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公开(公告)号：US20090081240A1
公开(公告)日：2009-03-26
申请号：US12244170
申请日：2008-10-02
申请人： Alessandro Moretta , Mariella Della Chiesa , Pascale Andre , Laurent Gauthier , Francois Romagne , Peter Andreas Nicolai Reumert Wagtmann , Ivan Svendsen , Stefan Zahn , Anders Svensson , Matthias Thorolfsson , Soren Berg Padkaer , Kristian Kjaergaard , Pieter Spee , Michael Wilken
发明人： Alessandro Moretta , Mariella Della Chiesa , Pascale Andre , Laurent Gauthier , Francois Romagne , Peter Andreas Nicolai Reumert Wagtmann , Ivan Svendsen , Stefan Zahn , Anders Svensson , Matthias Thorolfsson , Soren Berg Padkaer , Kristian Kjaergaard , Pieter Spee , Michael Wilken
CPC分类号： C07K16/42 , C07K16/28 , C07K16/2803 , C07K2299/00 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： Compositions and methods for regulating an immune response in a subject are described. More particularly, described are human antibodies that regulate the activity of NK cells and allow a potentiation of NK cell cytotoxicity in mammalian subjects, and antibodies having antigen-binding properties similar to those of human monoclonal antibody 1-7F9 or 1-4F1. Described also are also fragments and derivatives of such antibodies, as well as pharmaceutical compositions comprising the same and their uses, particularly for use in therapy, to increase NK cell activity or cytotoxicity in subjects.
摘要翻译： 描述了用于调节受试者的免疫应答的组合物和方法。 更具体地，描述了调节NK细胞活性并允许哺乳动物受试者中NK细胞细胞毒性增强的抗体，以及具有与人单克隆抗体1-7F9或1-4F1类似的抗原结合特性的抗体。 还描述了这种抗体的片段和衍生物，以及包含其的药物组合物及其用途，特别是用于治疗，以增加受试者的NK细胞活性或细胞毒性。
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公开(公告)号：US20090075340A1
公开(公告)日：2009-03-19
申请号：US12244101
申请日：2008-10-02
申请人： Soren Berg Padkaer , Peter Andreas Nicolai Reumert Wagtmann , Pieter Spee , Stefan Zahn , Kristian Kjaergaard , Anders Svensson
发明人： Soren Berg Padkaer , Peter Andreas Nicolai Reumert Wagtmann , Pieter Spee , Stefan Zahn , Kristian Kjaergaard , Anders Svensson
IPC分类号： C12P21/00 , C07K16/00 , A61K39/395 , C12N5/06 , C40B30/04 , A61K39/00 , C07H21/00 , C12N15/63 , C12N5/10
CPC分类号： C07K16/2803 , C07K16/28 , C07K2299/00 , C07K2317/55 , C07K2317/73 , C07K2317/76
摘要： The present invention relates to agents and methods that are capable of augmenting NK-mediated killing of target cells by reducing inhibitory KIR signalling without reducing the binding of KIR to HLA-C. As described herein, transduction of negative signaling via KIR, upon binding of KIR to its HLA class I ligand, can involve a ligand-binding induced, conformational reorientation of the KIR molecules allowing interactions to form between adjacent KIRs in specific domains, leading to accelerated clustering. Methods and agents such as monoclonal antibodies for reducing KIR-mediated inhibition of NK cell cytotoxicity without reducing or blocking HLA-binding by, e.g., reducing or blocking dimerization of KIR, are provided.
