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1.发明授权公开(公告)号：US09333363B2
公开(公告)日：2016-05-10
申请号：US14600763
申请日：2015-01-20
发明人： Joaquin Andres Hoffer , Gautam Sadarangani , Marc Andre Nolette , Viral Thakkar , Bao Dung Tran
CPC分类号： A61N1/36185 , A61B5/0205 , A61B5/0245 , A61B5/04001 , A61B5/0422 , A61B5/0488 , A61B5/05 , A61B5/08 , A61B5/145 , A61B5/4818 , A61B5/4836 , A61B5/4893 , A61B5/6852 , A61B5/7264 , A61B2562/043 , A61N1/0551 , A61N1/3611 , A61N1/36139
摘要： This disclosure describes, among other embodiments, systems and related methods for selecting electrode combinations to be used during nerve pacing procedures. A first set of electrode combinations of a nerve pacing system, such as a phrenic nerve pacing system for diaphragm activation, may be mapped (or tested) to determine the location of the electrode combinations relative to a target nerve. Once the general location of the target nerve is known, a more localized second set of electrode combinations may be tested to determine the most suitable electrode combinations for nerve stimulation. At various stages of the mapping process, electrode combinations that are non-optimal may be discarded as candidates for use in a nerve pacing procedure. The systems and methods described herein may allow for the selection of electrode combinations that are most suitable for stimulation of the left and right phrenic nerves during diaphragm pacing.
摘要翻译： 除了其它实施方式之外，本公开描述了用于选择在神经起搏过程中使用的电极组合的系统和相关方法。 可以映射（或测试）神经起搏系统的第一组电极组合，例如用于隔膜激活的膈神经起搏系统，以确定电极组合相对于目标神经的位置。 一旦目标神经的一般位置是已知的，可以测试更局限的第二组电极组合，以确定用于神经刺激的最合适的电极组合。 在映射过程的各个阶段，不优选的电极组合可被丢弃，作为在神经起搏过程中使用的候选。 本文描述的系统和方法可以允许选择最适合于在隔膜起搏期间刺激左膈神经和膈神经的电极组合。
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公开(公告)号：US09026231B2
公开(公告)日：2015-05-05
申请号：US14497858
申请日：2014-09-26
CPC分类号： A61N1/3611 , A61N1/05 , A61N1/0551 , A61N1/0558 , A61N1/3601 , A61N1/36139 , A61N1/36185
摘要： Electrode structures for transvascular nerve stimulation combine electrodes with an electrically-insulating backing layer. The backing layer increases the electrical impedance of electrical paths through blood in a lumen of a blood vessel and consequently increases the flow of electrical current through surrounding tissues. The electrode structures may be applied to stimulate nerves such as the phrenic, vagus, trigeminal, obturator or other nerves.
摘要翻译： 用于经血管神经刺激的电极结构将电极与电绝缘背衬层结合。 背衬层增加通过血管内腔中的血液的电路径的电阻抗，从而增加通过周围组织的电流的流动。 可以施加电极结构以刺激神经，例如膈神经，迷走神经，三叉神经，闭孔或其他神经。
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公开(公告)号：US20150045810A1
公开(公告)日：2015-02-12
申请号：US14383285
申请日：2013-03-04
IPC分类号： A61N1/05
摘要： The invention, in one aspect, relates to an intravascular electrode system. The system comprises one or more electrodes supported on an elongated resiliently flexible support member, and the support member may be used to introduce the electrodes into a blood vessel. As the support member is introduced into the blood vessel the support member bends to follow the path of the blood vessel.
摘要翻译： 本发明在一个方面涉及一种血管内电极系统。 该系统包括支撑在细长的弹性柔性支撑构件上的一个或多个电极，并且支撑构件可用于将电极引入血管。 当支撑构件被引入血管时，支撑构件弯曲以跟随血管的路径。
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公开(公告)号：US10391314B2
公开(公告)日：2019-08-27
申请号：US15427924
申请日：2017-02-08
发明人： Joaquin Andres Hoffer , Gautam Sadarangani , Marc-Andre Nolette , Viral Thakkar , Bao Dung Tran
IPC分类号： A61N1/36 , A61N1/05 , A61B5/00 , A61B5/0205 , A61B5/0245 , A61B5/04 , A61B5/042 , A61B5/0488 , A61B5/05 , A61B5/08 , A61B5/145
摘要： This disclosure describes, among other embodiments, systems and related methods for selecting electrode combinations to be used during nerve pacing procedures. A first set of electrode combinations of a nerve pacing system, such as a phrenic nerve pacing system for diaphragm activation, may be mapped (or tested) to determine the location of the electrode combinations relative to a target nerve. Once the general location of the target nerve is known, a more localized second set of electrode combinations may be tested to determine the most suitable electrode combinations for nerve stimulation. At various stages of the mapping process, electrode combinations that are non-optimal may be discarded as candidates for use in a nerve pacing procedure. The systems and methods described herein may allow for the selection of electrode combinations that are most suitable for stimulation of the left and right phrenic nerves during diaphragm pacing.
