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    Highly Active Glycoproteins-Process Conditions and an Efficient Method for their Production
    1.
    发明申请
    Highly Active Glycoproteins-Process Conditions and an Efficient Method for their Production 有权
    高活性糖蛋白 - 工艺条件和高效的生产方法

    公开(公告)号：US20080226681A1

    公开(公告)日：2008-09-18

    申请号：US10589447

    申请日：2005-02-14

    申请人： Steffen Goletz ,  Hans Baurneister ,  Ute Schoeber

    发明人： Steffen Goletz ,  Hans Baurneister ,  Ute Schoeber

    IPC分类号： A61K39/00 ,  C07K14/00 ,  C12P21/04 ,  C12Q1/02 ,  A61P37/00 ,  G01N33/53 ,  A61K38/00

    CPC分类号： C07K14/535 ,  C12P19/26

    摘要： The present invention relates to highly active glycoproteins with specific sialylation degrees, a pharmaceutical composition for use in diagnosis or therapy comprising the glycoproteins, a method for the determination of highly active glycoproteins and of the conditions for their production, a method for producing the highly active glycoproteins, and a method for differential sialylation of secretory glycoproteins. The invention also relates to the use of the recombinantly expressed highly active glycoproteins for biological purposes and for prophylactic and/or therapeutic treatment or diagnosis of diseases, particularly bone marrow transplantation, neutropenia, cytopenia, AML and myelodysplastic syndromes, cancer, HIV and/or diseases of hematopoietic systems.

    摘要翻译： 本发明涉及具有特定唾液酸化度的高活性糖蛋白，用于诊断或治疗的药物组合物，其包含糖蛋白，用于测定高活性糖蛋白的方法及其生产条件，生产高活性的方法 糖蛋白和分泌糖蛋白的差异唾液酸化的方法。 本发明还涉及重组表达的高活性糖蛋白用于生物学目的以及预防和/或治疗性治疗或诊断疾病，特别是骨髓移植，中性白细胞减少症，血细胞减少症，AML和骨髓增生异常综合征，癌症，HIV和/或 造血系统疾病

    Highly active glycoproteins-process conditions and an efficient method for their production
    2.
    发明授权
    Highly active glycoproteins-process conditions and an efficient method for their production 有权
    高活性糖蛋白 - 工艺条件和有效的生产方法

    公开(公告)号：US08609370B2

    公开(公告)日：2013-12-17

    申请号：US10589447

    申请日：2005-02-14

    申请人： Steffen Goletz ,  Hans Baumeister ,  Ute Schoeber

    发明人： Steffen Goletz ,  Hans Baumeister ,  Ute Schoeber

    IPC分类号： C12N15/09 ,  C12P21/06 ,  C12P19/00 ,  A61K38/16

    CPC分类号： C07K14/535 ,  C12P19/26

    摘要： The present invention relates to highly active glycoproteins with specific sialylation degrees, a pharmaceutical composition for use in diagnosis or therapy comprising the glycoproteins, a method for the determination of highly active glycoproteins and of the conditions for their production, a method for producing the highly active glycoproteins, and a method for differential sialylation of secretory glycoproteins. The invention also relates to the use of the recombinantly expressed highly active glycoproteins for biological purposes and for prophylactic and/or therapeutic treatment or diagnosis of diseases, particularly bone marrow transplantation, neutropenia, cytopenia, AML and myelodysplastic syndromes, cancer, HIV and/or diseases of hematopoietic systems.

    摘要翻译： 本发明涉及具有特定唾液酸化度的高活性糖蛋白，用于诊断或治疗的药物组合物，其包含糖蛋白，用于测定高活性糖蛋白的方法及其生产条件，生产高活性的方法 糖蛋白和分泌糖蛋白的差异唾液酸化的方法。 本发明还涉及重组表达的高活性糖蛋白用于生物学目的以及预防和/或治疗性治疗或诊断疾病，特别是骨髓移植，中性白细胞减少症，血细胞减少症，AML和骨髓增生异常综合征，癌症，HIV和/或 造血系统疾病

    CANCER STEM CELL MARKERS AND USES THEREOF
    4.
    发明申请
    CANCER STEM CELL MARKERS AND USES THEREOF 审中-公开
    癌症干细胞标记物及其用途

