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公开(公告)号：US07465449B2
公开(公告)日：2008-12-16
申请号：US10507662
申请日：2003-03-13
IPC分类号： A61K39/395 , G01N33/53 , C07K16/28
CPC分类号： C07K16/2839 , A61K47/48507 , A61K47/48561 , A61K47/48623 , A61K47/68 , A61K47/6835 , A61K47/6849 , A61K47/6851 , A61K47/6865 , A61K51/1027 , A61K51/1066 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92 , G01N33/57492 , G01N33/6893 , G01N2333/70546 , G01N2800/085 , G01N2800/205
摘要： Monoclonal antibodies that specifically bind to M.96. Also included are methods of using these antibodies to treat mammals having or at risk of having 006-mediated diseases, or to diagnose % Qmediated diseases.
摘要翻译： 特异性结合M.96的单克隆抗体。 还包括使用这些抗体治疗具有或具有006介导的疾病的风险的哺乳动物或诊断％Q介导的疾病的方法。
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公开(公告)号：US20120251532A1
公开(公告)日：2012-10-04
申请号：US13443261
申请日：2012-04-10
IPC分类号： A61K39/395 , A61P17/06
CPC分类号： C07K16/2839 , A61K47/48507 , A61K47/48561 , A61K47/48623 , A61K47/68 , A61K47/6835 , A61K47/6849 , A61K47/6851 , A61K47/6865 , A61K51/1027 , A61K51/1066 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92 , G01N33/57492 , G01N33/6893 , G01N2333/70546 , G01N2800/085 , G01N2800/205
摘要： Monoclonal antibodies that specifically bind to M.96. Also included are methods of using these antibodies to treat mammals having or at risk of having 006-mediated diseases, or to diagnose % Qmediated diseases.
摘要翻译： 特异性结合M.96的单克隆抗体。 还包括使用这些抗体治疗具有或具有006介导的疾病的风险的哺乳动物或诊断％Q介导的疾病的方法。
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公开(公告)号：US08153126B2
公开(公告)日：2012-04-10
申请号：US12260510
申请日：2008-10-29
IPC分类号： A61K39/395
CPC分类号： C07K16/2839 , A61K47/48507 , A61K47/48561 , A61K47/48623 , A61K47/68 , A61K47/6835 , A61K47/6849 , A61K47/6851 , A61K47/6865 , A61K51/1027 , A61K51/1066 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92 , G01N33/57492 , G01N33/6893 , G01N2333/70546 , G01N2800/085 , G01N2800/205
摘要： Monoclonal antibodies that specifically bind to □v□□. Also included are methods of using these antibodies to treat mammals having or at risk of having □v□6-mediated diseases, or to diagnose □V□6-mediated diseases.
摘要翻译： 特异性结合□v□□的单克隆抗体。 还包括使用这些抗体治疗具有或有V□6介导的疾病或具有□v□6介导的疾病风险的哺乳动物或诊断□V□6介导的疾病的方法。
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公开(公告)号：US20090186036A1
公开(公告)日：2009-07-23
申请号：US12260510
申请日：2008-10-29
IPC分类号： A61K39/395
CPC分类号： C07K16/2839 , A61K47/48507 , A61K47/48561 , A61K47/48623 , A61K47/68 , A61K47/6835 , A61K47/6849 , A61K47/6851 , A61K47/6865 , A61K51/1027 , A61K51/1066 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92 , G01N33/57492 , G01N33/6893 , G01N2333/70546 , G01N2800/085 , G01N2800/205
摘要： Monoclonal antibodies that specifically bind to M.96. Also included are methods of using these antibodies to treat mammals having or at risk of having O06-mediated diseases, or to diagnose % Qmediated diseases.
