-
1.发明申请COMPOSITIONS AND METHODS FOR PREPARING STAPHYLOCOCCUS AUREUS SEROTYPE 5 AND 8 CAPSULAR POLYSACCHARIDE CONJUGATE IMMUNOGENIC COMPOSITIONS 有权组合物及其制备方法用于制备油菜黄连蛋白5和8聚糖多糖共沉淀物免疫组合物公开(公告)号：US20120276137A1
公开(公告)日：2012-11-01
申请号：US13379291
申请日：2010-06-22
申请人： Stephen John Freese , Annaliesa Anderson , Viliam Pavliak , Kathrin Ute Jansen , Ingrid Lea Scully , Tracy Dee Scott , Jasdeep Singh Nanra , A. Krishna Prasad , Bruce Arthur Green
发明人： Stephen John Freese , Annaliesa Anderson , Viliam Pavliak , Kathrin Ute Jansen , Ingrid Lea Scully , Tracy Dee Scott , Jasdeep Singh Nanra , A. Krishna Prasad , Bruce Arthur Green
IPC分类号： A61K39/085 , A61P37/04 , A61P31/04 , C07K14/31
CPC分类号： A61K39/085 , A61K47/6415 , A61K47/646 , A61K2039/55505 , A61K2039/6037 , A61K2039/627 , A61K2039/64 , C08B37/00
摘要： The present invention relates to immunogenic conjugates comprising S. aureus serotype 5 and 8 capsular polysaccharides conjugated to carrier proteins and methods for their preparation and use. Methods for making the immunogenic conjugates of the invention involve covalent conjugation of the capsular polysaccharides with the carrier proteins using conjugation chemistry involving either 1,1-carboyl-di-1,2,4-triazole (CDT) or 3-(2-pyridyldithio)-propionyl hydrazide (PDPH).
摘要翻译： 本发明涉及包含金黄色葡萄球菌血清型5和8个与载体蛋白缀合的荚膜多糖的免疫原性缀合物及其制备和使用方法。 制备本发明的免疫原性缀合物的方法包括使用涉及1,1-碳基 - 二-1,2,4-三唑（CDT）或3-（2-吡啶基二硫代磷酸酯）的共轭化学，使荚膜多糖与载体蛋白共价共轭 ） - 丙酰肼（PDPH）。
-
2.发明授权Compositions and methods for preparing Staphylococcus aureus serotype 5 and 8 capsular polysaccharide conjugate immunogenic compositions 有权用于制备金黄色葡萄球菌血清型5和8的荚膜多糖缀合物免疫原性组合物的组合物和方法公开(公告)号：US09125951B2
公开(公告)日：2015-09-08
申请号：US13379291
申请日：2010-06-22
申请人： Stephen John Freese , Annaliesa Anderson , Viliam Pavliak , Kathrin Ute Jansen , Ingrid Lea Scully , Tracy Dee Scott , Jasdeep Singh Nanra , A. Krishna Prasad , Bruce Arthur Green
发明人： Stephen John Freese , Annaliesa Anderson , Viliam Pavliak , Kathrin Ute Jansen , Ingrid Lea Scully , Tracy Dee Scott , Jasdeep Singh Nanra , A. Krishna Prasad , Bruce Arthur Green
IPC分类号： A61K39/00 , A61K39/085 , A61K39/385 , A61K47/48
CPC分类号： A61K39/085 , A61K47/6415 , A61K47/646 , A61K2039/55505 , A61K2039/6037 , A61K2039/627 , A61K2039/64 , C08B37/00
摘要： The present invention relates to immunogenic conjugates comprising S. aureus serotype 5 and 8 capsular polysaccharides conjugated to carrier proteins and methods for their preparation and use. Methods for making the immunogenic conjugates of the invention involve covalent conjugation of the capsular polysaccharides with the carrier proteins using conjugation chemistry involving either 1,1-carboyl-di-1,2,4-triazole (CDT) or 3-(2-pyridyldithio)-propionyl hydrazide (PDPH).
