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公开(公告)号：US07939519B2
公开(公告)日：2011-05-10
申请号：US12024992
申请日：2008-02-01
申请人： Shifeng Pan , Wenqi Gao , Nathanael S Gray , Yuan Mi , Yi Fan
发明人： Shifeng Pan , Wenqi Gao , Nathanael S Gray , Yuan Mi , Yi Fan
IPC分类号： A61K31/397 , C07D205/00
CPC分类号： C07D205/04 , C07C251/48 , C07C251/52 , C07C251/54 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D207/16 , C07D211/60 , C07D213/30 , C07D213/53 , C07D213/61 , C07D217/04 , C07D295/06 , C07D307/10 , C07D307/12 , C07D307/52 , C07D333/12 , C07D333/16 , C07D333/22
摘要： The present invention relates to immunosuppressant, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG receptor mediated signal transduction.
摘要翻译： 本发明涉及免疫抑制剂，其生产方法及其用途和含有它们的药物组合物。 本发明提供了一类新颖的化合物，其可用于治疗或预防由淋巴细胞相互作用介导的疾病或病症，特别是与EDG受体介导的信号转导相关的疾病。
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公开(公告)号：US07462629B2
公开(公告)日：2008-12-09
申请号：US10849450
申请日：2004-05-19
申请人： Shifeng Pan , Nathanael S. Gray , Yuan Mi , Yi Fan , Wenqi Gao
发明人： Shifeng Pan , Nathanael S. Gray , Yuan Mi , Yi Fan , Wenqi Gao
IPC分类号： A61K31/4725 , A61K31/4035 , A61K31/397 , C07D217/12 , C07D209/44 , C07D205/12
CPC分类号： C07C323/32 , C07C317/32 , C07C2601/14 , C07D205/04
摘要： The present invention relates to immunosuppressant, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG receptor mediated signal transduction.
摘要翻译： 本发明涉及免疫抑制剂，其生产方法及其用途和含有它们的药物组合物。 本发明提供了一类新颖的化合物，其可用于治疗或预防由淋巴细胞相互作用介导的疾病或病症，特别是与EDG受体介导的信号转导相关的疾病。
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公开(公告)号：US20090036423A1
公开(公告)日：2009-02-05
申请号：US12024992
申请日：2008-02-01
申请人： Shifeng Pan , Wenqi Gao , Nathanael S. Gray , Yuan Mi , Yi Fan
发明人： Shifeng Pan , Wenqi Gao , Nathanael S. Gray , Yuan Mi , Yi Fan
IPC分类号： A61K31/192 , C07C207/00 , A61K31/397 , C07D205/04 , C07D213/55 , A61K31/44 , A61K31/445 , C07D211/60 , C07D307/02 , A61K31/34 , A61K31/381 , C07D333/22 , C07D207/04 , A61K31/40 , A61K31/472 , C07D217/00 , A61P29/00 , A61P37/00 , A61P9/00
CPC分类号： C07D205/04 , C07C251/48 , C07C251/52 , C07C251/54 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D207/16 , C07D211/60 , C07D213/30 , C07D213/53 , C07D213/61 , C07D217/04 , C07D295/06 , C07D307/10 , C07D307/12 , C07D307/52 , C07D333/12 , C07D333/16 , C07D333/22
摘要： The present invention relates to immunosuppressant, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG receptor mediated signal transduction.