摘要翻译： 特异性结合M.96的单克隆抗体。 还包括使用这些抗体来治疗具有O06介导的疾病或有O06介导的疾病的危险的哺乳动物的方法，或用于诊断％Q介导的疾病。
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公开(公告)号：US20080286269A1
公开(公告)日：2008-11-20
申请号：US11483190
申请日：2006-07-10
申请人： Shelia M. Violette , Louise A. Koopman , Kenneth J. Simon , Paul H. Weinreb , Herman W.T. van Vlijmen , Jose W. Saldanha , Alexey A. Lugovskoy
发明人： Shelia M. Violette , Louise A. Koopman , Kenneth J. Simon , Paul H. Weinreb , Herman W.T. van Vlijmen , Jose W. Saldanha , Alexey A. Lugovskoy
IPC分类号： A61K39/395 , C07K16/18 , C07H21/00 , A61P43/00 , G01N33/574 , C07K14/00
CPC分类号： C07K16/2839 , A61K2039/505 , A61K2039/545 , C07K16/30 , C07K2317/24 , C07K2317/41 , C07K2317/567 , C07K2317/76 , C07K2317/77 , G01N33/57407 , G01N33/57492 , G01N33/6893 , G01N2333/70546 , G01N2800/085 , G01N2800/12 , G01N2800/20 , G01N2800/347 , Y10S424/80 , Y10S424/801
摘要： The present invention is in the fields of cell biology, immunology and oncology. The invention provides humanized antibodies that recognize αvβ6 integrins, which antibodies comprise a variable region of nonhuman origin and at least a portion of an immunoglobulin of human origin. The invention also provides methods for preparation of such antibodies, pharmaceutical compositions comprising them, and methods of treating, diagnosing and/or preventing various diseases and disorders by administering the humanized anti-αvβ6 antibodies of the invention. The invention also relates to the identification of differential expression of the integrin αvβ6 on the surfaces of tumor cells and tissues, the use of this differential expression in determining the metastatic potential of tumor cells, and methods of diagnosis and treatment/prevention of tumor metastasis and for elimination of residual metastatic tumor cells using ligands, particularly antibodies, that bind to integrin αvβ6.
摘要翻译： 本发明涉及细胞生物学，免疫学和肿瘤学领域。 本发明提供识别α6β6E整联蛋白的人源化抗体，所述抗体包含非人来源的可变区和至少一部分人源免疫球蛋白。 本发明还提供了制备这种抗体的方法，包含它们的药物组合物，以及通过施用人源化抗α6β6来治疗，诊断和/或预防各种疾病和病症的方法 本发明的抗体。 本发明还涉及鉴定肿瘤细胞和组织表面上的整联蛋白α-β6-6的差异表达，该差异表达在确定转移性 肿瘤细胞的潜力，以及使用与整联蛋白α6β6结合的配体特别是抗体来诊断和治疗/预防肿瘤转移和消除残余转移性肿瘤细胞的方法， SUB>。
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公开(公告)号：US20110305629A1
公开(公告)日：2011-12-15
申请号：US13109168
申请日：2011-05-17
申请人： Shelia M. Violette , Louise A. Koopman , Kenneth J. Simon , Paul H. Weinreb , Herman W.T. van Vlijmen , Jose W. Saldanha , Alexey A. Lugovskoy
发明人： Shelia M. Violette , Louise A. Koopman , Kenneth J. Simon , Paul H. Weinreb , Herman W.T. van Vlijmen , Jose W. Saldanha , Alexey A. Lugovskoy
CPC分类号： C07K16/2839 , A61K2039/505 , A61K2039/545 , C07K16/30 , C07K2317/24 , C07K2317/41 , C07K2317/567 , C07K2317/76 , C07K2317/77 , G01N33/57407 , G01N33/57492 , G01N33/6893 , G01N2333/70546 , G01N2800/085 , G01N2800/12 , G01N2800/20 , G01N2800/347 , Y10S424/80 , Y10S424/801
摘要： The present invention is in the fields of cell biology, immunology and oncology. The invention provides humanized antibodies that recognize αvβ6 integrins, which antibodies comprise a variable region of nonhuman origin and at least a portion of an immunoglobulin of human origin. The invention also provides methods for preparation of such antibodies, pharmaceutical compositions comprising them, and methods of treating, diagnosing and/or preventing various diseases and disorders by administering the humanized anti-αvβ6 antibodies of the invention. The invention also relates to the identification of differential expression of the integrin αvβ6 on the surfaces of tumor cells and tissues, the use of this differential expression in determining the metastatic potential of tumor cells, and methods of diagnosis and treatment/prevention of tumor metastasis and for elimination of residual metastatic tumor cells using ligands, particularly antibodies, that bind to integrin αvβ6.
