公开(公告)号：US20070134813A1

公开(公告)日：2007-06-14

申请号：US11302994

申请日：2005-12-14

申请人： RameshBabu Boga ,  Sohail Malik ,  Stephen Quirk

发明人： RameshBabu Boga ,  Sohail Malik ,  Stephen Quirk

IPC分类号： G01N33/543

CPC分类号： G01N33/558 ,  G01N33/68 ,  G01N2333/4737 ,  G01N2333/78 ,  G01N2500/02 ,  Y10S436/815

摘要： Disclosed are screening processes for identification of compounds that may inhibit complex formation between C-reactive protein and fibronectin. Compounds identified by the disclosed methods may be utilized to inhibit the target analytes that are known to occur during skin aging as well as during the course of several diseases. Accordingly, inhibitory compounds identified by the disclosed methods may be utilized to prevent and treat damaged tissue, inflammatory conditions, cardiovascular conditions, renal conditions, periodontal conditions and obesity, among other conditions. For example, the compounds identified by the disclosed methods may be utilized to treat tissue that has suffered trauma, e.g., burns or wounds, as well as tissue that is inflamed due to any of several causes. The disclosed compounds may also be utilized to improve the accuracy of assays designed to assess CRP or Fn levels in a sample, for instance in a plasma sample, as a risk assessment tool in certain medical conditions and to discover new treatments.

摘要翻译： 公开了用于鉴定可能抑制C-反应蛋白和纤连蛋白之间的复合物形成的化合物的筛选方法。 通过公开的方法鉴定的化合物可以用于抑制已知在皮肤老化期间以及在几种疾病过程中发生的目标分析物。 因此，通过所公开的方法鉴定的抑制性化合物可用于预防和治疗损伤的组织，炎性病症，心血管病症，肾脏疾病，牙周病症和肥胖等疾病。 例如，通过所公开的方法鉴定的化合物可以用于治疗已经遭受创伤的组织，例如烧伤或伤口，以及由于几种原因中的任何一种而发炎的组织。 所公开的化合物还可以用于提高设计用于评估样品中的CRP或Fn水平的测定的准确度，例如在血浆样品中，作为某些医疗条件下的风险评估工具并发现新的治疗。

公开(公告)号：US07148194B2

公开(公告)日：2006-12-12

申请号：US10335207

申请日：2002-12-30

申请人： Sohail Malik ,  Stephen Quirk

发明人： Sohail Malik ,  Stephen Quirk

IPC分类号： A61K38/00 ,  A61K38/10

CPC分类号： A61K38/4886 ,  A61K8/64 ,  A61Q11/00

摘要： The invention provides peptides, and compositions containing those peptides, that increase the amount of fibronectin in tissue. These compositions are useful for encouraging the maintenance and development of healthy skin, for preventing and treating wrinkles, and for treating wounds. The peptides can be formulated into therapeutic compositions, lotions, creams, skin coverings and wound dressings that facilitate healing and healthy skin development, discourage scarring and wrinkling, and ameliorate the effects of healing.

摘要翻译： 本发明提供肽和含有这些肽的组合物，其增加组织中纤连蛋白的量。 这些组合物可用于促进健康皮肤的维护和发展，用于预防和治疗皱纹以及用于治疗伤口。 肽可以配制成治疗组合物，洗剂，霜剂，皮肤覆盖物和伤口敷料，其促进愈合和健康的皮肤发育，阻止瘢痕形成和起皱，并改善愈合的效果。

公开(公告)号：US20050131287A1

公开(公告)日：2005-06-16

申请号：US10736662

申请日：2003-12-16

申请人： Rosann Kaylor ,  RameshBabu Boga ,  Kaiyuan Yang ,  Shawn Feaster ,  Curtis Sayre ,  David Cohen ,  Ning Wei ,  Chibueze Chidebelu-Eze ,  Stephen Quirk

发明人： Rosann Kaylor ,  RameshBabu Boga ,  Kaiyuan Yang ,  Shawn Feaster ,  Curtis Sayre ,  David Cohen ,  Ning Wei ,  Chibueze Chidebelu-Eze ,  Stephen Quirk

IPC分类号： A61B5/00 ,  A61F13/15 ,  B65D81/00

CPC分类号： A61F13/84 ,  A61B5/00 ,  A61F2013/8473 ,  A61F2013/8491

摘要： The premature rupture of amniotic fluid (PROM) may be discovered through a number of inventive means. Methods of evaluating whether PROM is present include; a) through the testing of the pH of vaginal fluids using an irreversible pH test; b) through the detection of analytes (e.g. enzymes) specific to amniotic fluid in the vaginal fluids; c) though the detection of hydrogen peroxide (H2O2) in the vaginal fluid; and d) through the detection of cholesterol in vaginal fluid. While individually indicative of PROM, it is desirable to combine at least two of these techniques to yield a powerful tool of even greater reliability. Test devices and feminine hygiene pads into which the test methods may be incorporated are also included herein.

