摘要:
The present invention relates to a pharmaceutical oral fixed dose combination comprising a) a therapeutically effective amount of Aliskiren, or a pharmaceutically acceptable salt thereof, b) a therapeutically effective amount of Amlodipine, or a pharmaceutically acceptable salt thereof, wherein the pharmaceutical oral fixed dose combination shows an in vitro dissolution of component (a) of 60% or less after 10 minutes and 98% or less after 20 minutes, and a dissolution profile of component (b) of 50% or more after 20 minutes, and 70% or more after 30 minutes at pH 2, said pharmaceutical oral fixed dose combination being bioequivalent, or close to reaching bioequivalence, to a free dose combination of Aliskiren and Amlodipine.
摘要:
A foot member is disclosed for use in attaching a spring device to a rail for cushions, seats, or foundations for a bedding product. The foot member can straddle and snap into a frame rail, or be stapled or otherwise affixed to a frame rail.
摘要:
A pneumatic and load-supporting spring device for use in bedding, cushions and the like. The disclosed embodiments have tubular telescoping members that are biased apart by either an elastomer located in the overlapping region, or a helical spring located within the pneumatic cylinder formed by the tubes. A conical or dish-shaped head element with clips for securely engaging a typical wire grid found in many bedding products is also disclosed, as well as a dish-shaped head element using cooperating lobe and trough pairs to hold a grid wire therebetween to fix a spring device in place. A foot element is also disclosed for use in attaching a spring device on the base frame of a typical bedding product. The foot element can straddle and snap into a metal frame rail, or be stapled to a frame rail.
摘要:
An apparatus particularly suited for measuring the shape or contour of a surface under load, such as a mattress, is comprised of a humanoid having body limb extremities which are movable in a manner similar to the movement of comparable human extremities. Sensors are placed at joints, such as the knees and hips, to measure the amount of relative movement, i.e. deflection, that occurs at these joints when the humanoid is placed upon a mattress surface. The sensors provide an indication of the shape or contour of the mattress surface by correlation of the relative movement that occurs at these joints caused by the underlying mattress shape. In its preferred form, a movable frame is provided to raise and lower the humanoid in relation to the mattress surface to be tested. A "spine" is also advantageously provided with associated sensors to measure deflection, and thus surface contour, in the lower torso/abdominal region.
摘要:
A dumpster screen comprising a fenced enclosure around one (1) or more trash dumpsters commonly found by commercial establishments. The fence material is made of an outdoor weather-proof textile material supported on its vertical sides using fence posts and along its horizontal edges using cables. A front portion of the enclosure, typically accessed by trucks to empty the dumpsters, comprises a gate portion. This enables the incoming truck to lower its forks across the reinforced top of said gate and continue lowering it until it can remove the dumpster in the normal manner. After emptying, the dumpster is replaced in the same manner and the front barrier automatically returns to position.
摘要:
The invention relates to melt granulation processes for preparing immediate release and sustained release pharmaceutical formulations comprising valsartan.
摘要:
An elongate member of resilient material for use in the innerspring of a mattress, cushion or the like, is inserted between adjacent springs rows with its major cross-sectional axis extending perpendicular to the support surface. The cross-section of the resilient member is such that it increases from a minimum at or near the ends of a major axis to a maximum along a minor axis. The method of making the resilient member further contemplates matching the combination of cross-section and type of resilient material to the spring rate of the springs between which the member extends. When placed as a beam between springs defining the innerspring perimeter and interior springs adjacent thereto, this arrangement results in an assembly with a border of greater firmness, without a significantly harsh transition between compression of the border area and the innerspring interior area.
摘要:
A foundation spring module especially adapted for easy assembly in an interlocking spring and grid bedding foundation structure has a short generally vertical section which extends down from an interlockable wire grid-engaging horizontal top portion to position an upper end of each of two contiguous legs of the spring away from the area of intersection of the top portion and legs of the spring with the wire grid to greatly ease manipulation and assembly of the spring into the interlocked position in the wire grid of the foundation structure.