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    USE OF PLASMA IN FORMATION OF BIODEGRADABLE STENT COATING
    1.
    发明申请
    USE OF PLASMA IN FORMATION OF BIODEGRADABLE STENT COATING 审中-公开
    等离子体在生物降解性硬质合金涂层中的应用

    公开(公告)号：US20070281117A1

    公开(公告)日：2007-12-06

    申请号：US11757093

    申请日：2007-06-01

    申请人： Stephen Kaplan ,  Patrick Ruane ,  Eric Lang ,  Torsten Kimura

    发明人： Stephen Kaplan ,  Patrick Ruane ,  Eric Lang ,  Torsten Kimura

    IPC分类号： A61L33/00 ,  B32B1/08 ,  B32B27/08 ,  A61F2/06

    CPC分类号： A61F2/91 ,  A61F2/915 ,  A61F2002/826 ,  A61F2002/9155 ,  A61F2002/91558 ,  A61F2210/0004 ,  A61F2230/0013 ,  A61F2250/0067 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/606 ,  B05B13/0228 ,  B05B13/0442 ,  Y10T428/1352

    摘要： Metallic stents are treated with a gaseous species in a plasma state under conditions causing the species to polymerize and to be deposited in polymerized form on the metallic stent surface prior to the application of a drug-polymer mixture, which is done by conventional non-plasma deposition methods. The drug-polymer mixture once applied forms a coating on the stent surface that releases the drug in a time-release manner and gradually erodes, leaving only the underlying plasma-deposited polymer. In certain cases, the plasma-deposited polymer itself erodes or dissolves into the physiological medium over an extended period of time, leaving only the metallic stent. While the various polymers and drug remain on the stent, the plasma-deposited polymer enhances the adhesion of the drug-polymer anchor coating and maintains the coating intact upon exposure to the mechanical stresses encountered during stent deployment.

    摘要翻译： 在施加药物 - 聚合物混合物之前，在等离子体状态下，使物质聚合并以聚合形式沉积在金属支架表面上的条件下，处于等离子体状态的金属支架，其通过常规非等离子体 沉积方法。 一次施用的药物 - 聚合物混合物在支架表面上形成涂层，其以时间释放方式释放药物并逐渐侵蚀，仅留下下面的等离子体沉积聚合物。 在某些情况下，等离子体沉积的聚合物本身在延长的时间内侵蚀或溶解到生理介质中，仅留下金属支架。 虽然各种聚合物和药物保留在支架上，等离子体沉积的聚合物增强了药物 - 聚合物锚固涂层的粘附，并且在暴露于支架展开期间遇到的机械应力的同时保持涂层完整。

    Eluting, implantable medical device
    2.
    发明申请
    Eluting, implantable medical device 审中-公开
    洗脱，植入式医疗器械

    公开(公告)号：US20070073385A1

    公开(公告)日：2007-03-29

    申请号：US11523797

    申请日：2006-09-18

    申请人： Darin Schaeffer ,  David Grewe ,  Patrick Ruane

    发明人： Darin Schaeffer ,  David Grewe ,  Patrick Ruane

    IPC分类号： A61F2/90

    CPC分类号： A61L31/082 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/30322 ,  A61F2002/91508 ,  A61F2002/91516 ,  A61F2002/91525 ,  A61F2002/91533 ,  A61F2002/91575 ,  A61F2230/0054 ,  A61F2250/0023 ,  A61F2250/0026 ,  A61F2250/0068 ,  A61L31/146 ,  A61L31/16 ,  A61L2300/416

    摘要： An intraluminal device is provided with a porous structure. The porous structure may be loaded with a bioactive substance to treat surrounding tissues after the intraluminal device has been implanted. The porous structure may be made by depositing a metal film on a foam structure using chemical vapor deposition. Porous structures may also be made by sintering or applying a ceramic layer to the intraluminal device. An intraluminal device is also provided with a ceramic material applied to generally straight portions of the device structure but not to portions adapted to bend. One advantage is that the ceramic material is less likely to fracture since it is applied to regions that experience less strain.

