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公开(公告)号：US07349862B2
公开(公告)日：2008-03-25
申请号：US10078793
申请日：2002-02-19
申请人： Simon James Palmer , Michael John Craig , Dean Pignon , Charles Bailey , Grant Miller , Stephen Pollard , Mark Alder
发明人： Simon James Palmer , Michael John Craig , Dean Pignon , Charles Bailey , Grant Miller , Stephen Pollard , Mark Alder
IPC分类号： G06F9/44
CPC分类号： G06Q10/10 , G06F17/243 , G06Q30/0201
摘要： The present invention is directed to a business intelligence monitor method and system. Business intelligence indicators are monitored by generating a monitoring repository through selecting functions from a collection of functions, for receiving the business intelligence indicators as inputs. The thresholds for the business intelligence indicators are then established to define the states for the business intelligence indicators. Each state of the business intelligence indicators is assigned an associated priority. The monitoring repository is updated by retrieving a current value for each of the business intelligence indicators from a data source, thereby determining the state for each of the business intelligence indicators based on the current value. A report based on the updated monitoring repository is then created.
摘要翻译： 本发明涉及商业智能监控方法和系统。 通过从功能集合中选择功能来生成监控存储库来监视商业智能指标，以接收商业智能指标作为输入。 然后建立商业智能指标的阈值，以定义商业智能指标的状态。 每个状态的商业智能指标都被分配一个相关的优先级。 通过从数据源检索每个商业智能指标的当前值来更新监视存储库，从而基于当前值来确定每个商业智能指标的状态。 然后创建基于更新的监视存储库的报告。
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公开(公告)号：US20060273187A1
公开(公告)日：2006-12-07
申请号：US11419593
申请日：2006-05-22
摘要： The invention involves developing and stabilizing cultivating droplets within a matrix of a porous medium. A cultivation medium may be selected, prepared and mixed with a surfactant. Where cells are desired to be cultured in droplets, cells may be added. The mixture may be converted into cultivating droplets. The cultivating droplets may be stabilized by introducing them to a porous medium. The porous medium may contain hydrophobic particles. Stabilized, cultivating droplets having one or more cells may form an aseptic microenvironment for the concentrated growth of cells.
摘要翻译： 本发明涉及在多孔介质的基质内培养和稳定培养液滴。 培养基可以选择，制备并与表面活性剂混合。 当需要细胞培养液滴时，可加入细胞。 混合物可以转化为培养液滴。 培养液滴可以通过将它们引入多孔介质来稳定。 多孔介质可能含有疏水性颗粒。 具有一个或多个细胞的稳定化培养液滴可形成用于细胞浓缩生长的无菌微环境。
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公开(公告)号：US20050142550A1
公开(公告)日：2005-06-30
申请号：US10491582
申请日：2002-10-03
IPC分类号： C12N15/09 , C07K14/00 , C12N5/10 , C12N15/12 , C12N15/69 , C12N15/85 , C12P21/02 , C12Q1/02 , C12Q1/68 , C12P19/34
CPC分类号： C12N15/85 , C12N15/69 , C12N2830/00 , C12N2830/85
摘要： The present invention pertains to genetic screening methods and related cells and genetic constructs. In particular, the invention relates to a method of screening cells for an alteration, typically an amplification, in the copy number of a nucleic acid of interest using an amplifiable nucleic acid linked to a reporter nucleic acid; a method of screening cells for increased expression of a polypeptide of interest derived from the nucleic acid of interest; and related cells and genetic constructs. The method allows for high throughput screening of recombinant cells expressing a polypeptide or protein of interest and, in particular, for screening of cells expressing the polypeptide or protein of interest at elevated levels.
摘要翻译： 本发明涉及遗传筛选方法和相关细胞和遗传构建体。 特别地，本发明涉及一种使用与报道核酸连接的可扩增核酸筛选细胞的变异（通常为扩增）的目的核酸的拷贝数的方法; 一种筛选细胞以增加目的多核苷酸表达的方法，所述方法来源于感兴趣的核酸; 和相关细胞和遗传构建体。 该方法允许表达感兴趣的多肽或蛋白质的重组细胞的高通量筛选，特别是用于在升高的水平筛选表达目标多肽或蛋白质的细胞。
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公开(公告)号：US20050200148A1
公开(公告)日：2005-09-15
申请号：US10708561
申请日：2004-03-11
申请人： Charles Bailey , Mark Heinze , John Youngs , Tom Kopcha
发明人： Charles Bailey , Mark Heinze , John Youngs , Tom Kopcha
CPC分类号： B60R13/0243 , B60N2/78 , Y10T29/486 , Y10T29/49867
摘要： A trim assembly comprises a substrate member including a moveable panel integrally formed in the substrate and moveable between an open and closed position. A flexible skin overlies at least a portion of the substrate member and is integrally coupled to the substrate. The substrate and flexible skin are configured to define a cavity having an opening. The cavity opening is accessible when the moveable panel is in the open position. A resilient foam pad is positioned within the cavity to provide a soft feel to the trim assembly. The foam pad is inserted into the cavity using a tool that pulls a vacuum and compresses the foam pad. The foam pad is inserted into the cavity and the vacuum is released thereby expanding the foam pad to fill the cavity. The tool is removed and the moveable panel is moved to and secured in the closed position.
