公开(公告)号：US08822229B2

公开(公告)日：2014-09-02

申请号：US13142262

申请日：2009-12-24

申请人： Shigeyuki Wakitani ,  Hiroshi Fujita ,  Takeshi Ishimaru ,  Koji Yamamoto ,  Yasuhiro Kurahashi ,  Junichi Onaya ,  Hiroyuki Masuda

发明人： Shigeyuki Wakitani ,  Hiroshi Fujita ,  Takeshi Ishimaru ,  Koji Yamamoto ,  Yasuhiro Kurahashi ,  Junichi Onaya ,  Hiroyuki Masuda

IPC分类号： G01N33/564

CPC分类号： G01N33/53 ,  G01N2400/40 ,  G01N2800/102

摘要： The inventions provides a method for immunologically determining a keratan sulfate level which method includes bringing an anti-keratan sulfate monoclonal antibody into contact with a biological sample, the anti-keratan sulfate monoclonal antibody exhibiting a relative reaction specificity between keratan sulfate-I and keratan sulfate-II represented by IC50KS-I/KS-II of 0.4 to 5, to thereby provide a signal; and detecting keratan sulfate contained in the biological sample from the signal. On the basis of the method, the invention also provides a joint disease detection method and a method for assessing the effect of a remedy for a joint disease and a candidate substance therefor. Through these methods, a very small amount of keratan sulfate contained in a sample, can be determined. Particularly, these methods can determine, at high-sensitivity and high-specificity, the total keratan sulfate including keratan sulfate-I, which have been difficult to determine through a conventional technique. The methods also enables detect a joint disease and assess the effect of a remedy for a joint disease or a candidate substance therefor.

摘要翻译： 本发明提供了一种免疫测定硫酸角质素水平的方法，该方法包括使硫酸角质素硫酸单克隆抗体与生物样品接触，硫酸角质素-I与硫酸角质素之间呈现相对反应特异性的硫酸角质素单体抗体 -II由IC50KS-I / KS-II表示，为0.4〜5，从而提供信号; 并从信号中检测生物样品中所含的硫酸角质素。 在该方法的基础上，本发明还提供了关于联合疾病的检测方法和评估对于关节疾病及其候选物质的补救效果的方法。 通过这些方法，可以测定样品中所含的极少量硫酸角质素。 特别地，这些方法可以高灵敏度和高特异性地确定通过常规技术难以确定的总硫酸角质素，包括硫酸角质素-I。 该方法还能够检测关节疾病并评估对于关节疾病或候选物质的补救的效果。

公开(公告)号：US20110318759A1

公开(公告)日：2011-12-29

申请号：US13142262

申请日：2009-12-24

申请人： Shigeyuki Wakitani ,  Hiroshi Fujita ,  Takeshi Ishimaru ,  Koji Yamamoto ,  Yasuhiro Kurahashi ,  Junichi Onaya ,  Hiroyuki Masuda

发明人： Shigeyuki Wakitani ,  Hiroshi Fujita ,  Takeshi Ishimaru ,  Koji Yamamoto ,  Yasuhiro Kurahashi ,  Junichi Onaya ,  Hiroyuki Masuda

IPC分类号： G01N33/577 ,  C07K16/18

CPC分类号： G01N33/53 ,  G01N2400/40 ,  G01N2800/102

摘要： The inventions provides a method for immunologically determining a keratan sulfate level which method includes bringing an anti-keratan sulfate monoclonal antibody into contact with a biological sample, the anti-keratan sulfate monoclonal antibody exhibiting a relative reaction specificity between keratan sulfate-I and keratan sulfate-II represented by IC50KS-I/KS-II of 0.4 to 5, to thereby provide a signal; and detecting keratan sulfate contained in the biological sample from the signal. On the basis of the method, the invention also provides a joint disease detection method and a method for assessing the effect of a remedy for a joint disease and a candidate substance therefor. Through these methods, a very small amount of keratan sulfate contained in a sample, can be determined. Particularly, these methods can determine, at high-sensitivity and high-specificity, the total keratan sulfate including keratan sulfate-I, which have been difficult to determine through a conventional technique. The methods also enables detect a joint disease and assess the effect of a remedy for a joint disease or a candidate substance therefor.

