公开(公告)号：US4902677A

公开(公告)日：1990-02-20

申请号：US159747

申请日：1988-02-24

申请人： Shoichi Imai ,  Shigehiro Kataoka ,  Junko Isono ,  Nobuyuki Yamaji ,  Motohiko Kato

发明人： Shoichi Imai ,  Shigehiro Kataoka ,  Junko Isono ,  Nobuyuki Yamaji ,  Motohiko Kato

IPC分类号： C07H19/213 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7052 ,  A61K31/7076 ,  A61P9/04 ,  C07H19/20

CPC分类号： C07H19/20

摘要： A composition for use in the treatment of heart failure of mammals which comprises, as its active ingredient, an N.sup.6 -substututed-adenosine-3',5'-cyclic phosphate represented by the following general formula (I) or a physiologically acceptable salt thereof: ##STR1## wherein R represents alkyl or aralkyl group and a pharmaceutically acceptable carrier, as well as a method for treating heart failure of mammals which comprises administering said composition.

摘要翻译： 一种用于治疗哺乳动物心力衰竭的组合物，其包含作为其活性成分的由以下通式（I）表示的N 6 - 亚基 - 腺苷-3'，5'-环磷酸酯或其生理学上可接受的盐 ：其中R表示烷基或芳烷基和药学上可接受的载体，以及用于治疗哺乳动物心力衰竭的方法，其包括施用所述组合物。

公开(公告)号：US5246922A

公开(公告)日：1993-09-21

申请号：US571188

申请日：1990-08-23

申请人： Shigehiro Kataoka ,  Nobuyuki Yamaji ,  Motohiko Kato ,  Shoichi Imai

发明人： Shigehiro Kataoka ,  Nobuyuki Yamaji ,  Motohiko Kato ,  Shoichi Imai

IPC分类号： C07H19/213 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7052 ,  A61K31/7076 ,  A61P9/04 ,  C07H19/20

CPC分类号： C07H19/20 ,  Y02P20/55

摘要： The present invention relates to a N.sup.6,N.sup.6 -disubstituted-cyclic adenosine-3',5'-monophosphate represented by the formula ##STR1## wherein R represents a linear alkyl group having 3 or more carbon atoms or a branched alkyl group having 4 or more carbon atoms, an aralkyl group or an alkenyl group; A.sup..sym. represents a hydrogen ion, an alkali metal ion, an alkaline earth metal ion, an ammonium ion or an organoammonium ion, or a salt thereof, and a cardiac composition comprising it as an effective component, and further includes a process for preparing a compound represented by the formula ##STR2## wherein R.sub.1 represents an alkyl group, an aralkyl group or an alkenyl group and A.sup..sym. has the same meanings as defined above, or a salt thereof, characterized in that a 2'-O-protected-cyclic adenosine-3',5'-monophosphate represented by the formula ##STR3## wherein Y represents a protecting group and A.sup..sym. has the same meanings as defined above, or a salt thereof is reacted with an organic halide represented by the formulaR.sub.1 X (III) wherein X represents a halogen atom and R.sub.1 has the same meanings as defined above, and the protecting group is then removed.

摘要翻译： 本发明涉及由式（I）表示的N6，N6-二取代环腺苷-3'，5'-单磷酸酯，其中R表示具有3个或更多个碳原子的直链烷基或支链烷基 具有4个或更多个碳原子，芳烷基或烯基; A（+）表示氢离子，碱金属离子，碱土金属离子，铵离子或有机铵离子或其盐，以及包含其作为有效成分的心脏组合物，还包括 制备由式（I'）表示的化合物，其中R 1表示烷基，芳烷基或烯基，A（+）具有与上述相同的含义或其盐，其特征在于， 或其盐，其中Y表示保护基，A（+）与上述相同的含义，由式（II）表示的2'-O-保护环腺苷-3'，5'-单磷酸 与式R1X（III）表示的有机卤化物反应，其中X表示卤素原子，R 1具有与上述相同的含义，然后除去保护基。

