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公开(公告)号：US07608617B2
公开(公告)日：2009-10-27
申请号：US11821263
申请日：2007-06-22
申请人： Silvia Gatti McArthur , Cornelia Hertel , Matthias Heinrich Nettekoven , Jean-Marc Plancher , Susanne Raab , Olivier Roche , Rosa Maria Rodriguez-Sarmiento , Franz Schuler
发明人： Silvia Gatti McArthur , Cornelia Hertel , Matthias Heinrich Nettekoven , Jean-Marc Plancher , Susanne Raab , Olivier Roche , Rosa Maria Rodriguez-Sarmiento , Franz Schuler
IPC分类号： A61K31/4545 , A61K31/4725 , A61K31/496 , A61K31/5377 , A61K31/541 , C07D401/10 , C07D217/06 , C07D417/10 , C07D211/06 , C07D413/10
CPC分类号： C07D401/10 , C07D205/04 , C07D207/06 , C07D207/12 , C07D207/14 , C07D209/44 , C07D211/22 , C07D211/38 , C07D211/42 , C07D211/46 , C07D217/06 , C07D295/088 , C07D295/192
摘要： The present invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof, to the preparation of such compounds and pharmaceutical compositions containing them. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
摘要翻译： 本发明涉及式I化合物及其药学上可接受的盐，用于制备这些化合物和含有它们的药物组合物。 该化合物可用于治疗和/或预防与H3受体的调节相关的疾病。
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公开(公告)号：US07361682B2
公开(公告)日：2008-04-22
申请号：US11157093
申请日：2005-06-20
申请人： Silvia Gatti McArthur , Cornelia Hertel , Matthias Heinrich Nettekoven , Susanne Raab , Olivier Roche , Rosa Maria Rodriguez-Sarmiento , Franz Schuler , Jean-Marc Plancher
发明人： Silvia Gatti McArthur , Cornelia Hertel , Matthias Heinrich Nettekoven , Susanne Raab , Olivier Roche , Rosa Maria Rodriguez-Sarmiento , Franz Schuler , Jean-Marc Plancher
IPC分类号： A61K31/55 , A61K31/541 , A61K31/5377 , A61K31/454 , A61K31/4545 , A61K31/4045 , C07D209/42 , C07D401/02 , C07D413/02 , C07D417/02
CPC分类号： C07D405/14 , C07D209/42 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14
摘要： The present invention relates to compounds of formula I: wherein X, R1, R2, R3, R4 and R5 are as defined in the description and claims, and pharmaceutically acceptable salts thereof, to the preparation of such compounds and pharmaceutical compositions containing them. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
摘要翻译： 本发明涉及式I化合物：其中X，R 1，R 2，R 3，R 4， SUP和R 5如在说明书和权利要求书及其药学上可接受的盐中所定义，用于制备这些化合物和含有它们的药物组合物。 该化合物可用于治疗和/或预防与H3受体的调节相关的疾病。
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公开(公告)号：US07259158B2
公开(公告)日：2007-08-21
申请号：US11142738
申请日：2005-06-01
申请人： Silvia Gatti McArthur , Cornelia Hertel , Matthias Heinrich Nettekoven , Jean-Marc Plancher , Susanne Raab , Olivier Roche , Rosa Maria Rodriguez-Sarmiento , Franz Schuler
发明人： Silvia Gatti McArthur , Cornelia Hertel , Matthias Heinrich Nettekoven , Jean-Marc Plancher , Susanne Raab , Olivier Roche , Rosa Maria Rodriguez-Sarmiento , Franz Schuler
IPC分类号： C07D211/14 , C07D213/02 , C07D403/10 , C07D211/20 , C07D417/10 , C07D413/10 , C07D401/10
CPC分类号： C07D401/10 , C07D205/04 , C07D207/06 , C07D207/12 , C07D207/14 , C07D209/44 , C07D211/22 , C07D211/38 , C07D211/42 , C07D211/46 , C07D217/06 , C07D295/088 , C07D295/192
