮二环模拟物。 本发明还涉及这些模拟物用于诱导凋亡性细胞死亡和使细胞对细胞凋亡诱导剂敏感的用途。
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公开(公告)号：US20120309961A1
公开(公告)日：2012-12-06
申请号：US13557804
申请日：2012-07-25
Applicant: Shaomeng Wang , Yuefeng Peng , Haiying Sun , Qian Cai , Zaneta Nikolovska-Coleska , Jianfeng Lu , Su Qiu
Inventor： Shaomeng Wang , Yuefeng Peng , Haiying Sun , Qian Cai , Zaneta Nikolovska-Coleska , Jianfeng Lu , Su Qiu
IPC: C07D487/04
CPC classification number: G01N33/5011 , C07D487/04
Abstract: The invention relates to diazo bicyclic mimetics of Smac which function as inhibitors of Inhibitor of Apoptosis Proteins. The invention also relates to the use of these mimetics for inducing apoptotic cell death and for sensitizing cells to inducers of apoptosis.
Abstract translation: 本发明涉及作为细胞凋亡蛋白抑制剂抑制剂的Smac的重氮二环模拟物。 本发明还涉及这些模拟物用于诱导凋亡性细胞死亡和使细胞对细胞凋亡诱导剂敏感的用途。
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公开(公告)号：US20110046189A1
公开(公告)日：2011-02-24
申请号：US12937114
申请日：2009-04-13
Applicant: Shaomeng Wang , Haiying Sun , Zaneta Nikolovska-Coleska
Inventor： Shaomeng Wang , Haiying Sun , Zaneta Nikolovska-Coleska
IPC: A61K31/427 , A61K31/4178 , C07D487/04 , A61P35/00
CPC classification number: C07D487/04
Abstract: The invention relates to heteroaryl-substituted bicyclic mimetics of Smac which function as inhibitors of Inhibitor of Apoptosis Proteins. The invention also relates to the use of these mimetics for inducing apoptotic cell death and for sensitizing cells to inducers of apoptosis.
Abstract translation: 本发明涉及作为细胞凋亡蛋白抑制剂抑制剂的Smac的杂芳基取代的双环模拟物。 本发明还涉及这些模拟物用于诱导凋亡性细胞死亡和使细胞对细胞凋亡诱导剂敏感的用途。
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公开(公告)号：US20080089896A1
公开(公告)日：2008-04-17
申请号：US11800220
申请日：2007-05-04
Applicant: Shaomeng Wang , Haiying Sun , Dongguang Qin , Zaneta Nikolovska-Coleska , Jianfeng Lu , Su Qiu , Yuefeng Peng
Inventor： Shaomeng Wang , Haiying Sun , Dongguang Qin , Zaneta Nikolovska-Coleska , Jianfeng Lu , Su Qiu , Yuefeng Peng
IPC: A61K31/407 , A61K31/4192 , A61K31/496 , A61K38/19 , A61K39/395 , A61P35/00 , C07D487/04
CPC classification number: C07D519/00 , A61K38/191 , C07D487/04
Abstract: The invention relates to bivalent mimetics of Smac which function as inhibitors of Inhibitor of Apoptosis Proteins. The invention also relates to the use of these mimetics for inducing apoptotic cell death and for sensitizing cells to inducers of apoptosis.
Abstract translation: 本发明涉及Smac的二价模拟物，其作为细胞凋亡蛋白抑制剂的抑制剂。 本发明还涉及这些模拟物用于诱导凋亡性细胞死亡和使细胞对细胞凋亡诱导剂敏感的用途。
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公开(公告)号：US08278293B2
公开(公告)日：2012-10-02
申请号：US12159249
申请日：2008-04-14
Applicant: Shaomeng Wang , Yuefeng Peng , Haiying Sun , Qian Cai , Zaneta Nikolovska-Coleska , Jianfeng Lu , Su Qiu
Inventor： Shaomeng Wang , Yuefeng Peng , Haiying Sun , Qian Cai , Zaneta Nikolovska-Coleska , Jianfeng Lu , Su Qiu
IPC: A61K31/33 , C07D245/00
CPC classification number: G01N33/5011 , C07D487/04
Abstract: The invention relates to diazo bicyclic mimetics of Smac which function as inhibitors of Inhibitor of Apoptosis Proteins. The invention also relates to the use of these mimetics for inducing apoptotic cell death and for sensitizing cells to inducers of apoptosis.
Abstract translation: 本发明涉及作为细胞凋亡蛋白抑制剂抑制剂的Smac的重氮二环模拟物。 本发明还涉及这些模拟物用于诱导凋亡性细胞死亡和使细胞对细胞凋亡诱导剂敏感的用途。
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Patent Agency Ranking
公开(公告)号：US07674787B2
公开(公告)日：2010-03-09
申请号：US11632079
申请日：2005-07-11
Applicant: Shaomeng Wang , Haiying Sun , Zaneta Nikolovska-Coleska , Chao-Yie Yang , Liang Xu , Naoyuki G. Saito , Jianyong Chen
Inventor： Shaomeng Wang , Haiying Sun , Zaneta Nikolovska-Coleska , Chao-Yie Yang , Liang Xu , Naoyuki G. Saito , Jianyong Chen
IPC: C07D223/16 , A01N43/00 , A61K31/55
CPC classification number: C07D487/04 , C07D471/04
Abstract: The invention relates to conformationally constrained mimetics of Smac which function as inhibitors of Inhibitor of Apoptosis Proteins. The invention also relates to the use of these mimetics for inducing apoptotic cell death and for sensitizing cells to inducers of apoptosis.