公开(公告)号：US20060172039A1

公开(公告)日：2006-08-03

申请号：US11049267

申请日：2005-02-01

申请人： Shoichi Imai

发明人： Shoichi Imai

IPC分类号： B29C45/66

CPC分类号： B29C45/64 ,  B29C45/0408 ,  B29C45/062

摘要： An injection molding system has a plurality of movable sub-clamping units each having a mold therein and a main clamping unit for clamping the mold in the sub-clamping unit. Each of the sub-clamping units alternately enters the main clamping unit for only an filling process to receive the melted resin material from an injection unit. Each sub-clamping unit clamps the mold by its own clamping mechanism and moves to the main clamping unit where the mold is further clamped by a higher clamping pressure by the main clamping unit during the filling process. Each sub-clamping unit is retracted from the main clamping unit immediately after the filling process and stayed outside of the main clamping unit through the holding process and the cooling process, thereby dramatically improving the molding production efficiency.

摘要翻译： 注塑系统具有多个可移动子夹紧单元，每个可移动子夹紧单元各自具有模具，以及用于将模具夹紧在副夹紧单元中的主夹紧单元。 每个副夹紧单元交替地进入主夹紧单元仅用于从注射单元接收熔融树脂材料的填充过程。 每个子夹紧单元通过其自身的夹紧机构夹持模具并移动到主夹紧单元，在填充过程中，模具进一步被主夹紧单元的夹紧压力夹紧。 每个副夹紧单元在填充过程之后立即从主夹紧单元缩回，并通过保持过程和冷却过程停留在主夹紧单元的外部，从而显着提高模制生产效率。

公开(公告)号：US5215551A

公开(公告)日：1993-06-01

申请号：US582218

申请日：1990-10-01

申请人： Tetsuo Hatanaka ,  Tadashi Hiraiwa ,  Minoru Matsukura ,  Norimichi Aoki ,  Shoichi Imai

发明人： Tetsuo Hatanaka ,  Tadashi Hiraiwa ,  Minoru Matsukura ,  Norimichi Aoki ,  Shoichi Imai

IPC分类号： C04B35/111 ,  C09K3/14

CPC分类号： C09K3/1418 ,  C04B35/1115

摘要： An .alpha.-alumina-based ceramics material comprising crystals of a particle diameter of no greater than 0.2 .mu.m on an average or a particle diameter of substantially no greater than 0.2 .mu.m, and having a density of no lower than 95% of the theoretical density and a hardness of no lower than 2,000 kg/mm.sup.2, and a method for the production thereof.

公开(公告)号：US07198480B2

公开(公告)日：2007-04-03

申请号：US11049267

申请日：2005-02-01

申请人： Shoichi Imai

发明人： Shoichi Imai

IPC分类号： B29C45/04

CPC分类号： B29C45/64 ,  B29C45/0408 ,  B29C45/062

摘要： An injection molding system has a plurality of movable sub-clamping units each having a mold therein and a main clamping unit for clamping the mold in the sub-clamping unit. Each of the sub-clamping units alternately enters the main clamping unit for only a filling process to receive the melted resin material from an injection unit. Each sub-clamping unit clamps the mold by its own clamping mechanism and moves to the main clamping unit where the mold is further clamped by a higher clamping pressure by the main clamping unit during the filling process. Each sub-clamping unit is retracted from the main clamping unit immediately after the filling process and stayed outside of the main clamping unit through the holding process and the cooling process, thereby dramatically improving the molding production efficiency.

摘要翻译： 注塑系统具有多个可移动子夹紧单元，每个可移动子夹紧单元各自具有模具，以及用于将模具夹紧在副夹紧单元中的主夹紧单元。 每个副夹紧单元交替地进入主夹紧单元仅用于从注射单元接收熔融树脂材料的填充过程。 每个子夹紧单元通过其自身的夹紧机构夹持模具并移动到主夹紧单元，在填充过程中，模具进一步被主夹紧单元的夹紧压力夹紧。 每个副夹紧单元在填充过程之后立即从主夹紧单元缩回，并通过保持过程和冷却过程停留在主夹紧单元的外部，从而显着提高模制生产效率。

公开(公告)号：US07990165B2

公开(公告)日：2011-08-02

申请号：US12297732

申请日：2007-04-19

申请人： Masahiro Aoyagi ,  Katsuya Kikuchi ,  Hiroshi Nakagawa ,  Yoshikuni Okada ,  Hiroyuki Fujita ,  Shoichi Imai ,  Shigeo Kiyota

