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公开(公告)号：US20050032190A1
公开(公告)日：2005-02-10
申请号：US10480954
申请日：2002-05-17
申请人： Stephen Brady , James Bruce , Elizabeth Chen-Dodson , Victor Garsky , Yueming Li , Mohinder Sardana , Jules Shafer , Xiaoting Tang
发明人： Stephen Brady , James Bruce , Elizabeth Chen-Dodson , Victor Garsky , Yueming Li , Mohinder Sardana , Jules Shafer , Xiaoting Tang
IPC分类号： A61K38/00 , C07K5/107 , C07K5/11 , C07K5/113 , C07K7/06 , C07K14/47 , C07K16/18 , C12P21/06 , C12P21/08 , C12Q1/37 , G01N33/68 , C12N9/64 , C07K16/40 , G01N33/53 , G01N33/567
CPC分类号： C12Q1/37 , C07K7/06 , C07K14/4711 , C12P21/06 , G01N33/6896 , G01N2500/00
摘要： The present invention provides synthetic β-secretase peptide substrates useful in various assays for measuring β-secretase activity. Antibodies that recognize the synthetic substrates and uses of the antibodies in various assays are disclosed. The herein disclosed peptide substrates are hydrolyzed at rates substantially faster than the attendant Swedish mutant APP from which the substrate sequences are derived.
摘要翻译： 本发明提供用于测量β-分泌酶活性的各种测定中的合成β-分泌酶肽底物。 公开了在各种测定中识别合成底物和抗体应用的抗体。 本文所公开的肽底物的水解速度明显快于从其中衍生出底物序列的瑞典突变体APP。
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公开(公告)号：US20070184488A1
公开(公告)日：2007-08-09
申请号：US11523507
申请日：2006-09-19
申请人： Stephen Brady , James Bruce , Elizabeth Chen-Dodson , Victor Garsky , Yueming Li , Mohinder Sardana , Jules Shafer , Xiaoting Tang
发明人： Stephen Brady , James Bruce , Elizabeth Chen-Dodson , Victor Garsky , Yueming Li , Mohinder Sardana , Jules Shafer , Xiaoting Tang
CPC分类号： C12Q1/37 , C07K7/06 , C07K14/4711 , C12P21/06 , G01N33/6896 , G01N2500/00
摘要： The present invention provides synthetic β-secretase peptide substrates useful in various assays for measuring β-secretase activity. Antibodies that recognize the synthetic substrates and uses of the antibodies in various assays are disclosed. The herein disclosed peptide substrates are hydrolyzed at rates substantially faster than the attendant Swedish mutant APP from which the substrate sequences are derived.
摘要翻译： 本发明提供用于测量β-分泌酶活性的各种测定中的合成β-分泌酶肽底物。 公开了在各种测定中识别合成底物和抗体应用的抗体。 本文所公开的肽底物的水解速度明显快于从其中衍生出底物序列的瑞典突变体APP。
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公开(公告)号：US07479372B2
公开(公告)日：2009-01-20
申请号：US11523507
申请日：2006-09-19
申请人： Stephen F. Brady , James E. Bruce , Elizabeth Chen-Dodson , Victor Garsky , Yueming Li , Mohinder Sardana , Jules A. Shafer , Xiaoting Tang
发明人： Stephen F. Brady , James E. Bruce , Elizabeth Chen-Dodson , Victor Garsky , Yueming Li , Mohinder Sardana , Jules A. Shafer , Xiaoting Tang
IPC分类号： G01N33/53
CPC分类号： C12Q1/37 , C07K7/06 , C07K14/4711 , C12P21/06 , G01N33/6896 , G01N2500/00
摘要： The present invention provides synthetic β-secretase peptide substrates useful in various assays for measuring β-secretase activity. Antibodies that recognize the synthetic substrates and uses of the antibodies in various assays are disclosed. The herein disclosed peptide substrates are hydrolyzed at rates substantially faster than the attendant Swedish mutant APP from which the substrate sequences are derived.
摘要翻译： 本发明提供用于测量β-分泌酶活性的各种测定中的合成β-分泌酶肽底物。 公开了在各种测定中识别合成底物和抗体应用的抗体。 本文所公开的肽底物的水解速度明显快于从其中衍生出底物序列的瑞典突变体APP。
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公开(公告)号：US07132401B2
公开(公告)日：2006-11-07
申请号：US10480954
申请日：2002-05-17
申请人： Stephen F. Brady , James E. Bruce , Elizabeth Chen-Dodson , Victor Garsky , Yueming Li , Mohinder Sardana , Jules A. Shafer , Xiaoting Tang
发明人： Stephen F. Brady , James E. Bruce , Elizabeth Chen-Dodson , Victor Garsky , Yueming Li , Mohinder Sardana , Jules A. Shafer , Xiaoting Tang
IPC分类号： A61K38/08
CPC分类号： C12Q1/37 , C07K7/06 , C07K14/4711 , C12P21/06 , G01N33/6896 , G01N2500/00
摘要： The present invention provides synthetic β-secretase peptide substrates useful in various assays for measuring β-secretase activity. Antibodies that recognize the synthetic substrates and uses of the antibodies in various assays are disclosed. The herein disclosed peptide substrates are hydrolyzed at rates substantially faster than the attendant Swedish mutant APP from which the substrate sequences are derived.
