公开(公告)号：US20110318759A1

公开(公告)日：2011-12-29

申请号：US13142262

申请日：2009-12-24

申请人： Shigeyuki Wakitani ,  Hiroshi Fujita ,  Takeshi Ishimaru ,  Koji Yamamoto ,  Yasuhiro Kurahashi ,  Junichi Onaya ,  Hiroyuki Masuda

发明人： Shigeyuki Wakitani ,  Hiroshi Fujita ,  Takeshi Ishimaru ,  Koji Yamamoto ,  Yasuhiro Kurahashi ,  Junichi Onaya ,  Hiroyuki Masuda

IPC分类号： G01N33/577 ,  C07K16/18

CPC分类号： G01N33/53 ,  G01N2400/40 ,  G01N2800/102

摘要： The inventions provides a method for immunologically determining a keratan sulfate level which method includes bringing an anti-keratan sulfate monoclonal antibody into contact with a biological sample, the anti-keratan sulfate monoclonal antibody exhibiting a relative reaction specificity between keratan sulfate-I and keratan sulfate-II represented by IC50KS-I/KS-II of 0.4 to 5, to thereby provide a signal; and detecting keratan sulfate contained in the biological sample from the signal. On the basis of the method, the invention also provides a joint disease detection method and a method for assessing the effect of a remedy for a joint disease and a candidate substance therefor. Through these methods, a very small amount of keratan sulfate contained in a sample, can be determined. Particularly, these methods can determine, at high-sensitivity and high-specificity, the total keratan sulfate including keratan sulfate-I, which have been difficult to determine through a conventional technique. The methods also enables detect a joint disease and assess the effect of a remedy for a joint disease or a candidate substance therefor.

摘要翻译： 本发明提供了一种免疫测定硫酸角质素水平的方法，该方法包括使硫酸角质素硫酸单克隆抗体与生物样品接触，硫酸角质素-I与硫酸角质素之间呈现相对反应特异性的硫酸角质素单体抗体 -II由IC50KS-I / KS-II表示，为0.4〜5，从而提供信号; 并从信号中检测生物样品中所含的硫酸角质素。 在该方法的基础上，本发明还提供了关于联合疾病的检测方法和评估对于关节疾病及其候选物质的补救效果的方法。 通过这些方法，可以测定样品中所含的极少量硫酸角质素。 特别地，这些方法可以高灵敏度和高特异性地确定通过常规技术难以确定的总硫酸角质素，包括硫酸角质素-I。 该方法还能够检测关节疾病并评估对于关节疾病或候选物质的补救的效果。

公开(公告)号：US08822229B2

公开(公告)日：2014-09-02

申请号：US13142262

申请日：2009-12-24

申请人： Shigeyuki Wakitani ,  Hiroshi Fujita ,  Takeshi Ishimaru ,  Koji Yamamoto ,  Yasuhiro Kurahashi ,  Junichi Onaya ,  Hiroyuki Masuda

发明人： Shigeyuki Wakitani ,  Hiroshi Fujita ,  Takeshi Ishimaru ,  Koji Yamamoto ,  Yasuhiro Kurahashi ,  Junichi Onaya ,  Hiroyuki Masuda

IPC分类号： G01N33/564

CPC分类号： G01N33/53 ,  G01N2400/40 ,  G01N2800/102

摘要： The inventions provides a method for immunologically determining a keratan sulfate level which method includes bringing an anti-keratan sulfate monoclonal antibody into contact with a biological sample, the anti-keratan sulfate monoclonal antibody exhibiting a relative reaction specificity between keratan sulfate-I and keratan sulfate-II represented by IC50KS-I/KS-II of 0.4 to 5, to thereby provide a signal; and detecting keratan sulfate contained in the biological sample from the signal. On the basis of the method, the invention also provides a joint disease detection method and a method for assessing the effect of a remedy for a joint disease and a candidate substance therefor. Through these methods, a very small amount of keratan sulfate contained in a sample, can be determined. Particularly, these methods can determine, at high-sensitivity and high-specificity, the total keratan sulfate including keratan sulfate-I, which have been difficult to determine through a conventional technique. The methods also enables detect a joint disease and assess the effect of a remedy for a joint disease or a candidate substance therefor.

