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    Regulation of the serotonin reuptake transporter and disease
    3.
    发明申请
    Regulation of the serotonin reuptake transporter and disease 审中-公开
    调节血清素摄取转运蛋白和疾病

    公开(公告)号：US20070248576A1

    公开(公告)日：2007-10-25

    申请号：US11644198

    申请日：2006-12-22

    申请人： Robert Philibert ,  Anup Madan

    发明人： Robert Philibert ,  Anup Madan

    IPC分类号： C12Q1/68 ,  C12N5/00

    CPC分类号： C12Q1/6883 ,  C12Q2600/154 ,  C12Q2600/156 ,  C12Q2600/158

    摘要： Described herein is a CpG island in the 5′ region of the 5HTT gene that contains an alternative exon 1 and promoter for 5HTT. Methylation at this CpG island is associated with decreased levels of 5HTT mRNA, and this effect is evident when 5HTTLPR genotype is taken into account. Thus, this methylation status indicates 5HTT mRNA production, which serves as an indicator for the expression of the transporter and of a subject's vulnerability to diseases related to serotonergic activity. Accordingly, certain embodiments of the present invention provide diagnostic methods for determining whether a subject has, or is at risk for developing, a disease associated with serotonergic activity.

    摘要翻译： 本文描述的是5HTT基因的5'区域中的CpG岛，其含有替代外显子1和5HTT的启动子。 该CpG岛的甲基化与5HTT mRNA的水平降低相关，当考虑5HTTLPR基因型时，这种作用是明显的。 因此，该甲基化状态表明5HTT mRNA的产生，其作为转运蛋白表达和受试者对与5-羟色胺能活性有关的疾病的易感性的指标。 因此，本发明的某些实施方案提供了用于确定受试者是否具有或具有发展与血清素能活性相关的疾病的风险的诊断方法。

    REGULATION OF THE SEROTONIN REUPTAKE TRANSPORTER AND DISEASE
    5.
    发明申请
    REGULATION OF THE SEROTONIN REUPTAKE TRANSPORTER AND DISEASE 审中-公开
    丝氨酸激素转运和疾病的调控

    公开(公告)号：US20110318735A1

    公开(公告)日：2011-12-29

    申请号：US13087993

    申请日：2011-04-15

    申请人： Robert Philibert ,  Anup Madan

    发明人： Robert Philibert ,  Anup Madan

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6883 ,  C12Q2600/154 ,  C12Q2600/156 ,  C12Q2600/158

    摘要： Described herein is a CpG island in the 5′ region of the 5HTT gene that contains an alternative exon 1 and promoter for 5HTT. Methylation at this CpG island is associated with decreased levels of 5HTT mRNA, and this effect is evident when 5HTTLPR genotype is taken into account. Thus, this methylation status indicates 5HTT mRNA production, which serves as an indicator for the expression of the transporter and of a subject's vulnerability to diseases related to serotonergic activity. Accordingly, certain embodiments of the present invention provide diagnostic methods for determining whether a subject has, or is at risk for developing, a disease associated with serotonergic activity.

    摘要翻译： 本文描述的是5HTT基因的5'区域中的CpG岛，其含有替代外显子1和5HTT的启动子。 该CpG岛的甲基化与5HTT mRNA的水平降低相关，当考虑5HTTLPR基因型时，这种作用是明显的。 因此，该甲基化状态表明5HTT mRNA的产生，其作为转运蛋白表达和受试者对与5-羟色胺能活性有关的疾病的易感性的指标。 因此，本发明的某些实施方案提供了用于确定受试者是否具有或具有发展与血清素能活性相关的疾病的风险的诊断方法。

    Compositions and methods for detecting predisposition to a substance use disorder or to a mental illness or syndrome
    6.
    发明申请
    Compositions and methods for detecting predisposition to a substance use disorder or to a mental illness or syndrome 审中-公开
    检测物质使用障碍或精神疾病或综合征易感性的组成和方法

    公开(公告)号：US20070292880A1

    公开(公告)日：2007-12-20

    申请号：US11800629

    申请日：2007-05-07

    申请人： Robert Philibert ,  Anup Madan

    发明人： Robert Philibert ,  Anup Madan

    IPC分类号： C12Q1/68 ,  G01N33/00

    CPC分类号： C12Q1/6883 ,  C12Q2600/158 ,  Y10T436/143333

    摘要： The present invention provides screening kits, compositions, and diagnostic methods for determining whether a subject has a predisposition to, or likelihood of having, a substance use disorder or mental illness or syndrome by determining a nucleic acid expression profile from a biological sample from the subject, wherein a given profile indicates that the subject has a predisposition to a substance use disorder or mental illness or syndrome.

    摘要翻译： 本发明提供了筛选试剂盒，组合物和诊断方法，用于通过从来自受试者的生物样品中测定核酸表达谱来确定受试者是否患有物质使用障碍或精神疾病或综合征的倾向或可能性 其中给定的分布指示受试者具有物质使用障碍或精神疾病或综合征的倾向。