    摘要翻译： 管腔内装置具有多孔结构。 在植入腔内装置之后，多孔结构可装载生物活性物质以治疗周围组织。 多孔结构可以通过使用化学气相沉积在金属泡沫结构上沉积金属膜来制造。 也可以通过烧结或将陶瓷层施加到腔内装置来制造多孔结构。 管腔内装置还设置有施加到装置结构的大致直线部分的陶瓷材料，但是不适于弯曲的部分。 一个优点是陶瓷材料不太可能破裂，因为它被应用于经历较小应变的区域。

    Medical Devices Incorporating a Bioactive and Methods of Preparing Such Devices
    3.
    发明申请
    Medical Devices Incorporating a Bioactive and Methods of Preparing Such Devices 审中-公开
    纳入生物活性的医疗器械及其制备方法

    公开(公告)号：US20080108824A1

    公开(公告)日：2008-05-08

    申请号：US11862925

    申请日：2007-09-27

    申请人： Andrew Isch ,  Patrick Ruane ,  Waleska Perez-Segarra

    发明人： Andrew Isch ,  Patrick Ruane ,  Waleska Perez-Segarra

    IPC分类号： C07D211/08 ,  A61F2/02

    CPC分类号： A61L31/16 ,  A61L2300/402

    摘要： One embodiment provides a medical device comprising a base material and a bioactive in contact with the base material, the bioactive having a proton binding site with a non-ionic form and an ionic form, the bioactive being less soluble in water when the proton binding site is in the non-ionic form than when the proton binding site is in the ionic form, wherein at least 5% w/w of the bioactive is present with the proton binding site in the non-ionic form and wherein the bioactive is not an anesthetic. Another embodiment provides such a medical device where the bioactive is an anesthetic and where the device is not a ureteral stent. Another aspect provides method of manufacturing such devices.

    摘要翻译： 一个实施方案提供了包含基础材料和与基底材料接触的生物活性的医疗装置，所述生物活性物质具有非离子形式和离子形式的质子结合位点，当质子结合位点 与质子结合位点处于离子形式相比是非离子形式，其中至少5％w / w的生物活性存在于非离子形式的质子结合位点，并且其中生物活性物质不是 麻药。 另一个实施方案提供了这样的医疗装置，其中生物活性是麻醉剂，并且其中装置不是输尿管支架。 另一方面提供了制造这种装置的方法。

    Taxane coatings for implantable medical devices
    5.
    发明申请
    Taxane coatings for implantable medical devices 有权
    可植入医疗器械的紫杉烷涂层

    公开(公告)号：US20070212394A1

    公开(公告)日：2007-09-13

    申请号：US11715975

    申请日：2007-03-08

    申请人： Priscilla Reyes ,  William Moore ,  Patrick Ruane ,  Darin Schaeffer

    发明人： Priscilla Reyes ,  William Moore ,  Patrick Ruane ,  Darin Schaeffer

    IPC分类号： A61K31/337 ,  A61F2/02

    CPC分类号： A61L27/54 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/91533 ,  A61F2002/91575 ,  A61F2230/0054 ,  A61F2250/0067 ,  A61F2310/0097 ,  A61K31/337 ,  A61L29/16 ,  A61L31/08 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/606

    摘要： This disclosure relates to implantable medical devices coated with a taxane therapeutic agent, such as paclitaxel, in one or more solid form(s) having varying dissolution rates. Particularly preferred coatings comprise amorphous and/or solvated solid forms of taxane therapeutic agents that provide durable coatings that release the taxane over a desired period of time, which can be varied in the absence of a polymer by selecting the type and amount of solid forms of the taxane therapeutic agent in the coating. Other preferred embodiments relate to methods of coating medical devices and methods of treatment. The coatings can provide a sustained release of the taxane therapeutic agent within a body vessel without containing a polymer to achieve the desired rate of paclitaxel elution.

