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    Polypeptides their production and use
    3.
    发明授权
    Polypeptides their production and use 失效
    多肽的生产和使用

    公开(公告)号：US06228984B1

    公开(公告)日：2001-05-08

    申请号：US08776971

    申请日：1997-02-07

    申请人： Shuji Hinuma ,  Yugo Habata ,  Yuji Kawamata ,  Masaki Hosoya ,  Ryo Fujii ,  Shoji Fukusumi ,  Chieko Kitada

    发明人： Shuji Hinuma ,  Yugo Habata ,  Yuji Kawamata ,  Masaki Hosoya ,  Ryo Fujii ,  Shoji Fukusumi ,  Chieko Kitada

    IPC分类号： C07K1447

    CPC分类号： C07H21/04 ,  A61K38/00 ,  C07K14/575 ,  C07K14/705 ,  C07K14/72 ,  C07K16/28

    摘要： The present invention relates to the ligand polypeptide for the human pituitary- and mouse pancreas-derived G protein-coupled receptor proteins. The ligand polypeptide or the DNA which codes for the ligand polypeptide can be used for (1) development of medicines such as pituitary function modulators, central nervous system function modulators, and pancreatic function modulators, and (2) development of recombinant receptor proteins and screening of pharmaceutical candidate compounds. In particular, by the receptor binding assay systems utilizing the expression of recombinant G protein-coupled receptor proteins in accordance with the invention, agonists and antagonists of G protein-coupled receptors which are specific to human and other warm-blooded animals can be screened and the agonists or antagonists obtained can be used as therapeutic and prophylactic agents for various diseases.

    摘要翻译： 本发明涉及用于人垂体和小鼠胰腺衍生的G蛋白偶联受体蛋白质的配体多肽。 编码配体多肽的配体多肽或DNA可用于（1）开发药物如垂体功能调节剂，中枢神经系统功能调节剂和胰腺功能调节剂，以及（2）重组受体蛋白的发育和筛选 的药物候选化合物。 特别地，通过利用根据本发明的重组G蛋白偶联受体蛋白表达的受体结合测定系统，可以筛选对人类和其他温血动物特异性的G蛋白偶联受体的激动剂和拮抗剂， 获得的激动剂或拮抗剂可用作各种疾病的治疗和预防剂。

    Polypeptides, their production and use
    4.
    发明授权
    Polypeptides, their production and use 失效
    多肽，其生产和使用

    公开(公告)号：US06794491B1

    公开(公告)日：2004-09-21

    申请号：US09576290

    申请日：2000-05-23

    申请人： Shuji Hinuma ,  Yugo Habata ,  Yuji Kawamata ,  Masaki Hosoya ,  Ryo Fujii ,  Shoji Fukusumi ,  Chieko Kitada

    发明人： Shuji Hinuma ,  Yugo Habata ,  Yuji Kawamata ,  Masaki Hosoya ,  Ryo Fujii ,  Shoji Fukusumi ,  Chieko Kitada

    IPC分类号： C07K14475

    CPC分类号： C07H21/04 ,  A61K38/00 ,  C07K14/575 ,  C07K14/705 ,  C07K14/72 ,  C07K16/28

    摘要： The present invention relates to the ligand polypeptide for the human pituitary- and mouse pancreas-derived G protein-coupled receptor proteins. The ligand polypeptide or the DNA which codes for the ligand polypeptide can be used for (1) development of medicines such as pituitary function modulators, central nervious system function modulators, and pancreatic function modulators, and (2) development of receptor binding assay systems using the expression of recombinant receptor proteins and screening of pharmaceutical candidate compounds. In particular, by the receptor binding assay systems utilizing the expression of recombinant G protein-coupled receptor proteins in accordance with the invention, agonists and antagonists of G protein-coupled receptors which are specific to human and other warm-blooded animals can be screened and the agonists or antagonists obtained can be used as therapeutic and prophylactic agents for various diseases.

