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    Structure, production and use of heregulin 2 ligands
    2.
    发明授权
    Structure, production and use of heregulin 2 ligands 失效
    蛋白2配体的结构，生产和应用

    公开(公告)号：US06399746B1

    公开(公告)日：2002-06-04

    申请号：US09173480

    申请日：1998-10-14

    申请人： Richard L. Vandlen ,  William E. Holmes

    发明人： Richard L. Vandlen ,  William E. Holmes

    IPC分类号： C07K1400

    CPC分类号： C07K14/4756 ,  A61K38/00

    摘要： Novel polypeptides with binding affinity for the p185HER2 receptor, designated heregulin 2-&agr; and heregulin 2-&bgr;, have been identified and purified from human tissue. The cDNA encoding the novel heregulin 2-&agr; has been isolated from human tissue and sequenced. Provided herein is nucleic acid sequence of the heregulin 2-&agr; useful in the production of heregulin 2-&agr; by recombinant means. Further provided an amino acid sequence of heregulin 2-&agr; and heregulin 2-&bgr;. Heregulins and their antibodies are useful as therapeutic agents and in diagnostic methods.

    摘要翻译： 已经从人体组织中鉴定并纯化了对p185HER2受体具有结合亲和力的新型多肽，称为asgulin 2-α和asgulin 2-β。 已经从人体组织中分离出编码新型胰岛素2-α的cDNA并进行测序。 本文提供了可用于通过重组方法产生拟胰岛素2-α的调节蛋白2-α的核酸序列。 进一步提供了asgulin 2-α和asgulin 2-β的氨基酸序列。 本土及其抗体可用作治疗剂和诊断方法。

    ErbB2 and ErbB4 Chimeric Heteromultimeric Adhesins
    4.
    发明授权
    ErbB2 and ErbB4 Chimeric Heteromultimeric Adhesins 有权
    ErbB2和ErbB4嵌合异源多聚体粘附素

    公开(公告)号：US06696290B2

    公开(公告)日：2004-02-24

    申请号：US09267985

    申请日：1999-03-12

    申请人： Vincent Daniel Fitzpatrick ,  Mark Sliwkowski ,  Richard L. Vandlen

    发明人： Vincent Daniel Fitzpatrick ,  Mark Sliwkowski ,  Richard L. Vandlen

    IPC分类号： C07K1646

    CPC分类号： C07K14/4705 ,  A61K38/00 ,  C07K14/4756 ,  C07K14/71 ,  C07K19/00 ,  C07K2319/30

    摘要： Novel chimeric heteromultimer adhesins that bind the ligand of natural heteromultimeric receptors and uses therefor are disclosed. The chimeric molecules of the heteromultimer adhesins comprise an extracellular domain of a heteromultimeric receptor monomer and a multimerization domain for the stable interaction of the chimeric molecules in the adhesin. Specifically disclosed are heteromultimeric adhesins comprising the extracellular domains of ErbB2 and ErbB3 or ErbB2 and ErbB4. The chimeric ErbB heteromultimer adhesins of the present invention are useful as competitive antagonists or agonists of a neuregulin for the treatment of diseases such as various cancers.

    摘要翻译： 公开了结合天然异源多聚体受体的配体的新型嵌合杂多聚体粘附素及其用途。 杂多聚体粘附素的嵌合分子包含异源多聚体受体单体的细胞外结构域和用于粘附素中嵌合分子的稳定相互作用的多聚化结构域。 具体公开的是包含ErbB2和ErbB3或ErbB2和ErbB4的细胞外结构域的异源多聚体粘附素。 本发明的嵌合ErbB异源多聚体粘附素可用作神经调节蛋白的竞争性拮抗剂或激动剂用于治疗各种癌症等疾病。

    Nucleic acids vectors and host cells encoding and expressing heregulin 2-.alpha.
    5.
    发明授权
    Nucleic acids vectors and host cells encoding and expressing heregulin 2-.alpha. 失效
    核酸载体和宿主细胞编码和表达蛋白2α