    摘要翻译： 本公开涉及涂覆有紫杉烷治疗剂（例如紫杉醇）的可植入医疗装置，其具有不同溶解速率的一种或多种固体形式。 特别优选的涂层包括紫杉烷治疗剂的无定形和/或溶剂化固体形式，其提供耐久性涂层，其在期望的时间段内释放紫杉烷，其可以在不存在聚合物的情况下变化，通过选择固体形式的类型和量 紫杉烷治疗剂在涂层中。 其它优选实施方案涉及涂覆医疗装置的方法和治疗方法。 涂层可以在体内容器内提供紫杉烷治疗剂的持续释放而不含聚合物以达到期望的紫杉醇洗脱速率。

    Methods of manufacturing and modifying taxane coatings for implantable medical devices
    9.
    发明申请
    Methods of manufacturing and modifying taxane coatings for implantable medical devices 有权
    制造和修饰可植入医疗器械的紫杉烷涂层的方法

    公开(公告)号：US20080020013A1

    公开(公告)日：2008-01-24

    申请号：US11823283

    申请日：2007-06-27

    申请人： Priscilla Reyes ,  William Moore ,  Randy Myers ,  Patrick Ruane

    发明人： Priscilla Reyes ,  William Moore ,  Randy Myers ,  Patrick Ruane

    IPC分类号： A61F2/00 ,  A61K31/335

    CPC分类号： A61K31/335 ,  A61F2/0095 ,  A61F2/91 ,  A61F2250/0067 ,  A61F2250/0091

    摘要： This disclosure relates to endolumenal medical devices coated with a taxane therapeutic agent in one or more solid form(s) having varying dissolution rates. Particularly preferred coatings comprise amorphous paclitaxel, dihydrate paclitaxel, or combinations thereof that provide durable coatings that release paclitaxel over a desired period of time, which can be on the order of hours, days or weeks. Preferred embodiments relate to medical device coatings of paclitaxel, or paclitaxel analogs or derivatives, having one or more polymorph solid forms that provide a prolonged release of paclitaxel within a body vessel without requiring a polymer carrier or barrier layer to achieve the desired rate of paclitaxel elution.

    摘要翻译： 本公开涉及用一种或多种具有不同溶解速率的固体形式涂覆紫杉烷治疗剂的腔内医疗器械。 特别优选的涂层包括无定形紫杉醇，二水合紫杉醇或其组合，其提供耐久性涂层，其在期望的时间段内释放紫杉醇，其可以是数小时，数天或数周的数量级。 优选实施方案涉及具有一种或多种多晶型固体形式的紫杉醇或紫杉醇类似物或衍生物的医疗器械涂层，其提供紫杉醇在体内容器内的延长释放，而不需要聚合物载体或阻挡层来实现所需的紫杉醇洗脱速率 。

    Device with nanocomposite coating for controlled drug release
    10.
    发明申请
    Device with nanocomposite coating for controlled drug release 审中-公开
    具有用于受控药物释放的纳米复合涂层的装置

    公开(公告)号：US20070299518A1

    公开(公告)日：2007-12-27

    申请号：US11698407

    申请日：2007-01-26

    申请人： Patrick Ruane

    发明人： Patrick Ruane

    IPC分类号： A61F2/02

    CPC分类号： A61L27/34 ,  A61L27/50 ,  A61L27/54 ,  A61L2300/602 ,  A61L2400/12 ,  A61L2420/04

    摘要： An implantable medical device including a nanocomposite coating deposited on at least a portion of a surface of at least one structural element of the device to provide a controlled release of a bioactive agent in one or more dosages is described. The nanocomposite coating includes a matrix, a bioactive agent and inorganic particles. The inorganic particles respond to a stimulus, preferably by generating heat. The response of the particles to the stimulus causes the matrix of the nanocomposite coating to undergo a volume change by, for example, contracting or swelling, thereby releasing at least a portion of the bioactive agent. A method of providing a controlled release of a bioactive agent from a nanocomposite coating on an implantable medical device is described. A method for providing a nanocomposite coating for the controlled release of a bioactive agent on the implantable medical device is also described.

    摘要翻译： 描述了一种可植入医疗装置，其包括沉积在装置的至少一个结构元件的表面的至少一部分上以提供一种或多种剂量的生物活性剂的受控释放的纳米复合涂层。 纳米复合涂层包括基质，生物活性剂和无机颗粒。 无机颗粒对刺激作出反应，优选通过产生热量。 颗粒对刺激的反应导致纳米复合涂层的基质通过例如收缩或膨胀而经历体积变化，从而释放至少一部分生物活性剂。 描述了从可植入医疗装置上的纳米复合涂层提供生物活性剂的受控释放的方法。 还描述了提供用于在可植入医疗装置上控制释放生物活性剂的纳米复合涂层的方法。