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    Methods for inducing cell death in pluripotent stem cells and differentiated cells other than cardiac myocytes
    4.
    发明授权
    Methods for inducing cell death in pluripotent stem cells and differentiated cells other than cardiac myocytes 有权
    在多能干细胞和心肌细胞以外的分化细胞中诱导细胞死亡的方法

    公开(公告)号：US08735152B2

    公开(公告)日：2014-05-27

    申请号：US13260224

    申请日：2010-03-29

    申请人： Fumiyuki Hattori ,  Keiichi Fukuda

    发明人： Fumiyuki Hattori ,  Keiichi Fukuda

    IPC分类号： C12N5/00 ,  C12N5/02

    CPC分类号： C12N5/0657 ,  C12N5/0081 ,  C12N5/0696 ,  C12N2501/90 ,  C12N2506/02

    摘要： The present invention has as its object developing a method that does not involve genomic modification and which yet is capable of inducing cell death in pluripotent stem cells such as embryonic stem cells and induced pluripotent stem cells, as well as in differentiated cells other than cardiomyocytes derived from pluripotent stem cells, but not in cardiomyocytes. It has been revealed that by establishing a method capable of inducing cell death in cells other than cardiomyocytes in a very efficient manner by adding a substance having no recognized inherent toxicity or cell death inducing action to the culture conditions for pluripotent stem cells and non-cardiomyocytes, the stated problem can be solved without relying upon genomic modification.

    摘要翻译： 本发明的目的是开发一种不涉及基因组修饰并且能够在多能干细胞如胚胎干细胞和诱导的多能干细胞以及除了心肌细胞以外的分化细胞中诱导细胞死亡的方法 来自多能干细胞，但不在心肌细胞中。 已经揭示出，通过向多能干细胞和非心肌细胞的培养条件中加入不具有公认的固有毒性或细胞死亡诱导作用的物质，通过建立能够以非常有效的方式在除心肌细胞之外的细胞中诱导细胞死亡的方法 所述问题可以解决而不依赖于基因组修饰。

    THERAPEUTIC AGENTS FOR MUSCULAR DYSTROPHY
    5.
    发明申请
    THERAPEUTIC AGENTS FOR MUSCULAR DYSTROPHY 审中-公开
    用于肌肉晶状体的治疗剂

    公开(公告)号：US20130302272A1

    公开(公告)日：2013-11-14

    申请号：US13988255

    申请日：2011-11-17

    申请人： Keiichi Fukuda ,  Shinsuke Yuasa

    发明人： Keiichi Fukuda ,  Shinsuke Yuasa

    IPC分类号： A61K38/19

    CPC分类号： A61K38/193

    摘要： The present invention provides therapeutic agents for diseases associated with skeletal muscle degeneration comprising a granulocyte colony-stimulating factor (G-CSF) as an active ingredient. The therapeutic agents of the present invention are especially effective as therapeutic agents for muscular dystrophy.

    摘要翻译： 本发明提供与骨骼肌变性相关的疾病的治疗剂，其包含粒细胞集落刺激因子（G-CSF）作为活性成分。 本发明的治疗剂作为肌营养不良症的治疗剂是特别有效的。

    Methods of recruiting fibroblasts by administering G-CSF
    8.
    发明授权
    Methods of recruiting fibroblasts by administering G-CSF 有权
    通过给予G-CSF募集成纤维细胞的方法

    公开(公告)号：US07531510B2

    公开(公告)日：2009-05-12

    申请号：US10577241

    申请日：2004-10-27

    申请人： Keiichi Fukuda ,  Jun Fujita

    发明人： Keiichi Fukuda ,  Jun Fujita

    IPC分类号： A61K38/00 ,  A61K45/00

    CPC分类号： A61K38/193

    摘要： The object of the present invention is to achieve simple recruitment of fibroblasts into wounded tissues and engraftment of the fibroblasts in the wounded tissues, thereby healing the wounds without requiring fibroblast transplantation. Upon G-CSF administration, fibroblasts migrate into myocardial infarct lesions and prevent a reduction in cardiac function, thus alleviating cardiac remodeling.