摘要翻译： 修剪组件包括基底构件，该基底构件包括一体地形成在基底中并可在打开和关闭位置之间移动的可移动面板。 柔性皮肤覆盖在衬底构件的至少一部分上并与衬底一体地联接。 衬底和柔性表层构造成限定具有开口的空腔。 当可移动面板处于打开位置时，可以访问空腔开口。 弹性泡沫垫定位在空腔内以向装饰组件提供柔软的感觉。 使用拉动真空并压缩泡沫垫的工具将泡沫垫插入空腔中。 将泡沫垫插入空腔中并释放真空，从而使泡沫垫膨胀以填充空腔。 该工具被移除，并且可移动面板移动并固定在关闭位置。
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5.发明申请Electrospray Neutralization Process and Apparatus for Generation of Nano-Aerosol and Nano-Structured Materials 有权用于生成纳米气溶胶和纳米结构材料的电喷雾中和过程和装置公开(公告)号：US20070113530A1
公开(公告)日：2007-05-24
申请号：US11561138
申请日：2006-11-17
IPC分类号： B01D46/00
CPC分类号： B01D46/0001 , B01D39/1623 , B01D46/10 , B01D2239/0435 , B01D2275/10 , D01D5/0007
摘要： The claimed invention describes methods and apparatuses for manufacturing nano-aerosols and nano-structured materials based on the neutralization of charged electrosprayed products with oppositely charged electrosprayed products. Electrosprayed products include molecular ions, nano-clusters and nano-fibers. Nano-aerosols can be generated when neutralization occurs in the gas phase. Neutralization of electrospan nano-fibers with molecular ions and charged nano-clusters may result in the formation of fibrous aerosols or free nano-mats. Nano-mats can also be produced on a suitable substrate, forming efficient nano-filters.
摘要翻译： 所要求保护的发明描述了基于带有相反电荷的电喷雾产物的带电电喷雾产物的中和来制造纳米气溶胶和纳米结构材料的方法和装置。 电喷产品包括分子离子，纳米簇和纳米纤维。 当在气相中发生中和时，可产生纳米气溶胶。 用分子离子和带电荷的纳米簇中和电纺丝纳米纤维可能导致纤维状气溶胶或游离纳米垫的形成。 纳米垫也可以在合适的基底上生产，形成有效的纳米过滤器。
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公开(公告)号：US20060275824A1
公开(公告)日：2006-12-07
申请号：US11397908
申请日：2006-04-05
IPC分类号： G06F19/00
CPC分类号： C30B7/00 , C30B29/58 , Y10T436/105831 , Y10T436/12 , Y10T436/25 , Y10T436/2575
摘要： The invention contemplates a method for recognition of proteins and other biological molecules by imaging morphology, size and distribution of crystalline and amorphous dry residues in droplets (further referred to as “crystallization pattern”) containing predetermined amount of certain crystal-forming organic compounds (reporters) to which protein to be analyzed is added. It has been shown that changes in the crystallization patterns of a number of amino-acids can be used as a “signature” of a protein added. It was also found that both the character of changer in the crystallization patter and the fact of such changes can be used as recognition elements in analysis of protein molecules.
摘要翻译： 本发明考虑了通过将含有预定量的某些成晶有机化合物的液滴（进一步称为“结晶图案”）的晶体和无定形干燥残余物的形态，尺寸和分布进行成像，鉴定蛋白质和其他生物分子的方法。 ）加入待分析的蛋白质。 已经表明，许多氨基酸的结晶模式的变化可以用作加入的蛋白质的“特征”。 还发现，结晶模式中变换器的特征和这种变化的事实都可以用作分析蛋白质分子的识别元件。
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公开(公告)号：US20060263904A1
公开(公告)日：2006-11-23
申请号：US11397905
申请日：2006-04-05
IPC分类号： G01N33/543 , C12M1/34
CPC分类号： G01N33/544 , Y10T436/25375 , Y10T436/255
摘要： Analytes using an active assay may be detected by introducing an analyte solution containing a plurality of analytes to a lacquered membrane. The lacquered membrane may be a membrane having at least one surface treated with a layer of polymers. The lacquered membrane may be semi-permeable to nonanalytes. The layer of polymers may include cross-linked polymers. A plurality of probe molecules may be arrayed and immobilized on the lacquered membrane. An external force may be applied to the analyte solution to move the analytes towards the lacquered membrane. Movement may cause some or all of the analytes to bind to the lacquered membrane. In cases where probe molecules are presented, some or all of the analytes may bind to probe molecules. The direction of the external force may be reversed to remove unbound or weakly bound analytes. Bound analytes may be detected using known detection types.