摘要翻译： 本发明提供了一种免疫测定硫酸角质素水平的方法，该方法包括使硫酸角质素硫酸单克隆抗体与生物样品接触，硫酸角质素-I与硫酸角质素之间呈现相对反应特异性的硫酸角质素单体抗体 -II由IC50KS-I / KS-II表示，为0.4〜5，从而提供信号; 并从信号中检测生物样品中所含的硫酸角质素。 在该方法的基础上，本发明还提供了关于联合疾病的检测方法和评估对于关节疾病及其候选物质的补救效果的方法。 通过这些方法，可以测定样品中所含的极少量硫酸角质素。 特别地，这些方法可以高灵敏度和高特异性地确定通过常规技术难以确定的总硫酸角质素，包括硫酸角质素-I。 该方法还能够检测关节疾病并评估对于关节疾病或候选物质的补救的效果。

公开(公告)号：US20110151492A1

公开(公告)日：2011-06-23

申请号：US12525869

申请日：2008-02-05

申请人： Shigeyuki Wakitani ,  Masashi Nawata ,  Kyosuke Miyazaki ,  Hiroyuki Masuda ,  Hiroshi Fujita ,  Yasuhiro Kurahashi

发明人： Shigeyuki Wakitani ,  Masashi Nawata ,  Kyosuke Miyazaki ,  Hiroyuki Masuda ,  Hiroshi Fujita ,  Yasuhiro Kurahashi

IPC分类号： C12Q1/34

CPC分类号： G01N33/6887 ,  G01N33/6815 ,  G01N33/6893 ,  G01N2800/105 ,  G01N2800/52 ,  G01N2800/56

摘要： An object of the present invention is to provide a detection method capable of detecting articular cartilage degeneration or damage in which the abnormality cannot be detected in a radiograph in a simple method and with high accuracy, a method of evaluating the rate of progression of articular cartilage degeneration or damage, and the like.The present invention as a means for achieving the object provides a method of detecting articular cartilage degeneration or damage which cannot be detected in a radiograph, by using the concentration of keratan sulfate in a sample derived from blood as an index, and the like.Further, the present invention provides a method of evaluating the rate of progression of articular cartilage degeneration or damage by using the concentration of keratan sulfate in a sample derived from blood as an index, and the like.

摘要翻译： 本发明的目的是提供一种检测方法，其能够以简单的方法和高精度检测在放射线照相下无法检测到异常的关节软骨变性或损伤，评价关节软骨进展速度的方法 变性或损伤等。 作为实现该目的的手段的本发明提供了通过使用来自血液的样品中的硫酸角质素浓度作为指标，检测在放射照片中无法检测的关节软骨变性或损伤的方法等。 此外，本发明提供一种通过使用来自血液的样品中的硫酸角质素浓度作为指标来评价关节软骨退化或损伤的进展速度的方法等。

公开(公告)号：US08557536B2

公开(公告)日：2013-10-15

申请号：US12525869

申请日：2008-02-05

申请人： Shigeyuki Wakitani ,  Masashi Nawata ,  Kyosuke Miyazaki ,  Hiroyuki Masuda ,  Hiroshi Fujita ,  Yasuhiro Kurahashi

发明人： Shigeyuki Wakitani ,  Masashi Nawata ,  Kyosuke Miyazaki ,  Hiroyuki Masuda ,  Hiroshi Fujita ,  Yasuhiro Kurahashi

IPC分类号： C12Q1/34

CPC分类号： G01N33/6887 ,  G01N33/6815 ,  G01N33/6893 ,  G01N2800/105 ,  G01N2800/52 ,  G01N2800/56

摘要： An object of the present invention is to provide a detection method capable of detecting articular cartilage degeneration or damage in which the abnormality cannot be detected in a radiograph in a simple method and with high accuracy, a method of evaluating the rate of progression of articular cartilage degeneration or damage, and the like.The present invention as a means for achieving the object provides a method of detecting articular cartilage degeneration or damage which cannot be detected in a radiograph, by using the concentration of keratan sulfate in a sample derived from blood as an index, and the like.Further, the present invention provides a method of evaluating the rate of progression of articular cartilage degeneration or damage by using the concentration of keratan sulfate in a sample derived from blood as an index, and the like.

