摘要:
A methylation classification list comprising loci DNA, for which loci the methylation status of the DNA is indicative of likelihood of recurrence of cancer, is provided. Furthermore, a method, apparatus and use for predicting probability of relapse free survival of a subject diagnosed with cancer, are provided.
摘要:
An engine comprises a cylinder head at least partially defining a dry valley and a cover secured to the cylinder head. The cover defines a first aperture. A boss extends from the cylinder head toward the cover. The boss defines a second aperture. A fastener extends through the first aperture and at least partially through the second aperture to secure the cover to the cylinder head. The fastener defines a passage to fluidly connect the dry valley to an exterior of the engine.
摘要:
A control system for a hybrid vehicle including an engine with cylinder deactivation comprises an engine time off module that determines an engine time off value. A re-purge determining module estimates a re-purge time required to purge a hydraulic control system of the engine of air before initiating cylinder deactivation. The re-purge time is estimated based on the engine time off value and an engine temperature.
摘要:
A cylinder head including a dam defining a reservoir surrounding the periphery of the fuel pump tappet/roller follower mounting hole is provided. The cylinder head includes a tappet/roller follower mounted in the tappet/roller follower mounting hole and in communication with a cam and a fuel pump. The fuel pump is located on the high side of the head and oil drainage occurs in a direction away from the mounting hole. The dam and reservoir are configured to retain lubricant in the mounting hole and the sliding interface between the mounting hole and the tappet/roller follower. The dam and reservoir are configured to retain a minimum level of oil in the mounting hole when the head is in vehicle position. A method is provided for retaining lubrication in the tappet/roller follower hole by forming a dam defining a reservoir in the head and passively providing lubricant to the tappet/roller follower hole.
摘要:
A valve train for use in an engine is provided. The valve train includes a rocker arm assembly having a valve side arm and a cam side arm. A valve is coupled to the engine and is in contact with the valve side arm. A pushrod is reciprocatable by a camshaft and is in contact with the cam side arm. An overload feature is located on at least one of the rocker arm assembly or the pushrod. The overload feature has a reduced cross-sectional area calibrated to activate at a predefined load.
摘要:
An oil lubrication and control system, for an engine having cylinder deactivation switching lifters operated at the pressure of the full oil system, is provided with an auxiliary pressure relief valve which opens to control maximum oil pressure in the system whenever the engine speed and temperature conditions lie beyond the ability of the oil pump pressure control unit to maintain the maximum pressure limit. Addition of the auxiliary pressure relief valve allows extended operation of the switching lifters, which are limited by their construction to operation below a prescribed pressure limit. In a preferred embodiment, the auxiliary pressure relief valve is mounted in the engine crankcase in a bore connected directly with the main oil gallery to provide mounting and actuation of the auxiliary pressure relief valve with a minimum of modifications to the engine oil system design.
摘要:
A method of purging air from an oil passage in communication with a lifter assembly in an engine assembly may include isolating the oil passage from a pressurized oil source while the lifter assembly is engaged with a base region of a cam lobe to operate the first lifter assembly in the activated mode. The pressurized oil may be provided to the lifter assembly via the oil passage after the isolating when the lifter assembly is engaged with a lift region of the cam lobe. The lifter assembly may be maintained in the activated mode after the providing. Air may be purged from the oil passage based on the pressurized oil provided to the oil passage.
摘要:
The present invention provides methods and compositions related to genomic profiling, and in particular, to assigning probabilistic measure of clinical outcome for a patient having a disease or a tumor using segmented genomic profiles such as those produced by representational oligonucleotide microarray analysis (ROMA).
摘要:
A control system for a hybrid vehicle including an engine with cylinder deactivation comprises an engine time off module that determines an engine time off value. A re-purge determining module estimates a re-purge time required to purge a hydraulic control system of the engine of air before initiating cylinder deactivation. The re-purge time is estimated based on the engine time off value and an engine temperature.
摘要:
An engine has switching valve actuators with positive valve lash for actuating or deactivating valves of deactivation cylinders and conventional valve actuators with negligible valve lash for actuating valves of conventional cylinders. Cams for the deactivation cylinders have increased opening and closing ramps relative to cams of the conventional cylinders. This can lead to poor combustion quality at idle and light loads and result in perceived engine roughness by an operator. To compensate for this, timing of exhaust cams of the deactivation cylinders is advanced relative to those of the conventional cylinders to reduce valve overlap of the deactivation cylinders to sufficiently near that of the conventional cylinders to provide stable combustion at idle in both conventional and deactivation cylinders with nearly equivalent power operation of all the cylinders.