摘要翻译： 本发明提供了一种免疫测定硫酸角质素水平的方法，该方法包括使硫酸角质素硫酸单克隆抗体与生物样品接触，硫酸角质素-I与硫酸角质素之间呈现相对反应特异性的硫酸角质素单体抗体 -II由IC50KS-I / KS-II表示，为0.4〜5，从而提供信号; 并从信号中检测生物样品中所含的硫酸角质素。 在该方法的基础上，本发明还提供了关于联合疾病的检测方法和评估对于关节疾病及其候选物质的补救效果的方法。 通过这些方法，可以测定样品中所含的极少量硫酸角质素。 特别地，这些方法可以高灵敏度和高特异性地确定通过常规技术难以确定的总硫酸角质素，包括硫酸角质素-I。 该方法还能够检测关节疾病并评估对于关节疾病或候选物质的补救的效果。

公开(公告)号：US08557536B2

公开(公告)日：2013-10-15

申请号：US12525869

申请日：2008-02-05

申请人： Shigeyuki Wakitani ,  Masashi Nawata ,  Kyosuke Miyazaki ,  Hiroyuki Masuda ,  Hiroshi Fujita ,  Yasuhiro Kurahashi

发明人： Shigeyuki Wakitani ,  Masashi Nawata ,  Kyosuke Miyazaki ,  Hiroyuki Masuda ,  Hiroshi Fujita ,  Yasuhiro Kurahashi

IPC分类号： C12Q1/34

CPC分类号： G01N33/6887 ,  G01N33/6815 ,  G01N33/6893 ,  G01N2800/105 ,  G01N2800/52 ,  G01N2800/56

摘要： An object of the present invention is to provide a detection method capable of detecting articular cartilage degeneration or damage in which the abnormality cannot be detected in a radiograph in a simple method and with high accuracy, a method of evaluating the rate of progression of articular cartilage degeneration or damage, and the like.The present invention as a means for achieving the object provides a method of detecting articular cartilage degeneration or damage which cannot be detected in a radiograph, by using the concentration of keratan sulfate in a sample derived from blood as an index, and the like.Further, the present invention provides a method of evaluating the rate of progression of articular cartilage degeneration or damage by using the concentration of keratan sulfate in a sample derived from blood as an index, and the like.

摘要翻译： 本发明的目的是提供一种检测方法，其能够以简单的方法和高精度检测在放射线照相下无法检测到异常的关节软骨变性或损伤，评价关节软骨进展速度的方法 变性或损伤等。 作为实现该目的的手段的本发明提供了通过使用来自血液的样品中的硫酸角质素浓度作为指标，检测在放射照片中无法检测的关节软骨变性或损伤的方法等。 此外，本发明提供一种通过使用来自血液的样品中的硫酸角质素浓度作为指标来评价关节软骨退化或损伤的进展速度的方法等。

公开(公告)号：US20110151492A1

公开(公告)日：2011-06-23

申请号：US12525869

申请日：2008-02-05

申请人： Shigeyuki Wakitani ,  Masashi Nawata ,  Kyosuke Miyazaki ,  Hiroyuki Masuda ,  Hiroshi Fujita ,  Yasuhiro Kurahashi

发明人： Shigeyuki Wakitani ,  Masashi Nawata ,  Kyosuke Miyazaki ,  Hiroyuki Masuda ,  Hiroshi Fujita ,  Yasuhiro Kurahashi

IPC分类号： C12Q1/34

CPC分类号： G01N33/6887 ,  G01N33/6815 ,  G01N33/6893 ,  G01N2800/105 ,  G01N2800/52 ,  G01N2800/56

摘要： An object of the present invention is to provide a detection method capable of detecting articular cartilage degeneration or damage in which the abnormality cannot be detected in a radiograph in a simple method and with high accuracy, a method of evaluating the rate of progression of articular cartilage degeneration or damage, and the like.The present invention as a means for achieving the object provides a method of detecting articular cartilage degeneration or damage which cannot be detected in a radiograph, by using the concentration of keratan sulfate in a sample derived from blood as an index, and the like.Further, the present invention provides a method of evaluating the rate of progression of articular cartilage degeneration or damage by using the concentration of keratan sulfate in a sample derived from blood as an index, and the like.