摘要翻译： 本发明涉及细胞生物学，免疫学和肿瘤学领域。 本发明提供识别αv和bgr6整联蛋白的人源化抗体，所述抗体包含非人来源的可变区和至少一部分人源免疫球蛋白。 本发明还提供了制备这些抗体的方法，包含它们的药物组合物，以及通过施用本发明的人源化抗αv和bgr6抗体来治疗，诊断和/或预防各种疾病和病症的方法。 本发明还涉及确定肿瘤细胞和组织表面的整合素αv和bgr6的差异表达，使用该差异表达来确定肿瘤细胞的转移潜能，以及诊断和治疗/预防肿瘤的方法 转移和消除残留的转移性肿瘤细胞，使用结合整联蛋白αv＆bgr的配体，特别是抗体。
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公开(公告)号：US08992924B2
公开(公告)日：2015-03-31
申请号：US13109168
申请日：2011-05-17
申请人： Shelia M. Violette , Louise A. Koopman , Kenneth J. Simon , Paul H. Weinreb , Herman W. T. van Vlijmen , Jose W. Saldanha , Alexey A. Lugovskoy
发明人： Shelia M. Violette , Louise A. Koopman , Kenneth J. Simon , Paul H. Weinreb , Herman W. T. van Vlijmen , Jose W. Saldanha , Alexey A. Lugovskoy
IPC分类号： A61K39/395 , C07K16/28 , C07K16/30 , G01N33/574 , G01N33/68 , C07K14/71 , C07K14/715 , A61K39/00
CPC分类号： C07K16/2839 , A61K2039/505 , A61K2039/545 , C07K16/30 , C07K2317/24 , C07K2317/41 , C07K2317/567 , C07K2317/76 , C07K2317/77 , G01N33/57407 , G01N33/57492 , G01N33/6893 , G01N2333/70546 , G01N2800/085 , G01N2800/12 , G01N2800/20 , G01N2800/347 , Y10S424/80 , Y10S424/801
摘要： The present invention is in the fields of cell biology, immunology and oncology. The invention provides humanized antibodies that recognize αvβ6 integrins, which antibodies comprise a variable region of nonhuman origin and at least a portion of an immunoglobulin of human origin. The invention also provides methods for preparation of such antibodies, pharmaceutical compositions comprising them, and methods of treating, diagnosing and/or preventing various diseases and disorders by administering the humanized anti-αvβ6 antibodies of the invention. The invention also relates to the identification of differential expression of the integrin αvβ6 on the surfaces of tumor cells and tissues, the use of this differential expression in determining the metastatic potential of tumor cells, and methods of diagnosis and treatment/prevention of tumor metastasis and for elimination of residual metastatic tumor cells using ligands, particularly antibodies, that bind to integrin αvβ6.
摘要翻译： 本发明涉及细胞生物学，免疫学和肿瘤学领域。 本发明提供识别αv和bgr6整联蛋白的人源化抗体，所述抗体包含非人来源的可变区和至少一部分人源免疫球蛋白。 本发明还提供了制备这些抗体的方法，包含它们的药物组合物，以及通过施用本发明的人源化抗αv和bgr6抗体来治疗，诊断和/或预防各种疾病和病症的方法。 本发明还涉及确定肿瘤细胞和组织表面的整合素αv和bgr6的差异表达，使用该差异表达来确定肿瘤细胞的转移潜能，以及诊断和治疗/预防肿瘤的方法 转移和消除残留的转移性肿瘤细胞，使用结合整联蛋白αv＆bgr的配体，特别是抗体。
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公开(公告)号：US07943742B2
公开(公告)日：2011-05-17
申请号：US11483190
申请日：2006-07-10
申请人： Shelia M. Violette , Louise A. Koopman , Kenneth J. Simon , Paul H. Weinreb , Herman W. T. van Vlijmen , Jose W. Saldanha , Alexey A. Lugovskoy
发明人： Shelia M. Violette , Louise A. Koopman , Kenneth J. Simon , Paul H. Weinreb , Herman W. T. van Vlijmen , Jose W. Saldanha , Alexey A. Lugovskoy
IPC分类号： C12P21/08 , C07K16/00 , A61K39/395 , C12P21/04
CPC分类号： C07K16/2839 , A61K2039/505 , A61K2039/545 , C07K16/30 , C07K2317/24 , C07K2317/41 , C07K2317/567 , C07K2317/76 , C07K2317/77 , G01N33/57407 , G01N33/57492 , G01N33/6893 , G01N2333/70546 , G01N2800/085 , G01N2800/12 , G01N2800/20 , G01N2800/347 , Y10S424/80 , Y10S424/801
摘要： The present invention is in the fields of cell biology, immunology and oncology. The invention provides humanized antibodies that recognize αvβ6 integrins, which antibodies comprise a variable region of nonhuman origin and at least a portion of an immunoglobulin of human origin. The invention also provides methods for preparation of such antibodies, pharmaceutical compositions comprising them, and methods of treating, diagnosing and/or preventing various diseases and disorders by administering the humanized anti-αvβ6 antibodies of the invention. The invention also relates to the identification of differential expression of the integrin αvβ6 on the surfaces of tumor cells and tissues, the use of this differential expression in determining the metastatic potential of tumor cells, and methods of diagnosis and treatment/prevention of tumor metastasis and for elimination of residual metastatic tumor cells using ligands, particularly antibodies, that bind to integrin αvβ6.