摘要翻译： 本发明涉及包含金黄色葡萄球菌血清型5和8个与载体蛋白缀合的荚膜多糖的免疫原性缀合物及其制备和使用方法。 制备本发明的免疫原性缀合物的方法包括使用涉及1,1-碳基 - 二-1,2,4-三唑（CDT）或3-（2-吡啶基二硫代磷酸酯）的共轭化学，使荚膜多糖与载体蛋白共价共轭 ） - 丙酰肼（PDPH）。
-
公开(公告)号：US08568735B2
公开(公告)日：2013-10-29
申请号：US13379216
申请日：2010-06-22
申请人： Annaliesa Anderson , Viliam Pavliak , Kathrin Ute Jansen , Ingrid Lea Scully , Steven Morris Baker , Jasdeep Singh Nanra , Ellen Murphy , Bruce Arthur Green , Mark Edward Ruppen , Yekaterina Timofeyeva
发明人： Annaliesa Anderson , Viliam Pavliak , Kathrin Ute Jansen , Ingrid Lea Scully , Steven Morris Baker , Jasdeep Singh Nanra , Ellen Murphy , Bruce Arthur Green , Mark Edward Ruppen , Yekaterina Timofeyeva
IPC分类号： A61K39/085 , A61K39/40
CPC分类号： A61K39/085 , A61K2039/505 , A61K2039/55505 , A61K2039/6031 , A61K2039/6037 , C07K16/1271 , C07K2317/21 , C07K2317/73
摘要： The present invention relates to immunogenic compositions, comprising polypeptides and polysaccharides from Staphylococcus aureus. The present invention also relates to immunogenic compositions, comprising Staphylococcus aureus capsule polysaccharides conjugated to a carrier protein. In addition, the invention relates to methods of inducing an immune response in subjects against Staphylococcus aureus using immunogenic compositions of the Staphylococcus aureus polypeptides and capsule polysaccharides.
-
公开(公告)号：US20120107327A1
公开(公告)日：2012-05-03
申请号：US13379216
申请日：2010-06-22
申请人： Annaliesa Anderson , Viliam Pavliak , Kathrin Ute Jansen , Ingrid Lea Scully , Steven Morris Baker , Jasdeep Singh Nanra , Ellen Murphy , Bruce Arthur Green , Mark Edward Ruppen , Yekaterina Timofeyeva
发明人： Annaliesa Anderson , Viliam Pavliak , Kathrin Ute Jansen , Ingrid Lea Scully , Steven Morris Baker , Jasdeep Singh Nanra , Ellen Murphy , Bruce Arthur Green , Mark Edward Ruppen , Yekaterina Timofeyeva
IPC分类号： A61K39/085 , A61P31/04 , A61P37/04 , A61K39/385 , A61K39/40
CPC分类号： A61K39/085 , A61K2039/505 , A61K2039/55505 , A61K2039/6031 , A61K2039/6037 , C07K16/1271 , C07K2317/21 , C07K2317/73
摘要： The present invention relates to immunogenic compositions, comprising polypeptides and polysaccharides from Staphylococcus aureus. The present invention also relates to immunogenic compositions, comprising Staphylococcus aureus capsule polysaccharides conjugated to a carrier protein. In addition, the invention relates to methods of inducing an immune response in subjects against Staphylococcus aureus using immunogenic compositions of the Staphylococcus aureus polypeptides and capsule polysaccharides.
摘要翻译： 本发明涉及包含来自金黄色葡萄球菌的多肽和多糖的免疫原性组合物。 本发明还涉及包含与载体蛋白缀合的金黄色葡萄球菌胶囊多糖的免疫原性组合物。 此外，本发明涉及使用金黄色葡萄球菌多肽和胶囊多糖的免疫原性组合诱导针对金黄色葡萄球菌的受试者的免疫应答的方法。
-
公开(公告)号：US07531633B2
公开(公告)日：2009-05-12
申请号：US11014997
申请日：2004-12-20
申请人： Viliam Pavliak , Ali Ibrahim Fattom
发明人： Viliam Pavliak , Ali Ibrahim Fattom
IPC分类号： A61K39/395 , A61K39/00 , A61K39/40 , A61K38/00 , A61K35/14 , A01N37/18 , C12P21/08 , C07K16/00
CPC分类号： C07K16/1271 , A61K39/085 , A61K2039/6037 , A61K2039/6068 , C07K14/31 , Y10S435/975 , Y10S530/866
摘要： A negatively-charged Staphylococcus antigen contains amino acids and a N-acetylated hexosamine as a major carbohydrate component. The antigen is common to many coagulase-negative strains of Staphylococcus, including S. epidermidis, S. haemolyticus, and S. hominis. Staphylococcus strains that carry the antigen include many clinically significant strains of Staphylococcus. The antigen and antibodies to the antigen are useful in kits and assays for diagnosing Staphylococcus infection. Vaccines of the antigen and of whole cells that carry the antigen also are disclosed.
