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    Inhalation device for producing a drug aerosol
    1.
    发明授权
    Inhalation device for producing a drug aerosol 有权
    用于生产药物气溶胶的吸入装置

    公开(公告)号：US07913688B2

    公开(公告)日：2011-03-29

    申请号：US10442385

    申请日：2003-05-20

    申请人： Stephen Cross ,  Craig C. Hodges ,  Ron L. Hale ,  Peter M. Lloyd ,  Daniel J. Myers ,  Reynaldo J. Quintana ,  Joshua D. Rabinowitz ,  Curtis Tom ,  Martin J. Wensley

    发明人： Stephen Cross ,  Craig C. Hodges ,  Ron L. Hale ,  Peter M. Lloyd ,  Daniel J. Myers ,  Reynaldo J. Quintana ,  Joshua D. Rabinowitz ,  Curtis Tom ,  Martin J. Wensley

    IPC分类号： A61M15/08 ,  F23D11/00 ,  F23D14/00

    CPC分类号： A61M15/00 ,  A61M11/002 ,  A61M11/041 ,  A61M11/042 ,  A61M11/047

    摘要： A device for delivering a drug by inhalation is disclosed. The device includes a body defining an interior flow-through chamber having upstream and downstream chamber openings, and a drug supply unit contained within the chamber for producing, upon actuation, a heated drug vapor in a condensation region of the chamber. Gas drawn through the chamber region at a selected gas-flow rate is effective to form drug condensation particles from the drug vapor having a selected MMAD between 0.02 and 0.1 MMAD or between 1 and 3.5 μm. A gas-flow control valve disposed upstream of the unit functions to limit gas-flow rate through the condensation region to the selected gas-flow rate. An actuation switch in the device activates the drug-supply unit, such that the drug-supply unit can be controlled to produce vapor when the gas-flow rate through the chamber is at the selected flow rate.

    摘要翻译： 公开了一种通过吸入传送药物的装置。 该装置包括限定具有上游和下游室开口的内部流通室的主体，以及容纳在该室内的药物供应单元，用于在致动时产生在该室的冷凝区域中的加热的药物蒸气。 以选定的气体流速通过室区域抽吸的气体有效地从具有0.02至0.1MMAD的选定MMAD或1至3.5μm之间的药物蒸气形成药物凝结颗粒。 设置在单元上游的气体流量控制阀用于将通过冷凝区域的气体流量限制到所选择的气体流量。 装置中的致动开关激活药物供应单元，使得当通过腔室的气体流量处于所选择的流速时，可以控制药物供应单元产生蒸汽。

    Method Of Forming An Aerosol For Inhalation Delivery
    2.
    发明申请
    Method Of Forming An Aerosol For Inhalation Delivery 有权
    形成用于吸入输送的气雾剂的方法

    公开(公告)号：US20090229600A1

    公开(公告)日：2009-09-17

    申请号：US12471070

    申请日：2009-05-22

    申请人： Ron L. Hale ,  Craig C. Hodges ,  Peter M. Lloyd ,  Daniel Mufson ,  Daniel D. Rogers ,  Soonho Song ,  Martin J. Wensley ,  Daniel J. Myers ,  Jeffrey A. McKinney ,  Reynaldo J. Quintana ,  Joshua D. Rabinowitz

    发明人： Ron L. Hale ,  Craig C. Hodges ,  Peter M. Lloyd ,  Daniel Mufson ,  Daniel D. Rogers ,  Soonho Song ,  Martin J. Wensley ,  Daniel J. Myers ,  Jeffrey A. McKinney ,  Reynaldo J. Quintana ,  Joshua D. Rabinowitz

    IPC分类号： A61M11/00

    CPC分类号： A61M11/044 ,  A61K9/007 ,  A61K9/0073 ,  A61K31/235 ,  A61K31/4468 ,  A61K31/485 ,  A61K31/519 ,  A61M11/001 ,  A61M11/02 ,  A61M15/00 ,  A61M15/0028 ,  A61M16/109 ,  A61M2016/0039 ,  A61M2205/3606 ,  A61M2205/3653 ,  A61M2205/368 ,  A61M2205/50 ,  B05B7/1686 ,  B05B17/04

    摘要： The present invention relates to the inhalation delivery of aerosols containing small particles. Specifically, it relates to a method of forming an aerosol for use in inhalation therapy. In a method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug at a rate greater than 1000° C./s, thereby forming an vapor; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy. In another method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug to form a vapor, wherein the coated composition is in the form of a film less than 10μ thick; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy. In another method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug to form a vapor in less than 100 milliseconds, wherein the vapor has a mass greater than 0.1 mg; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy

