Highly active glycoproteins-process conditions and an efficient method for their production
    1.
    发明授权
    Highly active glycoproteins-process conditions and an efficient method for their production 有权
    高活性糖蛋白 - 工艺条件和有效的生产方法

    公开(公告)号:US08609370B2

    公开(公告)日:2013-12-17

    申请号:US10589447

    申请日:2005-02-14

    CPC分类号: C07K14/535 C12P19/26

    摘要: The present invention relates to highly active glycoproteins with specific sialylation degrees, a pharmaceutical composition for use in diagnosis or therapy comprising the glycoproteins, a method for the determination of highly active glycoproteins and of the conditions for their production, a method for producing the highly active glycoproteins, and a method for differential sialylation of secretory glycoproteins. The invention also relates to the use of the recombinantly expressed highly active glycoproteins for biological purposes and for prophylactic and/or therapeutic treatment or diagnosis of diseases, particularly bone marrow transplantation, neutropenia, cytopenia, AML and myelodysplastic syndromes, cancer, HIV and/or diseases of hematopoietic systems.

    摘要翻译: 本发明涉及具有特定唾液酸化度的高活性糖蛋白,用于诊断或治疗的药物组合物,其包含糖蛋白,用于测定高活性糖蛋白的方法及其生产条件,生产高活性的方法 糖蛋白和分泌糖蛋白的差异唾液酸化的方法。 本发明还涉及重组表达的高活性糖蛋白用于生物学目的以及预防和/或治疗性治疗或诊断疾病,特别是骨髓移植,中性白细胞减少症,血细胞减少症,AML和骨髓增生异常综合征,癌症,HIV和/或 造血系统疾病

    Highly Active Glycoproteins-Process Conditions and an Efficient Method for their Production
    2.
    发明申请
    Highly Active Glycoproteins-Process Conditions and an Efficient Method for their Production 有权
    高活性糖蛋白 - 工艺条件和高效的生产方法

    公开(公告)号:US20080226681A1

    公开(公告)日:2008-09-18

    申请号:US10589447

    申请日:2005-02-14

    CPC分类号: C07K14/535 C12P19/26

    摘要: The present invention relates to highly active glycoproteins with specific sialylation degrees, a pharmaceutical composition for use in diagnosis or therapy comprising the glycoproteins, a method for the determination of highly active glycoproteins and of the conditions for their production, a method for producing the highly active glycoproteins, and a method for differential sialylation of secretory glycoproteins. The invention also relates to the use of the recombinantly expressed highly active glycoproteins for biological purposes and for prophylactic and/or therapeutic treatment or diagnosis of diseases, particularly bone marrow transplantation, neutropenia, cytopenia, AML and myelodysplastic syndromes, cancer, HIV and/or diseases of hematopoietic systems.

    摘要翻译: 本发明涉及具有特定唾液酸化度的高活性糖蛋白,用于诊断或治疗的药物组合物,其包含糖蛋白,用于测定高活性糖蛋白的方法及其生产条件,生产高活性的方法 糖蛋白和分泌糖蛋白的差异唾液酸化的方法。 本发明还涉及重组表达的高活性糖蛋白用于生物学目的以及预防和/或治疗性治疗或诊断疾病,特别是骨髓移植,中性白细胞减少症,血细胞减少症,AML和骨髓增生异常综合征,癌症,HIV和/或 造血系统疾病

    Tumour Cell Lines and Uses Thereof
    3.
    发明申请
    Tumour Cell Lines and Uses Thereof 有权
    肿瘤细胞系及其用途

    公开(公告)号:US20110319590A1

    公开(公告)日:2011-12-29

    申请号:US13208253

    申请日:2011-08-11

    摘要: The present invention relates to a cell line selected from the group consisting of (a) a cell line denominated NM-F9 having the DSMZ accession number DSM ACC2606; (b) a cell line denominated NM-D4 having the DSMZ accession number DSM ACC2605; and subclones of (a) or (b). Additionally, the present invention provides a lysate of the cell lines or a molecule or mixture of molecules obtained from these cell lines as well as dendritic cells loaded with said lysate, co-cultivated or fused with cells from the cell lines, or a molecule or mixture of molecules obtained from these cell lines of the present invention. Moreover compositions, preferably pharmaceutical or vaccine compositions are provided which comprise the cell lines, lysate, molecules, mixture of molecules or dendritic cells of the present invention. In another aspect the present invention relates to methods for producing the aforementioned compositions. Furthermore, methods and uses for vaccination against or treatment or prevention of cancers and/or tumourous diseases are provided.

