公开(公告)号：US20130004455A1

公开(公告)日：2013-01-03

申请号：US13173783

申请日：2011-06-30

Applicant: Soo-Chang SONG ,  Thrimoorthy Potta ,  Mi-Ran Park

Inventor： Soo-Chang SONG ,  Thrimoorthy Potta ,  Mi-Ran Park

IPC: A61K31/80 ,  C12N9/96 ,  C08G69/48 ,  A61P19/04 ,  A61P9/00

CPC classification number: A61L27/18 ,  A61L27/52 ,  A61L27/54 ,  A61L2300/80 ,  C08G79/02 ,  C08G79/025 ,  C08J3/075 ,  C08J2385/02 ,  C08L85/02

Abstract: Provided are a use of chemically-crosslinkable, poly(organophosphazene)s for biomaterials, chemically-crosslinkable poly(organophosphazene)s with a physiologically active substance covalently-bonded thereto, a use thereof for biomaterials, and a process for preparing the same. The chemical crosslinkings can be made by UV irradiation, and/or a crosslinker, and/or an additive, and/or an enzyme, and/or a mixing of at least one polymer.

Abstract translation: 提供了用于生物材料的化学交联的聚（有机膦腈），与共价键合的生理活性物质的化学交联的聚（有机膦腈），其生物材料的用途及其制备方法的用途。 化学交联可以通过UV照射和/或交联剂，/或添加剂和/或酶进行，和/或至少一种聚合物的混合。

公开(公告)号：US20090047348A1

公开(公告)日：2009-02-19

申请号：US12122665

申请日：2008-05-17

Applicant: Soo-Chang SONG ,  Mi-Ran PARK ,  Sun-Mi LEE

Inventor： Soo-Chang SONG ,  Mi-Ran PARK ,  Sun-Mi LEE

IPC: A61K9/00 ,  C08G69/08 ,  A61K38/16 ,  A61K38/02 ,  A61K39/00 ,  A61K31/7052 ,  A61K35/00 ,  A61K38/14 ,  A61K38/21 ,  A61K38/20 ,  A61K38/28 ,  A61K39/395 ,  A61K38/43 ,  A61K38/13 ,  A61K39/29 ,  A61K31/56 ,  A61K35/12 ,  A61P43/00

CPC classification number: A61K31/56 ,  A61K9/06 ,  A61K31/7052 ,  A61K47/34 ,  C08G65/33306 ,  C08G79/025 ,  C08G2650/50 ,  C08L2203/02

Abstract: A biodegradable and thermosensitive poly(organophosphazene) with a functional group, a preparation method thereof, and a use thereof for delivery of bioactive substances are provided.

Abstract translation: 提供具有官能团的可生物降解和热敏聚（有机膦腈），其制备方法及其用于递送生物活性物质的用途。

公开(公告)号：US20140031289A1

公开(公告)日：2014-01-30

申请号：US13569737

申请日：2012-08-08

Applicant: Soo-Chang SONG ,  Young-Min Kim

Inventor： Soo-Chang SONG ,  Young-Min Kim

IPC: C08G79/02 ,  A61K47/34

CPC classification number: C08G79/025 ,  A61K47/34

Abstract: The present invention relates to a thermosensitive phosphazene-based polymer having a degradation controllable ionic group, a use thereof, and a use thereof as a material for delivering bioactive substances. The phosphazene-based polymer according to the present invention has the thermosensitivity of showing the temperature-dependent sol-gel phase transition. Thus, it forms a gel phase at the body temperature when it is injected into the body to make it easy to control the release of bioactive substances such as drugs, and has the functional groups capable of making chemical bonds such as ionic bond, covalent bond, coordinate bond, etc. with drugs and thus is excellent in bearing the drugs. Since it can control the degradation rate depending on the kind of ionic group, it can selectively control the release time depending on the characteristics of drugs. Furthermore, it has an excellent biocompatibility and thus is very useful as a material for delivery of bioactive substances such as drugs, etc.

Abstract translation: 本发明涉及具有降解可控离子基团的热敏磷腈基聚合物，其用途及其用作输送生物活性物质的材料的用途。 根据本发明的磷腈基聚合物具有显示温度依赖性溶胶 - 凝胶相变的热敏性。 因此，当其注入体内时，其在体温下形成凝胶相，以便容易地控制生物活性物质如药物的释放，并且具有能够进行化学键的官能团，例如离子键，共价键 ，配合药物等，因此具有优异的耐药性。 由于可以根据离子基团的种类控制降解速率，因此可根据药物的特性选择性地控制释放时间。 此外，它具有优异的生物相容性，因此作为用于递送生物活性物质如药物等的材料是非常有用的。

公开(公告)号：US20120121517A1

公开(公告)日：2012-05-17

申请号：US13173756

申请日：2011-06-30

Applicant: Soo-Chang SONG ,  Jang Il KIM

Inventor： Soo-Chang SONG ,  Jang Il KIM

IPC: A61K49/12 ,  C08G79/02 ,  A61K49/14 ,  A61P35/00 ,  C08G63/692 ,  A61K47/48 ,  B82Y30/00 ,  B82Y5/00 ,  B82Y25/00

CPC classification number: B82Y5/00 ,  A61K9/0009 ,  A61K49/1857 ,  B82Y15/00 ,  C08G79/025 ,  C08K3/22 ,  C08K2003/2265 ,  C08L85/02 ,  Y02A50/401

Abstract: The present invention relates to a poly(organophosphazene)-superparamagnetic nanoparticle complex including a biodegradable and thermosensitive poly(organophosphazene) and a iron oxide (Fe3O4, Magnetite)-series ferrite superparamagnetic nanoparticle, a preparation method, and uses of carrying a physiologically-active material, a bio-material and a biomaterial for cancer hyperthermia. The iron oxide is used as a MRI contrast agent for T-2 and T2* weighted image, and the poly(organophosphazene) shows a sol-to-gel behavior depending upon the temperature change. The complex is a bound-type where the superparamagnetic ferrite nanoparticle is bonded to phosphazene-based polymer via hydrophobic binding, and a mixed-type where the superparamagnetic ferrite nanoparticle is physically mixed with the phosphazene-based polymer.

Abstract translation: 本发明涉及包含可生物降解和热敏聚（有机膦腈）和氧化铁（Fe 3 O 4，磁铁矿）系列铁氧体超顺磁性纳米颗粒的聚（有机膦腈） - 超顺磁性纳米颗粒络合物，其制备方法和携带生理活性 材料，生物材料和癌症热疗的生物材料。 氧化铁用作T-2和T2 *加权图像的MRI造影剂，聚（有机膦腈）根据温度变化显示溶胶 - 凝胶行为。 复合物是超顺磁性铁氧体纳米颗粒通过疏水结合与磷腈基聚合物结合的结合型，以及超顺磁性铁氧体纳米颗粒与磷腈基聚合物物理混合的混合型。