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公开(公告)号：US07465449B2
公开(公告)日：2008-12-16
申请号：US10507662
申请日：2003-03-13
IPC分类号： A61K39/395 , G01N33/53 , C07K16/28
CPC分类号： C07K16/2839 , A61K47/48507 , A61K47/48561 , A61K47/48623 , A61K47/68 , A61K47/6835 , A61K47/6849 , A61K47/6851 , A61K47/6865 , A61K51/1027 , A61K51/1066 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92 , G01N33/57492 , G01N33/6893 , G01N2333/70546 , G01N2800/085 , G01N2800/205
摘要： Monoclonal antibodies that specifically bind to M.96. Also included are methods of using these antibodies to treat mammals having or at risk of having 006-mediated diseases, or to diagnose % Qmediated diseases.
摘要翻译： 特异性结合M.96的单克隆抗体。 还包括使用这些抗体治疗具有或具有006介导的疾病的风险的哺乳动物或诊断％Q介导的疾病的方法。
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公开(公告)号：US20120251532A1
公开(公告)日：2012-10-04
申请号：US13443261
申请日：2012-04-10
IPC分类号： A61K39/395 , A61P17/06
CPC分类号： C07K16/2839 , A61K47/48507 , A61K47/48561 , A61K47/48623 , A61K47/68 , A61K47/6835 , A61K47/6849 , A61K47/6851 , A61K47/6865 , A61K51/1027 , A61K51/1066 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92 , G01N33/57492 , G01N33/6893 , G01N2333/70546 , G01N2800/085 , G01N2800/205
摘要： Monoclonal antibodies that specifically bind to M.96. Also included are methods of using these antibodies to treat mammals having or at risk of having 006-mediated diseases, or to diagnose % Qmediated diseases.
摘要翻译： 特异性结合M.96的单克隆抗体。 还包括使用这些抗体治疗具有或具有006介导的疾病的风险的哺乳动物或诊断％Q介导的疾病的方法。
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公开(公告)号：US08153126B2
公开(公告)日：2012-04-10
申请号：US12260510
申请日：2008-10-29
IPC分类号： A61K39/395
CPC分类号： C07K16/2839 , A61K47/48507 , A61K47/48561 , A61K47/48623 , A61K47/68 , A61K47/6835 , A61K47/6849 , A61K47/6851 , A61K47/6865 , A61K51/1027 , A61K51/1066 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92 , G01N33/57492 , G01N33/6893 , G01N2333/70546 , G01N2800/085 , G01N2800/205
摘要： Monoclonal antibodies that specifically bind to □v□□. Also included are methods of using these antibodies to treat mammals having or at risk of having □v□6-mediated diseases, or to diagnose □V□6-mediated diseases.
摘要翻译： 特异性结合□v□□的单克隆抗体。 还包括使用这些抗体治疗具有或有V□6介导的疾病或具有□v□6介导的疾病风险的哺乳动物或诊断□V□6介导的疾病的方法。
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公开(公告)号：US20090186036A1
公开(公告)日：2009-07-23
申请号：US12260510
申请日：2008-10-29
IPC分类号： A61K39/395
CPC分类号： C07K16/2839 , A61K47/48507 , A61K47/48561 , A61K47/48623 , A61K47/68 , A61K47/6835 , A61K47/6849 , A61K47/6851 , A61K47/6865 , A61K51/1027 , A61K51/1066 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92 , G01N33/57492 , G01N33/6893 , G01N2333/70546 , G01N2800/085 , G01N2800/205
摘要： Monoclonal antibodies that specifically bind to M.96. Also included are methods of using these antibodies to treat mammals having or at risk of having O06-mediated diseases, or to diagnose % Qmediated diseases.
