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公开(公告)号：US06943161B2
公开(公告)日：2005-09-13
申请号：US10186161
申请日：2002-06-28
IPC分类号： C07D251/52 , C07D251/54 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/14 , C07D521/00 , A61K31/53 , A61P35/04
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D251/52 , C07D251/54 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/14
摘要： Compounds that selectively inhibit inappropriate kinase activities and methods for their preparation are disclosed. In one embodiment, the compounds are represented by Formula I, As selective inhibitors of inappropriate kinase activities, the compounds of the present invention are useful in the treatment of conditions associated with such activity, including, but not limited to, inflammatory and autoimmune responses, diabetes, asthma, psoriasis, inflammatory bowel disease, transplantation rejection, and tumor metastasis. Also disclosed are methods of inhibiting inappropriate kinase activities and methods of treating conditions associated with such activities.
摘要翻译： 公开了选择性抑制不适当激酶活性的化合物及其制备方法。 在一个实施方案中，化合物由式I代替，作为不适当激酶活性的选择性抑制剂，本发明的化合物可用于治疗与此类活性相关的病症，包括但不限于炎性和自身免疫应答， 糖尿病，哮喘，牛皮癣，炎症性肠病，移植排斥反应和肿瘤转移。 还公开了抑制不适当的激酶活性的方法和治疗与这些活性相关的病症的方法。
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2.发明授权公开(公告)号：US08350043B2
公开(公告)日：2013-01-08
申请号：US11422710
申请日：2006-06-07
申请人： Jeffrey John Letourneau , Koc-Kan Ho , Michael J. Ohlmeyer , Patrick Jokiel , Christopher Mark Riviello
发明人： Jeffrey John Letourneau , Koc-Kan Ho , Michael J. Ohlmeyer , Patrick Jokiel , Christopher Mark Riviello
IPC分类号： C07D213/02 , C07D213/24 , C07D213/63 , A61K31/44 , A61K31/4412 , A61P25/22 , A61P25/24
CPC分类号： C07D213/82 , C07D239/26 , C07D239/36 , C07D241/24 , C07D295/088 , C07D403/04 , C07D403/12 , C07D413/04
摘要： Substituted pyridines, pyrimidines, pyrazines, pyridinones, pyrimidinones, pyrazinones and phenylacetamides useful in treating depression, stress and other disorders are disclosed. The compounds are of the formualae: Other embodiments are also disclosed.
摘要翻译： 公开了用于治疗抑郁症，压力和其它疾病的取代的吡啶，嘧啶，吡嗪，吡啶酮，嘧啶酮，吡嗪酮和苯乙酰胺。 化合物是形式：其他实施方案也被公开。
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公开(公告)号：US07365209B2
公开(公告)日：2008-04-29
申请号：US10775963
申请日：2004-02-10
申请人： Jeffrey John Letourneau , Vidyahar Paradkar , Michael H. J. Ohlmeyer , Lawrence W. Dillard , John J. Baldwin , Christopher Mark Riviello , Angela Wong , Yaing Rong
发明人： Jeffrey John Letourneau , Vidyahar Paradkar , Michael H. J. Ohlmeyer , Lawrence W. Dillard , John J. Baldwin , Christopher Mark Riviello , Angela Wong , Yaing Rong
IPC分类号： A61K31/405 , A01N43/38 , C07D235/00
CPC分类号： C07D215/38 , C07D235/30 , C07D277/82 , C07D401/12 , C07D403/12 , C07D405/12
摘要： Nitrogen heterocycle biaryls having a carboxylate terminus are useful for treating endometriosis, osteoporosis, restenosis following angioplasty, rheumatoid arthritis, cancer, macular degeneration and obesity.Compounds of formula: are disclosed. A representative example is
摘要翻译： 具有羧酸酯末端的氮杂环联芳烃可用于治疗子宫内膜异位症，骨质疏松症，血管成形术后的再狭窄，类风湿性关节炎，癌症，黄斑变性和肥胖症。 公开了式的化合物。 一个代表性的例子是
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公开(公告)号：US06380187B2
公开(公告)日：2002-04-30
申请号：US09730015
申请日：2000-12-05
申请人： Dingwei Tim Yu , Orest Taras Macina , Ila Sircar , Jagadish Chandra Sircar , Christopher Mark Riviello
发明人： Dingwei Tim Yu , Orest Taras Macina , Ila Sircar , Jagadish Chandra Sircar , Christopher Mark Riviello
IPC分类号： C07D41710
CPC分类号： C07D277/28
摘要： Disclosed is a novel class of thiazole, thiadiazole, and oxadiazole compounds which are substituted at their nuclear carbons by aromatic moieties. These compounds exhibit antifungal activity against a variety of fungi including strains which have proven to be resistant to treatment with known antifungal agents such as Fluconazole.
