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267 条记录 (耗时 0.027 秒)

    Method and apparatus for molecular analysis using nanoelectronic circuits
    3.
    发明授权
    Method and apparatus for molecular analysis using nanoelectronic circuits 有权
    使用纳米电子电路进行分子分析的方法和装置

    公开(公告)号：US07947485B2

    公开(公告)日：2011-05-24

    申请号：US11144586

    申请日：2005-06-03

    申请人： Wei Wu ,  Zhiyong Li ,  Shih-Yuan Wang ,  Philip J. Kuekes

    发明人： Wei Wu ,  Zhiyong Li ,  Shih-Yuan Wang ,  Philip J. Kuekes

    IPC分类号： C12M1/00 ,  G01N15/06 ,  C07H21/04

    CPC分类号： G01N33/48721 ,  B82Y5/00 ,  B82Y10/00 ,  G01N27/414

    摘要： Devices and methods for detecting the constituent parts of biological polymers are disclosed. A molecular analysis device comprises a molecule sensor and a molecule guide. The molecule sensor comprises a single electron transistor including a first terminal, a second terminal, and a nanogap or at least one quantum dot positioned between the first terminal and the second terminal. A nitrogenous material disposed on the at least one quantum dot is configured for an interaction with an identifiable configuration of a molecule. The molecule sensor develops an electronic effect responsive to the interaction. The molecule guide is configured for guiding at least a portion of the molecule substantially near the molecule sensor to enable the interaction.

    摘要翻译： 公开了用于检测生物聚合物的组成部分的装置和方法。 分子分析装置包括分子传感器和分子引导件。 分子传感器包括单电子晶体管，其包括位于第一端子和第二端子之间的第一端子，第二端子和纳米隙隙或至少一个量子点。 设置在至少一个量子点上的含氮材料被配置用于与分子的可识别构型的相互作用。 分子传感器产生响应于相互作用的电子效应。 分子引导件被配置用于基本上在分子传感器附近引导分子的至少一部分，以实现相互作用。

    Optical sensor and method employing half-core hollow optical waveguide
    4.
    发明授权
    Optical sensor and method employing half-core hollow optical waveguide 失效
    采用半芯空心光波导的光学传感器和方法

    公开(公告)号：US07805028B2

    公开(公告)日：2010-09-28

    申请号：US12253123

    申请日：2008-10-16

    申请人： Zhiyong Li ,  Michael Tan ,  Shih-Yuan Wang ,  Wei Wu ,  Jing Tang

    发明人： Zhiyong Li ,  Michael Tan ,  Shih-Yuan Wang ,  Wei Wu ,  Jing Tang

    IPC分类号： G02B6/00 ,  G02B6/32 ,  G02B6/10

    CPC分类号： G02B6/02328 ,  B82Y20/00 ,  G01N21/05 ,  G01N21/31 ,  G01N21/645 ,  G01N21/658 ,  G01N2021/0346 ,  G01N2021/052 ,  G01N2021/6467 ,  G01N2021/7763 ,  G01N2021/7783 ,  G02B6/1226

    摘要： An optical sensor, sensing system and method of sensing employ a half-core hollow optical waveguide adjacent to a surface of an optical waveguide layer of a substrate. The half-core hollow optical waveguide and the adjacent optical waveguide layer cooperatively provide both an optical path that confines and guides an optical signal and an internal hollow channel. The optical path and channel extend longitudinally along a hollow core of the half-core hollow optical waveguide. The system further includes an optical source at an input of the optical path and an optical detector at an output of the optical path. A spectroscopic interaction between an analyte material that is introduced into the channel and an optical signal propagating along the optical path determines a characteristic of the analyte material.

