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公开(公告)号：US20130281445A1
公开(公告)日：2013-10-24
申请号：US13623962
申请日：2012-09-21
IPC分类号： C07D453/02 , A61K45/06 , A61K31/498 , A61K31/439 , A61K31/538
CPC分类号： C07D453/02 , A61K31/439 , A61K31/498 , A61K31/538 , A61K45/06 , C07D453/00 , Y02A50/411
摘要： The present invention relates to compounds useful as inhibitors of choline kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
摘要翻译： 本发明涉及可用作胆碱激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：US20130261114A1
公开(公告)日：2013-10-03
申请号：US13623970
申请日：2012-09-21
IPC分类号： C07D453/02 , A61K45/06 , A61K31/5377 , A61K31/439 , A61K31/496
CPC分类号： C07D453/02 , A61K31/439 , A61K31/496 , A61K31/5377 , A61K45/06
摘要： The present invention relates to compounds useful as inhibitors of choline kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
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公开(公告)号：US07767672B2
公开(公告)日：2010-08-03
申请号：US11592114
申请日：2006-11-03
申请人： Hayley Binch , Michael Mortimore , Chris Davis , Dean Boyall , Simon Everitt , Daniel Robinson , Sharn Ramaya , Damien Fraysse , John Studley , Andrew Miller , Michael O'Donnell , Alistair Rutherford , Joanne Pinder
发明人： Hayley Binch , Michael Mortimore , Chris Davis , Dean Boyall , Simon Everitt , Daniel Robinson , Sharn Ramaya , Damien Fraysse , John Studley , Andrew Miller , Michael O'Donnell , Alistair Rutherford , Joanne Pinder
IPC分类号： A61K31/506 , A61K31/5355 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D417/12 , C07D417/14 , C07D205/04 , C07D215/36 , C07D209/34 , C07C225/06 , A61P29/00 , A61P35/00 , A61P27/14
CPC分类号： C07D403/12 , C07D239/38 , C07D401/14 , C07D403/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含这些化合物的药学上可接受的组合物和使用该化合物和组合物治疗各种疾病，病症和障碍的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：US08637511B2
公开(公告)日：2014-01-28
申请号：US12796297
申请日：2010-06-08
申请人： Hayley Binch , Michael Mortimore , Chris Davis , Dean Boyall , Simon Everitt , Daniel Robinson , Sham Ramaya , Damien Fraysse , John Studley , Andrew Miller , Michael O'Donnell , Alistair Rutherford , Joanne Pinder
发明人： Hayley Binch , Michael Mortimore , Chris Davis , Dean Boyall , Simon Everitt , Daniel Robinson , Sham Ramaya , Damien Fraysse , John Studley , Andrew Miller , Michael O'Donnell , Alistair Rutherford , Joanne Pinder
IPC分类号： A61K31/506 , A61K31/5355 , A61P29/00 , A61P19/08 , A61P3/00 , A61P25/28 , A61P35/00 , A61P9/00 , A61P37/08
CPC分类号： C07D403/12 , C07D239/38 , C07D401/14 , C07D403/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含这些化合物的药学上可接受的组合物和使用该化合物和组合物治疗各种疾病，病症和障碍的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：US20070259869A1
公开(公告)日：2007-11-08
申请号：US11592114
申请日：2006-11-03
申请人： Hayley Binch , Michael Mortimore , Chris Davis , Dean Boyall , Simon Everitt , Daniel Robinson , Sharn Ramaya , Damien Fraysse , John Studley , Andrew Miller , Michael O'Donnell , Alistair Rutherford , Joanne Pinder
发明人： Hayley Binch , Michael Mortimore , Chris Davis , Dean Boyall , Simon Everitt , Daniel Robinson , Sharn Ramaya , Damien Fraysse , John Studley , Andrew Miller , Michael O'Donnell , Alistair Rutherford , Joanne Pinder
IPC分类号： A61K31/506 , A61K31/496 , A61K31/517 , A61K31/5377 , A61P35/00 , A61P35/02 , C07D239/47 , C07D239/48 , C07D239/50 , C07D413/14 , C12N5/02
CPC分类号： C07D403/12 , C07D239/38 , C07D401/14 , C07D403/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含这些化合物的药学上可接受的组合物和使用该化合物和组合物治疗各种疾病，病症和障碍的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：US20100222318A1
公开(公告)日：2010-09-02
申请号：US12642447
申请日：2009-12-18
申请人： Jean Damien Charrier , Steven Durrant , David Kay , Ronald Knegtel , Somhairle MacCormick , Michael Mortimore , Michael O'Donnell , Joanne Pinder , Alistair Rutherford , Anisa Nizarali Virani , Stephen Young , Philip Michael Reaper
发明人： Jean Damien Charrier , Steven Durrant , David Kay , Ronald Knegtel , Somhairle MacCormick , Michael Mortimore , Michael O'Donnell , Joanne Pinder , Alistair Rutherford , Anisa Nizarali Virani , Stephen Young , Philip Michael Reaper
IPC分类号： A61K31/497 , C12N5/02 , C07D413/14 , C07D413/04 , A61K31/5513 , C07D417/04 , A61K31/5377 , A61K31/553 , C07D403/10 , A61K35/04
CPC分类号： C07D413/14 , A61P35/00 , C07D241/28 , C07D401/04 , C07D401/10 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04
摘要： The present invention relates to pyrazine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.The compounds of this invention have formula I: wherein the variables are as defined herein.