摘要： The present invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof, to the preparation of such compounds and pharmaceutical compositions containing them. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
摘要翻译： 本发明涉及式I化合物及其药学上可接受的盐，用于制备这些化合物和含有它们的药物组合物。 该化合物可用于治疗和/或预防与H3受体的调节相关的疾病。
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公开(公告)号：US07534891B2
公开(公告)日：2009-05-19
申请号：US11251509
申请日：2005-10-14
申请人： Silvia Gatti McArthur , Cornelia Hertel , Matthias Heinrich Nettekoven , Susanne Raab , Hans Richter , Olivier Roche , Rosa Maria Rodriguez-Sarmiento , Franz Schuler
发明人： Silvia Gatti McArthur , Cornelia Hertel , Matthias Heinrich Nettekoven , Susanne Raab , Hans Richter , Olivier Roche , Rosa Maria Rodriguez-Sarmiento , Franz Schuler
IPC分类号： C07D215/38
CPC分类号： C07D401/14 , C07D215/48 , C07D401/12 , C07D405/14 , C07D417/12
摘要： The present invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof as well as to pharmaceutical compositions comprising these compounds and to methods for their preparation. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
摘要翻译： 本发明涉及式I化合物及其药学上可接受的盐以及包含这些化合物的药物组合物及其制备方法。 该化合物可用于治疗和/或预防与H3受体的调节相关的疾病。
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![Substituted pyrazolo [1,5-A] pyrimidines as metabotropic glutamate antagonists](/abs-image/US/2013/01/08/US08349844B2/abs.jpg.150x150.jpg)
5.发明授权Substituted pyrazolo [1,5-A] pyrimidines as metabotropic glutamate antagonists 失效取代的吡唑并[1,5-A]嘧啶作为代谢型谷氨酸拮抗剂公开(公告)号：US08349844B2
公开(公告)日：2013-01-08
申请号：US13283640
申请日：2011-10-28
IPC分类号： C07D487/04 , A61K31/519 , C07D471/04 , A61P25/28 , A61P25/16 , A61K31/437
CPC分类号： C07D487/04 , C07D471/04
摘要： The present invention relates to compounds of formula (I) wherein A, E G, J, L, M, R1, R2, and R3 are as defined in the specification and claims. The invention also relates to pharmaceutical compositions containing such compounds and methods for preparing the compounds and compositions. The compounds are metabotropic glutamate receptor antagonists and are useful for the treatment of a variety of CNS disorders.
摘要翻译： 本发明涉及式（I）化合物，其中A，E G，J，L，M，R 1，R 2和R 3如说明书和权利要求中所定义。 本发明还涉及含有这些化合物的药物组合物和用于制备化合物和组合物的方法。 化合物是代谢型谷氨酸受体拮抗剂，可用于治疗各种CNS疾病。
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![DIHYDRO-BENZO[B][1,4]DIAZEPIN-2-ONE SULFONAMIDE DERIVATIVES](/abs-image/US/2008/10/23/US20080261957A1/abs.jpg.150x150.jpg)
公开(公告)号：US20080261957A1
公开(公告)日：2008-10-23
申请号：US12102140
申请日：2008-04-14
IPC分类号： A61K31/551 , C07D243/12
CPC分类号： C07D243/24
摘要： The present invention relates to compounds of formula (I), a process for the manufacture thereof, their use for the preparation of medicaments for treating CNS disorders and pharmaceutical compositions containing them. Compounds of formula (I) are represented by general formula (I) wherein R1, R2, R3 and R4 are defined as in the specification.
