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23 条记录 (耗时 0.019 秒)

    Process for the preparation of D,L-methionine or the salt thereof
    4.
    发明授权
    Process for the preparation of D,L-methionine or the salt thereof 失效
    制备D，L-甲硫氨酸或其盐的方法

    公开(公告)号：US5990349A

    公开(公告)日：1999-11-23

    申请号：US37020

    申请日：1998-03-09

    申请人： Friedhelm Geiger ,  Baudouin Halsberghe ,  Hans-Joachim Hasselbach ,  Klaus Hentschel ,  Klaus Huthmacher ,  Martin Korfer ,  Sven-Peter Mannsfeld ,  Herbert Tanner ,  Ferdinand Theissen ,  Jose Vanrobaeys ,  Klaus Willigerodt

    发明人： Friedhelm Geiger ,  Baudouin Halsberghe ,  Hans-Joachim Hasselbach ,  Klaus Hentschel ,  Klaus Huthmacher ,  Martin Korfer ,  Sven-Peter Mannsfeld ,  Herbert Tanner ,  Ferdinand Theissen ,  Jose Vanrobaeys ,  Klaus Willigerodt

    IPC分类号： C07C319/20 ,  C07C319/28 ,  C07C323/58 ,  C07D233/76 ,  C07C321/00 ,  C07C315/00

    CPC分类号： C07C319/20 ,  C07C319/28 ,  C07D233/76

    摘要： A process for the preparation of methionine or a salt of methionine by reaction of the components 3-methylmercaptopropionaldhyde, hydrogen cyanide, ammonia and carbon dioxide or components from which the above-mentioned components can be prepared, optionally in the presence of water, to 5-(2-methylmercaptoethyl)-hydantoin and further reaction thereof to methionine or the salt thereof, characterised in that the reaction of the components is initiated by means of at least one premixture in such a way that a first mixture is formed containing at least the predominant proportion (at least 5/10) of the 3-methylmercaptopropionaldeyde and at least 1/10 of the hydrogen cyanide component or corresponding quantities of components from which these components can be prepared, and less than 5/10 of one of the components ammonia, carbon dioxide or of the components from which ammonia or carbon dioxide can be prepared, and in that this first mixture is combined with the other component(s) for the reactive conversion to 5-(2-methylmercaptoethyl)-hydantoin, wherein this (these) latter component(s) may be premixed in one or more other mixtures.

    摘要翻译： 通过将3-甲基巯基丙酸，氰化氢，氨和二氧化碳或可由其制备上述组分的组分，任选地在水存在下，将组分3-甲基巯基丙酸，氰化氢，氨和二氧化碳或组分反应制备甲硫氨酸或甲硫氨酸的方法， - （2-甲基巯基乙基） - 乙内酰脲及其与甲硫氨酸或其盐的反应，其特征在于，组分的反应通过至少一种预混物引发，使得形成第一混合物至少含有 3-甲基巯基丙酸的主要比例（至少+ E，fra 5/10 + EE）和氰化氢组分的至少+ E，fra 1/10 + EE或可以制备这些组分的相应量的组分， 并且可以制备氨，二氧化碳或其中可以制备氨或二氧化碳的组分之一的小于+ E，fra 5/10 + EE，并且因为该第一混合物与 反应转化成5-（2-甲基巯基乙基） - 乙内酰脲的其它组分，其中这些（这些）后一种组分可以在一种或多种其它混合物中预混合。

    Process for recovering 2-hydroxy-4-methylthiobutyric acid (MHA), MHA and its use
    6.
    发明授权
    Process for recovering 2-hydroxy-4-methylthiobutyric acid (MHA), MHA and its use 失效
    2-羟基-4-甲硫基丁酸（MHA），MHA及其用途的回收方法

    公开(公告)号：US5976609A

    公开(公告)日：1999-11-02

    申请号：US776217

    申请日：1997-01-13

    申请人： Hans-Albrecht Hasseberg ,  Klaus Huthmacher ,  Herbert Tanner ,  Volker Hafner ,  Harald Heinzel

    发明人： Hans-Albrecht Hasseberg ,  Klaus Huthmacher ,  Herbert Tanner ,  Volker Hafner ,  Harald Heinzel

    IPC分类号： A23K1/16 ,  C07C319/20 ,  C07C319/28 ,  C07C323/52 ,  C07C323/60 ,  A23L1/305 ,  A23L1/28 ,  C15C315/02 ,  C15C315/06

