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1.发明授权公开(公告)号：US06280745B1
公开(公告)日：2001-08-28
申请号：US09582508
申请日：2000-06-22
IPC分类号： A61K900
CPC分类号： A61K31/522 , A61K9/06 , A61K31/77 , A61K31/785 , A61K47/10 , A61K47/38 , B82Y5/00
摘要： The present invention provides a composition comprising one or more constitutive polymers and modifier polymers and/or hydrophilic co-surfactants useful for reducing adhesions or delivering bioactive agents. Methods for preventing and/or reducing post-surgical adhesions or delivering bioactive agents are provided.
摘要翻译： 本发明提供包含一种或多种构成型聚合物和改性聚合物和/或用于减少粘连或递送生物活性剂的亲水性辅助表面活性剂的组合物。 提供了用于预防和/或减少手术后粘连或递送生物活性剂的方法。
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公开(公告)号：US6034088A
公开(公告)日：2000-03-07
申请号：US141122
申请日：1998-08-27
CPC分类号： C08G65/2609 , A61L31/041 , A61L31/06 , A61L31/16 , A61L2300/204 , A61L2300/424 , A61L2300/802 , Y10S514/822 , Y10S514/885 , Y10S514/95 , Y10S514/975
摘要： A method and compositions for reducing post-surgical adhesion formation/reformation in mammals following surgical injury to a body cavity or organs situated therein. The aqueous compositions comprising pentoxifylline and a polyoxyalkylene block copolymer are applied to the injured areas subsequent to surgical injury.
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公开(公告)号：US06399624B1
公开(公告)日：2002-06-04
申请号：US09516640
申请日：2000-03-01
IPC分类号： A61K3152
CPC分类号： C08G65/2609 , A61L31/041 , A61L31/06 , A61L31/16 , A61L2300/204 , A61L2300/424 , A61L2300/802 , Y10S514/822 , Y10S514/885 , Y10S514/95 , Y10S514/975 , C08L71/02 , C08L89/06 , C08L5/08 , C08L5/04 , C08L5/00 , C08L1/28
摘要： A method and compositions for reducing post-surgical adhesion formation/reformation in mammals following surgical injury to a body cavity or organs situated therein. The aqueous compositions comprising pentoxifylline and a polyoxyalkylene block copolymer are applied to the injured areas subsequent to surgical injury.
摘要翻译： 一种用于减少手术后损伤哺乳动物的外科手术后粘连形成/改造的方法和组合物，其中所述体腔或器官位于其中。 包含己酮可可碱和聚氧化烯嵌段共聚物的含水组合物在手术损伤后被施用于受伤区域。
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4.发明授权公开(公告)号：US06436425B1
公开(公告)日：2002-08-20
申请号：US09499887
申请日：2000-02-08
IPC分类号： A61P4100
CPC分类号： A61K9/0014 , A61K9/1075 , A61K31/522 , A61K31/765 , A61K31/77 , A61K31/785 , A61K47/10 , A61K47/18 , A61L31/06 , C08L71/02
摘要： Non-gelling polyoxyalkylene compositions, and methods of their use for inhibiting surgical adhesion formation/reformation in mammals are disclosed. The useful non-gelling compositions preferably comprise polyoxyalkylene block copolymer at desired concentrations with or without a therapeutic agent. When used with an incorporated drug, the non-gelling compositions serve as a carrier providing sustained or prolonged release of the therapeutic agent.
摘要翻译： 公开了非胶凝聚氧化烯组合物及其用于抑制哺乳动物中外科粘连形成/重组的方法。 有用的非胶凝组合物优选包含具有或不具有治疗剂的所需浓度的聚氧化烯嵌段共聚物。 当与掺入的药物一起使用时，非胶凝组合物用作提供治疗剂持续或延长释放的载体。
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公开(公告)号：US5843470A
公开(公告)日：1998-12-01
申请号：US540229
申请日：1995-10-06
CPC分类号： C08G65/2609 , A61L31/041 , A61L31/06 , A61L31/16 , A61L2300/204 , A61L2300/424 , A61L2300/802 , Y10S514/822 , Y10S514/885 , Y10S514/95 , Y10S514/975
摘要： A method and compositions for reducing post-surgical adhesion formation/reformation in mammals following surgical injury to a body cavity or organs situated therein. The aqueous compositions comprising pentoxifylline and a polyoxyalkylene block copolymer are applied to the injured areas subsequent to surgical injury.
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公开(公告)号：US06977045B2
公开(公告)日：2005-12-20
申请号：US10766756
申请日：2004-01-28
CPC分类号： C08G65/30
摘要： A process for the purification or fractionation of aqueous soluble polymers using an aqueous two-phase system is described. The concentrations of the polymer to be fractionated and of an aqueous soluble salt, and the temperature of the aqueous fractionation medium are adjusted so that two phases form, the lower molecular weight polymer molecules partition into the high salt concentration phase, and the higher molecular weight polymer molecules partition into the low salt concentration phase. The resulting high molecular weight polymers are characterized by a higher average molecular weight and a narrower molecular weight distribution and decreased unsaturation than the unfractionated polymers. After being subjected to the fractionation process, polyol polymers that form hydrogels in aqueous solution exhibited higher viscosities and a liquid to gel transition over a narrower temperature range than the unfractionated polyol polymers.