摘要翻译： 本发明涉及能够通过减少抑制性KIR信号而不降低KIR与HLA-C的结合来增强NK介导的靶细胞杀伤的试剂和方法。 如本文所述，在KIR与其HLA I类配体结合时通过KIR转导负向信号可涉及KIR分子的配体结合诱导的构象重新取向，允许在特定结构域中的相邻KIR之间形成相互作用，从而导致 加速聚类。 提供了诸如单克隆抗体的方法和试剂，用于减少KIR介导的NK细胞细胞毒性的抑制，而不通过例如还原或阻断KIR的二聚化来减少或阻断HLA结合。
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公开(公告)号：US20080305117A1
公开(公告)日：2008-12-11
申请号：US11813402
申请日：2006-01-06
申请人： Soren Berg Padkaer , Peter Andreas Nicolai Reumert Wagtmann , Pieter Spee , Stefan Zahn , Kristian Kjaergaard
发明人： Soren Berg Padkaer , Peter Andreas Nicolai Reumert Wagtmann , Pieter Spee , Stefan Zahn , Kristian Kjaergaard
IPC分类号： A61K39/395 , C07K16/00 , C12N5/00 , G01N33/53 , C07H21/00 , C12N15/63 , C12P21/00 , A61P37/00
CPC分类号： C07K16/2803 , C07K16/28 , C07K2299/00 , C07K2317/55 , C07K2317/73 , C07K2317/76
摘要： The present invention relates to agents and methods that are capable of augmenting NK-mediated killing of target cells by reducing inhibitory KIR signalling without reducing the binding of KIR to HLA-C. As described herein, transduction of negative signaling via KIR, 5 upon binding of KIR to its HLA class I ligand, can involve a ligand-binding induced, conformational reorientation of the KIR molecules allowing interactions to form between adjacent KIRs in specific domains, leading to accelerated clustering. Methods and agents such as mono-clonal antibodies for reducing KIR-mediated inhibition of NK cell cytotoxicity without reducing or blocking HLA-binding by, e.g., reducing or blocking dimerization of KIR, are provided.
摘要翻译： 本发明涉及能够通过减少抑制性KIR信号而不降低KIR与HLA-C的结合来增强NK介导的靶细胞杀伤的试剂和方法。 如本文所述，在KIR与其HLA I类配体结合时通过KIR转导负向信号可涉及KIR分子的配体结合诱导的构象重新取向，允许在特定结构域中的相邻KIR之间形成相互作用，从而导致 加速聚类。 提供了用于减少KIR介导的NK细胞细胞毒性抑制的单克隆抗体的方法和试剂，而不通过例如还原或阻断KIR二聚化来降低或阻断HLA结合。
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公开(公告)号：US20120208237A1
公开(公告)日：2012-08-16
申请号：US13347832
申请日：2012-01-11
申请人： Alessandro Moretta , Mariella Della Chiesa , Pascale Andre , Laurent Gauthier , Francois Romagné , Peter Andreas Nicolai Reumert Wagtmann , Ivan Svendsen , Stefan Zahn , Anders Svensson , Matthias Thórólfsson , Søren Berg Padkær , Kristian Kjaergaard , Pieter Spee , Michael Wilken
发明人： Alessandro Moretta , Mariella Della Chiesa , Pascale Andre , Laurent Gauthier , Francois Romagné , Peter Andreas Nicolai Reumert Wagtmann , Ivan Svendsen , Stefan Zahn , Anders Svensson , Matthias Thórólfsson , Søren Berg Padkær , Kristian Kjaergaard , Pieter Spee , Michael Wilken
CPC分类号： C07K16/42 , C07K16/28 , C07K16/2803 , C07K2299/00 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： Compositions and methods for regulating an immune response in a subject are described. More particularly, described are human antibodies that regulate the activity of NK cells and allow a potentiation of NK cell cytotoxicity in mammalian subjects, and antibodies having antigen-binding properties similar to those of human monoclonal antibody 1-7F9 or 1-4F1. Described also are also fragments and derivatives of such antibodies, as well as pharmaceutical compositions comprising the same and their uses, particularly for use in therapy, to increase NK cell activity or cytotoxicity in subjects.