摘要翻译： 本发明的目的是提供一种检测方法，其能够以简单的方法和高精度检测在放射线照相下无法检测到异常的关节软骨变性或损伤，评价关节软骨进展速度的方法 变性或损伤等。 作为实现该目的的手段的本发明提供了通过使用来自血液的样品中的硫酸角质素浓度作为指标，检测在放射照片中无法检测的关节软骨变性或损伤的方法等。 此外，本发明提供一种通过使用来自血液的样品中的硫酸角质素浓度作为指标来评价关节软骨退化或损伤的进展速度的方法等。

公开(公告)号：US06973738B2

公开(公告)日：2005-12-13

申请号：US10168033

申请日：2001-07-18

申请人： Kiyoshi Kaneda ,  Yasuhiro Kurahashi

发明人： Kiyoshi Kaneda ,  Yasuhiro Kurahashi

IPC分类号： B23Q17/22 ,  G05B19/042 ,  G01D21/00

CPC分类号： B23Q17/22 ,  G05B19/042

摘要： A method of measuring the position of the cutting edge of a tool T mounted to a spindle 14 of an NC machine tool includes steps of measuring the dimension of the center of an end surface of the spindle 14 relative a reference position in a machine coordinate system of the machine tool in the axial directions of the X-, Y- and Z-axes, measuring the dimensions of the position of the cutting edge of the tool T mounted to the spindle 14 relative to the center of the end surface of the spindle 14 in the axial directions of the X-, Y- and Z-axes, obtaining the dimensions of the position of the cutting edge of the tool T mounted to the spindle 14 relative to the reference position in the machine coordinate system through a calculation on the basis of the relative dimensions of the center of the end surface of the spindle 14 in the machine coordinate system and the dimensions of the position of the cutting edge of the tool T mounted to the spindle 14.

摘要翻译： 测量安装在数控机床的主轴14上的工具T的切削刃的位置的方法包括以下步骤：相对于机床坐标系中的基准位置测量主轴14的端面中心的尺寸 在X，Y和Z轴的轴向方向上测量安装到主轴14上的工具T的切割边缘相对于主轴端面中心的尺寸的尺寸 14在X，Y和Z轴的轴向方向上，通过计算在机床坐标系中相对于基准位置获得安装到主轴14上的工具T的切削刃的位置的尺寸 机床坐标系中的心轴14的端面的中心的相对尺寸的基准和安装到主轴14上的工具T的切削刃的位置的尺寸。

公开(公告)号：US06602859B2

公开(公告)日：2003-08-05

申请号：US10024666

申请日：2001-12-18

申请人： Kenji Miyamoto ,  Yasuhiro Kurahashi ,  Hiroki Kano

发明人： Kenji Miyamoto ,  Yasuhiro Kurahashi ,  Hiroki Kano

IPC分类号： A61K31715

CPC分类号： C08B37/0072

摘要： A photocurable hyaluronic acid derivative of the present invention comprises hyaluronic acid and a photoreactive crosslinking group bonded thereto, wherein a 1.0 wt. % aqueous solution of the photocurable hyaluronic acid derivative obtained by dissolving the solid photocurable hyaluronic acid derivative in an aqueous solvent, is capable of passing through a porous filter having a pore size of 0.45 &mgr;m and a diameter of 25 mm at a rate of not less than 2 ml/minute at 24° C. under a pressure of 5.0 Kg/cm2; and a process for producing the photocurable hyaluronic acid derivative; and a photocured crosslinked-hyaluronic acid derivative; a medical material using the photoreactive hyaluronic acid derivative and a medical material using the photocured crosslinked-hyaluronic acid derivative.

