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公开(公告)号：US4670584A
公开(公告)日：1987-06-02
申请号：US873852
申请日：1986-06-10
IPC分类号： A61K38/28 , A61K45/06 , A61K47/18 , C07K5/065 , C07C101/08
CPC分类号： A61K47/183 , A61K38/28 , A61K45/06 , C07K5/06078
摘要： An absorption promoter is disclosed which interacts with hydrophobic amino acid residues of polypeptide derivative medications and substantially increases the absorption of that medication administered orally or rectally. The promoter and medication can be compounded into unit dosages in capsule, tablet, or suppository form, or combined into elixir solutions, suspensions, etc. The absorption promoters are phenylalanine derivatives which may be prepared through conventional N-acylation techniques.
摘要翻译： 公开了吸收促进剂，其与多肽衍生物药物的疏水性氨基酸残基相互作用，并且基本上增加了口服或直肠给药的药物的吸收。 启动子和药物可以复合成胶囊，片剂或栓剂形式的单位剂量，或组合成酏剂溶液，悬浮液等。吸收促进剂是可以通过常规N-酰化技术制备的苯丙氨酸衍生物。
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公开(公告)号：US4650785A
公开(公告)日：1987-03-17
申请号：US690839
申请日：1985-01-14
IPC分类号： A61K31/195 , A61K38/28 , A61K45/06 , A61K47/18 , A61K37/26
CPC分类号： A61K38/28 , A61K45/06 , A61K47/183
摘要： A compound represented by the formula: ##STR1## wherein R.sup.1 is a hydrogen atom, a fluorine atom, a nitro group, a hydroxyl group or a hydroxyl group protected by an esterifying group; X is CO or SO.sub.2 ; --Y-- is a straight bond, a lower alkylene group, a substituted or unsubstituted vinylene group, or group having the formula --CH.sub.2 --O-- or --O--CH.sub.2 --; R.sup.2 is a substituted or unsubstituted phenyl or naphthyl group, or R.sup.2 --Y--CO is N-benzyloxycarbonylphenylalanyl, N-benzyloxycarbonyl-4-fluorophenylalanyl or N-(m-methoxycinnamoyl)-phenylalanyl group; or a non-toxic salt thereof is disclosed along with pharmaceutical compositions containing these compounds and methods of using these compositions to increase the rate of absorption of medicines.
摘要翻译： 由下式表示的化合物：其中R1是氢原子，氟原子，硝基，羟基或被酯化基保护的羟基; X是CO或SO2; -Y-是直链，低级亚烷基，取代或未取代的亚乙烯基，或具有式-CH 2 -O-或-O-CH 2 - 的基团; R2是取代或未取代的苯基或萘基，或R2-Y-CO是N-苄氧基羰基苯丙氨酰，N-苄氧羰基-4-氟苯丙氨酰或N-（间甲氧基肉桂酰）苯丙氨酰基; 或其无毒盐以及包含这些化合物的药物组合物以及使用这些组合物增加药物吸收速率的方法。
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公开(公告)号：US4774259A
公开(公告)日：1988-09-27
申请号：US125572
申请日：1987-11-25
申请人： Koji Fukushima , Yoshiko Seto , Kazuhiro Kawada , Koji Toi , Izumi Kumashiro
发明人： Koji Fukushima , Yoshiko Seto , Kazuhiro Kawada , Koji Toi , Izumi Kumashiro
IPC分类号： A61K38/28 , A61K31/195 , A61K47/16 , C07C233/12 , C07C233/51
CPC分类号： A61K31/195 , C07C233/12
摘要： The invention provides a phenylalanine derivative having the structural formula: ##STR1## and salts thereof. The derivatives and salts are useful for promoting the absorption of medicaments such as insulin.
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公开(公告)号：US4714713A
公开(公告)日：1987-12-22
申请号：US901364
申请日：1986-08-28
申请人： Koji Fukushima , Yoshiko Seto , Kazuhiro Kawada , Koji Toi , Izumi Kumashiro
发明人： Koji Fukushima , Yoshiko Seto , Kazuhiro Kawada , Koji Toi , Izumi Kumashiro
IPC分类号： A61K38/28 , A61K31/195 , A61K47/16 , C07C233/12 , C07C233/51
CPC分类号： A61K31/195 , C07C233/12
摘要： The invention provides a phenylalanine derivative having the structural formula: ##STR1## and salts thereof. The derivatives and salts are useful for promoting the absorption of medicaments such as insulin.