    摘要翻译： 本发明涉及含有小颗粒的气溶胶的吸入输送。 具体地说，本发明涉及形成用于吸入治疗的气雾剂的方法。 在本发明的方法方面，提供了一种形成用于吸入治疗的气雾剂的方法。 该方法包括以下步骤：（a）以大于1000℃/ s的速率加热涂覆有包含药物的组合物的基底，从而形成蒸气; 和（b）允许蒸汽冷却，从而形成用于吸入治疗的气溶胶。 在本发明的另一方法方面，提供了形成用于吸入治疗的气雾剂的方法。 该方法包括以下步骤：（a）加热涂覆有包含药物的组合物的基底以形成蒸气，其中涂覆的组合物为小于10μm厚的膜的形式; 和（b）允许蒸汽冷却，从而形成用于吸入治疗的气溶胶。 在本发明的另一方法方面，提供了形成用于吸入治疗的气雾剂的方法。 该方法包括以下步骤：（a）加热涂覆有包含药物的组合物的基底以在小于100毫秒内形成蒸气，其中蒸气的质量大于0.1mg; 和（b）允许蒸汽冷却，从而形成用于吸入治疗的气溶胶

    Method of forming an aerosol for inhalation delivery
    3.
    发明授权
    Method of forming an aerosol for inhalation delivery 有权
    形成用于吸入输送的气溶胶的方法

    公开(公告)号：US08074644B2

    公开(公告)日：2011-12-13

    申请号：US12471070

    申请日：2009-05-22

    申请人： Ron L. Hale ,  Craig C. Hodges ,  Peter M. Lloyd ,  Daniel Mufson ,  Daniel D. Rogers ,  Soonho Song ,  Martin J. Wensley ,  Daniel J. Myers ,  Jeffrey A. McKinney ,  Reynaldo J. Quintana ,  Joshua D. Rabinowitz

    发明人： Ron L. Hale ,  Craig C. Hodges ,  Peter M. Lloyd ,  Daniel Mufson ,  Daniel D. Rogers ,  Soonho Song ,  Martin J. Wensley ,  Daniel J. Myers ,  Jeffrey A. McKinney ,  Reynaldo J. Quintana ,  Joshua D. Rabinowitz

    IPC分类号： A61L9/04

    CPC分类号： A61M11/044 ,  A61K9/007 ,  A61K9/0073 ,  A61K31/235 ,  A61K31/4468 ,  A61K31/485 ,  A61K31/519 ,  A61M11/001 ,  A61M11/02 ,  A61M15/00 ,  A61M15/0028 ,  A61M16/109 ,  A61M2016/0039 ,  A61M2205/3606 ,  A61M2205/3653 ,  A61M2205/368 ,  A61M2205/50 ,  B05B7/1686 ,  B05B17/04

    摘要： The present invention relates to the inhalation delivery of aerosols containing small particles. Specifically, it relates to a method of forming an aerosol for use in inhalation therapy. In a method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug at a rate greater than 1000° C./s, thereby forming an vapor; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy. In another method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug to form a vapor, wherein the coated composition is in the form of a film less than 10μ thick; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy. In another method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug to form a vapor in less than 100 milliseconds, wherein the vapor has a mass greater than 0.1 mg; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy.

    摘要翻译： 本发明涉及含有小颗粒的气溶胶的吸入输送。 具体地说，本发明涉及形成用于吸入治疗的气雾剂的方法。 在本发明的方法方面，提供了一种形成用于吸入治疗的气雾剂的方法。 该方法包括以下步骤：（a）以大于1000℃/ s的速率加热涂覆有包含药物的组合物的基底，从而形成蒸气; 和（b）允许蒸汽冷却，从而形成用于吸入治疗的气溶胶。 在本发明的另一方法方面，提供了形成用于吸入治疗的气雾剂的方法。 该方法包括以下步骤：（a）加热涂覆有包含药物的组合物的基底以形成蒸气，其中所述涂覆的组合物为小于10μ厚的膜的形式; 和（b）允许蒸汽冷却，从而形成用于吸入治疗的气溶胶。 在本发明的另一方法方面，提供了形成用于吸入治疗的气雾剂的方法。 该方法包括以下步骤：（a）加热涂覆有包含药物的组合物的基底以在小于100毫秒内形成蒸气，其中蒸气的质量大于0.1mg; 和（b）允许蒸汽冷却，从而形成用于吸入治疗的气溶胶。