发明人： Masahiro Aoyagi ,  Katsuya Kikuchi ,  Hiroshi Nakagawa ,  Yoshikuni Okada ,  Hiroyuki Fujita ,  Shoichi Imai ,  Shigeo Kiyota

IPC分类号： G01R31/02

CPC分类号： G01R3/00 ,  G01R1/06772 ,  G01R1/07342 ,  Y10T29/49117 ,  Y10T29/49126 ,  Y10T156/10

摘要： To provide a contact probe which can easily be connected with a measurement apparatus electrically, can measure a high speed and high frequency signal with a fine pitch easily and correctly, and can easily cope with signal measurement for a plurality of channels, and a method of making the contact probe.It includes a first printed wiring board 3 having a signal electrode 10a and a ground electrode 10b used as a contact part with respect to a measuring object, in which the signal electrode 10a and ground electrode 10b are formed of a metal wiring pattern on a substrate, and a second printed wiring board 2 with a coaxial line structure having shield electrodes 12, 17, 18 which enclose a signal line 15a and the surroundings of the signal line 15a through an insulating layer. The signal electrode 10a of the first printed wiring board 3 and the signal line 15a of the second printed wiring board 2 are electrically connected together, and the ground electrode 10b of the first printed wiring board 3 and the shield electrodes 12, 17, 18 of the second printed wiring board 2 are electrically connected together.

摘要翻译： 为了提供可以容易地与测量装置电连接的接触探针，可以容易且正确地测量具有细间距的高速和高频信号，并且可以容易地处理多个通道的信号测量，以及一种方法 使接触探针。 它包括具有信号电极10a和接地电极10b的第一印刷线路板3，该接地电极用作相对于测量对象的接触部分，其中信号电极10a和接地电极10b由基板上的金属布线图形成 以及具有同轴线结构的第二印刷布线板2，其具有通过绝缘层包围信号线15a和信号线15a的周围的屏蔽电极12,17,18。 第一印刷线路板3的信号电极10a和第二印刷线路板2的信号线15a电连接在一起，第一印刷线路板3的接地电极10b和屏蔽电极12,17,18的 第二印刷线路板2电连接在一起。

公开(公告)号：US5556862A

公开(公告)日：1996-09-17

申请号：US360630

申请日：1994-12-21

申请人： Shoichi Imai ,  Ken-ichi Mabuchi ,  Minoru Kawamura

发明人： Shoichi Imai ,  Ken-ichi Mabuchi ,  Minoru Kawamura

IPC分类号： C07D217/02 ,  A61K31/47 ,  A61K31/472 ,  A61K31/52 ,  A61K31/522 ,  A61P1/16 ,  A61P7/10 ,  A61P11/00 ,  A61P25/00 ,  A61P25/20 ,  A61P25/24 ,  A61P25/26 ,  A61P25/28 ,  A61P29/00 ,  A61P37/08 ,  A61P43/00 ,  C07D217/20 ,  C07D473/08

CPC分类号： A61K31/52 ,  A61K31/47

摘要： Pharmaceutical compositions containing an isoquinoline derivative exhibit an excellent inhibitory action to an isozyme of phosphodiesterase of the type IV (PDEIV). The active component of the pharmaceutical composition is an isoquinoline derivative which is represented by the general formula: ##STR1## wherein R is an ethoxy group, or which is a pharmaceutically-acceptable salt of a compound represented by said formula. The isoquinoline derivatives have an excellent inhibitory action which is highly specific to PDEIV. They are highly useful as pharmaceuticals such as antidepressive agents, tranquilizers, antidemential agents, antiinflammatory agents, antiallergic agents, antiasthmatic agents, liver-protecting agents, and diuretic agents.

摘要翻译： 含有异喹啉衍生物的药物组合物对IV型（PDEIV）的磷酸二酯酶的同功酶表现出优异的抑制作用。 药物组合物的活性成分是异喹啉衍生物，其由以下通式表示：其中R是乙氧基，或其是由所述式表示的化合物的药学上可接受的盐。 异喹啉衍生物具有优异的抑制作用，对PDEIV具有高度的特异性。 它们作为药物如抗抑郁药，镇静剂，抗抑郁剂，抗炎剂，抗过敏剂，止喘剂，肝保护剂和利尿剂是非常有用的。