摘要翻译： 特异性结合M.96的单克隆抗体。 还包括使用这些抗体来治疗具有O06介导的疾病或有O06介导的疾病的危险的哺乳动物的方法，或用于诊断％Q介导的疾病。
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公开(公告)号：US20080286269A1
公开(公告)日：2008-11-20
申请号：US11483190
申请日：2006-07-10
申请人： Shelia M. Violette , Louise A. Koopman , Kenneth J. Simon , Paul H. Weinreb , Herman W.T. van Vlijmen , Jose W. Saldanha , Alexey A. Lugovskoy
发明人： Shelia M. Violette , Louise A. Koopman , Kenneth J. Simon , Paul H. Weinreb , Herman W.T. van Vlijmen , Jose W. Saldanha , Alexey A. Lugovskoy
IPC分类号： A61K39/395 , C07K16/18 , C07H21/00 , A61P43/00 , G01N33/574 , C07K14/00
CPC分类号： C07K16/2839 , A61K2039/505 , A61K2039/545 , C07K16/30 , C07K2317/24 , C07K2317/41 , C07K2317/567 , C07K2317/76 , C07K2317/77 , G01N33/57407 , G01N33/57492 , G01N33/6893 , G01N2333/70546 , G01N2800/085 , G01N2800/12 , G01N2800/20 , G01N2800/347 , Y10S424/80 , Y10S424/801
摘要： The present invention is in the fields of cell biology, immunology and oncology. The invention provides humanized antibodies that recognize αvβ6 integrins, which antibodies comprise a variable region of nonhuman origin and at least a portion of an immunoglobulin of human origin. The invention also provides methods for preparation of such antibodies, pharmaceutical compositions comprising them, and methods of treating, diagnosing and/or preventing various diseases and disorders by administering the humanized anti-αvβ6 antibodies of the invention. The invention also relates to the identification of differential expression of the integrin αvβ6 on the surfaces of tumor cells and tissues, the use of this differential expression in determining the metastatic potential of tumor cells, and methods of diagnosis and treatment/prevention of tumor metastasis and for elimination of residual metastatic tumor cells using ligands, particularly antibodies, that bind to integrin αvβ6.
摘要翻译： 本发明涉及细胞生物学，免疫学和肿瘤学领域。 本发明提供识别α6β6E整联蛋白的人源化抗体，所述抗体包含非人来源的可变区和至少一部分人源免疫球蛋白。 本发明还提供了制备这种抗体的方法，包含它们的药物组合物，以及通过施用人源化抗α6β6来治疗，诊断和/或预防各种疾病和病症的方法 本发明的抗体。 本发明还涉及鉴定肿瘤细胞和组织表面上的整联蛋白α-β6-6的差异表达，该差异表达在确定转移性 肿瘤细胞的潜力，以及使用与整联蛋白α6β6结合的配体特别是抗体来诊断和治疗/预防肿瘤转移和消除残余转移性肿瘤细胞的方法， SUB>。
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公开(公告)号：US20110305629A1
公开(公告)日：2011-12-15
申请号：US13109168
申请日：2011-05-17
申请人： Shelia M. Violette , Louise A. Koopman , Kenneth J. Simon , Paul H. Weinreb , Herman W.T. van Vlijmen , Jose W. Saldanha , Alexey A. Lugovskoy
发明人： Shelia M. Violette , Louise A. Koopman , Kenneth J. Simon , Paul H. Weinreb , Herman W.T. van Vlijmen , Jose W. Saldanha , Alexey A. Lugovskoy
CPC分类号： C07K16/2839 , A61K2039/505 , A61K2039/545 , C07K16/30 , C07K2317/24 , C07K2317/41 , C07K2317/567 , C07K2317/76 , C07K2317/77 , G01N33/57407 , G01N33/57492 , G01N33/6893 , G01N2333/70546 , G01N2800/085 , G01N2800/12 , G01N2800/20 , G01N2800/347 , Y10S424/80 , Y10S424/801
摘要： The present invention is in the fields of cell biology, immunology and oncology. The invention provides humanized antibodies that recognize αvβ6 integrins, which antibodies comprise a variable region of nonhuman origin and at least a portion of an immunoglobulin of human origin. The invention also provides methods for preparation of such antibodies, pharmaceutical compositions comprising them, and methods of treating, diagnosing and/or preventing various diseases and disorders by administering the humanized anti-αvβ6 antibodies of the invention. The invention also relates to the identification of differential expression of the integrin αvβ6 on the surfaces of tumor cells and tissues, the use of this differential expression in determining the metastatic potential of tumor cells, and methods of diagnosis and treatment/prevention of tumor metastasis and for elimination of residual metastatic tumor cells using ligands, particularly antibodies, that bind to integrin αvβ6.