    METHOD OF FORMING AN AEROSOL FOR INHALATION DELIVERY
    4.
    发明申请
    METHOD OF FORMING AN AEROSOL FOR INHALATION DELIVERY 审中-公开
    形成用于吸入输送的气溶胶的方法

    公开(公告)号：US20110240013A1

    公开(公告)日：2011-10-06

    申请号：US13078606

    申请日：2011-04-01

    申请人： Ron L. Hale ,  Craig C. Hodges ,  Peter M. Lloyd ,  Daniel Mufson ,  Daniel D. Rogers ,  Soonho Song ,  Martin J. Wensley ,  Daniel J. Myers ,  Jeffrey A. McKinney ,  Reynaldo J. Quintana ,  Joshua D. Rabinowitz

    发明人： Ron L. Hale ,  Craig C. Hodges ,  Peter M. Lloyd ,  Daniel Mufson ,  Daniel D. Rogers ,  Soonho Song ,  Martin J. Wensley ,  Daniel J. Myers ,  Jeffrey A. McKinney ,  Reynaldo J. Quintana ,  Joshua D. Rabinowitz

    IPC分类号： A61M11/00

    CPC分类号： A61M11/044 ,  A61K9/007 ,  A61K9/0073 ,  A61K31/235 ,  A61K31/4468 ,  A61K31/485 ,  A61K31/519 ,  A61M11/001 ,  A61M11/02 ,  A61M15/00 ,  A61M15/0028 ,  A61M16/109 ,  A61M2016/0039 ,  A61M2205/3606 ,  A61M2205/3653 ,  A61M2205/368 ,  A61M2205/50 ,  B05B7/1686 ,  B05B17/04

    摘要： The present invention relates to the inhalation delivery of aerosols containing small particles. Specifically, it relates to a method of forming an aerosol for use in inhalation therapy. In a method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug at a rate greater than 1000° C./s, thereby forming a vapor; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy. In another method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug to form a vapor, wherein the coated composition is in the form of a film less than 10μ thick; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy. In another method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug to form a vapor in less than 100 milliseconds, wherein the vapor has a mass greater than 0.1 mg; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy.

    摘要翻译： 本发明涉及含有小颗粒的气溶胶的吸入输送。 具体地说，本发明涉及形成用于吸入治疗的气雾剂的方法。 在本发明的方法方面，提供了一种形成用于吸入治疗的气雾剂的方法。 该方法包括以下步骤：（a）以大于1000℃/ s的速率加热涂覆有包含药物的组合物的基底，从而形成蒸气; 和（b）允许蒸汽冷却，从而形成用于吸入治疗的气溶胶。 在本发明的另一方法方面，提供了形成用于吸入治疗的气雾剂的方法。 该方法包括以下步骤：（a）加热涂覆有包含药物的组合物的基底以形成蒸气，其中所述涂覆的组合物为小于10μ厚的膜的形式; 和（b）允许蒸汽冷却，从而形成用于吸入治疗的气溶胶。 在本发明的另一方法方面，提供了形成用于吸入治疗的气雾剂的方法。 该方法包括以下步骤：（a）加热涂覆有包含药物的组合物的基底以在小于100毫秒内形成蒸气，其中蒸气的质量大于0.1mg; 和（b）允许蒸汽冷却，从而形成用于吸入治疗的气溶胶。

    Method of forming an aerosol for inhalation delivery
    5.
    发明授权
    Method of forming an aerosol for inhalation delivery 有权
    形成用于吸入输送的气溶胶的方法

    公开(公告)号：US07537009B2

    公开(公告)日：2009-05-26

    申请号：US10146088

    申请日：2002-05-13

    申请人： Ron L. Hale ,  Craig C. Hodges ,  Peter M. Lloyd ,  Daniel Mufson ,  Daniel D. Rogers ,  Soonho Song ,  Martin J. Wensley ,  Daniel J. Myers ,  Jeffrey A. McKinney ,  Reynaldo J. Quintana ,  Joshua D. Rabinowitz

    发明人： Ron L. Hale ,  Craig C. Hodges ,  Peter M. Lloyd ,  Daniel Mufson ,  Daniel D. Rogers ,  Soonho Song ,  Martin J. Wensley ,  Daniel J. Myers ,  Jeffrey A. McKinney ,  Reynaldo J. Quintana ,  Joshua D. Rabinowitz

    IPC分类号： A61L9/04

    CPC分类号： A61M11/044 ,  A61K9/007 ,  A61K9/0073 ,  A61K31/235 ,  A61K31/4468 ,  A61K31/485 ,  A61K31/519 ,  A61M11/001 ,  A61M11/02 ,  A61M15/00 ,  A61M15/0028 ,  A61M16/109 ,  A61M2016/0039 ,  A61M2205/3606 ,  A61M2205/3653 ,  A61M2205/368 ,  A61M2205/50 ,  B05B7/1686 ,  B05B17/04