摘要翻译： 带负电荷的葡萄球菌抗原含有氨基酸和N-乙酰化的己糖胺作为主要的碳水化合物成分。 抗原是许多葡萄球菌的凝固酶阴性菌株常见的，包括表皮葡萄球菌，溶血性链球菌和人血清。 携带抗原的葡萄球菌菌株包括许多临床上显着的葡萄球菌菌株。 抗原和抗原抗体可用于诊断葡萄球菌感染的试剂盒和测定。 还公开了携带抗原的抗原和全细胞的疫苗。
-
6.发明申请Polysaccharide-staphylococcal surface adhesin carrier protein conjugates for immunization against nosocomial infections 有权多糖 - 葡萄球菌表面粘附素载体蛋白结合物免疫接种医院感染公开(公告)号：US20070087014A1
公开(公告)日：2007-04-19
申请号：US10548507
申请日：2004-03-04
IPC分类号： A61K39/116 , A61K39/085 , C07K14/31
CPC分类号： C07K14/31 , A61K39/085 , A61K39/092 , A61K47/61 , A61K47/646 , A61K2039/6068
摘要： Immunogenic polysaccharide-protein conjugates having a polysaccharide antigen (or its oligosaccharide fragment representing one or more antigenic epitopes) derived from a nosocomial pathogen conjugated to a staphylococcal surface adhesin carrier protein are used in immunogenic compositions to elicit antibody responses to both the polysaccharide antigen and the staphylococcal surface adhesion carrier protein. Such immunogenic compositions are used to immunize against diseases caused by Staphylococcal aureus, Staphylococcal epidermidis or other nosocomial pathogens.
摘要翻译： 具有衍生自与葡萄球菌表面粘附素载体蛋白缀合的医院病原体的多糖抗原（或其代表一个或多个抗原表位的寡糖片段）的免疫原性多糖 - 蛋白质缀合物用于免疫原性组合物中以引发对多糖抗原和 葡萄球菌表面粘附载体蛋白。 这样的免疫原性组合物用于免疫金黄色葡萄球菌，表皮葡萄球菌或其他医院病原体引起的疾病。
-
7.发明申请Neisseria meningitdis inner core lipo-oligosaccharide epitopes, multivalent conjugates thereof and immunogenic compositions thereof 有权脑膜炎奈瑟氏球菌内核脂寡糖表位，其多价轭合物和其免疫原性组合物公开(公告)号：US20060047106A1
公开(公告)日：2006-03-02
申请号：US11212307
申请日：2005-08-26
CPC分类号： C07K1/1077 , C07K14/195 , C07K14/22
摘要： The present invention is directed to novel Neisseria meningitidis lipo-oligosaccharide inner core molecules, conjugates thereof and immunogenic compositions thereof. In particular embodiments, the invention relates to multivalent immunogenic compositions comprising five distinct Neisseria meningitidis inner core lipo-oligosaccharide epitope groups, wherein the multivalent compositions induce cross-reactive immune responses against Neisseria meningitidis lipo-oligosaccharide immunotypes.
摘要翻译： 本发明涉及新型脑膜炎奈瑟氏球菌脂多糖内核分子，其结合物及其免疫原性组成。 在具体实施方案中，本发明涉及包含五种不同的脑膜炎奈瑟氏球菌内核脂寡糖表位基团的多价免疫原性组合物，其中所述多价组合物诱导针对脑膜炎奈瑟氏球菌低聚糖免疫型的交叉反应性免疫应答。
-
公开(公告)号：US06936258B1
公开(公告)日：2005-08-30
申请号：US09272359
申请日：1999-03-19
申请人： Viliam Pavliak , Ali Ibrahim Fattom
发明人： Viliam Pavliak , Ali Ibrahim Fattom
IPC分类号： G01N33/569 , A61K39/00 , A61K39/085 , A61K39/385 , A61K39/395 , A61K47/48 , A61L29/00 , A61P9/00 , A61P19/08 , A61P31/04 , C07K14/31 , C07K16/12 , C12P21/08 , G01N33/577 , A61K39/02 , A61K38/00 , C07K14/00
CPC分类号： C07K16/1271 , A61K39/085 , A61K2039/6037 , A61K2039/6068 , C07K14/31 , Y10S435/975 , Y10S530/866
摘要： A negatively-charged Staphylococcus antigen contains amino acids and a N-acetylated hexosamine as a major carbohydrate component. The antigen is common to many coagulase-negative strains of Staphylococcus, including S. epidermidis, S. haemolyticus, and S. hominis. Staphylococcus strains that carry the antigen include many clinically significant strains of Staphylococcus. The antigen and antibodies to the antigen are useful in kits and assays for diagnosing Staphylococcus infection. Vaccines of the antigen and of whole cells that carry the antigen also are disclosed.