公开(公告)号：US09453716B2

公开(公告)日：2016-09-27

申请号：US13824278

申请日：2011-10-21

申请人： Yasuhiro Kurahashi

发明人： Yasuhiro Kurahashi

IPC分类号： G01B11/00 ,  B23Q17/24

CPC分类号： G01B11/002 ,  B23Q17/2457

摘要： Provided are a method for measuring tool dimensions and a measurement device, whereby if a machine tool (10) cannot fit the overall outline of a tool (20) inside the field of vision (V) for an image from an imaging device (33), the field of vision (V) of the imaging device (33) is moved by relatively moving the imaging device (33) and the tool (20). In addition, the imaging device (33) can follow the outline (54) of the tool (20) by moving the field of vision (V), because the movement direction (53) for the field of vision (V) is determined on the basis of the partial outline (51) specified based on image data. In this way, even when measuring dimensions for a tool (20) with a larger diameter than the field of vision (V) of the imaging device (33), a partial outline (51) of a desired range, for example, is specified. An outline of a desired range for the tool (20) is extracted if a plurality of specified partial outlines (51) are combined. Measurement of the dimensions of the tool (20) is possible by using such outlines.

摘要翻译： 提供了一种用于测量工具尺寸的方法和测量装置，其中如果机床（10）不能将来自成像装置（33）的图像的视野范围（V）内的工具（20）的总体轮廓拟合， 通过相对移动成像装置（33）和工具（20）来移动成像装置（33）的视野（V）。 此外，由于用于视野（V）的移动方向（53）是通过视场（V）的移动方向（53）确定的，所以通过移动视场（V），成像装置（33）可以跟随工具（20）的轮廓（54） 基于图像数据指定的部分轮廓（51）的基础。 以这种方式，即使当测量具有比成像装置（33）的视野（V）更大的直径的工具（20）的尺寸时，指定例如期望范围的局部轮廓（51） 。 如果组合多个指定的部分轮廓（51），则提取工具（20）的期望范围的轮廓。 可以通过使用这样的轮廓来测量工具（20）的尺寸。

公开(公告)号：US09188437B2

公开(公告)日：2015-11-17

申请号：US13881605

申请日：2011-10-27

申请人： Yasuhiro Kurahashi

发明人： Yasuhiro Kurahashi

IPC分类号： G01C11/00 ,  B23Q17/24 ,  G01B11/24 ,  G06F3/041 ,  G06F3/0481

CPC分类号： G01C11/00 ,  B23Q17/2409 ,  B23Q17/2452 ,  B23Q17/2457 ,  G01B11/2433 ,  G06F3/041 ,  G06F3/0481

摘要： In the machine tool (10) pertaining to the present invention, the contour lines (51) of a tool (20) are displayed on a display screen (S). When an operator measuring the dimensions traces a contour line (51) on the display screen (S) of a touch panel (45) with a finger, it is possible to automatically identify, on the display screen (S), the site to be measured (i.e., the contour line (51)) on the tool (20). In this way, an operator can measure the dimensions of the tool (20) in an extremely simple manner. Additionally, it is possible to automatically measure the tool diameter or the blade position of the tool (20) as the operator designates a specific position on the contour line (51) of the tool (20). Thus, with such a method for measuring the dimensions of the tool (20), it is possible to easily identify an unexpected site to be measured on a tool having complex contour lines, such as a multi-stage tool.

摘要翻译： 在本发明的机床（10）中，工具（20）的轮廓线（51）显示在显示画面（S）上。 当测量尺寸的操作者用手指在触摸面板（45）的显示屏（S）上跟踪轮廓线（51）时，可以在显示屏幕（S）上自动识别要被 测量（即，轮廓线（51））在工具（20）上。 以这种方式，操作者可以以非常简单的方式测量工具（20）的尺寸。 此外，当操作者指定工具（20）的轮廓线（51）上的特定位置时，可以自动测量刀具（20）的刀具直径或刀片位置。 因此，通过这种用于测量工具（20）的尺寸的方法，可以容易地识别具有复杂轮廓线的工具（例如多级工具）上要测量的意外位置。