    摘要： The present invention relates to the inhalation delivery of aerosols containing small particles. Specifically, it relates to a method of forming an aerosol for use in inhalation therapy. In a method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug at a rate greater than 1000° C./s, thereby forming an vapor; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy. In another method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug to form a vapor, wherein the coated composition is in the form of a film less than 10 μ thick; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy. In another method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug to form a vapor in less than 100 milliseconds, wherein the vapor has a mass greater than 0.1 mg; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy.

    摘要翻译： 本发明涉及含有小颗粒的气溶胶的吸入输送。 具体地说，本发明涉及形成用于吸入治疗的气雾剂的方法。 在本发明的方法方面，提供了一种形成用于吸入治疗的气雾剂的方法。 该方法包括以下步骤：（a）以大于1000℃/ s的速率加热涂覆有包含药物的组合物的基底，从而形成蒸气; 和（b）允许蒸汽冷却，从而形成用于吸入治疗的气溶胶。 在本发明的另一方法方面，提供了形成用于吸入治疗的气雾剂的方法。 该方法包括以下步骤：（a）加热涂覆有包含药物的组合物以形成蒸气的基底，其中涂覆的组合物为小于10微米的膜的形式; 和（b）允许蒸汽冷却，从而形成用于吸入治疗的气溶胶。 在本发明的另一方法方面，提供了形成用于吸入治疗的气雾剂的方法。 该方法包括以下步骤：（a）加热涂覆有包含药物的组合物的基底以在小于100毫秒内形成蒸气，其中蒸气的质量大于0.1mg; 和（b）允许蒸汽冷却，从而形成用于吸入治疗的气溶胶。

    Drug condensation aerosols and kits
    8.
    发明授权
    Drug condensation aerosols and kits 有权
    药物冷凝气溶胶和试剂盒

    公开(公告)号：US07090830B2

    公开(公告)日：2006-08-15

    申请号：US10718982

    申请日：2003-11-20

    申请人： Ron L. Hale ,  Craig C. Hodges ,  Peter M. Lloyd ,  Amy T. Lu ,  Daniel J. Myers ,  Joshua D. Rabinowitz ,  Martin J. Wensley

    发明人： Ron L. Hale ,  Craig C. Hodges ,  Peter M. Lloyd ,  Amy T. Lu ,  Daniel J. Myers ,  Joshua D. Rabinowitz ,  Martin J. Wensley

    IPC分类号： A61K9/12 ,  A61K9/14 ,  A61M15/00

    CPC分类号： A61K9/007 ,  A61K9/0073 ,  A61K9/1694 ,  A61M11/001 ,  A61M11/002 ,  A61M11/005 ,  A61M11/041 ,  A61M11/042 ,  A61M15/00 ,  A61M15/002 ,  Y10S514/958

    摘要： The present invention provides novel condensation aerosols for the treatment of disease and/or intermittent or acute conditions. These condensation aerosols have little or no pyrolysis degradation products and are characterized by having an MMAD of between 1–3 microns. These aerosols are made by rapidly heating a substrate coated with a thin film of drug having a thickness of between 0.05 and 20 μm, while passing a gas over the film, to form particles of a desirable particle size for inhalation. Kits comprising a drug and a device for producing a condensation aerosol are also provided. The device contained in the kit typically, has an element for heating the drug which is coated as a film on the substrate and contains a therapeutically effective dose of a drug when the drug is administered in aerosol form, and an element allowing the vapor to cool to form an aerosol. Also disclosed, are methods for using these aerosols and kits.

    摘要翻译： 本发明提供用于治疗疾病和/或间歇或急性病症的新型凝结气溶胶。 这些凝结气溶胶几乎没有或没有热解降解产物，其特征在于MMAD为1-3微米。 这些气溶胶是通过在使薄膜上的气体通过膜的同时，快速加热涂覆有厚度为0.05至20μm的药物的薄膜的基材，以形成用于吸入的理想颗粒尺寸的颗粒。 还提供了包含药物和用于产生冷凝气溶胶的装置的试剂盒。 包含在试剂盒中的装置通常具有用于加热药物的元件，其作为膜被涂覆在基底上并且当药物以气溶胶形式施用时含有治疗有效剂量的药物，以及允许蒸气冷却的元件 以形成气溶胶。 还公开了使用这些气溶胶和试剂盒的方法。