摘要翻译： 本发明提供具有以下结构式的苯丙氨酸衍生物及其盐。 衍生物和盐可用于促进胰岛素等药物的吸收。
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5.发明授权Toner for full-color image formation, developer composition, and method of forming multicolor image 失效用于全色图像形成的调色剂，显影剂组合物和形成多色图像的方法
公开(公告)号：US5738962A
公开(公告)日：1998-04-14
申请号：US730936
申请日：1996-10-16
申请人： Masanori Ichimura , Hiroshi Takano , Masaki Hashimoto , Hideyuki Akagi , Kazuya Furuta , Koji Fukushima
发明人： Masanori Ichimura , Hiroshi Takano , Masaki Hashimoto , Hideyuki Akagi , Kazuya Furuta , Koji Fukushima
CPC分类号： G03G9/0819 , G03G13/013 , G03G9/09
摘要： The toner for full-color image formation of the invention comprises a binder resin and a colorant, wherein the toner has a volume-average particle diameter of from 3.0 to 9.0 .mu.m and satisfies relationship (1) between the volume-average particle diameter and a colorant content thereof: 11.0/R.ltoreq.C.ltoreq.21.5/R (1) wherein R is 1/2 of the volume-average particle diameter of the toner (.mu.m) and C is the colorant content of the toner (wt %). This toner for full-color image formation is used to conduct development in such a manner that the toner amount transferred to the receiving paper satisfies relationship (2): 0.116R.ltoreq.TMA.ltoreq..ltoreq.0.0223R (2) wherein R is 1/2 of the volume-average particle diameter of the toner (.mu.m) and TMA is the weight of the toner (mg/cm.sup.2) transferred to the receiving paper in a monochromatic solid part thereof.
摘要翻译： 本发明的全色图像形成用调色剂包括粘合剂树脂和着色剂，其中调色剂的体积平均粒径为3.0〜9.0μm，并且满足体积平均粒径与 其着色剂含量为：11.0 / R C = 21.5 / R（1）其中R是调色剂的体积平均粒径（μm）的C + E， 调色剂的着色剂含量（重量％）。 用于全色图像形成的这种调色剂用于进行显影，使得转印到接收纸的调色剂量满足关系式（2）：0.116R≤TMA
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公开(公告)号：US5529871A
公开(公告)日：1996-06-25
申请号：US276488
申请日：1994-07-18
申请人： Masanori Ichimura , Hiroshi Takayama , Michio Take , Hideyuki Akagi , Takashi Imai , Satoshi Inoue , Yasuo Yamamoto , Yutaka Sugizaki , Koji Fukushima , Masayuki Takei , Masaru Miura
发明人： Masanori Ichimura , Hiroshi Takayama , Michio Take , Hideyuki Akagi , Takashi Imai , Satoshi Inoue , Yasuo Yamamoto , Yutaka Sugizaki , Koji Fukushima , Masayuki Takei , Masaru Miura
CPC分类号： G03G9/0804 , G03G9/081 , G03G9/09 , G03G9/0906
摘要： A color toner providing a toner image excellent in brightness, clearness and graininess and a process for producing the same are disclosed, wherein a proportion of dispersed pigment particles having a circle-equivalent diameter of 0.3 .mu.m or greater does not exceed 0.1% of the total number of said dispersed pigment particles. The process comprises kneading a water-containing pigment paste and a binder resin at a temperature of 100.degree. C. or higher under pressure in a heat and pressure kneader to remove a water content to obtain a pigment dispersion, melt-kneading the resulting pigment dispersion together with a binder resin, and grinding the mixture.
摘要翻译： 本发明提供一种提供亮度，清晰度和颗粒度优异的调色剂图像的彩色调色剂，其中，当量圆直径为0.3μm以上的分散颜料颗粒的比例不超过0.1μm 所述分散的颜料颗粒的总数。 该方法包括在100℃或更高的温度下在加压和捏合机中捏合含水颜料糊和粘合剂树脂以除去水分，得到颜料分散体，将得到的颜料分散体 与粘合剂树脂一起研磨混合物。
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公开(公告)号：US5175005A
公开(公告)日：1992-12-29
申请号：US416066
申请日：1989-10-02
CPC分类号： A61K38/005 , Y10S530/851
摘要： A method of controlling tumor cell metastasis comprising administering to a human a therapeutically effective amount of a ribonuclease inhibitor.