摘要翻译： 本发明涉及式（I）化合物，其制备方法，其用于制备用于治疗CNS障碍的药物的用途和含有它们的药物组合物。 式（I）化合物由通式（I）表示，其中R 1，R 2，R 3和R 4 如说明书中所定义。
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公开(公告)号：US20110263615A1
公开(公告)日：2011-10-27
申请号：US13178531
申请日：2011-07-08
IPC分类号： A61K31/506 , C07D409/14 , A61K31/4439 , A61P25/00 , C07D409/04 , C07D401/14
CPC分类号： C07D409/14 , C07D401/04 , C07D401/14 , C07D409/04
摘要： The present invention relates to compounds of formula (I) wherein A, B, Q, X, Y, R1, and R2 are as defined herein; pharmaceutical compositions containing them; a process for their manufacture; and methods for treating CNS disorders with the same.
摘要翻译： 本发明涉及其中A，B，Q，X，Y，R 1和R 2如本文所定义的式（I）化合物; 含有它们的药物组合物; 一个制造过程; 以及用于治疗CNS病症的方法。
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![SUBSTITUTED PYRAZOLO [1,5-a] PYRIMIDINES AS METABOTROPIC GLUTAMATE ANTAGONISTS](/abs-image/US/2009/06/04/US20090143580A1/abs.jpg.150x150.jpg)
8.发明申请SUBSTITUTED PYRAZOLO [1,5-a] PYRIMIDINES AS METABOTROPIC GLUTAMATE ANTAGONISTS 失效取代的吡唑并[1,5-a]吡啶类作为代谢型谷氨酸拮抗剂公开(公告)号：US20090143580A1
公开(公告)日：2009-06-04
申请号：US12348962
申请日：2009-01-06
IPC分类号： C07D487/04 , C07D471/04
CPC分类号： C07D487/04 , C07D471/04
摘要： The present invention relates to compounds of formula (I) wherein A, E G, J, L, M, R1, R2, and R3 are as defined in the specification and claims. The invention also relates to pharmaceutical compositions containing such compounds and methods for preparing the compounds and compositions. The compounds are metabotropic glutamate receptor antagonists and are useful for the treatment of a variety of CNS disorders.
摘要翻译： 本发明涉及式（I）化合物，其中A，E G，J，L，M，R 1，R 2和R 3如说明书和权利要求中所定义。 本发明还涉及含有这些化合物的药物组合物和用于制备化合物和组合物的方法。 化合物是代谢型谷氨酸受体拮抗剂，可用于治疗各种CNS疾病。
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公开(公告)号：US20070232583A1
公开(公告)日：2007-10-04
申请号：US11726575
申请日：2007-03-22
IPC分类号： A61K31/513 , A61K31/506 , C07D405/14 , C07D403/02 , C07D409/14
CPC分类号： C07D239/30 , C07D213/61 , C07D213/64 , C07D213/79 , C07D213/81 , C07D213/84 , C07D239/28 , C07D239/34 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/12 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/14 , C07F5/025
摘要： The present invention relates to compounds of formula (I), a process for the manufacture thereof, pharmaceutical compositions containing them, and their use for treating CNS disorders: wherein A, B, X, Y, R1, R2, R3 and R4 are as defined in the description and claims.
摘要翻译： 本发明涉及式（I）化合物，其制备方法，含有它们的药物组合物及其用于治疗CNS病症的用途：其中A，B，X，Y，R 1， R 2，R 3和R 4如在说明书和权利要求书中所定义。
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公开(公告)号：US20060183756A1
公开(公告)日：2006-08-17
申请号：US11348105
申请日：2006-02-06
IPC分类号： A61K31/519 , C07D487/04
CPC分类号： C07D487/04
摘要： The present invention relates to pyrrazolo-pyrimidine derivatives of formula (I): wherein R1 to R4 and A are as defined in the specification, a process for the manufacture thereof, their use for treating or preventing metabotropic glutamate receptors mediated disorders, their use for the preparation of medicaments for treating such disorders and pharmaceutical compositions containing said derivatives.
摘要翻译： 本发明涉及式（I）的吡唑并嘧啶衍生物：其中R 1至R 4和A如说明书中所定义，其制备方法 ，它们用于治疗或预防代谢型谷氨酸受体介导的病症，其用于制备用于治疗这种病症的药物的用途和含有所述衍生物的药物组合物。
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