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公开(公告)号：US08992924B2
公开(公告)日：2015-03-31
申请号：US13109168
申请日：2011-05-17
申请人： Shelia M. Violette , Louise A. Koopman , Kenneth J. Simon , Paul H. Weinreb , Herman W. T. van Vlijmen , Jose W. Saldanha , Alexey A. Lugovskoy
发明人： Shelia M. Violette , Louise A. Koopman , Kenneth J. Simon , Paul H. Weinreb , Herman W. T. van Vlijmen , Jose W. Saldanha , Alexey A. Lugovskoy
IPC分类号： A61K39/395 , C07K16/28 , C07K16/30 , G01N33/574 , G01N33/68 , C07K14/71 , C07K14/715 , A61K39/00
CPC分类号： C07K16/2839 , A61K2039/505 , A61K2039/545 , C07K16/30 , C07K2317/24 , C07K2317/41 , C07K2317/567 , C07K2317/76 , C07K2317/77 , G01N33/57407 , G01N33/57492 , G01N33/6893 , G01N2333/70546 , G01N2800/085 , G01N2800/12 , G01N2800/20 , G01N2800/347 , Y10S424/80 , Y10S424/801
摘要： The present invention is in the fields of cell biology, immunology and oncology. The invention provides humanized antibodies that recognize αvβ6 integrins, which antibodies comprise a variable region of nonhuman origin and at least a portion of an immunoglobulin of human origin. The invention also provides methods for preparation of such antibodies, pharmaceutical compositions comprising them, and methods of treating, diagnosing and/or preventing various diseases and disorders by administering the humanized anti-αvβ6 antibodies of the invention. The invention also relates to the identification of differential expression of the integrin αvβ6 on the surfaces of tumor cells and tissues, the use of this differential expression in determining the metastatic potential of tumor cells, and methods of diagnosis and treatment/prevention of tumor metastasis and for elimination of residual metastatic tumor cells using ligands, particularly antibodies, that bind to integrin αvβ6.
摘要翻译： 本发明涉及细胞生物学，免疫学和肿瘤学领域。 本发明提供识别αv和bgr6整联蛋白的人源化抗体，所述抗体包含非人来源的可变区和至少一部分人源免疫球蛋白。 本发明还提供了制备这些抗体的方法，包含它们的药物组合物，以及通过施用本发明的人源化抗αv和bgr6抗体来治疗，诊断和/或预防各种疾病和病症的方法。 本发明还涉及确定肿瘤细胞和组织表面的整合素αv和bgr6的差异表达，使用该差异表达来确定肿瘤细胞的转移潜能，以及诊断和治疗/预防肿瘤的方法 转移和消除残留的转移性肿瘤细胞，使用结合整联蛋白αv＆bgr的配体，特别是抗体。
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公开(公告)号：US07943742B2
公开(公告)日：2011-05-17
申请号：US11483190
申请日：2006-07-10
申请人： Shelia M. Violette , Louise A. Koopman , Kenneth J. Simon , Paul H. Weinreb , Herman W. T. van Vlijmen , Jose W. Saldanha , Alexey A. Lugovskoy
发明人： Shelia M. Violette , Louise A. Koopman , Kenneth J. Simon , Paul H. Weinreb , Herman W. T. van Vlijmen , Jose W. Saldanha , Alexey A. Lugovskoy
IPC分类号： C12P21/08 , C07K16/00 , A61K39/395 , C12P21/04
CPC分类号： C07K16/2839 , A61K2039/505 , A61K2039/545 , C07K16/30 , C07K2317/24 , C07K2317/41 , C07K2317/567 , C07K2317/76 , C07K2317/77 , G01N33/57407 , G01N33/57492 , G01N33/6893 , G01N2333/70546 , G01N2800/085 , G01N2800/12 , G01N2800/20 , G01N2800/347 , Y10S424/80 , Y10S424/801
摘要： The present invention is in the fields of cell biology, immunology and oncology. The invention provides humanized antibodies that recognize αvβ6 integrins, which antibodies comprise a variable region of nonhuman origin and at least a portion of an immunoglobulin of human origin. The invention also provides methods for preparation of such antibodies, pharmaceutical compositions comprising them, and methods of treating, diagnosing and/or preventing various diseases and disorders by administering the humanized anti-αvβ6 antibodies of the invention. The invention also relates to the identification of differential expression of the integrin αvβ6 on the surfaces of tumor cells and tissues, the use of this differential expression in determining the metastatic potential of tumor cells, and methods of diagnosis and treatment/prevention of tumor metastasis and for elimination of residual metastatic tumor cells using ligands, particularly antibodies, that bind to integrin αvβ6.