    CPC分类号： C07C319/28 ,  A23K20/105 ,  C07C319/20 ,  Y10S426/807

    摘要： It is known to isolate MHA from a reaction mixture obtained by the addition of hydrocyanic acid (HCN) to methyl mercaptopropionic aldehyde (MMP) and the hydrolysis of the methyl mercapto propionic aldehyde cyanohydrine (MMP-CH) obtained thereby with sulphuric acid, in which the reaction mixture is brought into contact with a substantially non-water-miscible organic solvent, in order to form an extraction solution having the solvent and MHA transferred from the reaction mixture, and the MHA is obtained as an extract from this extraction solution by concentration. The simplest and most economical process of the invention concerning the processing of the reaction product which facilitates the production of a highly concentrated product with an extremely low dimer, oligomer and by-product content, is characterised in that the concentration is conducted in such a way that the remaining extract contains less than 4 wt % and preferably less than 2 wt % of water. Animal feed supplement, mixtures for supplementing animal feed, e.g. with methionine or ammonium-MHA.

    摘要翻译： PCT No.PCT / EP95 / 02515 Sec。 371日期1997年1月13日 102（e）日期1997年1月13日PCT提交1995年6月28日PCT公布。 公开号WO96 / 01809 日本1996年1月25日已知通过将氢氰酸（HCN）加入到甲基巯基丙醛（MMP）中获得的反应混合物和由此获得的甲基巯基丙醛氰基氢醌（MMP-CH）的水解来分离MHA 硫酸，其中使反应混合物与基本上不与水混溶的有机溶剂接触，以形成从反应混合物中转移有溶剂和MHA的提取溶液，并且获得MHA作为 该提取液通过浓缩。 关于有助于生产具有极低二聚体，低聚物和副产物含量的高浓缩产物的反应产物的加工的本发明的最简单和最经济的方法的特征在于以这种方式进行浓缩 剩余的提取物含有小于4重量％，优选小于2重量％的水。 动物饲料补充剂，补充动物饲料的混合物。 与甲硫氨酸或铵-MAA。

    Active-substance preparation for oral administration, especially to ruminants
    10.
    发明授权
    Active-substance preparation for oral administration, especially to ruminants 失效
    用于口服给药的活性物质制剂，特别是反刍动物

    公开(公告)号：US5279832A

    公开(公告)日：1994-01-18

    申请号：US820777

    申请日：1992-01-15

    申请人： Dieter Greissinger ,  Heidermarie Kniesel ,  Winfried Heimbeck ,  Herbert Tanner

    发明人： Dieter Greissinger ,  Heidermarie Kniesel ,  Winfried Heimbeck ,  Herbert Tanner

    IPC分类号： A23K40/35 ,  A61K9/22 ,  A61K9/36 ,  A61K9/50 ,  A61K9/52 ,  A61K45/08 ,  A61P3/00 ,  A61K9/44

    CPC分类号： A61K9/5073 ,  A23K40/35

    摘要： A dosage form for administering physiologically active substances to animals, especially ruminant animals. The dosage unit includes a core which contains the active substance and a coating. The coating has selected areas which are thinner than the average thickness of the coating and/or areas which are predetermined rupture sites. These thin areas or predetermined rupture sites are constructed and arranged so as to detach and/or rupture under the conditions which are present after oral administration of the dosage form. As a result, the delayed release of the physiologically-active substance is accelerated. For example, the coating may be formulated to not be affected in the first stomach of a ruminant but to rapidly disintegrate in the animal's second stomach.

    摘要翻译： 2.1饲料添加剂和药物等活性成分通常以延迟方式释放，或者经口给药缓慢释放。 特别是在反刍动物的情况下，在瘤胃中应该释放很少或没有。 适当的封装是昂贵的，并且特别是对于相对大量的产品的管理而言是不合适的并且太昂贵。 这种类型的已知包封也具有可疑的生理可接受性和/或不允许的缺点。 2.2新型封装包含相对薄的区域和/或预定的断裂点，与基本上均匀的涂层相比，其加速了释放。 诸如颗粒的角度细节优选地被包封，所述包封以这样的方式形成，使得在口服给药之后胶囊可以在边缘断裂。 封装优选由两层组成，内层含有填料加成膜剂，外层仅含有成膜剂。 2.3包封适用于营养目的的活性剂的保护管理，例如甲硫氨酸，或用于医疗，特别是兽医，特别是反刍动物的治疗。