Abstract translation: 本发明涉及Smac的构象约束模拟物，其作为细胞凋亡蛋白抑制剂的抑制剂。 本发明还涉及这些模拟物用于诱导凋亡性细胞死亡和使细胞对细胞凋亡诱导剂敏感的用途。
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公开(公告)号：US20120263675A1
公开(公告)日：2012-10-18
申请号：US13503366
申请日：2010-10-20
Applicant: Shaomeng Wang , Haiying Sun
Inventor： Shaomeng Wang , Haiying Sun
IPC: A61K31/4184 , A61K31/437 , A61K31/52 , A61K31/423 , A61K31/428 , A61K31/427 , C12N5/071 , A61K38/19 , A61K38/17 , A61K39/395 , A61P35/00 , A61P27/02 , A61P29/00 , A61P19/02 , A61P17/06 , A61P9/10 , A61P27/06 , A61P9/00 , A61P1/00 , A61P17/00 , A61P17/02 , A61M37/00 , C07D487/04
CPC classification number: C07D519/00 , C07D487/04
Abstract: The invention relates to diazo bicyclic Smac mimetics that are tethered through a covalent linker to give a bivalent species. Bivalent diazo bicyclic Smac mimetics function as inhibitors of Inhibitor of Apoptosis Proteins (IAPs). The invention also relates to the use of bivalent diazo bicyclic Smac mimetics for inducing or sensitizing cells to the induction of apoptotic cell death. Thus, compounds of the invention are useful in the treatment, amelioration, or prevention of hyperproliferative diseases such as cancer.
Abstract translation: 本发明涉及通过共价接头连接以产生二价物质的重氮二环Smac模拟物。 二价重氮双环Smac模拟物作为细胞凋亡蛋白抑制剂（IAP）的抑制剂起作用。 本发明还涉及二价重氮二环Smac模拟物用于诱导或致敏细胞诱导凋亡细胞死亡的用途。 因此，本发明的化合物可用于治疗，改善或预防过度增殖性疾病如癌症。
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公开(公告)号：US07932382B2
公开(公告)日：2011-04-26
申请号：US10586271
申请日：2005-01-18
Applicant: Shaomeng Wang , Haiying Sun , Zaneta Nikolovska-Coleska , Chao-Yie Yang , Liang Xu
Inventor： Shaomeng Wang , Haiying Sun , Zaneta Nikolovska-Coleska , Chao-Yie Yang , Liang Xu
IPC: C07D487/00
CPC classification number: C07K5/0806 , C07D487/04 , C07K5/0808 , C07K5/0827
Abstract: The invention relates to conformationally constrained mimetics of Smac which function as inhibitors of Inhibitor of Apoptosis Proteins. The invention also relates to the use of these mimetics for inducing apoptotic cell death and for sensitizing cells to inducers of apoptosis.
Abstract translation: 本发明涉及Smac的构象约束模拟物，其作为细胞凋亡蛋白抑制剂的抑制剂。 本发明还涉及这些模拟物用于诱导凋亡性细胞死亡和使细胞对细胞凋亡诱导剂敏感的用途。
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公开(公告)号：US20090123480A1
公开(公告)日：2009-05-14
申请号：US12270374
申请日：2008-11-13
Applicant: Shaomeng Wang , Haiying Sun , Dongguang Qin , Zaneta Nikolovska-Coleska , Jianfeng Lu , Su Qiu , Yuefeng Peng , Qian Cai
Inventor： Shaomeng Wang , Haiying Sun , Dongguang Qin , Zaneta Nikolovska-Coleska , Jianfeng Lu , Su Qiu , Yuefeng Peng , Qian Cai
IPC: A61K31/403 , C07D403/04 , A61K31/4192 , A61K38/19 , A61K39/395 , A61P35/00
CPC classification number: A61K38/191 , C07D487/04 , C07D519/00
Abstract: The invention relates to bivalent mimetics of Smac which function as inhibitors of Inhibitor of Apoptosis Proteins. The invention also relates to the use of these mimetics for inducing apoptotic cell death and for sensitizing cells to inducers of apoptosis.
Abstract translation: 本发明涉及Smac的二价模拟物，其作为细胞凋亡蛋白抑制剂的抑制剂。 本发明还涉及这些模拟物用于诱导凋亡性细胞死亡和使细胞对细胞凋亡诱导剂敏感的用途。
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公开(公告)号：US20100273812A1
公开(公告)日：2010-10-28
申请号：US12159249
申请日：2008-04-14
Applicant: Shaomeng Wang , Yuefeng Peng , Haiying Sun , Qian Cai , Zaneta Nikolovska-Coleska , Jianfeng Lu , Su Qiu
Inventor： Shaomeng Wang , Yuefeng Peng , Haiying Sun , Qian Cai , Zaneta Nikolovska-Coleska , Jianfeng Lu , Su Qiu
IPC: A61K31/497 , C07D487/04 , A61K31/407 , A61K31/4025 , A61K31/4439 , A61P35/00 , C12N5/00
CPC classification number: G01N33/5011 , C07D487/04
Abstract: The invention relates to diazo bicyclic mimetics of Smac which function as inhibitors of Inhibitor of Apoptosis Proteins. The invention also relates to the use of these mimetics for inducing apoptotic cell death and for sensitizing cells to inducers of apoptosis.
Abstract translation: 本发明涉及作为细胞凋亡蛋白抑制剂抑制剂的Smac的重氮二环模拟物。 本发明还涉及这些模拟物用于诱导凋亡性细胞死亡和使细胞对细胞凋亡诱导剂敏感的用途。
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