摘要翻译： 本发明涉及细胞生物学，免疫学和肿瘤学领域。 本发明提供识别αv和bgr6整联蛋白的人源化抗体，所述抗体包含非人来源的可变区和至少一部分人源免疫球蛋白。 本发明还提供了制备这些抗体的方法，包含它们的药物组合物，以及通过施用本发明的人源化抗αv和bgr6抗体来治疗，诊断和/或预防各种疾病和病症的方法。 本发明还涉及确定肿瘤细胞和组织表面的整合素αv和bgr6的差异表达，使用该差异表达来确定肿瘤细胞的转移潜能，以及诊断和治疗/预防肿瘤的方法 转移和消除残留的转移性肿瘤细胞，使用结合整联蛋白αv＆bgr的配体，特别是抗体。
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公开(公告)号：US20080286269A1
公开(公告)日：2008-11-20
申请号：US11483190
申请日：2006-07-10
申请人： Shelia M. Violette , Louise A. Koopman , Kenneth J. Simon , Paul H. Weinreb , Herman W.T. van Vlijmen , Jose W. Saldanha , Alexey A. Lugovskoy
发明人： Shelia M. Violette , Louise A. Koopman , Kenneth J. Simon , Paul H. Weinreb , Herman W.T. van Vlijmen , Jose W. Saldanha , Alexey A. Lugovskoy
IPC分类号： A61K39/395 , C07K16/18 , C07H21/00 , A61P43/00 , G01N33/574 , C07K14/00
CPC分类号： C07K16/2839 , A61K2039/505 , A61K2039/545 , C07K16/30 , C07K2317/24 , C07K2317/41 , C07K2317/567 , C07K2317/76 , C07K2317/77 , G01N33/57407 , G01N33/57492 , G01N33/6893 , G01N2333/70546 , G01N2800/085 , G01N2800/12 , G01N2800/20 , G01N2800/347 , Y10S424/80 , Y10S424/801
摘要： The present invention is in the fields of cell biology, immunology and oncology. The invention provides humanized antibodies that recognize αvβ6 integrins, which antibodies comprise a variable region of nonhuman origin and at least a portion of an immunoglobulin of human origin. The invention also provides methods for preparation of such antibodies, pharmaceutical compositions comprising them, and methods of treating, diagnosing and/or preventing various diseases and disorders by administering the humanized anti-αvβ6 antibodies of the invention. The invention also relates to the identification of differential expression of the integrin αvβ6 on the surfaces of tumor cells and tissues, the use of this differential expression in determining the metastatic potential of tumor cells, and methods of diagnosis and treatment/prevention of tumor metastasis and for elimination of residual metastatic tumor cells using ligands, particularly antibodies, that bind to integrin αvβ6.