摘要翻译： 描述了用于调节受试者的免疫应答的组合物和方法。 更具体地，描述了调节NK细胞活性并允许在哺乳动物受试者中增强NK细胞细胞毒性的人抗体，以及具有与人单克隆抗体1-7F9或1-4F1类似的抗原结合特性的抗体。 还描述了这种抗体的片段和衍生物，以及包含其的药物组合物及其用途，特别是用于治疗，以增加受试者的NK细胞活性或细胞毒性。
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公开(公告)号：US08119775B2
公开(公告)日：2012-02-21
申请号：US12244170
申请日：2008-10-02
申请人： Alessandro Moretta , Mariella Della Chiesa , Pascale Andre , Laurent Gauthier , Francois Romagné , Peter Andreas Nicolai Reumert Wagtmann , Ivan Svendsen , Stefan Zahn , Anders Svensson , Matthias Thórólfsson , Søren Berg Padkær , Kristian Kjaergaard , Pieter Spee , Michael Wilken
发明人： Alessandro Moretta , Mariella Della Chiesa , Pascale Andre , Laurent Gauthier , Francois Romagné , Peter Andreas Nicolai Reumert Wagtmann , Ivan Svendsen , Stefan Zahn , Anders Svensson , Matthias Thórólfsson , Søren Berg Padkær , Kristian Kjaergaard , Pieter Spee , Michael Wilken
CPC分类号： C07K16/42 , C07K16/28 , C07K16/2803 , C07K2299/00 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： Compositions and methods for regulating an immune response in a subject are described. More particularly, described are human antibodies that regulate the activity of NK cells and allow a potentiation of NK cell cytotoxicity in mammalian subjects, and antibodies having antigen-binding properties similar to those of human monoclonal antibody 1-7F9 or 1-4F1. Described also are also fragments and derivatives of such antibodies, as well as pharmaceutical compositions comprising the same and their uses, particularly for use in therapy, to increase NK cell activity or cytotoxicity in subjects.
摘要翻译： 描述了用于调节受试者的免疫应答的组合物和方法。 更具体地，描述了调节NK细胞活性并允许在哺乳动物受试者中增强NK细胞细胞毒性的人抗体，以及具有与人单克隆抗体1-7F9或1-4F1类似的抗原结合特性的抗体。 还描述了这种抗体的片段和衍生物，以及包含其的药物组合物及其用途，特别是用于治疗，以增加受试者的NK细胞活性或细胞毒性。
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公开(公告)号：US08614307B2
公开(公告)日：2013-12-24
申请号：US13347832
申请日：2012-01-11
申请人： Alessandro Moretta , Mariella Della Chiesa , Pascale Andre , Laurant Gauthier , Francois Romagne , Peter Andreas Nicolai Reumert Wagtmann , Ivan Svendsen , Stefan Zahn , Anders Svensson , Matthias Thorolfsson , Soren Berg Padkjaer , Kristian Kjaergaard , Petrus Johannes Loius Spee , Milchael Wilken
发明人： Alessandro Moretta , Mariella Della Chiesa , Pascale Andre , Laurant Gauthier , Francois Romagne , Peter Andreas Nicolai Reumert Wagtmann , Ivan Svendsen , Stefan Zahn , Anders Svensson , Matthias Thorolfsson , Soren Berg Padkjaer , Kristian Kjaergaard , Petrus Johannes Loius Spee , Milchael Wilken
IPC分类号： C07H21/04
CPC分类号： C07K16/42 , C07K16/28 , C07K16/2803 , C07K2299/00 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： Compositions and methods for regulating an immune response in a subject are described. More particularly, described are human antibodies that regulate the activity of NK cells and allow a potentiation of NK cell cytotoxicity in mammalian subjects, and antibodies having antigen-binding properties similar to those of human monoclonal antibody 1-7F9 or 1-4F1. Described also are also fragments and derivatives of such antibodies, as well as pharmaceutical compositions comprising the same and their uses, particularly for use in therapy, to increase NK cell activity or cytotoxicity in subjects.
摘要翻译： 描述了用于调节受试者的免疫应答的组合物和方法。 更具体地，描述了调节NK细胞活性并允许在哺乳动物受试者中增强NK细胞细胞毒性的人抗体，以及具有与人单克隆抗体1-7F9或1-4F1类似的抗原结合特性的抗体。 还描述了这种抗体的片段和衍生物，以及包含其的药物组合物及其用途，特别是用于治疗，以增加受试者的NK细胞活性或细胞毒性。
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公开(公告)号：US20090182127A1
公开(公告)日：2009-07-16
申请号：US12305669
申请日：2007-06-22
CPC分类号： C07K16/468 , C07K16/2803 , C07K16/36 , C07K2317/52
摘要： Bispecific antibodies comprising (a) a first light-heavy chain pair having specificity for a first target and a sufficient number of substitutions in its heavy chain constant domain with respect to a corresponding wild-type antibody of the same isotype to significantly reduce the formation of first heavy chain-first heavy chain dimers and (b) a second light-heavy chain pair comprising a heavy chain having a sequence that is complementary to the sequence of the first pair heavy chain sequence with respect to the formation of intramolecular ionic interactions, wherein the first pair or second pair comprises a substitution in the light chain and complementary substitution in the heavy chain that reduces the ability of the light chain to interact with the heavy chain of the other light chain-heavy chain pair are provided. Methods of producing such antibodies in one or more cells also are provided.