    公开(公告)号：US5834229A

    公开(公告)日：1998-11-10

    申请号：US330161

    申请日：1994-10-25

    申请人： Richard L. Vandlen ,  William E. Holmes

    发明人： Richard L. Vandlen ,  William E. Holmes

    IPC分类号： A61K38/00 ,  C07K14/475 ,  C12N15/00 ,  C07H21/04 ,  C12N7/00 ,  C12N15/63 ,  C12N15/85

    CPC分类号： C07K14/4756 ,  A61K38/00

    摘要： Novel 2 polypeptides with binding affinity for the p185.sup.HER2 receptor, designated heregulin 2-.alpha. and heregulin 2-.beta., have been identified and purified from human tissue. The cDNA encoding the novel heregulin 2-.alpha. has been isolated from human tissue and sequenced. Provided herein is nucleic acid sequence of the heregulin 2-.alpha. useful in the production of heregulin 2-.alpha. by recombinant means. Further provided an amino acid sequence of heregulin 2-.alpha. and heregulin 2-.beta.. Heregulins and their antibodies are useful as therapeutic agents and in diagnostic methods.

    摘要翻译： 已经从人体组织中鉴定并纯化具有与p185HER2受体结合亲和力的新型2多肽，称为asgulin 2-α和asgulin 2-β。 已经从人组织中分离出编码新型拟胰岛素2-α的cDNA并测序。 本文提供了可用于通过重组方法产生拟胰岛素2-α的asgulin 2-α的核酸序列。 进一步提供了asgulin 2-α和asgulin 2-beta的氨基酸序列。 本土及其抗体可用作治疗剂和诊断方法。

    MULTISPECIFIC ANTIBODIES, ANTIBODY ANALOGS, COMPOSITIONS, AND METHODS
    6.
    发明申请
    MULTISPECIFIC ANTIBODIES, ANTIBODY ANALOGS, COMPOSITIONS, AND METHODS 审中-公开
    多重抗体，抗体模拟物，组合物和方法

    公开(公告)号：US20130017200A1

    公开(公告)日：2013-01-17

    申请号：US13510145

    申请日：2010-12-03

    申请人： Justin Scheer ,  Richard L. Vandlen

    发明人： Justin Scheer ,  Richard L. Vandlen

    IPC分类号： C07K16/28 ,  A61P35/00 ,  A61K39/395

    CPC分类号： C07K16/468 ,  A61K2039/505 ,  C07K16/283 ,  C07K16/2863 ,  C07K16/32 ,  C07K2317/31 ,  C07K2317/55 ,  C07K2317/73 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/90

    摘要： Multispecific antibodies that specifically bind at least two different epitopes are provided. Structural variants of native antibodies (antibody analogs) are also provided. Also provided are multispecific antibodies and antibody analogs having a range of biological activities. Agonist and antagonist multispecific antibodies and agonist and antagonist antibody analogs are provided. Multispecific antibodies and antibody analogs conjugated with therapeutic and/or diagnostic agents are also provided, as are multispecific antibodies and antibody analogs conjugated with agents to increase in vivo half-life compared to multispecific antibodies and antibody analogs lacking such agents. In addition, methods of making multispecific antibodies and antibody analogs and compositions comprising multispecific antibodies and antibody analogs are provided. Therapeutic, research, and diagnostic uses of multispecific antibodies and antibody analogs are also provided.

    摘要翻译： 提供特异性结合至少两个不同表位的多特异性抗体。 还提供天然抗体（抗体类似物）的结构变体。 还提供了具有一系列生物活性的多特异性抗体和抗体类似物。 提供激动剂和拮抗剂多特异性抗体和激动剂和拮抗剂抗体类似物。 还提供与治疗和/或诊断试剂缀合的多特异性抗体和抗体类似物，多特异性抗体和与试剂结合的抗体类似物与缺乏这种试剂的多特异性抗体和抗体类似物相比增加体内半衰期。 此外，提供制备多特异性抗体和抗体类似物的方法以及包含多特异性抗体和抗体类似物的组合物。 还提供了多特异性抗体和抗体类似物的治疗，研究和诊断用途。