摘要翻译： 本发明涉及细胞生物学，免疫学和肿瘤学领域。 本发明提供识别αv和bgr6整联蛋白的人源化抗体，所述抗体包含非人来源的可变区和至少一部分人源免疫球蛋白。 本发明还提供了制备这些抗体的方法，包含它们的药物组合物，以及通过施用本发明的人源化抗αv和bgr6抗体来治疗，诊断和/或预防各种疾病和病症的方法。 本发明还涉及确定肿瘤细胞和组织表面的整合素αv和bgr6的差异表达，使用该差异表达来确定肿瘤细胞的转移潜能，以及诊断和治疗/预防肿瘤的方法 转移和消除残留的转移性肿瘤细胞，使用结合整联蛋白αv＆bgr的配体，特别是抗体。
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公开(公告)号：US08992924B2
公开(公告)日：2015-03-31
申请号：US13109168
申请日：2011-05-17
申请人： Shelia M. Violette , Louise A. Koopman , Kenneth J. Simon , Paul H. Weinreb , Herman W. T. van Vlijmen , Jose W. Saldanha , Alexey A. Lugovskoy
发明人： Shelia M. Violette , Louise A. Koopman , Kenneth J. Simon , Paul H. Weinreb , Herman W. T. van Vlijmen , Jose W. Saldanha , Alexey A. Lugovskoy
IPC分类号： A61K39/395 , C07K16/28 , C07K16/30 , G01N33/574 , G01N33/68 , C07K14/71 , C07K14/715 , A61K39/00
CPC分类号： C07K16/2839 , A61K2039/505 , A61K2039/545 , C07K16/30 , C07K2317/24 , C07K2317/41 , C07K2317/567 , C07K2317/76 , C07K2317/77 , G01N33/57407 , G01N33/57492 , G01N33/6893 , G01N2333/70546 , G01N2800/085 , G01N2800/12 , G01N2800/20 , G01N2800/347 , Y10S424/80 , Y10S424/801
摘要： The present invention is in the fields of cell biology, immunology and oncology. The invention provides humanized antibodies that recognize αvβ6 integrins, which antibodies comprise a variable region of nonhuman origin and at least a portion of an immunoglobulin of human origin. The invention also provides methods for preparation of such antibodies, pharmaceutical compositions comprising them, and methods of treating, diagnosing and/or preventing various diseases and disorders by administering the humanized anti-αvβ6 antibodies of the invention. The invention also relates to the identification of differential expression of the integrin αvβ6 on the surfaces of tumor cells and tissues, the use of this differential expression in determining the metastatic potential of tumor cells, and methods of diagnosis and treatment/prevention of tumor metastasis and for elimination of residual metastatic tumor cells using ligands, particularly antibodies, that bind to integrin αvβ6.
摘要翻译： 本发明涉及细胞生物学，免疫学和肿瘤学领域。 本发明提供识别αv和bgr6整联蛋白的人源化抗体，所述抗体包含非人来源的可变区和至少一部分人源免疫球蛋白。 本发明还提供了制备这些抗体的方法，包含它们的药物组合物，以及通过施用本发明的人源化抗αv和bgr6抗体来治疗，诊断和/或预防各种疾病和病症的方法。 本发明还涉及确定肿瘤细胞和组织表面的整合素αv和bgr6的差异表达，使用该差异表达来确定肿瘤细胞的转移潜能，以及诊断和治疗/预防肿瘤的方法 转移和消除残留的转移性肿瘤细胞，使用结合整联蛋白αv＆bgr的配体，特别是抗体。
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公开(公告)号：US07943742B2
公开(公告)日：2011-05-17
申请号：US11483190
申请日：2006-07-10
申请人： Shelia M. Violette , Louise A. Koopman , Kenneth J. Simon , Paul H. Weinreb , Herman W. T. van Vlijmen , Jose W. Saldanha , Alexey A. Lugovskoy
发明人： Shelia M. Violette , Louise A. Koopman , Kenneth J. Simon , Paul H. Weinreb , Herman W. T. van Vlijmen , Jose W. Saldanha , Alexey A. Lugovskoy
IPC分类号： C12P21/08 , C07K16/00 , A61K39/395 , C12P21/04
CPC分类号： C07K16/2839 , A61K2039/505 , A61K2039/545 , C07K16/30 , C07K2317/24 , C07K2317/41 , C07K2317/567 , C07K2317/76 , C07K2317/77 , G01N33/57407 , G01N33/57492 , G01N33/6893 , G01N2333/70546 , G01N2800/085 , G01N2800/12 , G01N2800/20 , G01N2800/347 , Y10S424/80 , Y10S424/801
摘要： The present invention is in the fields of cell biology, immunology and oncology. The invention provides humanized antibodies that recognize αvβ6 integrins, which antibodies comprise a variable region of nonhuman origin and at least a portion of an immunoglobulin of human origin. The invention also provides methods for preparation of such antibodies, pharmaceutical compositions comprising them, and methods of treating, diagnosing and/or preventing various diseases and disorders by administering the humanized anti-αvβ6 antibodies of the invention. The invention also relates to the identification of differential expression of the integrin αvβ6 on the surfaces of tumor cells and tissues, the use of this differential expression in determining the metastatic potential of tumor cells, and methods of diagnosis and treatment/prevention of tumor metastasis and for elimination of residual metastatic tumor cells using ligands, particularly antibodies, that bind to integrin αvβ6.
