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1.发明申请公开(公告)号：US20080294063A1
公开(公告)日：2008-11-27
申请号：US12148151
申请日：2008-04-17
申请人： Stephane Bibian , Tatjana Zikov , Guy Albert Dumont , Craig Robert Ries , Ernest Puil , Hosaain Cyrus Ahimadi , Mihai Huzmezan , Bernard Ansell MacLeod
发明人： Stephane Bibian , Tatjana Zikov , Guy Albert Dumont , Craig Robert Ries , Ernest Puil , Hosaain Cyrus Ahimadi , Mihai Huzmezan , Bernard Ansell MacLeod
IPC分类号： A61B5/0476
CPC分类号： A61B5/4821 , A61B5/048 , A61B5/4035 , A61B5/7217 , A61B5/726 , A61B5/7267
摘要： A method and apparatus to monitor the neurologic state of a patient undergoing general anesthesia is provided. Previous automated systems to monitor the neurologic state of a patient undergoing general anesthesia involve a significant time delay between the patients true hypnotic state and the computed indices. The present invention reduces this time delay by using a different analysis technique applied to spontaneous EEG. A wavelet decomposition and statistical analysis of the observed EEG is conducted and compared to reference data to provide a numerical indicator. In addition, this indicator is more consistent with the patient's loss of consciousness indicated by the loss of count event than previous systems.
摘要翻译： 提供了一种监测患有全身麻醉的患者的神经状态的方法和装置。 以前的自动化系统来监测经历全身麻醉的患者的神经系统状态，包括患者真正催眠状态和计算出的指数之间的显着时间延迟。 本发明通过使用应用于自发性EEG的不同分析技术来减少该时间延迟。 进行观察脑电图的小波分解和统计分析，并与参考数据进行比较以提供数值指标。 此外，该指标与以前系统的计数事件丢失所表示的患者意识丧失更为一致。
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公开(公告)号：US07603168B2
公开(公告)日：2009-10-13
申请号：US12148151
申请日：2008-04-17
申请人： Stéphane Bibian , Tatjana Zikov , Guy Albert Dumont , Craig Robert Ries , Ernest Puil , Hosaain Cyrus Ahmadi , Mihai Huzmezan , Bernard Ansell MacLeod
发明人： Stéphane Bibian , Tatjana Zikov , Guy Albert Dumont , Craig Robert Ries , Ernest Puil , Hosaain Cyrus Ahmadi , Mihai Huzmezan , Bernard Ansell MacLeod
IPC分类号： A61B5/04
CPC分类号： A61B5/4821 , A61B5/048 , A61B5/4035 , A61B5/7217 , A61B5/726 , A61B5/7267
摘要： A method and apparatus to monitor and control the anesthesia state of a patient undergoing general anesthesia is provided. Previous automated systems to monitor the anesthesia state of a patient undergoing general anesthesia involve a significant time delay between the patient's true anesthesia state and the computed indices. The present invention reduces this time delay by using a novel analysis technique applied to spontaneous electrophysiological activity. A transformation and statistical analysis of the observed electrophysiological activity is conducted and compared to reference data to provide numerical indicators. In addition, these indicators are consistent with the levels of depression of patients CNS and ANS states. This method is illustrated in detail by CNS monitoring of electroencephalogram signals.
摘要翻译： 提供了一种用于监测和控制进行全身麻醉的患者的麻醉状态的方法和装置。 以前的自动系统监测患者进行全身麻醉的麻醉状态涉及患者真实麻醉状态与计算出的指数之间的显着时间延迟。 本发明通过使用应用于自发电生理活动的新型分析技术来减少该时间延迟。 对观察到的电生理活动进行转化和统计分析，并与参考数据进行比较以提供数值指标。 此外，这些指标与患者CNS和ANS状态的抑郁水平一致。 CNS对脑电图信号的监测详细说明了该方法。
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3.发明授权公开(公告)号：US07373198B2
公开(公告)日：2008-05-13
申请号：US10616997
申请日：2003-07-11
申请人： Stéphane Bibian , Tatjana Zikov , Guy Albert Dumont , Craig Robert Ries , Ernest Puil , Hossain Cyrus Ahmadi , Mihai Huzmezan , Bernard Ansell Macleod
发明人： Stéphane Bibian , Tatjana Zikov , Guy Albert Dumont , Craig Robert Ries , Ernest Puil , Hossain Cyrus Ahmadi , Mihai Huzmezan , Bernard Ansell Macleod
IPC分类号： A61B5/04
CPC分类号： A61B5/4821 , A61B5/048 , A61B5/4035 , A61B5/7217 , A61B5/726 , A61B5/7267
摘要： A method and apparatus to monitor the neurologic state of a patient undergoing general anesthesia is provided. Previous automated systems to monitor the neurologic state of a patient undergoing general anesthesia involve a significant time delay between the patient's true hypnotic state and the computed indices. The present invention reduces this time delay by using a different analysis technique applied to spontaneous EEG. A wavelet decomposition and statistical analysis of the observed EEG is conducted and compared to reference data to provide a numerical indicator. In addition, this indicator is more consistent with the patient's loss of consciousness indicated by the loss of count event than previous systems.