    公开(公告)号：US20120294859A1

    公开(公告)日：2012-11-22

    申请号：US13574260

    申请日：2011-01-20

    申请人： Steffen Goletz ,  Uwe Karsten

    发明人： Steffen Goletz ,  Uwe Karsten

    IPC分类号： A61K39/395 ,  A61P35/02 ,  C12N5/00 ,  A61P35/00 ,  G01N33/53 ,  G01N33/566

    CPC分类号： G01N33/57469 ,  G01N2333/70596

    摘要： The present invention inter alia pertains to therapeutic methods which are based on the use of an agent specifically binding a tumor-associated carbohydrate antigen for the treatment of cancer stem cells and related diseases. Also provided are diagnostic and prognostic methods using a tumor-associated carbohydrate antigen as marker for cancer stem cells.

    摘要翻译： 本发明尤其涉及基于特异性结合肿瘤相关碳水化合物抗原用于治疗癌症干细胞和相关疾病的试剂的使用的治疗方法。 还提供了使用肿瘤相关碳水化合物抗原作为癌症干细胞的标志物的诊断和预后方法。

    FERMENTATION PROCESS
    5.
    发明申请
    FERMENTATION PROCESS 有权
    发酵过程

    公开(公告)号：US20110129570A1

    公开(公告)日：2011-06-02

    申请号：US12991827

    申请日：2009-05-13

    申请人： Steffen Goletz

    发明人： Steffen Goletz

    IPC分类号： A23C9/12 ,  C12N1/20 ,  A23J3/34 ,  A23L1/28

    CPC分类号： A23C9/1203 ,  A61K39/0011 ,  A61K2039/523 ,  A61K2039/542

    摘要： The present disclosure relates in one embodiment to a method of producing a fermented food, wherein a raw food material is combined with a starter culture for fermentation, wherein at least one microorganism of the genus Bacteroides and/or at least one microorganism having at least a cell surface structure which corresponds to a human carbohydrate structure is added. Further disclosed are processing aids and fermented foods containing respective microorganisms.

    摘要翻译： 在一个实施方案中，本公开涉及一种生产发酵食品的方法，其中将生食材料与用于发酵的起始培养物组合，其中至少一种拟杆菌属和/或至少一种微生物的微生物具有至少一种 加入对应于人碳水化合物结构的细胞表面结构。 进一步公开的是加工助剂和含有微生物的发酵食品。

    HUMANIZED EGFR ANTIBODIES
    7.
    发明申请
    HUMANIZED EGFR ANTIBODIES 有权
    人类EGFR抗体

    公开(公告)号：US20130273033A1

    公开(公告)日：2013-10-17

    申请号：US13814779

    申请日：2011-08-10

    申请人： Steffen Goletz ,  Antje Danielczyk

    发明人： Steffen Goletz ,  Antje Danielczyk

    IPC分类号： C07K16/28

    CPC分类号： C07K16/2863 ,  C07K2317/24 ,  C07K2317/565 ,  C07K2317/567

    摘要： The present invention pertains to humanized anti-EGFR antibodies having antigen binding properties similar to those of the murine or chimeric anti-EGFR antibody from which they are derived. In particular, the present invention is directed to humanized anti-EGFR antibodies which are useful in the treatment of cancer.

    摘要翻译： 本发明涉及具有与从其衍生的鼠抗体或嵌合抗EGFR抗体相似的抗原结合特性的人源化抗EGFR抗体。 特别地，本发明涉及可用于治疗癌症的人源化抗EGFR抗体。

    Tumour Cell Lines and Uses Thereof
    9.
    发明申请
    Tumour Cell Lines and Uses Thereof 有权
    肿瘤细胞系及其用途

    公开(公告)号：US20110319590A1

    公开(公告)日：2011-12-29

    申请号：US13208253

    申请日：2011-08-11

    申请人： Steffen Goletz ,  Hans Baumeister ,  Marion Schlangstedt ,  Ute SCHÖBER

    发明人： Steffen Goletz ,  Hans Baumeister ,  Marion Schlangstedt ,  Ute SCHÖBER

    IPC分类号： C07K14/62 ,  C07K14/435 ,  C07K14/575 ,  C07K14/52 ,  C07K14/54 ,  C07K14/59 ,  C07K14/53 ,  C07K14/55 ,  C12P21/02 ,  C07K16/18