摘要翻译： 本发明涉及细胞生物学，免疫学和肿瘤学领域。 本发明提供识别α6β6E整联蛋白的人源化抗体，所述抗体包含非人来源的可变区和至少一部分人源免疫球蛋白。 本发明还提供了制备这种抗体的方法，包含它们的药物组合物，以及通过施用人源化抗α6β6来治疗，诊断和/或预防各种疾病和病症的方法 本发明的抗体。 本发明还涉及鉴定肿瘤细胞和组织表面上的整联蛋白α-β6-6的差异表达，该差异表达在确定转移性 肿瘤细胞的潜力，以及使用与整联蛋白α6β6结合的配体特别是抗体来诊断和治疗/预防肿瘤转移和消除残余转移性肿瘤细胞的方法， SUB>。
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公开(公告)号：US20110305629A1
公开(公告)日：2011-12-15
申请号：US13109168
申请日：2011-05-17
申请人： Shelia M. Violette , Louise A. Koopman , Kenneth J. Simon , Paul H. Weinreb , Herman W.T. van Vlijmen , Jose W. Saldanha , Alexey A. Lugovskoy
发明人： Shelia M. Violette , Louise A. Koopman , Kenneth J. Simon , Paul H. Weinreb , Herman W.T. van Vlijmen , Jose W. Saldanha , Alexey A. Lugovskoy
CPC分类号： C07K16/2839 , A61K2039/505 , A61K2039/545 , C07K16/30 , C07K2317/24 , C07K2317/41 , C07K2317/567 , C07K2317/76 , C07K2317/77 , G01N33/57407 , G01N33/57492 , G01N33/6893 , G01N2333/70546 , G01N2800/085 , G01N2800/12 , G01N2800/20 , G01N2800/347 , Y10S424/80 , Y10S424/801
摘要： The present invention is in the fields of cell biology, immunology and oncology. The invention provides humanized antibodies that recognize αvβ6 integrins, which antibodies comprise a variable region of nonhuman origin and at least a portion of an immunoglobulin of human origin. The invention also provides methods for preparation of such antibodies, pharmaceutical compositions comprising them, and methods of treating, diagnosing and/or preventing various diseases and disorders by administering the humanized anti-αvβ6 antibodies of the invention. The invention also relates to the identification of differential expression of the integrin αvβ6 on the surfaces of tumor cells and tissues, the use of this differential expression in determining the metastatic potential of tumor cells, and methods of diagnosis and treatment/prevention of tumor metastasis and for elimination of residual metastatic tumor cells using ligands, particularly antibodies, that bind to integrin αvβ6.
摘要翻译： 本发明涉及细胞生物学，免疫学和肿瘤学领域。 本发明提供识别αv和bgr6整联蛋白的人源化抗体，所述抗体包含非人来源的可变区和至少一部分人源免疫球蛋白。 本发明还提供了制备这些抗体的方法，包含它们的药物组合物，以及通过施用本发明的人源化抗αv和bgr6抗体来治疗，诊断和/或预防各种疾病和病症的方法。 本发明还涉及确定肿瘤细胞和组织表面的整合素αv和bgr6的差异表达，使用该差异表达来确定肿瘤细胞的转移潜能，以及诊断和治疗/预防肿瘤的方法 转移和消除残留的转移性肿瘤细胞，使用结合整联蛋白αv＆bgr的配体，特别是抗体。
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5.发明申请HETERODIMERIC FC REGIONS, BINDING MOLECULES COMPRISING SAME, AND METHODS RELATING THERETO 有权杂交FC区域，包含其的结合分子以及与其相关的方法公开(公告)号：US20140341906A1
公开(公告)日：2014-11-20
申请号：US14232868
申请日：2012-07-13
申请人： Frederick R. Taylor , Justin A. Caravella , Alexey A. Lugovskoy , Amna Saeed-Kothe , Ellen A. Garber
发明人： Frederick R. Taylor , Justin A. Caravella , Alexey A. Lugovskoy , Amna Saeed-Kothe , Ellen A. Garber
IPC分类号： C07K16/18
CPC分类号： C07K16/18 , C07K16/00 , C07K2317/31 , C07K2317/522 , C07K2317/524 , C07K2317/53 , C07K2317/60 , C07K2317/66
摘要： The present invention features inter alia polypeptides comprising heterodimeric Fc regions. In addition, the instant invention provides methods for treating or preventing a disease or disorder in subject by administering the polypeptides of the invention to said subject.
摘要翻译： 本发明特别包括包含异二聚体Fc区的多肽。 此外，本发明提供了通过向所述受试者施用本发明的多肽来治疗或预防受试者的疾病或病症的方法。
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公开(公告)号：US20120157443A1
公开(公告)日：2012-06-21
申请号：US13393192
申请日：2010-09-03
申请人： Minna Bui , Patrick Conlon , Julio H. Cuervo , Daniel A. Erlanson , Junfa Fan , Bing Guan , Brian T. Hopkins , Tracy J. Jenkins , Gnanasambandam Kumaravel , Alexey A. Lugovskoy , Doug Marcotte , Noel Powell , Daniel Scott , Laura Silvian , Art Taveras , Deping Wang , Min Zhong
发明人： Minna Bui , Patrick Conlon , Julio H. Cuervo , Daniel A. Erlanson , Junfa Fan , Bing Guan , Brian T. Hopkins , Tracy J. Jenkins , Gnanasambandam Kumaravel , Alexey A. Lugovskoy , Doug Marcotte , Noel Powell , Daniel Scott , Laura Silvian , Art Taveras , Deping Wang , Min Zhong
IPC分类号： A61K31/553 , C07D487/04 , A61K31/519 , C07D401/04 , A61K31/506 , C07D473/34 , A61K31/52 , C07D417/14 , C07D413/12 , C07D401/14 , A61K31/55 , A61P37/06 , A61P29/00 , A61P35/00 , A61P35/02 , C12N9/99
CPC分类号： C07D487/14 , A61K31/519 , C07D401/04 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/34 , C07D487/04
摘要： The present invention provides compounds useful as inhibitors of Btk, compositions thereof, and methods of using the same.