    摘要翻译： 本发明的目的是实现将伤口组织中的成纤维细胞简单地募集到受伤组织中的成纤维细胞，从而使伤口愈合而不需要成纤维细胞移植。 在G-CSF施用后，成纤维细胞迁移到心肌梗塞病变中并防止心脏功能的降低，从而减轻心脏重塑。

    Method of Selecting a Cardiomyoctye Using Intracellular Mitochondria as an Indicator
    9.
    发明申请
    Method of Selecting a Cardiomyoctye Using Intracellular Mitochondria as an Indicator 有权
    使用细胞内线粒体作为指标选择心肌细胞的方法

    公开(公告)号：US20080090266A1

    公开(公告)日：2008-04-17

    申请号：US11660581

    申请日：2005-08-26

    申请人： Fumiyuki Hattori ,  Keiichi Fukuda

    发明人： Fumiyuki Hattori ,  Keiichi Fukuda

    IPC分类号： C12Q1/02 ,  C12N5/00 ,  C12N5/02

    CPC分类号： C12N5/0657 ,  C12N2506/02 ,  G01N33/56966

    摘要： The invention relates to methods of selecting a cardiomyocyte from a cell population derived from a whole heart or a differentiated cell population derived from a stem cell without genetic alteration. Specifically, the invention relates to a method of selecting a cardiomyocyte from a cardiomyocyte-containing cell mixture without genetic alteration of a cardiomyocyte, on the basis of a relative content of cellular mitochondria and/or a relative mitochondrial transmembrane potential of the cell. The invention also relates to methods of enriching a cardiomyocyte from a cardiomyocyte-containing cell mixture without genetic alteration of a cardiomyocyte, producing a cardiomyocyte without genetic alteration of a cardiomyocyte, and evaluating the ratio of a cardiomyocyte in a cardiomyocyte-containing cell mixture.

    摘要翻译： 本发明涉及从源自全部心脏的细胞群体或源自干细胞的分化细胞群体中选择心肌细胞而不进行遗传改变的方法。 具体地说，本发明涉及一种基于细胞线粒体的相对含量和/或细胞的相对线粒体跨膜电位从含有心肌细胞的细胞混合物中选择心肌细胞而不对心肌细胞进行遗传改变的方法。 本发明还涉及从含有心肌细胞的细胞混合物中丰富心肌细胞的方法，而没有心肌细胞的遗传改变，产生心肌细胞而没有心肌细胞的遗传改变，以及评估心肌细胞含有心​​肌细胞的细胞混合物中的比例。

    Contents data transmission/reception system, contents data transmitter, contents data receiver and contents data transmission/reception method
    10.
    发明授权
    Contents data transmission/reception system, contents data transmitter, contents data receiver and contents data transmission/reception method 有权
    内容数据发送/接收系统，内容数据发送器，内容数据接收器和内容数据发送/接收方法

    公开(公告)号：US07213156B2

    公开(公告)日：2007-05-01

    申请号：US10400491

    申请日：2003-03-28

    申请人： Keiichi Fukuda

    发明人： Keiichi Fukuda

    IPC分类号： H04L9/32

    CPC分类号： H04N21/4367 ,  H04N7/163 ,  H04N7/1675 ,  H04N21/4405 ,  H04N21/4408

    摘要： An object of the invention is to prevent original high quality contents data from being illegally obtained by extracting encryption breaking information from data transmitted through a single signal line for connecting two apparatuses and by using the encryption breaking information to decrypt encrypted contents data. In a contents data transmission/reception system, a contents data transmitter encrypts contents data by using key information, transmits the key information through plural signal lines to a contents data receiver, and then, transmits the encrypted contents data through the plural signal lines to the contents data receiver. The contents data receiver acquires the key information from data transmitted from the contents data transmitter through the plural signal lines, receives the encrypted contents data transmitted from the contents data transmitter through the plural signal lines, and decrypts the encrypted contents data by using the key information.

    摘要翻译： 本发明的目的是通过从通过用于连接两个装置的单个信号线发送的数据提取加密分解信息，并且通过使用加密分解信息来解密加密的内容数据来防止原始的高质量内容数据被非法获得。 在内容数据发送/接收系统中，内容数据发送器通过使用密钥信息来加密内容数据，通过多个信号线将密钥信息发送到内容数据接收机，然后通过多个信号线将加密的内容数据发送到 内容数据接收器。 内容数据接收器从通过多条信号线从内容数据发送机发送的数据中获取密钥信息，通过多条信号线接收从内容数据发送机发送的加密内容数据，并通过使用密钥信息对加密的内容数据进行解密 。