    摘要翻译: 本发明涉及选自(a)具有DSMZ登录号DSM ACC2606的称为NM-F9的细胞系的细胞系; (b)具有DSMZ登录号DSM ACC2605的称为NM-D4的细胞系; 和(a)或(b)的亚克隆。 此外,本发明提供细胞系的裂解物或从这些细胞系获得的分子或分子混合物以及负载有所述裂解物的树突状细胞,与来自细胞系的细胞共培养或融合,或分子或 从本发明的这些细胞系获得的分子的混合物。 此外,提供了包含本发明的细胞系,裂解物,分子,分子或树突状细胞的混合物的组合物,优选药物或疫苗组合物。 另一方面,本发明涉及制备上述组合物的方法。 此外,提供了针对或治疗或预防癌症和/或肿瘤疾病的疫苗接种的方法和用途。

    Tumour cell lines nm-f9 (dsm acc2606) and nm-d4 (dsm acc2605), uses thereof
    4.
    发明申请
    Tumour cell lines nm-f9 (dsm acc2606) and nm-d4 (dsm acc2605), uses thereof 有权
    肿瘤细胞系nm-f9(dsm acc2606)和nm-d4(dsm acc2605),其用途

    公开(公告)号:US20060292129A1

    公开(公告)日:2006-12-28

    申请号:US10568098

    申请日:2004-08-18

    IPC分类号: A61K48/00 C12N5/08

    摘要: The present invention relates to a cell line selected from the group consisting of (a) a cell line denominated NM-F9 having the DSMZ accession number DSM ACC2606; (b) a cell line denominated NM-D4 having the DSMZ accession number DSM ACC2605; and subclones of (a) or (b). Additionally, the present invention provides a lysate of the cell lines or a molecule or mixture of molecules obtained from these cell lines as well as dendritic cells loaded with said lysate, co-cultivated or fused with cells from the cell lines, or a molecule or mixture of molecules obtained from these cell lines of the present invention. Moreover compositions, preferably pharmaceutical or vaccine compositions are provided which comprise the cell lines, lysate, molecules, mixture of molecules or dendritic cells of the present invention. In another aspect the present invention relates to methods for producing the aforementioned compositions. Furthermore, methods and uses for vaccination against or treatment or prevention of cancers and/or tumourous diseases are provided.

    摘要翻译: 本发明涉及选自(a)具有DSMZ登录号DSM ACC2606的称为NM-F9的细胞系的细胞系; (b)具有DSMZ登录号DSM ACC2605的称为NM-D4的细胞系; 和(a)或(b)的亚克隆。 此外,本发明提供细胞系的裂解物或从这些细胞系获得的分子或分子混合物以及负载有所述裂解物的树突状细胞,与来自细胞系的细胞共培养或融合,或分子或 从本发明的这些细胞系获得的分子的混合物。 此外,提供了包含本发明的细胞系,裂解物,分子,分子或树突状细胞的混合物的组合物,优选药物或疫苗组合物。 另一方面,本发明涉及制备上述组合物的方法。 此外,提供了针对或治疗或预防癌症和/或肿瘤疾病的疫苗接种的方法和用途。

    Tumour cell lines and uses thereof
    7.
    发明授权
    Tumour cell lines and uses thereof 有权
    肿瘤细胞系及其用途

    公开(公告)号:US08283161B2

    公开(公告)日:2012-10-09

    申请号:US13208253

    申请日:2011-08-11

    IPC分类号: C12N5/00 C12P21/06

    摘要: The present invention relates to a cell line selected from the group consisting of (a) a cell line denominated NM-F9 having the DSMZ accession number DSM ACC2606; (b) a cell line denominated NM-D4 having the DSMZ accession number DSM ACC2605; and subclones of (a) or (b). Additionally, the present invention provides a lysate of the cell lines or a molecule or mixture of molecules obtained from these cell lines as well as dendritic cells loaded with said lysate, co-cultivated or fused with cells from the cell lines, or a molecule or mixture of molecules obtained from these cell lines of the present invention. Moreover compositions, preferably pharmaceutical or vaccine compositions are provided which comprise the cell lines, lysate, molecules, mixture of molecules or dendritic cells of the present invention. In another aspect the present invention relates to methods for producing the aforementioned compositions. Furthermore, methods and uses for vaccination against or treatment or prevention of cancers and/or tumourous diseases are provided.