摘要翻译： 本发明涉及可用作ATR蛋白激酶抑制剂的吡嗪化合物。 本发明还涉及包含本发明化合物的药学上可接受的组合物; 使用本发明化合物治疗各种疾病，病症和病症的方法; 制备本发明化合物的方法; 用于制备本发明化合物的中间体; 以及在体外应用中使用化合物的方法，如生物和病理现象中激酶的研究; 由这种激酶介导的细胞内信号转导途径的研究; 和新型激酶抑制剂的比较评估。 本发明的化合物具有式I：其中变量如本文所定义。
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公开(公告)号：US20100310675A1
公开(公告)日：2010-12-09
申请号：US12796297
申请日：2010-06-08
申请人： Hayley Binch , Michael Mortimore , Chris Davis , Dean Boyall , Simon Everitt , Daniel Robinson , Sharn Ramaya , Damien Fraysse , John Studley , Andrew Miller , Michael O'Donnell , Alistair Rutherford , Joanne Pinder
发明人： Hayley Binch , Michael Mortimore , Chris Davis , Dean Boyall , Simon Everitt , Daniel Robinson , Sharn Ramaya , Damien Fraysse , John Studley , Andrew Miller , Michael O'Donnell , Alistair Rutherford , Joanne Pinder
IPC分类号： A61K31/506 , A61K31/5377 , A61K31/517 , A61K33/24 , A61K31/704 , A61P35/00 , A61P35/02 , C12N9/99 , A61K31/397
CPC分类号： C07D403/12 , C07D239/38 , C07D401/14 , C07D403/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含这些化合物的药学上可接受的组合物和使用该化合物和组合物治疗各种疾病，病症和障碍的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：US07041687B2
公开(公告)日：2006-05-09
申请号：US10350806
申请日：2003-01-23
申请人： Hayley Binch , Guy Brenchley , Julian M. C. Golec , Ronald Knegtel , Michael Mortimore , Sanjay Patel , Alistair Rutherford
发明人： Hayley Binch , Guy Brenchley , Julian M. C. Golec , Ronald Knegtel , Michael Mortimore , Sanjay Patel , Alistair Rutherford
IPC分类号： A61K31/41
CPC分类号： C07D417/12 , C07D231/56 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12
摘要： The present invention provides compounds of formula I: or a pharmaceutically acceptable derivative thereof, wherein R1, R2, V1, V2, and V3 are as described in the specification. These compounds are inhibitors of protein kinase, particularly inhibitors of AKT, PKA, PDK1, p70S6K, or ROCK kinase, mammalian protein kinases involved in proliferative and neurodegenerative disorders. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of utilizing those compositions in the treatment of various disorders.
摘要翻译： 本发明提供式I化合物或其药学上可接受的衍生物，其中R 1，R 2，V 1，V SUP > 2 和V 3 3如说明书中所述。 这些化合物是蛋白激酶的抑制剂，特别是AKT，PKA，PDK1，p70S6K或ROCK激酶的抑制剂，涉及增殖性和神经变性疾病的哺乳动物蛋白激酶。 本发明还提供包含本发明化合物的药物组合物和利用这些组合物治疗各种疾病的方法。
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公开(公告)号：US07820685B2
公开(公告)日：2010-10-26
申请号：US11592113
申请日：2006-11-03
IPC分类号： C07D403/14 , A61K31/4155
CPC分类号： C07D403/12 , C07D239/38 , C07D401/14 , C07D403/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The present invention relates to compounds useful as inhibitors of Aurora protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.
摘要翻译： 本发明涉及可用作Aurora蛋白激酶抑制剂的化合物。 本发明还提供包含这些化合物的药学上可接受的组合物和使用该化合物和组合物治疗各种疾病，病症和障碍的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：US08557833B2
公开(公告)日：2013-10-15
申请号：US12894465
申请日：2010-09-30
IPC分类号： A61K31/4155 , C07D403/14
CPC分类号： C07D403/12 , C07D239/38 , C07D401/14 , C07D403/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The present invention relates to compounds useful as inhibitors of Aurora protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.
摘要翻译： 本发明涉及可用作Aurora蛋白激酶抑制剂的化合物。 本发明还提供包含这些化合物的药学上可接受的组合物和使用该化合物和组合物治疗各种疾病，病症和障碍的方法。 本发明还提供了制备本发明化合物的方法。
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