    Structure, production and use of heregulin
    9.
    发明授权
    Structure, production and use of heregulin 失效
    结构，生产和使用调味肽多肽

    公开(公告)号：US5367060A

    公开(公告)日：1994-11-22

    申请号：US847743

    申请日：1992-03-06

    申请人： Richard L. Vandlen ,  William E. Holmes

    发明人： Richard L. Vandlen ,  William E. Holmes

    IPC分类号： A61K38/00 ,  C07K14/475 ,  C07K13/00 ,  A61K37/36

    CPC分类号： C07K14/4756 ,  A61K38/00

    摘要： A novel polypeptide with binding affinity for the p185.sup.HER2 receptor, designated heregulin-.alpha., has been identified and purified from cultured human cells. DNA sequences encoding additional heregulin polypeptides, designated heregulin-.alpha., heregulin-.beta.1, heregulin-.beta.2, heregulin-.beta.2-like, and heregulin-.beta.3, have been isolated, sequenced and expressed. Provided herein are nucleic acid sequences encoding the amino acid sequences of heregulins useful in the production of heregulins by recombinant means. Further provided are the amino acid sequences of heregulins and purification methods therefor. Heregulins and their antibodies are useful as therapeutic agents and in diagnostic methods.

    摘要翻译： 已经鉴定并从培养的人细胞中纯化了对p185HER2受体具有结合亲和力的新型多肽，命名为asgulin-α。 已经分离，测序和表达编码附加的调节蛋白多肽的DNA序列，称为asgulin-α，asgulin-β1，heregulin-β2，heregulin-β2样和asgulin-β3。 本文提供了通过重组方法编码可用于生产本身的古菌素的氨基酸序列的核酸序列。 此外还提供了本文的氨基酸序列及其纯化方法。 本土及其抗体可用作治疗剂和诊断方法。

    ErbB2 and ErbB3 chimeric heteromultimer receptors
    10.
    发明授权
    ErbB2 and ErbB3 chimeric heteromultimer receptors 有权
    ErbB2和ErbB3嵌合异源多聚体受体

    公开(公告)号：US08226935B2

    公开(公告)日：2012-07-24

    申请号：US12639822

    申请日：2009-12-16

    申请人： Vincent Danial Fitzpatrick ,  Mark Sliwkowski ,  Richard L. Vandlen

    发明人： Vincent Danial Fitzpatrick ,  Mark Sliwkowski ,  Richard L. Vandlen

    IPC分类号： C07K14/00 ,  C07H21/02 ,  C07H21/04 ,  A61K39/00 ,  A61K39/385 ,  A61K48/00

    CPC分类号： C07K14/71 ,  A61K38/00 ,  A61K2039/505 ,  C07K14/4756 ,  C07K16/32 ,  C07K19/00 ,  Y02A50/466 ,  Y10S435/971

    摘要： Chimeric heteromultimer adhesins that bind the ligand of natural heromultimeric receptors and uses therefor are disclosed. The chimeric molecules of the heteromultimer adhesins comprise an extracellular domain of a heteromultimeric receptor monomer and a multimerization domain for the stable interaction of the chimeric molecules in the adhesin. Specifically disclosed are heteromultimeric adhesins comprising the extracellular domains of the ErbB2 and ErbB3 and ErbB2 and ErbB4. The chimeric ErB heteromultimer adhesins of the present invention are useful as competitive antagonists or agonists of a neuregulin for the treatment of diseases such as various cancers.

    摘要翻译： 公开了结合天然heromultimeric受体的配体的嵌合杂多聚体粘附素及其用途。 杂多聚体粘附素的嵌合分子包含异源多聚体受体单体的细胞外结构域和用于粘附素中嵌合分子的稳定相互作用的多聚化结构域。 具体公开的是包含ErbB2和ErbB3以及ErbB2和ErbB4的细胞外结构域的异源多聚体粘附素。 本发明的嵌合ErB异源多聚体粘附素可用作神经调节蛋白的竞争性拮抗剂或激动剂，用于治疗各种癌症等疾病。