    摘要翻译: 本发明涉及选自(a)具有DSMZ登录号DSM ACC2606的称为NM-F9的细胞系的细胞系; (b)具有DSMZ登录号DSM ACC2605的称为NM-D4的细胞系; 和(a)或(b)的亚克隆。 此外,本发明提供细胞系的裂解物或从这些细胞系获得的分子或分子混合物以及负载有所述裂解物的树突状细胞,与来自细胞系的细胞共培养或融合,或分子或 从本发明的这些细胞系获得的分子的混合物。 此外,提供了包含本发明的细胞系,裂解物,分子,分子或树突状细胞的混合物的组合物,优选药物或疫苗组合物。 另一方面,本发明涉及制备上述组合物的方法。 此外,提供了针对或治疗或预防癌症和/或肿瘤疾病的疫苗接种的方法和用途。

    Tumour cell lines and uses thereof
    8.
    发明授权
    Tumour cell lines and uses thereof 有权
    肿瘤细胞系及其用途

    公开(公告)号:US08017388B2

    公开(公告)日:2011-09-13

    申请号:US10568098

    申请日:2004-08-18

    IPC分类号: C12N5/00

    摘要: The present invention relates to a cell line selected from the group consisting of (a) a cell line denominated NM-F9 having the DSMZ accession number DSM ACC2606; (b) a cell line denominated NM-D4 having the DSMZ accession number DSM ACC2605; and subclones of (a) or (b). Additionally, the present invention provides a lysate of the cell lines or a molecule or mixture of molecules obtained from these cell lines as well as dendritic cells loaded with said lysate, co-cultivated or fused with cells from the cell lines, or a molecule or mixture of molecules obtained from these cell lines of the present invention. Moreover compositions, preferably pharmaceutical or vaccine compositions are provided which comprise the cell lines, lysate, molecules, mixture of molecules or dendritic cells of the present invention. In another aspect the present invention relates to methods for producing the aforementioned compositions. Furthermore, methods and uses for vaccination against or treatment or prevention of cancers and/or tumourous diseases are provided.

    摘要翻译: 本发明涉及选自(a)具有DSMZ登录号DSM ACC2606的称为NM-F9的细胞系的细胞系; (b)具有DSMZ登录号DSM ACC2605的称为NM-D4的细胞系; 和(a)或(b)的亚克隆。 此外,本发明提供细胞系的裂解物或从这些细胞系获得的分子或分子混合物以及负载有所述裂解物的树突状细胞,与来自细胞系的细胞共培养或融合,或分子或 从本发明的这些细胞系获得的分子的混合物。 此外,提供了包含本发明的细胞系,裂解物,分子,分子或树突状细胞的混合物的组合物,优选药物或疫苗组合物。 另一方面,本发明涉及制备上述组合物的方法。 此外,提供了针对或治疗或预防癌症和/或肿瘤疾病的疫苗接种的方法和用途。

    Process for the production of temperature-induced tumor cell lysates for use as immunogenic compounds
    10.
    发明授权
    Process for the production of temperature-induced tumor cell lysates for use as immunogenic compounds 有权
    用于产生用作免疫原性化合物的温度诱导的肿瘤细胞裂解物的方法

    公开(公告)号:US07595192B2

    公开(公告)日:2009-09-29

    申请号:US10524738

    申请日:2003-08-18

    IPC分类号: C12N5/00

    摘要: The present invention relates to a process for the production of an immunogenic compound comprising inducing necrosis by temperature in tumor cells and lysing said necrotic tumor cells so as to obtain a lysate. Furthermore, the invention provides a method for the production of a pharmaceutical composition. Additionally, the invention relates to a pharmaceutical composition comprising a lysate obtainable by the aforementioned process. Moreover, methods and uses for vaccination against cancers, tumorous diseases, infections and/or autoimmune diseases comprising administering the cell lysates of the invention or dendritic cells loaded with the cell lysate loaded to an individual are provided.

    摘要翻译: 本发明涉及一种生产免疫原性化合物的方法,包括在肿瘤细胞中通过温度诱导坏死并裂解所述坏死肿瘤细胞以获得裂解物。 此外,本发明提供了制备药物组合物的方法。 另外,本发明涉及包含可通过上述方法获得的裂解物的药物组合物。 此外,提供了针对癌症,肿瘤疾病,感染和/或自身免疫性疾病的疫苗接种的方法和用途,其包括施用本发明的细胞裂解物或负载有加载到个体的细胞裂解物的树突状细胞。