摘要翻译： 提供了一种监测患有全身麻醉的患者的神经状态的方法和装置。 以前用于监测患有全身麻醉的患者的神经状态的自动化系统涉及患者真实催眠状态与计算出的指数之间的显着时间延迟。 本发明通过使用应用于自发性EEG的不同分析技术来减少该时间延迟。 进行观察脑电图的小波分解和统计分析，并与参考数据进行比较以提供数值指标。 此外，该指标与以前系统的计数事件丢失所表示的患者意识丧失更为一致。
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4.发明授权公开(公告)号：US08798735B1
公开(公告)日：2014-08-05
申请号：US12584083
申请日：2009-08-31
申请人： Stéphane Bibian , Tatjana Zikov , Guy Albert Dumont , Craig Robert Ries , Ernest Puil , Hossain Cyrus Ahmadi , Mihai Huzmezan , Bernard Ansell Macleod
发明人： Stéphane Bibian , Tatjana Zikov , Guy Albert Dumont , Craig Robert Ries , Ernest Puil , Hossain Cyrus Ahmadi , Mihai Huzmezan , Bernard Ansell Macleod
IPC分类号： A61B5/00
CPC分类号： A61B5/4821 , A61B5/048 , A61B5/4035 , A61B5/7217 , A61B5/726 , A61B5/7267
摘要： A method and apparatus to monitor the neurologic state of a patient undergoing general anesthesia is provided. Previous automated systems to monitor the neurologic state of a patient undergoing general anesthesia involve a significant time delay between the patient's true hypnotic state and the computed indices. The present invention reduces this time delay by using a different analysis technique applied to spontaneous EEG. A wavelet decomposition and statistical analysis of the observed EEG is conducted and compared to reference data to provide a numerical indicator. In addition, this indicator is more consistent with the patient's loss of consciousness indicated by the loss of count event than previous systems.
摘要翻译： 提供了一种监测患有全身麻醉的患者的神经状态的方法和装置。 以前用于监测患有全身麻醉的患者的神经状态的自动化系统涉及患者真实催眠状态与计算出的指数之间的显着时间延迟。 本发明通过使用应用于自发性EEG的不同分析技术来减少该时间延迟。 进行观察脑电图的小波分解和统计分析，并与参考数据进行比较以提供数值指标。 此外，该指标与以前系统的计数事件丢失所表示的患者意识丧失更为一致。
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公开(公告)号：US20100137438A1
公开(公告)日：2010-06-03
申请号：US12441054
申请日：2007-09-12
IPC分类号： A61K31/197 , A61P25/02
CPC分类号： A61K31/198
摘要： The invention provides for the use of isovaline or a pharmaceutically acceptable salt thereof for the treatment of Pain in a mammalian subject in some preferred embodiments, the invention provides for the treatment of acute and chronic Pain syndromes where other drug therapies have limited efficacy or unacceptable toxicity in said subject.
摘要翻译： 本发明在一些优选实施方案中提供异缬氨酸或其药学上可接受的盐在哺乳动物受试者中用于治疗疼痛的用途，本发明提供治疗急性和慢性疼痛综合征，其中其它药物疗法具有有限的功效或不可接受的毒性 在所述主题。
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公开(公告)号：US08278355B2
公开(公告)日：2012-10-02
申请号：US12441054
申请日：2007-09-12
CPC分类号： A61K31/198
摘要： The invention provides for the use of isovaline or a pharmaceutically acceptable salt thereof for the treatment of Pain in a mammalian subject in some preferred embodiments, the invention provides for the treatment of acute and chronic Pain syndromes where other drug therapies have limited efficacy or unacceptable toxicity in said subject.
摘要翻译： 本发明在一些优选实施方案中提供异缬氨酸或其药学上可接受的盐在哺乳动物受试者中用于治疗疼痛的用途，本发明提供治疗急性和慢性疼痛综合征，其中其它药物疗法具有有限的功效或不可接受的毒性 在所述主题。
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公开(公告)号：US20110092564A1
公开(公告)日：2011-04-21
申请号：US12919657
申请日：2009-02-26
申请人： Ernest Puil , Bernard A. Macleod , Richard Wall
发明人： Ernest Puil , Bernard A. Macleod , Richard Wall
IPC分类号： A61K31/198 , C07C229/48 , A61P29/00 , C07D313/04 , A61K31/335 , A61K31/351 , A61K31/34 , A61K31/337 , C07D309/14 , C07D307/24 , C07D305/08 , C07D337/04 , C07D335/02 , C07D333/38 , C07D331/04 , A61K31/382 , A61K31/381 , A61K31/38
CPC分类号： C07C229/48 , A61K31/198 , C07D205/04 , C07D305/06 , C07D331/04
摘要： Compositions comprising cyclic amino acids or pharmaceutically acceptable salts thereof and a pharmaceutically acceptable carrier. Said composition are for use in the treatment of pain. Pain includes both acute and chronic forms of pain. The preferred cyclic amino acid is 1-aminocyclobutane-1-carboxylic acid (ACBC).
摘要翻译： 包含环状氨基酸或其药学上可接受的盐的组合物和药学上可接受的载体。 所述组合物用于治疗疼痛。 疼痛包括急性和慢性疼痛形式。 优选的环状氨基酸是1-氨基环丁烷-1-羧酸（ACBC）。
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