摘要翻译： 本发明提供了可用作Btk抑制剂的化合物，其组合物及其使用方法。
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公开(公告)号：US08785440B2
公开(公告)日：2014-07-22
申请号：US13393192
申请日：2010-09-03
申请人： Minna Bui , Patrick Conlon , Julio H. Cuervo , Daniel A. Erlanson , Junfa Fan , Bing Guan , Brian T. Hopkins , Tracy J. Jenkins , Gnanasambandam Kumaravel , Alexey A. Lugovskoy , Doug Marcotte , Noel Powell , Daniel Scott , Laura Silvian , Art Taveras , Deping Wang , Min Zhong
发明人： Minna Bui , Patrick Conlon , Julio H. Cuervo , Daniel A. Erlanson , Junfa Fan , Bing Guan , Brian T. Hopkins , Tracy J. Jenkins , Gnanasambandam Kumaravel , Alexey A. Lugovskoy , Doug Marcotte , Noel Powell , Daniel Scott , Laura Silvian , Art Taveras , Deping Wang , Min Zhong
IPC分类号： A61K31/535
CPC分类号： C07D487/14 , A61K31/519 , C07D401/04 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/34 , C07D487/04
摘要： The present invention provides compounds useful as inhibitors of Btk, compositions thereof, and methods of using the same.
摘要翻译： 本发明提供了可用作Btk抑制剂的化合物，其组合物及其使用方法。
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8.发明授权公开(公告)号：US09738707B2
公开(公告)日：2017-08-22
申请号：US14232868
申请日：2012-07-13
申请人： Frederick R. Taylor , Justin A. Caravella , Alexey A. Lugovskoy , Amna Saeed-Kothe , Ellen A. Garber
发明人： Frederick R. Taylor , Justin A. Caravella , Alexey A. Lugovskoy , Amna Saeed-Kothe , Ellen A. Garber
CPC分类号： C07K16/18 , C07K16/00 , C07K2317/31 , C07K2317/522 , C07K2317/524 , C07K2317/53 , C07K2317/60 , C07K2317/66
摘要： The present invention features inter alia polypeptides comprising heterodimeric Fc regions. In addition, the instant invention provides methods for treating or preventing a disease or disorder in subject by administering the polypeptides of the invention to said subject.
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公开(公告)号：US20120003235A1
公开(公告)日：2012-01-05
申请号：US13141297
申请日：2009-12-31
申请人： Ann M. Ranger , Ellen Garber , Justin A. Caravella , Alexey A. Lugovskoy , Joseph Arndt , Frederick R. Taylor , Giovanna Antognetti , Eric Day
发明人： Ann M. Ranger , Ellen Garber , Justin A. Caravella , Alexey A. Lugovskoy , Joseph Arndt , Frederick R. Taylor , Giovanna Antognetti , Eric Day
IPC分类号： A61K39/395 , C12N15/13 , C12N15/63 , C12N1/21 , C12N1/19 , C12N5/10 , C12P21/00 , A61P29/00 , A61P19/02 , A61P25/00 , A61P17/06 , A61P3/10 , A61P9/10 , A61P35/00 , C07K16/24
CPC分类号： C07K14/5255 , A61K2039/505 , C07K16/242 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The instant invention is based, at least in part on the identification of a new class of antibodies that result, e.g., in improved LT blocking capabilities. Methods of making the subject binding molecules and methods of using the binding molecules of the invention to antagonize LTβR signaling are also provided.
摘要翻译： 本发明至少部分地基于导致例如改进的LT阻断能力的新类型的抗体的鉴定。 还提供了制备受试者结合分子的方法和使用本发明的结合分子拮抗LT＆bgr R信号的方法。
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