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1.发明申请公开(公告)号：US20150320944A1
公开(公告)日：2015-11-12
申请号：US14423046
申请日：2014-05-23
Applicant: Stamford Devices Limited
Inventor： Joseph GREHAN , Niall SMITH
CPC classification number: A61M11/005 , A61M11/001 , A61M2205/33 , A61M2205/3317 , B05B12/004 , B05B12/081 , B05B15/14 , B05B17/0646 , B05B17/0669 , B06B1/0253 , G01N29/22 , G01N29/42 , G06F19/00 , G06F19/3456 , G16H20/13
Abstract: A nebulizer has an aperture plate, a mounting, an actuator, and an aperture plate drive circuit (2-4). A controller measures an electrical drive parameter at each of a plurality of measuring points, each measuring point having a drive frequency; and based on the values of the parameter at the measuring points makes a determination of optimum drive frequency and also an end-of-dose prediction. The controller performs a short scan at regular sub-second intervals at which drive current is measured at two measuring points with different drive frequencies. According to drive parameter measurements at these points the controller determines if a full scan sweeping across a larger number of measuring points should be performed. The full scan provides the optimum drive frequency for the device and also an end of dose indication.
Abstract translation: 喷雾器具有孔板，安装件，致动器和孔板驱动电路（2-4）。 控制器测量多个测量点中的每一个的电驱动参数，每个测量点具有驱动频率; 并且基于测量点处的参数的值来确定最佳驱动频率以及剂量结束预测。 控制器以规定的次秒间隔执行短扫描，在两个间隔，在具有不同驱动频率的两个测量点处测量驱动电流。 根据这些点的驱动参数测量，控制器确定是否应执行扫描更大数量的测量点的全扫描。 全扫描可为设备提供最佳的驱动频率，同时也为剂量指示结束。
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公开(公告)号：US20190224709A1
公开(公告)日：2019-07-25
申请号：US16314830
申请日：2017-06-29
Applicant: Stamford Devices Limited
Inventor： Patrick Martin KELLY , Joseph GREHAN , Finbarr MAGUIRE
Abstract: An aperture plate 1 comprises an inlet surface 2 for receiving a liquid to be aerosolised, an outlet surface 3 and a plurality of apertures 4 extending therebetween. The apertures 4 are tapered from an inlet opening 10 at the inlet surface 2 to an outlet or exit opening 12. The aperture plate 1 is convex in the direction of the inlet openings 10 and concave in the direction of the exit openings 12. The aerosol exits on the concave side of the aperture plate. The aperture plate of the invention generates an aerosol plume which converges and is particularly suitable for application to the eye.
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公开(公告)号：US20200156098A1
公开(公告)日：2020-05-21
申请号：US16621604
申请日：2018-08-23
Applicant: STAMFORD DEVICES LIMITED
Inventor： Joseph GREHAN , Noel COYLE , Russell GREANEY , Stephen THORNTON
Abstract: An aerosol delivery system has an aerosol generator with a vibrating aperture plate (10) and an actuator (11, 16, 17, 19), a controller (18, 19). The controller in real time monitors (201) the aerosol generator as it is driven for vibration of the aperture plate, and detects (202) a change in an electrical characteristic in response to a transition from a wet state to a dry state of the aperture plate. It automatically modifies (203, 205, 206), during the transition, operation of the aerosol generator in response to the detected change. The modification includes reducing applied power (203). The controller continues (204) to monitor during the transition, including monitoring the aperture plate for presence of residual liquid on the aperture plate first surface. The controller monitors at a number of drive frequencies and maintains data representing trends in a combination of the electrical characteristic signals at the different frequencies, and identifies a start of a transition if a calculated value rises above a threshold. There is one threshold for triggering a check scan for residual volume and a higher threshold to trigger an immediate shut down.
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公开(公告)号：US20200009332A1
公开(公告)日：2020-01-09
申请号：US16572298
申请日：2019-09-16
Applicant: Stamford Devices Limited
Inventor： Joseph GREHAN , Niall SMITH
Abstract: A nebulizer has an aperture plate, a mounting, an actuator, and an aperture plate drive circuit (2-4). A controller measures an electrical drive parameter at each of a plurality of measuring points, each measuring point having a drive frequency; and based on the values of the parameter at the measuring points makes a determination of optimum drive frequency and also an end-of-dose prediction. The controller performs a short scan at regular sub-second intervals at which drive current is measured at two measuring points with different drive frequencies. According to drive parameter measurements at these points the controller determines if a full scan sweeping across a larger number of measuring points should be performed. The full scan provides the optimum drive frequency for the device and also an end of dose indication.