    摘要翻译： 本发明涉及用于人垂体和小鼠胰腺衍生的G蛋白偶联受体蛋白质的配体多肽。配体多肽或编码配体多肽的DNA可用于（1）开发诸如垂体的药物 功能调节剂，中枢神经系统功能调节剂和胰腺功能调节剂，以及（2）使用重组受体蛋白质的表达和药物候选化合物的筛选开发受体结合测定系统。特别地，通过受体结合测定系统利用表达 根据本发明的重组G蛋白偶联受体蛋白质，可以筛选对人类和其他温血动物特异性的G蛋白偶联受体的激动剂和拮抗剂，并且所获得的激动剂或拮抗剂可用作治疗和预防 各种疾病的代理

    Polypeptides, their production and use
    6.
    发明授权
    Polypeptides, their production and use 失效
    多肽，其生产和使用

    公开(公告)号：US06881545B1

    公开(公告)日：2005-04-19

    申请号：US09716147

    申请日：2000-11-17

    申请人： Shuji Hinuma ,  Yugo Habata ,  Yuji Kawamata ,  Masaki Hosoya ,  Ryo Fujii ,  Shoji Fukusumi ,  Chieko Kitada

    发明人： Shuji Hinuma ,  Yugo Habata ,  Yuji Kawamata ,  Masaki Hosoya ,  Ryo Fujii ,  Shoji Fukusumi ,  Chieko Kitada

    IPC分类号： C07K14/575 ,  C07K14/705 ,  G01N33/53 ,  C07K7/08 ,  C07K14/72

    CPC分类号： C07K14/705 ,  C07K14/575

    摘要： The present invention relates to the ligand polypeptide for the human pituitary- and mouse pancreas-derived G protein-coupled receptor proteins.The ligand polypeptide or the DNA which codes for the ligand polypeptide can be used for (1) development of medicines such as pituitary function modulators, central nervious system function modulators, and pancreatic function modulators, and (2) development of receptor binding assay systems using the expression of recombinant receptor proteins and screening of pharmaceutical candidate compounds.In particular, by the receptor binding assay systems utilizing the expression of recombinant G protein-coupled receptor proteins in accordance with the invention, agonists and antagonists of G protein-coupled receptors which are specific to human and other warm-blooded animals can be screened and the agonists or antagonists obtained can be used as therapeutic and prophylactic agents for various diseases.

    摘要翻译： 本发明涉及用于人垂体和小鼠胰腺衍生的G蛋白偶联受体蛋白质的配体多肽。 编码配体多肽的配体多肽或DNA可用于（1）开发药物，例如垂体功能调节剂，中枢神经系统功能调节剂和胰功能调节剂，以及（2）开发受体结合测定系统，其使用 重组受体蛋白的表达和药物候选化合物的筛选。 特别地，通过利用根据本发明的重组G蛋白偶联受体蛋白表达的受体结合测定系统，可以筛选对人类和其他温血动物特异性的G蛋白偶联受体的激动剂和拮抗剂， 获得的激动剂或拮抗剂可用作各种疾病的治疗和预防剂。

    G protein-coupled receptor protein, its DNA and ligand thereof
    8.
    发明授权
    G protein-coupled receptor protein, its DNA and ligand thereof 失效
    G蛋白偶联受体蛋白，其DNA及其配体

    公开(公告)号：US07192723B2

    公开(公告)日：2007-03-20

    申请号：US10719587

    申请日：2003-11-21

    申请人： Takuya Watanabe ,  Kuniko Kikuchi ,  Yasuko Terao ,  Yasushi Shintani ,  Shuji Hinuma ,  Shoji Fukusumi ,  Ryo Fujii ,  Masaki Hosoya ,  Chieko Kitada

    发明人： Takuya Watanabe ,  Kuniko Kikuchi ,  Yasuko Terao ,  Yasushi Shintani ,  Shuji Hinuma ,  Shoji Fukusumi ,  Ryo Fujii ,  Masaki Hosoya ,  Chieko Kitada

    IPC分类号： C07K7/08 ,  C07K14/47 ,  G01N33/566

    CPC分类号： C07K14/705 ,  C07K14/723 ,  C07K16/28 ,  G01N33/566 ,  G01N33/74 ,  G01N2333/726

    摘要： The polypeptides in the present invention possess the effects of promoting and inhibiting the secretion of prolactin, and are thus useful as drugs for the prevention and treatment of various diseases, in terms of prolactin secretion stimulants, which are associated with the secretion of prolactin, such as hypoovarianism, spermatic underdevelopment, menopausal symptoms, hypothyroidism, etc. The polypeptides are useful as drugs for the prevention and treatment of various diseases, in terms of prolactin secretion inhibitors, which are associated with the secretion of prolactin, such as pituitary tumor, diencephalon tumor, menstrual disorder, autoimmune diseases, prolactinoma, sterility, impotence, amenorrhea, lactorrhea, acromegaly, Chiari-Frommel syndrome, Argonz-del Castilo syndrome, Forbes-Albright syndrome, lymphoma, Sheehan's syndrome, spermatogenesis disorder, etc.