摘要翻译： 本发明涉及免疫抑制剂，其生产方法及其用途和含有它们的药物组合物。 本发明提供了一类新颖的化合物，其可用于治疗或预防由淋巴细胞相互作用介导的疾病或病症，特别是与EDG受体介导的信号转导相关的疾病。
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公开(公告)号：US07256206B2
公开(公告)日：2007-08-14
申请号：US10776946
申请日：2004-02-11
申请人： Shifeng Pan , Nathanael S. Gray , Yuan Mi , Wenqi Gao , Yi Fan , Sophie Lefebvre
发明人： Shifeng Pan , Nathanael S. Gray , Yuan Mi , Wenqi Gao , Yi Fan , Sophie Lefebvre
IPC分类号： A61K31/421 , C07D263/30 , C07D261/06
CPC分类号： C07D213/30 , C07C251/48 , C07C251/52 , C07C251/54 , C07D307/42 , C07D333/16 , C07F9/094 , C07F9/655345
摘要： The present invention relates to bicyclic derivatives, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG/S1P receptor mediated signal transduction.
摘要翻译： 本发明涉及双环衍生物，其制备方法及其用途和含有它们的药物组合物。 本发明提供了一类新颖的化合物，其可用于治疗或预防由淋巴细胞相互作用介导的疾病或病症，特别是与EDG / S1P受体介导的信号转导相关的疾病。
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公开(公告)号：US20090221547A1
公开(公告)日：2009-09-03
申请号：US12063804
申请日：2006-08-22
申请人： Wenqi Gao , Yongqin Wan , Jiqing Jiang , Yi Fan , Nathanael S. Gray , Shifeng Pan
发明人： Wenqi Gao , Yongqin Wan , Jiqing Jiang , Yi Fan , Nathanael S. Gray , Shifeng Pan
IPC分类号： A61K31/397 , C07D213/79 , A61K31/44 , C07D233/54 , A61K31/4164 , C07D213/02 , C07D401/02 , A61K31/4439 , C07D417/02 , A61K31/4436 , C07D239/02 , A61K31/505 , C07D241/10 , A61K31/4965 , A61P37/06 , A61P29/00 , A61P35/00
CPC分类号： C07D213/79 , C07D209/12 , C07D213/54 , C07D213/80 , C07D213/81 , C07D213/84 , C07D213/86 , C07D213/89 , C07D231/12 , C07D233/90 , C07D239/28 , C07D239/30 , C07D241/24 , C07D277/56 , C07D401/04 , C07D401/06 , C07D413/04 , C07D417/12
摘要： The present invention relates to immunosuppressants, processes for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG receptor mediated signal transduction. This application relates to compounds selected from Formula (Ia), (Ib), (Ic) and (Id).
摘要翻译： 本发明涉及免疫抑制剂，其制备方法及其用途和含有它们的药物组合物。 本发明提供了一类新颖的化合物，其可用于治疗或预防由淋巴细胞相互作用介导的疾病或病症，特别是与EDG受体介导的信号转导相关的疾病。 本申请涉及选自式（Ia），（Ib），（Ic）和（Id）的化合物。
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公开(公告)号：US20050014728A1
公开(公告)日：2005-01-20
申请号：US10849323
申请日：2004-05-19
申请人： Shifeng Pan , Wenqi Gao , Nathanael Gray , Yuan Mi , Yi Fan
发明人： Shifeng Pan , Wenqi Gao , Nathanael Gray , Yuan Mi , Yi Fan
IPC分类号： A41H43/04 , A61K20060101 , A61K31/135 , A61K31/195 , A61K31/41 , A61K31/66 , B29C65/50 , C07D211/28 , C07F9/28 , D06H5/00
CPC分类号： C07D205/04 , C07C251/48 , C07C251/52 , C07C251/54 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D207/16 , C07D211/60 , C07D213/30 , C07D213/53 , C07D213/61 , C07D217/04 , C07D295/06 , C07D307/10 , C07D307/12 , C07D307/52 , C07D333/12 , C07D333/16 , C07D333/22
摘要： The present invention relates to immunosuppressant, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG receptor mediated signal transduction.