摘要翻译： 一种控制肿瘤细胞转移的方法，包括给予人治疗有效量的核糖核酸酶抑制剂。
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公开(公告)号：US4263881A
公开(公告)日：1981-04-28
申请号：US969319
申请日：1978-12-14
申请人： Hiroshi Isobe , Masao Yoshino , Koji Fukushima
发明人： Hiroshi Isobe , Masao Yoshino , Koji Fukushima
CPC分类号： F16F15/14 , F02D1/04 , Y10T464/50
摘要： A vibration absorber which comprises a damper provided between the flyweights and the shifter of a centrifugal governor for absorbing or lessening axial and/or radial vibrations produced in the flyweights. The absorber has a very simple construction, of which manufacture, mounting and maintenance can be carried out with facility. Also, it is free from resonance of the damper and its neighboring parts.
摘要翻译： 一种减振器，包括设置在飞轮和离心调速器的换档器之间的阻尼器，用于吸收或减轻在飞轮中产生的轴向和/或径向振动。 吸收器具有非常简单的结构，其制造，安装和维护可以用设施进行。 此外，它没有阻尼器及其相邻部件的共振。
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9.发明申请HOLDING AND SEALING MATERIAL FOR CATALYTIC CONVERTER AND METHOD OF MANUFACTURING THE HOLDING SEAL MATERIAL 审中-公开用于催化转化器的保持和密封材料以及制造保持密封材料的方法公开(公告)号：US20080312071A1
公开(公告)日：2008-12-18
申请号：US11833804
申请日：2007-08-03
申请人： Yoshio NISHIKAWA , Koji Fukushima , Keiji Yamada
发明人： Yoshio NISHIKAWA , Koji Fukushima , Keiji Yamada
IPC分类号： B01J31/02
CPC分类号： D04H1/46 , C04B35/62245 , C04B35/6263 , C04B35/62675 , C04B35/63416 , C04B2235/3463 , C04B2235/444 , C04B2235/526 , C04B2235/5264 , C04B2235/5268 , C04B2235/763 , C04B2235/80 , D04H1/4209 , F01N3/2853
摘要： A holding and sealing material for a catalytic converter for disposition between a cylindrical catalyst carrier and a metal shell covering the outer periphery of the catalyst carrier. The holding and sealing material includes a fiber aggregate mainly formed of alumina-silica based ceramic fibers having a mullite crystal content of 10 wt % or less, and the fiber aggregate is subjected to a needle punch treatment. Owing to the improved holding and sealing material, a catalytic converter having excellent durability and assemblage and having extremely low pollution characteristics is provided.
摘要翻译： 用于催化转化器的保持和密封材料，用于在圆柱形催化剂载体和覆盖催化剂载体的外周的金属壳之间进行配置。 保持密封材料包括主要由富铝红柱石结晶含量为10重量％以下的氧化铝 - 二氧化硅系陶瓷纤维形成的纤维集合体，对该纤维集合体进行针刺处理。 由于改进的保持和密封材料，提供了具有优异的耐久性和组合性并且具有极低污染特性的催化转化器。
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公开(公告)号：US5992560A
公开(公告)日：1999-11-30
申请号：US945177
申请日：1997-10-20
CPC分类号： F01N13/18 , F01N1/24 , F01N13/16 , F01N2310/02 , F01N2450/06
摘要： The invention provides a muffler for an internal combustion engine having excellent durability (resistance to scattering) even when being exposed to a high-temperature exhaust gas and capable of maintaining a high sound absorption coefficient over a long period. Such a muffler comprises a metal tube provided with a plurality of small holes, an inorganic fiber sound-absorbing material arranged on the outer periphery thereof and a metal shell covering the outside of the sound-absorbing material, in which a scattering prevention member is disposed between the metal tube and the sound-absorbing material. The sound-absorbing material is a laminated structure of crystalline alumna fiber mat and glass fiber mat. As the scattering prevention member, there is used a stainless woven wire cloth, a woven fabric made from inorganic fiber and a metal roll.
摘要翻译： PCT No.PCT / JP96 / 02732 Sec。 371日期：1997年10月20日 102（e）1997年10月20日PCT PCT 1996年9月20日PCT公布。 公开号WO97 / 31181 日期：1997年8月28日本发明提供了即使暴露在高温废气中并能够长时间保持高吸声系数的耐久性（耐散射性）的内燃机用消声器。 这种消音器包括设置有多个小孔的金属管，设置在其外周的无机纤维吸声材料和覆盖吸声材料外侧的金属壳，其中设置有防散射构件 在金属管和吸音材料之间。 吸声材料是结晶铝纤维毡和玻璃纤维垫的叠层结构。 作为防散射构件，使用不锈钢编织线，由无机纤维制成的织物和金属辊。
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