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17 条记录 (耗时 0.051 秒)

    Polypeptide and DNA thereof
    5.
    发明授权
    Polypeptide and DNA thereof 失效
    多肽及其DNA

    公开(公告)号：US06797483B1

    公开(公告)日：2004-09-28

    申请号：US10019455

    申请日：2001-12-28

    申请人： Yasuaki Itoh ,  Kazunori Nishi ,  Kazuhiro Ogi ,  Shoichi Ohkubo ,  Shinichi Mogi ,  Yuko Noguchi ,  Koji Yoshimura ,  Hideyuki Tanaka

    发明人： Yasuaki Itoh ,  Kazunori Nishi ,  Kazuhiro Ogi ,  Shoichi Ohkubo ,  Shinichi Mogi ,  Yuko Noguchi ,  Koji Yoshimura ,  Hideyuki Tanaka

    IPC分类号： G01N3353

    CPC分类号： C07K14/4703 ,  A61K38/00

    摘要： The present invention relates to novel secretory polypeptides and precursor proteins thereof, which show a high homology to MIA (melanoma inhibitor activity)/CD-RAP (bovine cartilage-derived retinoic acid-sensitive protein); are specifically expressed in the cartilage tissue; and have an effect on the cartilage differentiation. The polypeptides and the DNAs encoding the same can be used for the diagnosis, treatment, or prevention of bone and joint diseases or pathological angiogenesis. As well, the polypeptides are useful as a reagent for screening a compound that promotes or inhibits the activity of the polypeptides. The antibody to the polypeptides can be used for the detection, quantification, or neutralization of the polypeptide in a test sample fluid. Further by using the promoter of the present invention, a therapeutic protein can be expressed predominantly in the cartilage tissue for a gene therapy.

    摘要翻译： 本发明涉及与MIA（黑素瘤抑制剂活性）/ CD-RAP（牛软骨衍生的视黄酸敏感蛋白）高同源性的新型分泌多肽及其前体蛋白; 在软骨组织中特异性表达; 并对软骨分化有影响。 编码该多肽和DNA的DNA可用于诊断，治疗或预防骨和关节疾病或病理性血管生成。 同样，多肽可用作筛选促进或抑制多肽活性的化合物的试剂。 多肽的抗体可用于在测试样品流体中检测，定量或中和多肽。 此外，通过使用本发明的启动子，治疗性蛋白质主要在软骨组织中表达用于基因治疗。

    Screening Method
    6.
    发明申请
    Screening Method 失效
    筛选方法

    公开(公告)号：US20080103215A1

    公开(公告)日：2008-05-01

    申请号：US11661555

    申请日：2005-08-29

    申请人： Yasuaki Ito ,  Kazunori Nishi ,  Shoichi Ohkubo ,  Masataka Harada

    发明人： Yasuaki Ito ,  Kazunori Nishi ,  Shoichi Ohkubo ,  Masataka Harada

    IPC分类号： A61K45/00 ,  G01N33/53 ,  G01N33/15 ,  A61P1/00 ,  A61P3/10 ,  A61P35/00 ,  A61P37/00 ,  A61P3/04

    CPC分类号： G01N33/6893 ,  C07K14/705 ,  G01N33/574 ,  G01N2500/00

    摘要： The present invention provides a method of screening a compound or its salt that alters binding properties of a protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1, or a salt thereof, and a ligand capable of specifically binding to the protein or its salt, which comprises using (a) the protein, its partial peptide, or a salt thereof and (b) the ligand; a screening kit therefor, and so on. The screening method and kit of the present invention are useful for screening an agent for the prevention/treatment of, e.g., digestive tract disorders, cancer, immune disorders, type II diabetes mellitus or obesity, etc.

    摘要翻译： 本发明提供一种筛选化合物或其盐的方法，其改变包含与SEQ ID NO：1所示的氨基酸序列相同或基本上相同的氨基酸序列的蛋白质的结合性，或其盐，和 能够特异性结合蛋白质或其盐的配体，其包括使用（a）蛋白质，其部分肽或其盐和（b）配体; 一个筛选工具，等等。 本发明的筛选方法和试剂盒可用于筛选用于预防/治疗例如消化道疾病，癌症，免疫疾病，II型糖尿病或肥胖症等的药剂。