摘要翻译： 带负电荷的葡萄球菌抗原含有氨基酸和N-乙酰化的己糖胺作为主要的碳水化合物成分。 抗原是许多葡萄球菌的凝固酶阴性菌株常见的，包括表皮葡萄球菌，溶血性链球菌和人血清。 携带抗原的葡萄球菌菌株包括许多临床上显着的葡萄球菌菌株。 抗原和抗原抗体可用于诊断葡萄球菌感染的试剂盒和测定。 还公开了携带抗原的抗原和全细胞的疫苗。
-
9.发明授权Polysaccharide-staphylococcal surface adhesin carrier protein conjugates for immunization against nosocomial infections 有权多糖 - 葡萄球菌表面粘附素载体蛋白结合物免疫接种医院感染公开(公告)号：US09296795B2
公开(公告)日：2016-03-29
申请号：US10548507
申请日：2004-03-04
IPC分类号： C07K14/31 , A61K39/085 , A61K39/09 , A61K47/48 , A61K39/00
CPC分类号： C07K14/31 , A61K39/085 , A61K39/092 , A61K47/61 , A61K47/646 , A61K2039/6068
摘要： Immunogenic polysaccharide-protein conjugates having a polysaccharide antigen (or its oligosaccharide fragment representing one or more antigenic epitopes) derived from a nosocomial pathogen conjugated to a staphylococcal surface adhesin carrier protein are used in immunogenic compositions to elicit antibody responses to both the polysaccharide antigen and the staphylococcal surface adhesion carrier protein. Such immunogenic compositions are used to immunize against diseases caused by Staphylococcal aureus, Staphylococcal epidermidis or other nosocomial pathogens.
摘要翻译： 具有衍生自与葡萄球菌表面粘附素载体蛋白缀合的医院病原体的多糖抗原（或其代表一个或多个抗原表位的寡糖片段）的免疫原性多糖 - 蛋白质缀合物用于免疫原性组合物以引发对多糖抗原和 葡萄球菌表面粘附载体蛋白。 这样的免疫原性组合物用于免疫金黄色葡萄球菌，表皮葡萄球菌或其他医院病原体引起的疾病。
-
10.发明授权Polysaccharide-staphylococcal surface adhesin carrier protein conjugates for immunization against nosocomial infections 有权多糖 - 葡萄球菌表面粘附素载体蛋白结合物免疫接种医院感染公开(公告)号：US08377451B2
公开(公告)日：2013-02-19
申请号：US11593481
申请日：2006-11-07
申请人： Viliam Pavliak , Steven Morris Baker , Subramonia Padmanaba Pillai , Joseph M. Patti , Bradley D. Prater
发明人： Viliam Pavliak , Steven Morris Baker , Subramonia Padmanaba Pillai , Joseph M. Patti , Bradley D. Prater
IPC分类号： A61K39/02
CPC分类号： C07K14/31 , A61K39/085 , A61K39/092 , A61K47/61 , A61K47/646 , A61K2039/6068
摘要： Immunogenic polysaccharide-protein conjugates having a polysaccharide antigen (or its oligosaccharide fragment representing one or more antigenic epitopes) derived from a nosocomial pathogen conjugated to a staphylococcal surface adhesin carrier protein are used in immunogenic compositions to elicit antibody responses to both the polysaccharide antigen and the staphylococcal surface adhesin carrier protein. Such immunogenic compositions are used to immunize against diseases caused by Staphylococcal aureus, Staphylococcal epidermidis or other nosocomial pathogens.
摘要翻译： 具有衍生自与葡萄球菌表面粘附素载体蛋白缀合的医院病原体的多糖抗原（或其代表一个或多个抗原表位的寡糖片段）的免疫原性多糖 - 蛋白质缀合物用于免疫原性组合物以引发对多糖抗原和 葡萄球菌表面粘附素载体蛋白。 这样的免疫原性组合物用于免疫金黄色葡萄球菌，表皮葡萄球菌或其他医院病原体引起的疾病。
-
-
-
-
-
-
-
-
-
搜索结果
15 条记录 (耗时 0.049 秒)