摘要翻译： 本发明的目的是提供一种检测方法，其能够以简单的方法和高精度检测在放射线照相下无法检测到异常的关节软骨变性或损伤，评价关节软骨进展速度的方法 变性或损伤等。 作为实现该目的的手段的本发明提供了通过使用来自血液的样品中的硫酸角质素浓度作为指标，检测在放射照片中无法检测的关节软骨变性或损伤的方法等。 此外，本发明提供一种通过使用来自血液的样品中的硫酸角质素浓度作为指标来评价关节软骨退化或损伤的进展速度的方法等。

公开(公告)号：US09710907B2

公开(公告)日：2017-07-18

申请号：US14005708

申请日：2012-03-13

申请人： Hiroshi Fujita ,  Takeshi Hara ,  Akitoshi Katsumata ,  Tatsuro Hayashi

发明人： Hiroshi Fujita ,  Takeshi Hara ,  Akitoshi Katsumata ,  Tatsuro Hayashi

IPC分类号： G06T7/00 ,  A61B6/14 ,  A61B6/00 ,  G06F19/00

CPC分类号： G06T7/0012 ,  A61B6/14 ,  A61B6/5217 ,  A61B6/5241 ,  G06F19/00 ,  G06F19/321 ,  G16H50/20 ,  G16H50/50

摘要： A diagnosis support system includes a diagnosis support computer that includes a model data acquisition unit configured to obtain a plurality of mandible model data, a contour model creation unit configured to create contour model data from the mandible model data, a contour database storage unit configured to construct a contour model database from the contour model data, a diagnosis image data receiving unit configured to receive an input of diagnosis image data of an examinee, an edge extraction unit configured to extract edge data from the diagnosis image data, a similar model searching unit configured to search contour model data based on the edge data, a position judgment unit and an image quality judgment unit configured to judge an imaging position and an image quality based on imaging information, respectively, and a diagnosis support information provision unit configured to provide diagnosis support information based on provider information.

公开(公告)号：US09005502B2

公开(公告)日：2015-04-14

申请号：US13405996

申请日：2012-02-27

申请人： Tsuyoshi Chiba ,  Hiroshi Fujita ,  Yuki Aritsuka

发明人： Tsuyoshi Chiba ,  Hiroshi Fujita ,  Yuki Aritsuka

IPC分类号： B29C33/40 ,  B29C33/64 ,  B82Y10/00 ,  B29C33/42

CPC分类号： B29C33/40 ,  B29C33/405 ,  B29C33/424 ,  B29C33/64 ,  B29K2883/00 ,  B82Y10/00

摘要： The object of the invention is to provide a mold that is capable of high-precision, stable patterning, and improved in terms of handleability as well, and a manufacturing method thereof. The mold of the invention has a pattern-formation surface defined by one surface, wherein the pattern-formation layer has a projection-and-depression structure area for patterning, and a base surface defined by another surface. At least the pattern-formation layer and the base surface each comprise a polydimethylsiloxane layer. Given a low-molecular-weight siloxane of a cyclic structure represented by [—Si(CH3)2O—]k where k is an integer of 3 to 20 inclusive, the polydimethylsiloxane layer positioned on the pattern-formation layer comprises a high-content polydimethylsiloxane layer containing the low-molecular-weight siloxane in a larger amount, and the polydimethylsiloxane layer positioned on the base surface comprises a low-content polydimethylsiloxane layer containing the low-molecular-weight siloxane in a smaller amount.

摘要翻译： 本发明的目的是提供一种能够高精度，稳定地图案化并且在可操作性方面得到改进的模具及其制造方法。 本发明的模具具有由一个表面限定的图形形成表面，其中图案形成层具有用于图案化的突起 - 凹陷结构区域和由另一个表面限定的基底表面。 至少图案形成层和基底表面各自包含聚二甲基硅氧烷层。 给出由[-Si（CH3）2O-] k表示的环状结构的低分子量硅氧烷，其中k是3至20的整数，其中位于图案形成层上的聚二甲基硅氧烷层包含高含量 含有较大量的低分子量硅氧烷的聚二甲基硅氧烷层和位于基材表面上的聚二甲基硅氧烷层包含含有较少量的低分子量硅氧烷的低含量聚二甲基硅氧烷层。

公开(公告)号：US08547930B2

公开(公告)日：2013-10-01

申请号：US11826500

申请日：2007-07-16

申请人： Hiroshi Fujita ,  Yoshiharu Tajima

发明人： Hiroshi Fujita ,  Yoshiharu Tajima

IPC分类号： H04W4/00

CPC分类号： H04W36/26 ,  H04W72/10

摘要： A problem is to provide a base station apparatus, a mobile communication system and a priority setting method for easing abrupt decrease of the transmission speed when performing handover between wireless systems in which transmission speeds are different, and the problem is solved by providing priority higher than normal to a terminal that comes from a second wireless system, by handover, in which transmission speed is greater than a first wireless system.