    Screening method
    7.
    发明授权
    Screening method 失效
    筛选方法

    公开(公告)号：US07892755B2

    公开(公告)日：2011-02-22

    申请号：US11661555

    申请日：2005-08-29

    申请人： Yasuaki Ito ,  Kazunori Nishi ,  Shoichi Ohkubo ,  Masataka Harada

    发明人： Yasuaki Ito ,  Kazunori Nishi ,  Shoichi Ohkubo ,  Masataka Harada

    IPC分类号： G01N33/566 ,  A61K38/00

    CPC分类号： G01N33/6893 ,  C07K14/705 ,  G01N33/574 ,  G01N2500/00

    摘要： The present invention provides a method of screening a compound or its salt that alters binding properties of a protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1, or a salt thereof, and a ligand capable of specifically binding to the protein or its salt, which comprises using (a) the protein, its partial peptide, or a salt thereof and (b) the ligand; a screening kit therefor, and so on. The screening method and kit of the present invention are useful for screening an agent for the prevention/treatment of, e.g., digestive tract disorders, cancer, immune disorders, type II diabetes mellitus or obesity, etc.

    摘要翻译： 本发明提供一种筛选化合物或其盐的方法，其改变包含与SEQ ID NO：1所示的氨基酸序列相同或基本上相同的氨基酸序列的蛋白质的结合性，或其盐，和 能够特异性结合蛋白质或其盐的配体，其包括使用（a）蛋白质，其部分肽或其盐和（b）配体; 一个筛选工具，等等。 本发明的筛选方法和试剂盒可用于筛选用于预防/治疗例如消化道疾病，癌症，免疫疾病，II型糖尿病或肥胖症等的药剂。

    Human LH-RH receptor expression cells and use thereof
    8.
    发明授权
    Human LH-RH receptor expression cells and use thereof 失效
    人LH-RH受体表达细胞及其用途

    公开(公告)号：US6117645A

    公开(公告)日：2000-09-12

    申请号：US867260

    申请日：1997-06-02

    申请人： Haruo Onda ,  Shoichi Ohkubo ,  Shuji Hinuma

    发明人： Haruo Onda ,  Shoichi Ohkubo ,  Shuji Hinuma

    IPC分类号： A61K38/00 ,  A61K39/00 ,  C07K7/23 ,  C07K14/72 ,  C12N15/12 ,  G01N33/53

    CPC分类号： C07K7/23 ,  C07K14/723 ,  A61K38/00 ,  A61K39/00

    摘要： Disclosed are CHO cells which are capable of continued production of human LH-RH receptor proteins, or cell membrane fractions thereof; recombinant human LH-RH receptor proteins or partial peptides thereof; methods for screening compounds which have affinity for an LH-RH receptor by contacting the compound with the CHO cells or the cell membrane fractions thereof, or the recombinant human LH-RH receptor proteins or the partial peptides thereof; kits for screening them; the compounds which have affinity for the LH-RH receptor obtained by methods for the screening or kits for the screening; and pharmaceutical compositions containing the compound, thereby being able to early provide prophylactic or therapeutic compositions, for example, for prostate cancer, uterine cancer, breast cancer, a pituitary tumor, endometriosis, hysteromyoma or precocious puberty. They are also useful as a pregnancy controlling composition such as contraceptive or a menstrual cycle controlling composition.

    摘要翻译： 公开了能够连续产生人LH-RH受体蛋白质或其细胞膜级分的CHO细胞; 重组人LH-RH受体蛋白或其部分肽; 通过使化合物与CHO细胞或其细胞膜级分或重组人LH-RH受体蛋白质或其部分肽接触来筛选对LH-RH受体具有亲和性的化合物的方法; 用于筛选它们的试剂盒 通过筛选方法获得的对LH-RH受体具有亲和力的化合物或用于筛选的试剂盒; 以及含有该化合物的药物组合物，从而能够早期提供例如前列腺癌，子宫癌，乳腺癌，垂体瘤，子宫内膜异位症，子宫肌瘤或早熟青春期的预防或治疗组合物。 它们也可用作妊娠控制组合物，例如避孕或月经周期控制组合物。

    CHO cells that express human LH-RH receptor
    9.
    发明授权
    CHO cells that express human LH-RH receptor 失效
    表达人LH-RH受体的CHO细胞