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公开(公告)号：US09968785B2
公开(公告)日：2018-05-15
申请号：US15408193
申请日：2017-01-17
CPC分类号： A61N1/3611 , A61N1/05 , A61N1/0551 , A61N1/0558 , A61N1/3601 , A61N1/36139 , A61N1/36185
摘要： Electrode structures for transvascular nerve stimulation combine electrodes with an electrically-insulating backing layer. The backing layer increases the electrical impedance of electrical paths through blood in a lumen of a blood vessel and consequently increases the flow of electrical current through surrounding tissues. The electrode structures may be applied to stimulate nerves such as the phrenic, vagus, trigeminal, obturator or other nerves.
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公开(公告)号：US09931504B2
公开(公告)日：2018-04-03
申请号：US15370864
申请日：2016-12-06
CPC分类号： A61N1/3601 , A61B5/0245 , A61B5/0422 , A61B5/6852 , A61B2562/043 , A61M25/00 , A61M25/0029 , A61M25/0147 , A61M2025/0034 , A61N1/05 , A61N1/0551 , A61N1/3611 , A61N1/36185
摘要： A catheter may include electrodes for transvascular nerve stimulation. The electrodes may be positioned within lumens of the catheter and aligned with apertures in the outer wall of the catheter. The electrodes may produce focused electrical fields for stimulation of one or more nerves. In one embodiment, the catheter may include a set of proximal electrodes and a set of distal electrodes, and the proximal electrodes may stimulate a patient's left phrenic nerve and the distal electrodes may stimulate a patient's right phrenic nerve.
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公开(公告)号：US09597509B2
公开(公告)日：2017-03-21
申请号：US15095773
申请日：2016-04-11
发明人： Joaquin Andres Hoffer , Gautam Sadarangani , Marc-Andre Nolette , Viral Thakkar , Bao Dung Tran
CPC分类号： A61N1/36185 , A61B5/0205 , A61B5/0245 , A61B5/04001 , A61B5/0422 , A61B5/0488 , A61B5/05 , A61B5/08 , A61B5/145 , A61B5/4818 , A61B5/4836 , A61B5/4893 , A61B5/6852 , A61B5/7264 , A61B2562/043 , A61N1/0551 , A61N1/3611 , A61N1/36139
摘要： This disclosure describes, among other embodiments, systems and related methods for selecting electrode combinations to be used during nerve pacing procedures. A first set of electrode combinations of a nerve pacing system, such as a phrenic nerve pacing system for diaphragm activation, may be mapped (or tested) to determine the location of the electrode combinations relative to a target nerve. Once the general location of the target nerve is known, a more localized second set of electrode combinations may be tested to determine the most suitable electrode combinations for nerve stimulation. At various stages of the mapping process, electrode combinations that are non-optimal may be discarded as candidates for use in a nerve pacing procedure. The systems and methods described herein may allow for the selection of electrode combinations that are most suitable for stimulation of the left and right phrenic nerves during diaphragm pacing.
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公开(公告)号：US09566436B2
公开(公告)日：2017-02-14
申请号：US14792006
申请日：2015-07-06
CPC分类号： A61N1/3611 , A61N1/05 , A61N1/0551 , A61N1/0558 , A61N1/3601 , A61N1/36139 , A61N1/36185
摘要： Electrode structures for transvascular nerve stimulation combine electrodes with an electrically-insulating backing layer. The backing layer increases the electrical impedance of electrical paths through blood in a lumen of a blood vessel and consequently increases the flow of electrical current through surrounding tissues. The electrode structures may be applied to stimulate nerves such as the phrenic, vagus, trigeminal, obturator or other nerves.
摘要翻译： 用于经血管神经刺激的电极结构将电极与电绝缘背衬层结合。 背衬层增加通过血管内腔中的血液的电路径的电阻抗，从而增加通过周围组织的电流的流动。 可以施加电极结构以刺激神经，例如膈神经，迷走神经，三叉神经，闭孔或其他神经。
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公开(公告)号：US10035017B2
公开(公告)日：2018-07-31
申请号：US15273196
申请日：2016-09-22
CPC分类号： A61N1/3601 , A61B5/0245 , A61B5/0422 , A61B5/6852 , A61B2562/043 , A61M25/00 , A61M25/0029 , A61M25/0147 , A61M2025/0034 , A61N1/05 , A61N1/0551 , A61N1/3611 , A61N1/36185
摘要： A catheter may include electrodes for transvascular nerve stimulation. The electrodes may be positioned within lumens of the catheter and aligned with apertures in the outer wall of the catheter. The electrodes may produce focused electrical fields for stimulation of one or more nerves. In one embodiment, the catheter may include a set of proximal electrodes and a set of distal electrodes, and the proximal electrodes may stimulate a patient's left phrenic nerve and the distal electrodes may stimulate a patient's right phrenic nerve.
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公开(公告)号：US09950167B2
公开(公告)日：2018-04-24
申请号：US15252722
申请日：2016-08-31
CPC分类号： A61N1/3611 , A61N1/05 , A61N1/0551 , A61N1/0558 , A61N1/3601 , A61N1/36139 , A61N1/36185
摘要： Electrode structures for transvascular nerve stimulation combine electrodes with an electrically-insulating backing layer. The backing layer increases the electrical impedance of electrical paths through blood in a lumen of a blood vessel and consequently increases the flow of electrical current through surrounding tissues. The electrode structures may be applied to stimulate nerves such as the phrenic, vagus, trigeminal, obturator or other nerves.
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