摘要翻译： 使用活性测定法的分析物可以通过将含有多种分析物的分析物溶液引入涂漆膜来检测。 漆膜可以是具有用聚合物层处理的至少一个表面的膜。 漆膜可能对非分析物半渗透。 聚合物层可以包括交联聚合物。 可以将多个探针分子排列并固定在涂漆膜上。 可以将外力施加到分析物溶液以将分析物移动到漆膜。 运动可能导致部分或全部分析物结合到漆膜上。 在存在探针分子的情况下，部分或全部分析物可能与探针分子结合。 外力的方向可以颠倒以去除未结合或弱结合的分析物。 可以使用已知的检测类型检测结合的分析物。
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公开(公告)号：US20110046039A1
公开(公告)日：2011-02-24
申请号：US12530538
申请日：2008-03-06
申请人： Serguei G. Popov , Taissia Popov , Virginia Espina , Charles Bailey , Lance A. Liotta , Emanuel Petricoin
发明人： Serguei G. Popov , Taissia Popov , Virginia Espina , Charles Bailey , Lance A. Liotta , Emanuel Petricoin
CPC分类号： A61K45/06 , A61K31/496 , A61K2300/00
摘要： The invention provides methods and materials for identifying agents for preventing and/or treating anthrax and similar diseases. Embodiments provide strains and model systems for studying non-lethal and lethal exposure to anthrax and similar disease vectors. Embodiments provide materials and methods for using the strains and model systems for differential profiling, such as proteomic profiling, such as differentiation phosphorylation profiling, to target identification and therapeutics discovery and development. Embodiments provide pharmaceutically acceptable compositions, and methods for using them to prevent and/or treat anthrax and similar diseases comprising an agent that decreases the activity of caspase ¼, such as YVAD, and/or an agent that increases the phosphorylation of AKT, such as IB-MECA or Cl-IB-MECA, together with, in particular embodiments, an antibiotic, such as ciprofloxacin. Kits comprising the same are provided as well, among other things.
摘要翻译： 本发明提供用于鉴定用于预防和/或治疗炭疽和类似疾病的药剂的方法和材料。 实施例提供用于研究非致死和致死性暴露于炭疽和类似疾病载体的菌株和模型系统。 实施例提供了用于使用菌株和模型系统进行差异分析的材料和方法，例如蛋白质组学分析，例如分化磷酸化分析，以靶向鉴定和治疗发现和发展。 实施方案提供了药学上可接受的组合物，以及使用它们来预防和/或治疗炭疽和类似疾病的方法，其包括降低半胱天冬酶（例如YVAD）的活性的试剂和/或增加AKT磷酸化的试剂，例如 在特定实施方案中，IB-MECA或Cl-IB-MECA，以及抗生素，如环丙沙星。 还提供了包括其的套件，以及其他。
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公开(公告)号：US20090048293A1
公开(公告)日：2009-02-19
申请号：US11913518
申请日：2006-05-05
申请人： Serguei Popov , Taissia Popova , Svetlana Nazarenko , Charles Bailey , Chris Bradburne , Bryan Millis , Vikas Chandhoke
发明人： Serguei Popov , Taissia Popova , Svetlana Nazarenko , Charles Bailey , Chris Bradburne , Bryan Millis , Vikas Chandhoke
CPC分类号： A61K38/40
摘要： The present invention provides compositions and methods for detecting, treating, and preventing microbial infection, especially infection caused by Bacillus anthracis (“anthrax”).
摘要翻译： 本发明提供用于检测，治疗和预防微生物感染，特别是由炭疽芽孢杆菌（“炭疽”）引起的感染的组合物和方法。
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公开(公告)号：US20060117540A1
公开(公告)日：2006-06-08
申请号：US11275570
申请日：2006-01-17
申请人： Charles Bailey , Mark Heinze , John Youngs , Tom Kopcha
发明人： Charles Bailey , Mark Heinze , John Youngs , Tom Kopcha
CPC分类号： B60R13/0243 , B60N2/78 , Y10T29/486 , Y10T29/49867
摘要： A trim assembly comprises a substrate member including a moveable panel integrally formed in the substrate and moveable between an open and closed position. A flexible skin overlies at least a portion of the substrate member and is integrally coupled to the substrate. The substrate and flexible skin are configured to define a cavity having an opening. The cavity opening is accessible when the moveable panel is in the open position. A resilient foam pad is positioned within the cavity to provide a soft feel to the trim assembly. The foam pad is inserted into the cavity using a tool that pulls a vacuum and compresses the foam pad. The foam pad is inserted into the cavity and the vacuum is released thereby expanding the foam pad to fill the cavity. The tool is removed and the moveable panel is moved to and secured in the closed position.
摘要翻译： 修剪组件包括基底构件，该基底构件包括一体地形成在基底中并可在打开和关闭位置之间移动的可移动面板。 柔性皮肤覆盖在衬底构件的至少一部分上并与衬底一体地联接。 衬底和柔性表层构造成限定具有开口的空腔。 当可移动面板处于打开位置时，可以访问空腔开口。 弹性泡沫垫定位在空腔内以向装饰组件提供柔软的感觉。 使用拉动真空并压缩泡沫垫的工具将泡沫垫插入空腔中。 将泡沫垫插入空腔中并释放真空，从而使泡沫垫膨胀以填充空腔。 该工具被移除，并且可移动面板移动并固定在关闭位置。
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