摘要翻译： 公开了一类新的噻唑，噻二唑和恶二唑化合物，它们在其核碳上被芳族部分取代。 这些化合物对各种真菌表现出抗真菌活性，包括已被证明对已知的抗真菌剂例如氟康唑的治疗具有抗性的菌株。
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5.发明授权
公开(公告)号：US6156776A
公开(公告)日：2000-12-05
申请号：US275863
申请日：1999-03-25
申请人： Dingwei Tim Yu , Orest Taras Macina , Ila Sircar , Jagadish Chandra Sircar , Christopher Mark Riviello
发明人： Dingwei Tim Yu , Orest Taras Macina , Ila Sircar , Jagadish Chandra Sircar , Christopher Mark Riviello
IPC分类号： C07D277/28 , A61K31/426
CPC分类号： C07D277/28
摘要： Disclosed is a novel class of thiazole, thiadiazole, and oxadiazole compounds which are substituted at their nuclear carbons by aromatic moieties. These compounds exhibit antifungal activity against a variety of fungi including strains which have proven to be resistant to treatment with known antifungal agents such as Fluconazole.
摘要翻译： 公开了一类新的噻唑，噻二唑和恶二唑化合物，它们在其核碳上被芳族部分取代。 这些化合物对各种真菌表现出抗真菌活性，包括已被证明对已知的抗真菌剂例如氟康唑的治疗具有抗性的菌株。
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公开(公告)号：US06281217B1
公开(公告)日：2001-08-28
申请号：US09729902
申请日：2000-12-05
申请人： Dingwei Tim Yu , Orest Taras Macina , Ila Sircar , Jagadish Chandra Sircar , Christopher Mark Riviello
发明人： Dingwei Tim Yu , Orest Taras Macina , Ila Sircar , Jagadish Chandra Sircar , Christopher Mark Riviello
IPC分类号： A61K31496
摘要： Disclosed is a novel class of thiazole, thiadiazole, and oxadiazole compounds which are substituted at their nuclear carbons by aromatic moieties. These compounds exhibit antifungal activity against a variety of fungi including strains which have proven to be resistant to treatment with known antifungal agents such as Fluconazole.
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公开(公告)号：US06277873B1
公开(公告)日：2001-08-21
申请号：US09729901
申请日：2000-12-05
申请人： Dingwei Tim Yu , Orest Taras Macina , Ila Sircar , Jagadish Chandra Sircar , Christopher Mark Riviello
发明人： Dingwei Tim Yu , Orest Taras Macina , Ila Sircar , Jagadish Chandra Sircar , Christopher Mark Riviello
IPC分类号： A61K314245
CPC分类号： C07D277/28
摘要： Disclosed is a novel class of thiazole, thiadiazole, and oxadiazole compounds which are substituted at their nuclear carbons by aromatic moieties. These compounds exhibit antifungal activity against a variety of fungi including strains which have proven to be resistant to treatment with known antifungal agents such as Fluconazole.
摘要翻译： 公开了一类新的噻唑，噻二唑和恶二唑化合物，它们在其核碳上被芳族部分取代。 这些化合物对各种真菌表现出抗真菌活性，包括已被证明对已知的抗真菌剂例如氟康唑的治疗具有抗性的菌株。
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