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公开(公告)号：US20070021350A1
公开(公告)日：2007-01-25
申请号：US11481999
申请日：2006-09-26
申请人： Stephen Brady , Dong-Mei Feng , Victor Garsky
发明人： Stephen Brady , Dong-Mei Feng , Victor Garsky
CPC分类号： C07K5/1013 , A61K38/00 , A61K47/65 , C07K5/1016 , C07K7/02 , C07K7/06 , C07K14/47
摘要： Chemical conjugates which comprise oligopeptides, having amino acid sequences that are selectively proteolytically cleaved by free prostate specific antigen (PSA) and known cytotoxic agents are disclosed. The conjugates of the invention are characterized by attachment of the cleavable oligopeptide to the oxygen atom at the 4-position on a vinca drug that has be desacetylated. Such conjugates are useful in the treatment of prostatic cancer and benign prostatic hypertrophy (BPH).
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公开(公告)号：US20060148718A1
公开(公告)日：2006-07-06
申请号：US11362251
申请日：2006-02-24
申请人： Stephen Brady , Dong-Mei Feng , Victor Garsky
发明人： Stephen Brady , Dong-Mei Feng , Victor Garsky
CPC分类号： C07K5/1013 , A61K38/00 , A61K47/65 , C07K5/1016 , C07K7/02 , C07K7/06 , C07K14/47
摘要： Chemical conjugates which comprise oligopeptides, having amino acid sequences that are selectively proteolytically cleaved by free prostate specific antigen (PSA) and known cytotoxic agents are disclosed. The conjugates of the invention are characterized by attachment of the cleavable oligopeptide to the oxygen atom at the 4-position on a vinca drug that has be desacetylated. Such conjugates are useful in the treatment of prostatic cancer and benign prostatic hypertrophy (BPH).
摘要翻译： 公开了包含具有由游离前列腺特异性抗原（PSA）和已知的细胞毒性剂选择性蛋白水解切割的氨基酸序列的寡肽的化学共轭物。 本发明的缀合物的特征在于将可切割的寡肽与已经脱乙酰化的长春花药物的4-位上的氧原子连接。 这种缀合物可用于治疗前列腺癌和良性前列腺肥大（BPH）。
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公开(公告)号：US20070244055A1
公开(公告)日：2007-10-18
申请号：US11810824
申请日：2007-06-06
申请人： Stephen Brady , Dong-Mei Feng , Victor Garsky
发明人： Stephen Brady , Dong-Mei Feng , Victor Garsky
CPC分类号： C07K14/47 , A61K38/00 , C07K5/1013 , C07K5/1016
摘要： Chemical conjugates which comprise oligopeptides, having amino acid sequences that are selectively proteolytically cleaved by free prostate specific antigen (PSA) and known cytotoxic agents are disclosed. The conjugates of the invention are characterized by attachment of the cleavable oligopeptide to the oxygen atom at the 4-position on a vinca drug that has be desacetylated. Such conjugates are useful in the treatment of prostatic cancer and benign prostatic hypertrophy (BPH).
摘要翻译： 公开了包含具有由游离前列腺特异性抗原（PSA）和已知的细胞毒性剂选择性蛋白水解切割的氨基酸序列的寡肽的化学共轭物。 本发明的缀合物的特征在于将可切割的寡肽与已经脱乙酰化的长春花药物的4-位上的氧原子连接。 这种缀合物可用于治疗前列腺癌和良性前列腺肥大（BPH）。
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公开(公告)号：US20070129309A1
公开(公告)日：2007-06-07
申请号：US11654881
申请日：2007-01-18
申请人： Stephen Brady , Dong-Mei Feng , Victor Garsky
发明人： Stephen Brady , Dong-Mei Feng , Victor Garsky
CPC分类号： C07K14/47 , A61K38/00 , C07K5/1013 , C07K5/1016
摘要： Chemical conjugates which comprise oligopeptides, having amino acid sequences that are selectively proteolytically cleaved by free prostate specific antigen (PSA) and known cytotoxic agents are disclosed. The conjugates of the invention are characterized by attachment of the cleavable oligopeptide to the oxygen atom at the 4-position on a vinca drug that has be deacetylated. Such conjugates are useful in the treatment of prostatic cancer and benign prostatic hypertrophy (BPH).
摘要翻译： 公开了包含具有由游离前列腺特异性抗原（PSA）和已知的细胞毒性剂选择性蛋白水解切割的氨基酸序列的寡肽的化学共轭物。 本发明的缀合物的特征在于将可切割寡肽连接到已经脱乙酰化的长春花药物上的4-位上的氧原子。 这种缀合物可用于治疗前列腺癌和良性前列腺肥大（BPH）。
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公开(公告)号：US20050119166A1
公开(公告)日：2005-06-02
申请号：US11005075
申请日：2004-12-06
申请人： Stephen Brady , Dong-Mei Feng , Victor Garsky
发明人： Stephen Brady , Dong-Mei Feng , Victor Garsky
摘要： Chemical conjugates which comprise oligopeptides, having amino acid sequences that are selectively proteolytically cleaved by free prostate specific antigen (PSA) and known cytotoxic agents are disclosed. The conjugates of the invention are characterized by attachment of the cleavable oligopeptide to the oxygen atom at the 4-position on a vinca drug that has be desacetylated. Such conjugates are useful in the treatment of prostatic cancer and benign prostatic hypertrophy (BPH).
摘要翻译： 公开了包含具有由游离前列腺特异性抗原（PSA）和已知的细胞毒性剂选择性蛋白水解切割的氨基酸序列的寡肽的化学共轭物。 本发明的缀合物的特征在于将可切割的寡肽与已经脱乙酰化的长春花药物的4-位上的氧原子连接。 这种缀合物可用于治疗前列腺癌和良性前列腺肥大（BPH）。
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