摘要翻译： 通过许多创造性手段可以发现羊水过早破裂（PROM）。 评估PROM是否存在的方法包括： a）通过使用不可逆的pH测试来测试阴道液的pH值; b）通过检测阴道液中特异于羊水的分析物（例如酶）; c）尽管在阴道液中检测过氧化氢（H 2 O 2 O 2）; 和d）通过检测阴道液中的胆固醇。 虽然单独指示PROM，但是期望将这些技术中的至少两种组合以产生更大可靠性的强大工具。 本文还包括其中可以并入测试方法的测试装置和女性卫生衬垫。

公开(公告)号：US20090089116A1

公开(公告)日：2009-04-02

申请号：US11865618

申请日：2007-10-01

申请人： Stephen Quirk ,  Colin Meldrum ,  Claude P. Carlier

发明人： Stephen Quirk ,  Colin Meldrum ,  Claude P. Carlier

IPC分类号： G06Q30/00 ,  G06Q10/00

CPC分类号： G06Q30/02 ,  G06Q30/0233 ,  G06Q30/0236

摘要： Improved approaches to generate, distribute, redeem or return codes are disclosed. The codes can be used (i.e., redeemed) to purchase products from an online store. The codes can be electronically requested and received. In one embodiment, the codes can be acquired from a server via a network. The codes can be content specific codes that are redeemable for particular content, such as specific digital media assets. The codes can be returnable, and royalty obligations that may be due can be adjusted for returns.

摘要翻译： 公开了改进的生成，分发，兑换或返回代码的方法。 可以使用代码（即兑换）从在线商店购买产品。 代码可以电子请求和接收。 在一个实施例中，可以经由网络从服务器获取代码。 代码可以是针对特定内容（例如特定数字媒体资产）可兑换的内容特定代码。 代码可以退回，可以根据退货进行调整。

公开(公告)号：US20080248517A1

公开(公告)日：2008-10-09

申请号：US12136154

申请日：2008-06-10

申请人： Stephen Quirk ,  Robert John Lyng ,  Rosann Marie Kaylor

发明人： Stephen Quirk ,  Robert John Lyng ,  Rosann Marie Kaylor

IPC分类号： C12Q1/24 ,  G01N1/00

CPC分类号： G01N21/4788 ,  Y10T436/2575

摘要： Diagnostic devices for detecting the presence of an analyte in a sample are provided. Devices of the present invention comprise a means for inducing a pressure differential on a sample to direct the sample to a test surface. In one embodiment, the means for inducing a pressure differential on a sample to direct the sample to a test surface comprises a syringe that can be used to draw a sample from an opening to a test surface. In other embodiments, the device also provides means for diluting a sample. In yet other embodiments, the device also provides a means

摘要翻译： 提供了用于检测样品中分析物的存在的诊断装置。 本发明的装置包括用于诱导样品上的压力差以将样品引导到测试表面的装置。 在一个实施例中，用于诱导样品上的压力差以将样品引导到测试表面的装置包括可用于将样品从开口抽出到测试表面的注射器。 在其他实施方案中，该装置还提供用于稀释样品的装置。 在其他实施例中，该装置还提供了一种装置

公开(公告)号：US07384598B2

公开(公告)日：2008-06-10

申请号：US10026610

申请日：2001-12-21

申请人： Stephen Quirk ,  Robert John Lyng ,  Rosann Marie Kaylor

发明人： Stephen Quirk ,  Robert John Lyng ,  Rosann Marie Kaylor

IPC分类号： G01N21/00 ,  G01N21/03 ,  G01N33/558

CPC分类号： G01N21/4788 ,  Y10T436/2575

摘要： Diagnostic devices for detecting the presence of an analyte in a sample are provided. Devices of the present invention comprise a means for inducing a pressure differential on a sample to direct the sample to a test surface. In one embodiment, the means for inducing a pressure differential on a sample to direct the sample to a test surface comprises a syringe that can be used to draw a sample from an opening to a test surface. In other embodiments, the device also provides means for diluting a sample. In yet other embodiments, the device also provides a means.