    公开(公告)号：US5677184A

    公开(公告)日：1997-10-14

    申请号：US423691

    申请日：1995-04-18

    申请人： Haruo Onda ,  Shoichi Ohkubo ,  Shuji Hinuma ,  Hidekazu Sawada

    发明人： Haruo Onda ,  Shoichi Ohkubo ,  Shuji Hinuma ,  Hidekazu Sawada

    IPC分类号： A61K38/00 ,  A61K39/00 ,  C07K7/23 ,  C07K14/72 ,  C12N15/12 ,  G01N33/53 ,  C12N15/85

    CPC分类号： C07K7/23 ,  C07K14/723 ,  A61K38/00 ,  A61K39/00

    摘要： Disclosed are CHO cells which are capable of continued production of human LH-RH receptor proteins, or cell membrane fractions thereof; recombinant human LH-RH receptor proteins or partial peptides thereof; methods for screening compounds which have affinity for an LH-RH receptor by contacting the compound with the CHO cells or the cell membrane fractions thereof, or the recombinant human LH-RH receptor proteins or the partial peptides thereof; kits for screening them; the compounds which have affinity for the LH-RH receptor obtained by methods for the screening or kits for the screening; and pharmaceutical compositions containing the compound, thereby being able to early provide prophylactic or therapeutic compositions, for example, for prostate cancer, uterine cancer, breast cancer, a pituitary tumor, endometriosis, hysteromyoma or precocious puberty. They are also useful as a pregnancy controlling composition such as contraceptive or a menstrual cycle controlling composition.

    摘要翻译： 公开了能够连续产生人LH-RH受体蛋白质或其细胞膜级分的CHO细胞; 重组人LH-RH受体蛋白或其部分肽; 通过使化合物与CHO细胞或其细胞膜级分或重组人LH-RH受体蛋白或其部分肽接触来筛选对LH-RH受体具有亲和力的化合物的方法; 用于筛选它们的试剂盒 通过筛选方法获得的对LH-RH受体具有亲和力的化合物或用于筛选的试剂盒; 以及含有该化合物的药物组合物，从而能够早期提供例如前列腺癌，子宫癌，乳腺癌，垂体瘤，子宫内膜异位症，子宫肌瘤或早熟青春期的预防或治疗组合物。 它们也可用作妊娠控制组合物，例如避孕或月经周期控制组合物。

    Flame-retardant isocyanate-based foams and method of producing the same
    10.
    发明授权
    Flame-retardant isocyanate-based foams and method of producing the same 失效
    阻燃型异氰酸酯类泡沫及其制造方法

    公开(公告)号：US4220729A

    公开(公告)日：1980-09-02

    申请号：US815681

    申请日：1977-07-14

    申请人： Shinzi Uchida ,  Takashi Yokoyama ,  Shoichi Ohkubo

    发明人： Shinzi Uchida ,  Takashi Yokoyama ,  Shoichi Ohkubo

    IPC分类号： C08J9/00 ,  C08G18/14 ,  C08G18/22 ,  C08G18/58

    CPC分类号： C08J9/0014 ,  C08J2375/04 ,  Y10S521/902 ,  Y10S521/906

    摘要： A method of producing foams by utilizing the reactivity of isocyanate groups comprising the steps of reacting an organic polyisocyanate in the presence of a foaming agent and, optionally, at least one member selected from the group consisting of polyols, polyepoxides, polycarboxylic acids, acid anhydrides and other compounds capable of reacting with the isocyanate groups and, if necessary, a catalyst, a foam stabilizer and other additives, the improvement wherein at least one organic amine-metal complex soluble in the liquid raw material and containing a metal selected from the group consisting of copper, nickel, lead, cobalt, manganese, zinc, and chromium is added to the reaction system in an amount of 0.5 to 30 weight % based on the total weight of the raw materials used for the preparation of foams. The foams containing flame-retardant organic amine-metal complexes prepared by the aforementioned method.

    摘要翻译： 通过利用异氰酸酯基团的反应性生产泡沫的方法，包括以下步骤：在发泡剂存在下使有机多异氰酸酯和任选的至少一种选自多元醇，聚环氧化物，多元羧酸，酸酐 以及能够与异氰酸酯基团反应的其它化合物，以及必要时的催化剂，泡沫稳定剂和其它添加剂的改进，其中至少一种可溶于液体原料并含有选自下组的金属的有机胺金属络合物 以用于制备泡沫体的原材料的总重量为基准，以0.5〜30重量％的量向反应体系中添加铜，镍，铅，钴，锰，锌，铬。 含有通过上述方法制备的阻燃有机胺 - 金属络合物的泡沫体。