摘要翻译： 双特异性抗体包含（a）相对于相同同种型的相应野生型抗体，其第一轻链与第一靶具有特异性的重链和其重链恒定结构域中的足够数量的取代，以显着减少 第一重链首先重链二聚体和（b）第二轻 - 重链对，其包含相对于形成分子内离子相互作用而具有与第一对重链序列互补的序列的重链，其中 第一对或第二对包括轻链中的取代和重链中的互补取代，其降低轻链与另一轻链 - 重链对的重链相互作用的能力。 还提供了在一个或多个细胞中产生此类抗体的方法。
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公开(公告)号：US20130004514A1
公开(公告)日：2013-01-03
申请号：US13490093
申请日：2012-06-06
IPC分类号： C07K16/28 , A61P37/04 , A61P29/00 , A61P19/02 , A61P11/06 , A61P1/00 , A61P1/04 , A61P9/00 , A61P25/28 , A61P37/08 , A61K39/395 , A61P3/10
CPC分类号： C07K16/2896 , A61K2039/505 , C07K2317/21 , C07K2317/52 , C07K2317/565 , C07K2317/71 , C07K2317/76 , C07K2317/92
摘要： The present invention concerns human antibodies recognising the human C5a receptor. By binding to C5aR the antibodies inhibit C5a signalling, whereby the pro-inflammatory signal is inhibited. Based on the role of C5a and its receptor in stimulation of inflammation the invention further relates to therapeutic use of said human anti-C5aR antibodies and in particular in relation to treatment of immunological disorders.
摘要翻译： 本发明涉及识别人C5a受体的人抗体。 通过结合C5aR，抗体抑制C5a信号传导，从而抑制促炎信号。 基于C5a及其受体在炎症刺激中的作用，本发明进一步涉及所述人类抗C5aR抗体的治疗用途，特别是涉及免疫学疾病的治疗。
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公开(公告)号：US20050106139A1
公开(公告)日：2005-05-19
申请号：US10699362
申请日：2003-10-31
申请人： Ivan Svendsen , Kristian Kjaergaard , Stefan Zahn
发明人： Ivan Svendsen , Kristian Kjaergaard , Stefan Zahn
IPC分类号： A61K39/395 , C07K16/36 , C07K16/44
CPC分类号： C07K16/36 , A61K2039/505 , C07K2317/24
摘要： Provided are novel isolated humanized antibodies that immunoreact with human tissue factor (TF) so as to inhibit the binding of coagulation factor Vila (FVIIa), pharmaceutical compositions comprising the same, methods of making the same, cells producing such antibodies, and methods of treating disease comprising administering such antibodies and/or compositions to a subject in need thereof. General methods for preparing humanized antibodies also are provided.
摘要翻译： 提供了与人组织因子（TF）免疫反应的新型分离的人源化抗体，以抑制凝血因子Vila（FVIIa）的结合，包含其的药物组合物，其制备方法，产生此类抗体的细胞，以及治疗方法 疾病，包括向有需要的受试者施用此类抗体和/或组合物。 还提供了制备人源化抗体的一般方法。
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公开(公告)号：US08613926B2
公开(公告)日：2013-12-24
申请号：US13490093
申请日：2012-06-06
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/2896 , A61K2039/505 , C07K2317/21 , C07K2317/52 , C07K2317/565 , C07K2317/71 , C07K2317/76 , C07K2317/92
摘要： The present invention concerns human antibodies recognizing the human C5a receptor. By binding to C5aR the antibodies inhibit C5a signalling, whereby the pro-inflammatory signal is inhibited. Based on the role of C5a and its receptor in stimulation of inflammation the invention further relates to therapeutic use of said human anti-C5aR antibodies and in particular in relation to treatment of immunological disorders.
摘要翻译： 本发明涉及识别人C5a受体的人抗体。 通过结合C5aR，抗体抑制C5a信号传导，从而抑制促炎信号。 基于C5a及其受体在炎症刺激中的作用，本发明进一步涉及所述人类抗C5aR抗体的治疗用途，特别是涉及免疫学疾病的治疗。
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