摘要翻译： 问题在于提供一种基站装置，移动通信系统以及优先级设定方法，用于在传输速度不同的无线系统之间进行切换时，缓解传输速度的急剧下降，并且通过提供高于 通过切换，来自第二无线系统的终端的正常通信，其中传输速度大于第一无线系统。

公开(公告)号：US08517035B2

公开(公告)日：2013-08-27

申请号：US11625592

申请日：2007-01-22

申请人： Takahiko Wakatsuki ,  Naoya Hayamizu ,  Hiroshi Fujita ,  Akiko Saito ,  Toshihide Hayashi ,  Yukinobu Nishibe

发明人： Takahiko Wakatsuki ,  Naoya Hayamizu ,  Hiroshi Fujita ,  Akiko Saito ,  Toshihide Hayashi ,  Yukinobu Nishibe

IPC分类号： B08B3/00

CPC分类号： B08B3/022 ,  B08B7/00 ,  H01L21/67028 ,  H01L21/67051 ,  Y10T137/0318

摘要： A processing apparatus includes: a processing chamber configured to contain a workpiece; a first nozzle provided in the processing chamber, the first nozzle discharging vapor onto the workpiece; a wall enclosing the processing chamber; a fluid channel provided inside the wall; a fluid inlet; and a fluid outlet.The fluid inlet is provided in communication with the fluid channel. The fluid outlet is provided in communication with the fluid channel, where a fluid flows into the fluid inlet, passes through the fluid channel, and flows out of the fluid outlet. A processing method for processing a workpiece moving in a processing chamber, the processing method includes: discharging a vapor from a first nozzle toward the workpiece while flowing a fluid through a fluid channel which is provided inside a wall, the wall enclosing the processing chamber.

摘要翻译： 一种处理装置，包括：处理室，被配置为容纳工件; 设置在所述处理室中的第一喷嘴，所述第一喷嘴将蒸气喷射到所述工件上; 封闭处理室的墙壁; 设置在壁内的流体通道; 流体入口; 和流体出口。 流体入口设置成与流体通道连通。 流体出口设置成与流体通道连通，流体流入流体入口，通过流体通道并从流体出口流出。 一种用于处理在处理室中移动的工件的处理方法，所述处理方法包括：使流体从第一喷嘴朝向工件排出，同时使流体流过设置在壁内部的流体通道，所述流体通道围绕处理室。

公开(公告)号：US20130207448A1

公开(公告)日：2013-08-15

申请号：US13369489

申请日：2012-02-09

申请人： Kazuki Koshiyama ,  Hiroshi Fujita

发明人： Kazuki Koshiyama ,  Hiroshi Fujita

IPC分类号： B60B1/04

CPC分类号： B60B27/045 ,  B60B1/042

摘要： A force-distributing apparatus for a bicycle wheel spoke includes a force-distributing body having a free-end first surface and a second surface disposed at an opposite side of the first surface. The first surface substantially has the shape of a truncated sphere, and the force-distributing body has a spoke-receiving opening that extends through the first surface.

摘要翻译： 用于自行车车轮辐条的力分配装置包括具有自由端第一表面的力分布体和设置在第一表面的相对侧的第二表面。 第一表面基本上具有截头球的形状，并且分力体具有延伸穿过第一表面的轮辐容纳孔。

公开(公告)号：US20100177181A1

公开(公告)日：2010-07-15

申请号：US12352387

申请日：2009-01-12

申请人： Daisuke Ayame ,  Shuichi Ishii ,  Shinji Takeuchi ,  Hiroshi Fujita

发明人： Daisuke Ayame ,  Shuichi Ishii ,  Shinji Takeuchi ,  Hiroshi Fujita

IPC分类号： A61B1/04

CPC分类号： A61B1/042 ,  A61B1/00009 ,  A61B1/043 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084

摘要： A method capable of obtaining a fluorescence image and a background image with a simple configuration. A color image is obtained, when excitation light is emitted on a subject, by imaging excitation light reflected from the subject and fluorescence emitted from the subject. Thereafter, an estimated spectral image that includes a background image representing the excitation light and a fluorescence image representing the fluorescence is generated by allocating a wavelength component of the excitation light and a wavelength component of the fluorescence included in the obtained color image to different primary color components.

摘要翻译： 能够以简单的结构获得荧光图像和背景图像的方法。 通过对从被检体反射的激发光进行成像，从被检体发出的荧光进行成像，当对被检体发射激发光时，获得彩色图像。 此后，通过将所获得的彩色图像中包含的激发光的波长分量和包含的荧光的波长分量分配给不同的原色来生成包括表示激发光的背景图像和表示荧光的荧光图像的估计光谱图像 组件。