公开(公告)号：US07331739B2

公开(公告)日：2008-02-19

申请号：US10538148

申请日：2004-08-12

申请人： Jun Yoshida ,  Akira Kawana ,  Yasuhiro Kurahashi

发明人： Jun Yoshida ,  Akira Kawana ,  Yasuhiro Kurahashi

IPC分类号： B23Q15/28 ,  B23Q15/16 ,  B23Q17/22 ,  B23Q17/09 ,  G05B19/404

CPC分类号： B23Q17/09 ,  B23Q15/16 ,  B23Q15/28 ,  B23Q17/2233 ,  G05B19/404 ,  Y10T409/300896 ,  Y10T409/30112 ,  Y10T409/303752 ,  Y10T409/306832

摘要： A wear amount of a working tool T during the machining of a workpiece is estimated during the machining, and a positional command generated in accordance with a predetermined machining program is sequentially corrected during the machining based on the estimated wear amount of the working tool T. The workpiece W is machined in accordance with the corrected positional command. Also, the wear amount of the working tool T upon the interruption of the machining operation is calculated, and the positional command generated in accordance with the predetermined machining program is corrected based on the calculated wear amount of the working tool so that a tool edge position of the working tool T upon the interruption of the machining operation coincides with the tool edge position of the working tool T upon the restart of the machining operation when the machining operation is restarted at a position where the machining operation has been interrupted. The workpiece is machined in accordance with the corrected positional command.

摘要翻译： 在加工期间估计加工工具T的磨损量，并且根据预定的加工程序生成的位置指令在加工期间根据加工工具T的估计磨损量被依次校正。 工件W根据校正的位置指令进行加工。 此外，计算加工工具中断时的加工工具T的磨损量，并且根据计算出的加工工具的磨损量来校正根据预定加工程序生成的位置指令，使得刀具刃位置 在加工操作中断的位置重新开始加工操作时，加工操作中断时的加工工具T与工作工具T的刀沿位置一致。 根据校正的位置指令对工件进行加工。

公开(公告)号：US09329029B2

公开(公告)日：2016-05-03

申请号：US13880015

申请日：2011-10-27

申请人： Yasuhiro Kurahashi

发明人： Yasuhiro Kurahashi

IPC分类号： G01B11/24 ,  B23Q17/24 ,  G01B11/04 ,  B23Q17/09 ,  B23Q17/22 ,  B23Q17/00

CPC分类号： G01B11/24 ,  B23Q17/0914 ,  B23Q17/22 ,  B23Q17/2409 ,  B23Q17/249 ,  B23Q2017/001 ,  G01B11/04 ,  G01B11/2433

摘要： In the machine tool (10) pertaining to the present invention, an imaging device (33) takes an image of a tool (20) being moved in the feeding direction. Contour lines (51) are identified by means of the plurality of sets of image data generated from imaging. The movement trajectory (52) and the central axis (53) of the tool (20) are identified on the basis of the contour lines (51). When the movement trajectory (52) and the central axis (53) are offset, said offset can be used to correct the positioning of the tool (20) with the machine tool (10). As a result, the processing accuracy of a workpiece improves. Moreover, when the dimensions of a tool (20) that has a tilted posture are measured, it is possible to determine the actual tool diameter or the actual blade position in the tilted posture. The aforementioned blade position and tool diameter can be used to correct the positioning of the machine tool (10). Thus, the processing accuracy of the workpiece improves even more.

摘要翻译： 在本发明的机床（10）中，成像装置（33）拍摄沿进给方向移动的工具（20）的图像。 轮廓线（51）通过从成像产生的多组图像数据来识别。 基于轮廓线（51）来识别工具（20）的运动轨迹（52）和中心轴线（53）。 当移动轨迹（52）和中心轴线（53）偏移时，所述偏移可用于校正工具（20）与机床（10）的定位。 结果，工件的加工精度提高。 此外，当测量具有倾斜姿势的工具（20）的尺寸时，可以确定倾斜姿势下的实际刀具直径或实际刀片位置。 可以使用上述刀片位置和刀具直径来校正机床（10）的定位。 因此，工件的加工精度进一步提高。