摘要翻译： 描述了使用水性两相体系纯化或分级水溶性聚合物的方法。 要分级分离的聚合物和水溶性盐的浓度以及水分级分离介质的温度调节成两相，低分子量聚合物分子分配成高盐浓度相，分子量越高 聚合物分子分成低盐浓度相。 所得到的高分子量聚合物的特征在于比未分级聚合物更高的平均分子量和更窄的分子量分布和降低的不饱和度。 在进行分馏工艺后，在水溶液中形成水凝胶的多元醇聚合物在比未分级多元醇聚合物更窄的温度范围内表现出较高的粘度和液体至凝胶转变。
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公开(公告)号：US5593683A
公开(公告)日：1997-01-14
申请号：US205305
申请日：1994-03-03
CPC分类号： A61K47/18 , A61K47/10 , A61K9/0014 , Y10S514/912 , Y10S514/944
摘要： Compositions based upon aqueous gels for medical application, comprising polyoxyalkylene copolymers. Such gels which are isotonic, iso-osmotic, pH balanced, thermo-reversible gels are ideal vehicles for drug or diagnostic agent delivery.
摘要翻译： 基于用于医疗应用的含水凝胶的组合物，包含聚氧化烯共聚物。 这种等渗，等渗，pH平衡，热可逆凝胶的凝胶是用于药物或诊断剂递送的理想载体。
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8.发明授权Drug delivery by injection with thermoreversible gels containing polyoxyalkylene copolymers 失效通过注射含有聚氧化烯共聚物的热可逆凝胶进行药物递送
公开(公告)号：US5306501A
公开(公告)日：1994-04-26
申请号：US791119
申请日：1991-11-08
CPC分类号： A61K47/18 , A61K47/10 , A61K9/0019 , Y10S514/944
摘要： Isotonic, iso-osmotic, pH balanced thermoreversible gels are ideal medical devices or vehicles for drug injection into the body of a mammal. The osmolality in the gel state can be calculated by assuming that a polyoxyalkylene block copolymer or polyether present in said gel does not contribute to the osmolality in the gel state, although it does contribute to the osmolality in the liquid state.
摘要翻译： 等渗，等渗，pH平衡的热可逆凝胶是用于药物注射到哺乳动物体内的理想医疗装置或载体。 可以通过假设存在于所述凝胶中的聚氧化烯嵌段共聚物或聚醚在凝胶状态下不影响重量摩尔渗透压浓度来计算凝胶状态下的重量摩尔渗透压浓度，尽管它确实有助于液态渗透压。
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9.发明授权Body cavity drug delivery with thermo-irreversible polyoxyalkylene and ionic polysaccharide gels 失效体腔药物递送与热不可逆的聚氧化烯和离子多糖凝胶
公开(公告)号：US5143731A
公开(公告)日：1992-09-01
申请号：US563640
申请日：1990-08-07
CPC分类号： A61K47/36 , A61K47/10 , A61K47/18 , A61K9/0014 , A61K9/0048 , Y10S424/14 , Y10S514/944 , Y10S514/966 , Y10S514/967
摘要： Balanced pH, thermo-irreversible gels are ideal vehicles for drug delivery to a body cavity of a mammal. The gels contain a mixture of a polyoxyalkylene block copolymer or polyether together with an ionic polysaccharide which is thermo-irreversibly gelled in the presence of a counter-ion.
摘要翻译： 平衡的pH，热不可逆凝胶是药物递送到哺乳动物体腔的理想载体。 凝胶含有聚氧化烯嵌段共聚物或聚醚与在抗衡离子存在下不可逆地凝胶化的离子多糖的混合物。
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公开(公告)号：US6136334A
公开(公告)日：2000-10-24
申请号：US330618
申请日：1999-06-11
IPC分类号： A61F9/008 , A61K9/00 , A61L15/22 , A61L15/44 , A61L24/00 , A61L24/04 , A61L27/26 , A61L27/52 , A61L27/54 , A61L31/04 , A61L31/16 , A61K31/74 , A61K9/50 , A61K31/765 , A61K31/785
CPC分类号： A61L31/16 , A61F9/00819 , A61K9/0048 , A61L15/225 , A61L15/44 , A61L24/0015 , A61L24/0031 , A61L24/043 , A61L27/26 , A61L27/52 , A61L27/54 , A61L31/041 , A61F2009/00872 , A61L2300/00 , A61L2430/16 , Y10S514/912 , Y10S514/913 , Y10S514/914 , Y10S514/944 , Y10S514/966 , Y10S514/967 , Y10S623/905
摘要： Balanced pH, hyperosmotic, hypoosmotic, or isoosmotic gels are ideal vehicles for drug delivery. They are especially suited for topical body cavity or injection application of drugs or diagnostic agents; for drug or diagnostic agent delivery to the eye of a mammal; as protective corneal shields; or as ablatable corneal masks useful in laser reprofiling of the cornea. The compositions without the addition of a drug or diagnostic agent are useful as medical devices, for instance, in separating surgically or otherwise injured tissue as a means of preventing adhesions.
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