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Patent Agency Ranking
公开(公告)号：US20250058059A1
公开(公告)日：2025-02-20
申请号：US18720321
申请日：2022-11-30
Applicant: STAMFORD DEVICES LIMITED
Inventor： Joseph GREHAN , Aidan DUFFY , Anthony REDMOND
IPC: A61M11/00
Abstract: A nebulizer (1, 102) has a liquid reservoir (3, 112) for supply of liquid to be aerosolized to a first surface of a vibratable aperture plate (41) with apertures having a size in the range of 1 pm to 10 pm. A drive has a piezoelectric annular element on an aperture plate support to cause the aperture plate to vibrate at a drive frequency of 128 kHz to cause droplets to separate from a side of the aperture plate opposed to the reservoir. An outlet conduit (6, 114) is for flow of droplets from the aperture plate. A sensor is arranged with an acoustic transducer in contact with the conduit outer surface to pick up an acoustic signal which is representative of a droplet plume in the conduit, and a processor analyses the signal to provide an output representative of a plume. The monitored acoustic signal frequency band is centred around half of the drive frequency because it takes on average more than one aperture plate cycle to separate a droplet.
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公开(公告)号：US20210308387A1
公开(公告)日：2021-10-07
申请号：US17350562
申请日：2021-06-17
Applicant: Stamford Devices Limited
Inventor： Joseph GREHAN , Niall Smith
IPC: A61M11/00 , G01N29/22 , G01N29/42 , B05B17/00 , B05B17/06 , B06B1/02 , B05B15/14 , G16H20/10 , G16H20/13
Abstract: A nebulizer has an aperture plate, a mounting, an actuator, and an aperture plate drive circuit (2-4). A controller measures an electrical drive parameter at each of a plurality of measuring points, each measuring point having a drive frequency; and based on the values of the parameter at the measuring points makes a determination of optimum drive frequency and also an end-of-dose prediction. The controller performs a short scan at regular sub-second intervals at which drive current is measured at two measuring points with different drive frequencies. According to drive parameter measurements at these points the controller determines if a full scan sweeping across a larger number of measuring points should be performed. The full scan provides the optimum drive frequency for the device and also an end of dose indication.
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公开(公告)号：US20240066542A1
公开(公告)日：2024-02-29
申请号：US18495066
申请日：2023-10-26
Applicant: STAMFORD DEVICES LIMITED
Inventor： Joseph GREHAN , Noel COYLE , Russell GREANEY , Stephen THORNTON
CPC classification number: B05B12/081 , A61M11/005 , A61M15/0085 , B05B17/0646 , B05B17/0669 , A61M2205/3317 , A61M2205/50
Abstract: An aerosol delivery system has an aerosol generator with a vibrating aperture plate (10) and an actuator (11, 16, 17, 19), a controller (18, 19). The controller in real time monitors (201) the aerosol generator as it is driven for vibration of the aperture plate, and detects (202) a change in an electrical characteristic in response to a transition from a wet state to a dry state of the aperture plate. It automatically modifies (203, 205, 206), during the transition, operation of the aerosol generator in response to the detected change. The modification includes reducing applied power (203). The controller continues (204) to monitor during the transition, including monitoring the aperture plate for presence of residual liquid on the aperture plate first surface. The controller monitors at a number of drive frequencies and maintains data representing trends in a combination of the electrical characteristic signals at the different frequencies, and identifies a start of a transition if a calculated value rises above a threshold. There is one threshold for triggering a check scan for residual volume and a higher threshold to trigger an immediate shut down.
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公开(公告)号：US20230248921A1
公开(公告)日：2023-08-10
申请号：US18304854
申请日：2023-04-21
Applicant: Stamford Devices Limited
Inventor： Joseph GREHAN , Niall SMITH
IPC: A61M11/00 , G01N29/22 , G01N29/42 , B05B17/00 , B05B17/06 , B06B1/02 , B05B15/14 , G16H20/10 , G16H20/13
CPC classification number: A61M11/005 , A61M11/001 , G01N29/22 , G01N29/42 , B05B17/0646 , B05B17/0669 , B06B1/0253 , B05B15/14 , G16H20/10 , G16H20/13 , B05B12/004
Abstract: A nebulizer has an aperture plate, a mounting, an actuator, and an aperture plate drive circuit (2-4). A controller measures an electrical drive parameter at each of a plurality of measuring points, each measuring point having a drive frequency; and based on the values of the parameter at the measuring points makes a determination of optimum drive frequency and also an end-of-dose prediction. The controller performs a short scan at regular sub-second intervals at which drive current is measured at two measuring points with different drive frequencies. According to drive parameter measurements at these points the controller determines if a full scan sweeping across a larger number of measuring points should be performed. The full scan provides the optimum drive frequency for the device and also an end of dose indication.
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公开(公告)号：US20180256829A1
公开(公告)日：2018-09-13
申请号：US15762387
申请日：2016-09-22
Applicant: Stamford Devices Limited
Inventor： Joseph GREHAN , Michael CASEY , Shaun PORTER , Niall SMITH
IPC: A61M11/00
Abstract: A digital processor of a nebulizer controller controls and monitors drive current (I) applied to an aperture plate. The drive current is detected as a series of discrete values at each of multiple measuring points, each having a particular drive frequency The processor in real time calculates a slope or rate of change of drive current with frequency and additionally determines a minimum value for drive current leading up to the peak value. The processor uses both the value of the minimum drive current during the scan and also the maximum slope value to achieve reliable prediction of end of dose, when the aperture plate becomes dry.
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