摘要翻译： 本发明涉及免疫抑制剂，其生产方法及其用途和含有它们的药物组合物。 本发明提供了一类新颖的化合物，其可用于治疗或预防由淋巴细胞相互作用介导的疾病或病症，特别是与EDG受体介导的信号转导相关的疾病。
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公开(公告)号：US07417065B2
公开(公告)日：2008-08-26
申请号：US10849458
申请日：2004-05-19
申请人： Yuan Mi , Shifeng Pan , Nathanael Schiander Gray , Wenqi Gao , Yi Fan , Tao Jiang
发明人： Yuan Mi , Shifeng Pan , Nathanael Schiander Gray , Wenqi Gao , Yi Fan , Tao Jiang
IPC分类号： A61K31/381 , C07D333/62
CPC分类号： C07D333/58 , C07D261/20 , C07D409/06 , C07D471/04 , C07D473/00 , C07D513/04
摘要： The present invention relates to immunosuppressant, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG receptor mediated signal transduction.
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公开(公告)号：US20090131400A1
公开(公告)日：2009-05-21
申请号：US12180479
申请日：2008-07-25
申请人： Yuan Mi , Shifeng Pan , Nathanael Schiander Gray , Wenqi Gao , Yi Fan , Tao Jiang
发明人： Yuan Mi , Shifeng Pan , Nathanael Schiander Gray , Wenqi Gao , Yi Fan , Tao Jiang
IPC分类号： A61K31/397 , C07D333/50 , A61K31/381 , C07D409/02 , A61K31/4535 , C07D495/02 , A61K31/4365
CPC分类号： C07D333/58 , C07D261/20 , C07D409/06 , C07D471/04 , C07D473/00 , C07D513/04
摘要： The present invention relates to immunosuppressant, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG receptor mediated signal transduction.
摘要翻译： 本发明涉及免疫抑制剂，其生产方法及其用途和含有它们的药物组合物。 本发明提供了一类新颖的化合物，其可用于治疗或预防由淋巴细胞相互作用介导的疾病或病症，特别是与EDG受体介导的信号转导相关的疾病。
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公开(公告)号：US07750021B2
公开(公告)日：2010-07-06
申请号：US12180479
申请日：2008-07-25
申请人： Yuan Mi , Shifeng Pan , Nathanael Schiander Gray , Wenqi Gao , Yi Fan , Tao Jiang
发明人： Yuan Mi , Shifeng Pan , Nathanael Schiander Gray , Wenqi Gao , Yi Fan , Tao Jiang
IPC分类号： A61K31/343 , A61K31/352 , A61K31/396 , A61K31/4035 , A61K31/404 , A61K31/416 , A61K31/423 , A61K31/428 , A61K31/4365 , A61K31/437 , C07D263/56 , C07D277/64 , C07D231/56 , C07D209/04 , C07D513/04 , C07D493/04
CPC分类号： C07D333/58 , C07D261/20 , C07D409/06 , C07D471/04 , C07D473/00 , C07D513/04
摘要： The present invention relates to immunosuppressant, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG receptor mediated signal transduction.
摘要翻译： 本发明涉及免疫抑制剂，其生产方法及其用途和含有它们的药物组合物。 本发明提供了一类新颖的化合物，其可用于治疗或预防由淋巴细胞相互作用介导的疾病或病症，特别是与EDG受体介导的信号转导相关的疾病。
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公开(公告)号：US20050014725A1
公开(公告)日：2005-01-20
申请号：US10849458
申请日：2004-05-19
申请人： Yuan Mi , Shifeng Pan , Nathanael Gray , Wenqi Gao , Yi Fan , Tao Jiang
发明人： Yuan Mi , Shifeng Pan , Nathanael Gray , Wenqi Gao , Yi Fan , Tao Jiang
IPC分类号： A61K31/185 , A61K31/195 , A61K31/41 , A61K31/66 , A61K31/675 , C07D333/60 , C07F9/28
CPC分类号： C07D333/58 , C07D261/20 , C07D409/06 , C07D471/04 , C07D473/00 , C07D513/04
摘要： The present invention relates to immunosuppressant, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG receptor mediated signal transduction.
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