    CPC分类号： C12N5/0693 ,  A61K39/0011 ,  A61K2039/5154 ,  A61K2039/5158 ,  A61K2039/55566

    摘要： The present invention relates to a cell line selected from the group consisting of (a) a cell line denominated NM-F9 having the DSMZ accession number DSM ACC2606; (b) a cell line denominated NM-D4 having the DSMZ accession number DSM ACC2605; and subclones of (a) or (b). Additionally, the present invention provides a lysate of the cell lines or a molecule or mixture of molecules obtained from these cell lines as well as dendritic cells loaded with said lysate, co-cultivated or fused with cells from the cell lines, or a molecule or mixture of molecules obtained from these cell lines of the present invention. Moreover compositions, preferably pharmaceutical or vaccine compositions are provided which comprise the cell lines, lysate, molecules, mixture of molecules or dendritic cells of the present invention. In another aspect the present invention relates to methods for producing the aforementioned compositions. Furthermore, methods and uses for vaccination against or treatment or prevention of cancers and/or tumourous diseases are provided.

    摘要翻译： 本发明涉及选自（a）具有DSMZ登录号DSM ACC2606的称为NM-F9的细胞系的细胞系; （b）具有DSMZ登录号DSM ACC2605的称为NM-D4的细胞系; 和（a）或（b）的亚克隆。 此外，本发明提供细胞系的裂解物或从这些细胞系获得的分子或分子混合物以及负载有所述裂解物的树突状细胞，与来自细胞系的细胞共培养或融合，或分子或 从本发明的这些细胞系获得的分子的混合物。 此外，提供了包含本发明的细胞系，裂解物，分子，分子或树突状细胞的混合物的组合物，优选药物或疫苗组合物。 另一方面，本发明涉及制备上述组合物的方法。 此外，提供了针对或治疗或预防癌症和/或肿瘤疾病的疫苗接种的方法和用途。

    Tumour cell lines nm-f9 (dsm acc2606) and nm-d4 (dsm acc2605), uses thereof
    10.
    发明申请
    Tumour cell lines nm-f9 (dsm acc2606) and nm-d4 (dsm acc2605), uses thereof 有权
    肿瘤细胞系nm-f9（dsm acc2606）和nm-d4（dsm acc2605），其用途

    公开(公告)号：US20060292129A1

    公开(公告)日：2006-12-28

    申请号：US10568098

    申请日：2004-08-18

    申请人： Steffen Goletz ,  Hans Baumeister ,  Marion Schlangstedt ,  Ute Schober

    发明人： Steffen Goletz ,  Hans Baumeister ,  Marion Schlangstedt ,  Ute Schober

    IPC分类号： A61K48/00 ,  C12N5/08

    CPC分类号： C12N5/0693 ,  A61K39/0011 ,  A61K2039/5154 ,  A61K2039/5158 ,  A61K2039/55566

    摘要： The present invention relates to a cell line selected from the group consisting of (a) a cell line denominated NM-F9 having the DSMZ accession number DSM ACC2606; (b) a cell line denominated NM-D4 having the DSMZ accession number DSM ACC2605; and subclones of (a) or (b). Additionally, the present invention provides a lysate of the cell lines or a molecule or mixture of molecules obtained from these cell lines as well as dendritic cells loaded with said lysate, co-cultivated or fused with cells from the cell lines, or a molecule or mixture of molecules obtained from these cell lines of the present invention. Moreover compositions, preferably pharmaceutical or vaccine compositions are provided which comprise the cell lines, lysate, molecules, mixture of molecules or dendritic cells of the present invention. In another aspect the present invention relates to methods for producing the aforementioned compositions. Furthermore, methods and uses for vaccination against or treatment or prevention of cancers and/or tumourous diseases are provided.

    摘要翻译： 本发明涉及选自（a）具有DSMZ登录号DSM ACC2606的称为NM-F9的细胞系的细胞系; （b）具有DSMZ登录号DSM ACC2605的称为NM-D4的细胞系; 和（a）或（b）的亚克隆。 此外，本发明提供细胞系的裂解物或从这些细胞系获得的分子或分子混合物以及负载有所述裂解物的树突状细胞，与来自细胞系的细胞共培养或融合，或分子或 从本发明的这些细胞系获得的分子的混合物。 此外，提供了包含本发明的细胞系，裂解物，分子，分子或树突状细胞的混合物的组合物，优选药物或疫苗组合物。 另一方面，本发明涉及制备上述组合物的方法。 此外，提供了针对或治疗或预防癌症和/或肿瘤疾病的疫苗接种的方法和用途。