摘要翻译： 本发明涉及细胞生物学，免疫学和肿瘤学领域。 本发明提供识别αv和bgr6整联蛋白的人源化抗体，所述抗体包含非人来源的可变区和至少一部分人源免疫球蛋白。 本发明还提供了制备这些抗体的方法，包含它们的药物组合物，以及通过施用本发明的人源化抗αv和bgr6抗体来治疗，诊断和/或预防各种疾病和病症的方法。 本发明还涉及确定肿瘤细胞和组织表面的整合素αv和bgr6的差异表达，使用该差异表达来确定肿瘤细胞的转移潜能，以及诊断和治疗/预防肿瘤的方法 转移和消除残留的转移性肿瘤细胞，使用结合整联蛋白αv＆bgr的配体，特别是抗体。
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公开(公告)号：US09316641B2
公开(公告)日：2016-04-19
申请号：US13521311
申请日：2011-01-11
IPC分类号： C12Q1/70 , G01N33/569
CPC分类号： G01N33/56983 , G01N2333/025 , G01N2469/20 , G01N2800/50
摘要： The disclosure relates to methods and reagents for analyzing samples for the presence of JC virus antibodies. Disclosed is a method that includes obtaining a biological sample from a subject (e.g., plasma, serum, blood, urine, or cerebrospinal fluid), contacting the sample with highly purified viral-like particles (HPVLPs) under conditions suitable for binding of a JCV antibody in the sample to an HPVLP, and detecting the level of JCV antibody binding in the sample to HPVLP. In one embodiment, determining the level of anti-JCV antibodies in the subject sample provides a method of identifying PML risk in a subject.
摘要翻译： 本公开涉及用于分析样品存在JC病毒抗体的方法和试剂。 公开了一种方法，其包括从受试者（例如血浆，血清，血液，尿液或脑脊髓液）获得生物样品，在适合于结合JCV的条件下使样品与高度纯化的病毒样颗粒（HPVLP）接触 样品中的抗体与HPVLP的检测，并检测JCV抗体在样品中与HPVLP结合的水平。 在一个实施方案中，确定受试样品中抗JCV抗体的水平提供了在受试者中鉴定PML风险的方法。
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公开(公告)号：US20130022961A1
公开(公告)日：2013-01-24
申请号：US13521311
申请日：2011-01-11
CPC分类号： G01N33/56983 , G01N2333/025 , G01N2469/20 , G01N2800/50
摘要： The disclosure relates to methods and reagents for analyzing samples for the presence of JC virus antibodies. Disclosed is a method that includes obtaining a biological sample from a subject (e.g., plasma, serum, blood, urine, or cerebrospinal fluid), contacting the sample with highly purified viral-like particles (HPVLPs) under conditions suitable for binding of a JCV antibody in the sample to an HPVLP, and detecting the level of JCV antibody binding in the sample to HPVLP. In one embodiment, determining the level of anti-JCV antibodies in the subject sample provides a method of identifying PML risk in a subject.
摘要翻译： 本公开涉及用于分析样品存在JC病毒抗体的方法和试剂。 公开了一种方法，其包括从受试者（例如血浆，血清，血液，尿液或脑脊髓液）获得生物样品，在适合于结合JCV的条件下使样品与高度纯化的病毒样颗粒（HPVLP）接触 样品中的抗体与HPVLP的检测，并检测JCV抗体在样品中与HPVLP结合的水平。 在一个实施方案中，确定受试样品中抗JCV抗体的水平提供了在受试者中鉴定PML风险的方法。
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