    摘要翻译： 光学传感器，感测系统和感测方法使用与衬底的光波导层的表面相邻的半芯空心光波导。 半芯空心光波导和相邻的光波导层协同地提供限制和引导光信号和内部中空通道的光路。 光路和通道沿半芯空心光波导的中空芯纵向延伸。 该系统还包括在光路的输入处的光源和在光路的输出处的光学检测器。 引入到通道中的分析物质与沿光路传播的光信号之间的光谱相互作用决定了分析物质的特性。

    TUNABLE APPARATUS FOR PERFORMING SERS
    7.
    发明申请
    TUNABLE APPARATUS FOR PERFORMING SERS 审中-公开
    用于执行人员的装置

    公开(公告)号：US20120236298A1

    公开(公告)日：2012-09-20

    申请号：US13048594

    申请日：2011-03-15

    申请人： Michael Josef Stuke ,  Zhiyong Li ,  Wei Wu ,  Shih-Yuan Wang ,  Min Hu ,  Fung Suong Ou

    发明人： Michael Josef Stuke ,  Zhiyong Li ,  Wei Wu ,  Shih-Yuan Wang ,  Min Hu ,  Fung Suong Ou

    IPC分类号： G01J3/44

    CPC分类号： G01N21/658

    摘要： A tunable apparatus for performing Surface Enhanced Raman Spectroscopy (SERS) includes a deformable substrate and a plurality of SERS-active nanoparticles disposed at a plurality of locations on the deformable substrate. The plurality of SERS-active nanoparticles are to enhance Raman scattered light emission from an analyte molecule located in close proximity to the SERS-active nanoparticles. In addition, the deformable substrate is to be deformed to vary distances between the SERS-active nanoparticles, in which varying distances between the SERS-active nanoparticles varies enhancement of an intensity of Raman scattered light emission from the analyte molecule.

    摘要翻译： 用于执行表面增强拉曼光谱（SERS）的可调谐装置包括可变形基板和设置在可变形基板上的多个位置处的多个SERS活性纳米颗粒。 多个SERS活性纳米颗粒是增强来自位于紧邻SERS活性纳米颗粒的分析物分子的拉曼散射光发射。 此外，可变形基底将变形以改变SERS活性纳米粒子之间的距离，其中SERS-活性纳米粒子之间的变化距离改变了来自分析物分子的拉曼散射光发射强度的增强。

    Systems and methods for detection of Raman scattered photons
    10.
    发明授权
    Systems and methods for detection of Raman scattered photons 有权
    用于检测拉曼散射光子的系统和方法

    公开(公告)号：US07405822B2

    公开(公告)日：2008-07-29

    申请号：US11584020

    申请日：2006-10-20

    申请人： Zhiyong Li ,  Wei Wu ,  Shih-Yuan Wang

    发明人： Zhiyong Li ,  Wei Wu ,  Shih-Yuan Wang

    IPC分类号： G01J3/44 ,  G01N21/65

    CPC分类号： G01J3/44 ,  G01N21/658

    摘要： Raman spectroscopy systems include an analyte, a radiation source configured to emit incident radiation having a wavelength, and a detector that is capable of detecting only radiation having wavelengths within a detectable range that includes at least one wavelength corresponding to hyper Raman scattered radiation scattered by the analyte. The wavelength of the incident radiation is outside the detectable range. In particular systems, all wavelengths of radiation that are scattered in the direction of the detector impinge on the detector. Raman spectroscopy methods include providing an analyte and irradiating the analyte with incident radiation having a wavelength, providing a detector capable of detecting only wavelengths of radiation within a detectable range that does not include the wavelength of the incident radiation, and detecting Raman scattered radiation scattered by the analyte. A continuous path free of radiation filters may be provided between the analyte and the detector.

    摘要翻译： 拉曼光谱系统包括分析物，被配置为发射具有波长的入射辐射的辐射源，以及检测器，其能够仅检测波长在可检测范围内的辐射，所述波长包括对应于由所述波长散射的超拉曼散射辐射的至少一个波长 分析物。 入射辐射的波长在可检测范围之外。 在特定系统中，在检测器的方向上散射的所有辐射波长都照射在检测器上。 拉曼光谱方法包括提供分析物并用具有波长的入射辐射照射分析物，提供检测器，该检测器仅能够检测不包括入射辐射波长的可检测范围内的辐射波长，并且检测散射的拉曼散射辐射 分析物。 可以在分析物和检测器之间提供不含辐射过滤器的连续路径。