摘要翻译： 本发明涉及细胞生物学，免疫学和肿瘤学领域。 本发明提供识别αv和bgr6整联蛋白的人源化抗体，所述抗体包含非人来源的可变区和至少一部分人源免疫球蛋白。 本发明还提供了制备这些抗体的方法，包含它们的药物组合物，以及通过施用本发明的人源化抗αv和bgr6抗体来治疗，诊断和/或预防各种疾病和病症的方法。 本发明还涉及确定肿瘤细胞和组织表面的整合素αv和bgr6的差异表达，使用该差异表达来确定肿瘤细胞的转移潜能，以及诊断和治疗/预防肿瘤的方法 转移和消除残留的转移性肿瘤细胞，使用结合整联蛋白αv＆bgr的配体，特别是抗体。
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9.发明申请公开(公告)号：US20150315267A1
公开(公告)日：2015-11-05
申请号：US14650200
申请日：2013-12-06
申请人： Thierry BUSSIERE , Paul H. WEINREB , Thomas ENGBER , Kenneth RHODES , Joseph ARNDT , Fang QIAN , Robert W. DUNSTAN , Shailendra PATEL , BIOGEN IDEC INTERNATIONAL NEUROSCIENCE GMBH , Neurimmune Holding AG
发明人： Thierry Bussiere , Paul H. Weinreb , Thomas Engber , Kenneth Rhodes , Joseph Arndt , Fang Qian , Robert W. Dunstan , Shailendra Patel , Jan Grimm , Marcel Maier
CPC分类号： C07K16/18 , A61K51/1018 , A61K51/1093 , A61K2039/505 , A61K2039/545 , C07K2299/00 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/92
摘要： This disclosure relates to the use of anti-Aβ antibody or antigen-binding fragment thereof to reduce brain amyloid plaques, or minimizes the occurrence of microhemorrhage during chronic dosing of an anti-Aβ antibody or antigen-binding fragment thereof. For example, the disclosure relates to the method of reducing brain amyloid plaques, comprising administering to a subject an anti-Aβ antibody or antigen-binding fragment thereof that binds to the same epitope as BIIB037 antibody, wherein the administration can reduce amyloid plaques in brain without affecting vascular amyloid, and wherein BIIB037 antibody binds to an epitope comprising amino acids 3-6 of Aβ.
摘要翻译： 本公开涉及抗A＆bgr的用途; 抗体或其抗原结合片段以减少脑淀粉样蛋白斑块，或者在慢性给药抗A药物期间最小化微出血的发生; 抗体或其抗原结合片段。 例如，本公开涉及减少脑淀粉样蛋白斑块的方法，包括向受试者施用抗Aβ抗体; 抗体或抗原结合片段，其结合与BIIB037抗体相同的表位，其中所述施用可以减少脑中的淀粉样蛋白斑，而不影响血管淀粉样蛋白，并且其中BIIB037抗体结合包含A＆bgr的氨基酸3-6的表位。
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公开(公告)号：US20090054632A1
公开(公告)日：2009-02-26
申请号：US11894745
申请日：2007-08-20
申请人： R. Blake Pepinsky , Alphonse Galdes , Ellen A. Garber , Darren P. Baker , Jeffery A. Porter , Frederick R. Taylor , Kevin P. Williams , Russell C. Petter , Kathryn Strauch , Paul H. Weinreb , Dingyi Wen , Chenhui Zeng
发明人： R. Blake Pepinsky , Alphonse Galdes , Ellen A. Garber , Darren P. Baker , Jeffery A. Porter , Frederick R. Taylor , Kevin P. Williams , Russell C. Petter , Kathryn Strauch , Paul H. Weinreb , Dingyi Wen , Chenhui Zeng
CPC分类号： C07K14/46 , A61K38/1709 , C07K2319/00
摘要： Hydrophobically-modified proteins and methods of making them are described. A hydrophobic moiety is attached to a surface amino acid residue of the protein. The hydrophobic moiety can be a lipid or a peptide. Alternatively, the protein can be derivatized by a wide variety of chemical reactions that append a hydrophobic structure to the protein. The preferred protein is of mammalian origin and is selected from the group consisting of Sonic, Indian, and Desert hedgehog. The hydrophobic moiety is used as a convenient tether to which may be attached a vesicle such as a cell membrane, liposome, or micelle.
摘要翻译： 描述了疏水性修饰的蛋白质及其制备方法。 疏水部分连接到蛋白质的表面氨基酸残基。 疏水部分可以是脂质或肽。 或者，蛋白质可以通过向蛋白质附加疏水结构的各种化学反应衍生化。 优选的蛋白质是哺乳动物来源的，并且选自Sonic，Indian和Desert hedgehog。 疏水部分用作方便的系链，其可以连接囊泡，例如细胞膜，脂质体或胶束。
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