    摘要翻译： 本发明中的多肽具有促进和抑制催乳素分泌的作用，因此可用作预防和治疗与催乳素分泌有关的催乳激素分泌兴奋剂的各种疾病的药物，例如 作为低血糖症，精神发育不良，绝经期症状，甲状腺机能减退等。多肽可用作预防和治疗各种疾病的催乳素分泌抑制剂，其与催乳素分泌相关，例如垂体瘤，间脑瘤 肿瘤，月经紊乱，自身免疫性疾病，催乳素瘤，不育症，阳ence，闭经，泌乳，肢端肥大症，Chiari-Frommel综合征，阿尔贡兹 - 德尔卡斯蒂略综合征，福布斯 - 奥尔布赖特综合征，淋巴瘤，Sheehan综合征，精子发生障碍等。

    G-protein coupled receptor protein and a DNA encoding the receptor
    10.
    发明授权
    G-protein coupled receptor protein and a DNA encoding the receptor 失效
    G蛋白偶联受体蛋白和编码受体的DNA

    公开(公告)号：US6114139A

    公开(公告)日：2000-09-05

    申请号：US513974

    申请日：1995-09-14

    申请人： Shuji Hinuma ,  Masaki Hosoya ,  Ryo Fujii ,  Tetsuya Ohtaki ,  Shoji Fukusumi ,  Kazuhiro Ohgi

    发明人： Shuji Hinuma ,  Masaki Hosoya ,  Ryo Fujii ,  Tetsuya Ohtaki ,  Shoji Fukusumi ,  Kazuhiro Ohgi

    IPC分类号： C07K14/705 ,  C07K14/72 ,  C12N15/12 ,  C12Q1/68 ,  C12N5/10 ,  C12N15/63

    CPC分类号： C12Q1/6876 ,  C07K14/705 ,  C07K14/70571 ,  C07K14/723 ,  C12Q2600/158

    摘要： DNA primers effective in screening G protein coupled receptor protein-encoding DNA fragments are provided. The primers which are complementary to nucleotide sequences that are in community with (homologous to) the nucleotide sequences encoding amino acid sequences corresponding to or near the first membrane-spanning domain or the sixth membrane-spanning domain each of known various G protein coupled receptor proteins were designed and synthesized. Methods of amplifying G protein coupled receptor protein-encoding DNAs using the above DNA primers, and novel target G protein coupled receptor protein-encoding DNAs are also provided. Screening of DNA libraries can be efficiently carried out. Human pituitary gland or amygdala-derived and mouse pancreas-derived G protein coupled receptor proteins, etc. or salts thereof, partial peptides thereof, DNAs coding for the above G protein coupled receptor proteins, processes for producing the above G protein coupled receptor proteins, methods of determining ligands for the above G protein coupled receptor proteins, methods of screening compounds that inhibit the binding between the ligand and the G protein coupled receptor proteins or screening kits therefor, compounds or salts thereof obtained by the above screening method or the screening kit, pharmaceutical compositions containing the above compounds or salts thereof, and antibodies against the above protein coupled receptor proteins or partial peptides thereof are provided.

    摘要翻译： PCT No.PCT / JP95 / 01599 Sec。 371 1995年9月14日第 102（e）1995年9月14日PCT PCT 1995年8月10日PCT公布。 出版物WO96 / 05302 日期1996年2月22日提供了有效筛选编码G蛋白偶联受体蛋白的DNA片段的DNA引物。 与与编码对应于或接近第一跨膜结构域或第六跨膜结构域的氨基酸序列的核苷酸序列（同源的）的核苷酸序列互补的引物，每个已知的各种G蛋白偶联受体蛋白 被设计和合成。 还提供了使用上述DNA引物扩增G蛋白偶联受体蛋白质编码DNA的方法，以及新的靶向G蛋白偶联受体蛋白质编码DNA。 可以有效地进行DNA文库的筛选。 人类垂体腺或来自扁桃体的小鼠胰腺衍生的G蛋白偶联受体蛋白等，或其盐，其部分肽，编码上述G蛋白偶联受体蛋白质的DNA，用于产生上述G蛋白偶联受体蛋白质的方法， 确定上述G蛋白偶联受体蛋白质的配体的方法，筛选抑制配体和G蛋白偶联受体蛋白质或其筛选试剂盒之间的结合的化合物的方法，通过上述筛选方法获得的化合物或其盐或筛选试剂盒 提供含有上述化合物或其盐的药物组合物和针对上述蛋白质偶联受体蛋白质或其部分肽的抗体。