摘要翻译： 提供了用于检测样品中分析物的存在的诊断装置。 本发明的装置包括用于诱导样品上的压力差以将样品引导到测试表面的装置。 在一个实施例中，用于诱导样品上的压力差以将样品引导到测试表面的装置包括可用于将样品从开口抽出到测试表面的注射器。 在其他实施方案中，该装置还提供用于稀释样品的装置。 在其他实施例中，该装置还提供了一种装置。

公开(公告)号：US07060795B2

公开(公告)日：2006-06-13

申请号：US10325446

申请日：2002-12-19

申请人： Stephen Quirk

发明人： Stephen Quirk

IPC分类号： C07K14/00 ,  C12N15/09 ,  A61K38/00

CPC分类号： C07K14/8146 ,  A61K38/55

摘要： The invention provides polypeptides that can inhibit the activity of matrix metalloproteinases. Such polypeptides are useful for treating wounds, for example, chronic wounds.

摘要翻译： 本发明提供可抑制基质金属蛋白酶活性的多肽。 这样的多肽可用于治疗伤口，例如慢性伤口。

公开(公告)号：US07056535B2

公开(公告)日：2006-06-06

申请号：US10027441

申请日：2001-12-20

申请人： Stephen Quirk

发明人： Stephen Quirk

IPC分类号： A61K9/16

CPC分类号： A61K47/46 ,  A61K9/1641 ,  A61K9/1658 ,  C08G69/10

摘要： The invention provides proteinoid microsphere made up of a mixture of thermally condensed amino acids that are crosslinked with a bis dithiol crosslinker reagent. The proteinoid microspheres of the invention may be used to encapsulate a material or a compound and to provide slow, sustained or timed release of the material or compound. The proteinoid microspheres are stable in solution until exposed to a reducing agent. However, the in vivo environment provides a sufficient reduction potential to provide slow, sustained release of materials contained therein from the proteinoid microspheres of the present invention.

公开(公告)号：US06696254B2

公开(公告)日：2004-02-24

申请号：US09991552

申请日：2001-11-21

申请人： Stephen Quirk

发明人： Stephen Quirk

IPC分类号： C12Q168

CPC分类号： C12Q1/689 ,  C12Q1/04 ,  C12Q1/10 ,  C12Q1/26 ,  Y02A50/451

摘要： The invention provides probes, antibodies and methods for detecting a gene that is only found in Enterobacteriaceae, the deoxyguanosine triphosphate triphosphohydrolase gene. These probes and methods are useful for the detecting whether test samples, including food and water samples, are infected with enteric bacteria.

摘要翻译： 本发明提供了探针，抗体和检测仅在肠杆菌科，脱氧鸟苷三磷酸三磷酸酶基因中发现的基因的方法。 这些探针和方法可用于检测包括食物和水样品在内的测试样品是否被肠道细菌感染。

公开(公告)号：US07645583B2

公开(公告)日：2010-01-12

申请号：US11302994

申请日：2005-12-14

申请人： RameshBabu Boga ,  Sohail Malik ,  Stephen Quirk

发明人： RameshBabu Boga ,  Sohail Malik ,  Stephen Quirk

IPC分类号： G01N33/53 ,  G01N33/533 ,  G01N21/76

CPC分类号： G01N33/558 ,  G01N33/68 ,  G01N2333/4737 ,  G01N2333/78 ,  G01N2500/02 ,  Y10S436/815

摘要： Disclosed are screening processes for identification of compounds that may inhibit complex formation between C-reactive protein and fibronectin. Compounds identified by the disclosed methods may be utilized to inhibit the target analytes that are known to occur during skin aging as well as during the course of several diseases. Accordingly, inhibitory compounds identified by the disclosed methods may be utilized to prevent and treat damaged tissue, inflammatory conditions, cardiovascular conditions, renal conditions, periodontal conditions and obesity, among other conditions. For example, the compounds identified by the disclosed methods may be utilized to treat tissue that has suffered trauma, e.g., burns or wounds, as well as tissue that is inflamed due to any of several causes. The disclosed compounds may also be utilized to improve the accuracy of assays designed to assess CRP or Fn levels in a sample, for instance in a plasma sample, as a risk assessment tool in certain medical conditions and to discover new treatments.

摘要翻译： 公开了用于鉴定可能抑制C-反应蛋白和纤连蛋白之间的复合物形成的化合物的筛选方法。 通过公开的方法鉴定的化合物可以用于抑制已知在皮肤老化期间以及在几种疾病过程中发生的目标分析物。 因此，通过所公开的方法鉴定的抑制性化合物可以用于预防和治疗受损组织，炎性病症，心血管病，肾病，牙周病和肥胖等疾病。 例如，通过所公开的方法鉴定的化合物可以用于治疗已经遭受创伤的组织，例如烧伤或伤口，以及由于几种原因中的任何一种而发炎的组织。 所公开的化合物还可以用于提高设计用于评估样品中的CRP或Fn水平的测定的准确度，例如在血浆样品中，作为某些医疗条件下的风险评估工具并发现新的治疗。