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公开(公告)号：US6083929A
公开(公告)日：2000-07-04
申请号：US174166
申请日：1993-12-29
IPC分类号： A61K31/715 , A61K39/00 , C07H15/00 , C07H17/00 , C08B37/00
CPC分类号： A61K31/715 , C08B37/006 , C07K2317/732 , C07K2317/734
摘要： A variety of compounds are provided which are usefdl as immunogens and as tumor markers. The present invention discloses methods relating to the detection of cancer. Extended forms of the lacto-series type 1 chain are shown to be present in various cancer tissues. The present invention also provides a cell line and the monoclonal antibody produced therefrom. Such an antibody has a number of uses, including in diagnostic or therapeutic methods.
摘要翻译： 提供了各种化合物，其用作免疫原和肿瘤标志物。 本发明公开了与癌症的检测有关的方法。 乳糖系列1型链的延伸形式显示存在于各种癌组织中。 本发明还提供了由其制备的细胞系和单克隆抗体。 这样的抗体具有许多用途，包括诊断或治疗方法。
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公开(公告)号：US5030723A
公开(公告)日：1991-07-09
申请号：US200160
申请日：1988-05-31
申请人： Edward D. Nudelman , Steven B. Levery , Mark R. Stroud , Mary Ellen K. Salvan , Sen-itiroh Hakomori
发明人： Edward D. Nudelman , Steven B. Levery , Mark R. Stroud , Mary Ellen K. Salvan , Sen-itiroh Hakomori
IPC分类号： G01N33/574 , A61K38/00 , A61K39/00 , A61P35/00 , C07H15/10 , C07K14/435 , C07K16/00 , C07K16/30 , C08B37/00 , C12P21/08 , C12R1/91 , G01N33/577 , G01N33/66 , G01N33/92
摘要： A substantially pure unbranched ceramide polysaccharide type 2 chain compound having the following structure: ##STR1## wherein Gal represents galactose, GlcNAc represents N-acetylglucosamine, Fuc represents fucose Glc represents glucose and Cer represents ceramide. A substantially pure unbranched ceramide polysaccharide type 2 chain compound having the following structure: ##STR2## wherein Gal represents galatose, GlcNAc represents N-acetylglucosamine. Fuc represents fucose, Glc represents glucose, Cer represents ceramide and NeuAc represents sialic acid. Antibodies that are specific to portions of the above-described compounds, wherein the portions comprise the internal .alpha.1-.fwdarw.3 fucosyl residue and/or the terminal sialic acid residue. Immuogens for producing antibodies to the above-described compounds or portions thereof. A method of actively immunizing against tumors that express the above-described compounds.
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公开(公告)号：US06294523B1
公开(公告)日：2001-09-25
申请号：US09272755
申请日：1999-03-22
IPC分类号： A61K31715
CPC分类号： A61K31/715 , C07K2317/732 , C07K2317/734 , C08B37/006
摘要： A variety of compounds are provided which are useful as immunogens and as tumor markers. The present invention discloses methods relating to the detection of cancer. Extended forms of the lacto-series type 1 chain are shown to be present in various cancer tissues. The present invention also provides a cell line and the monoclonal antibody produced therefrom. Such an antibody has a number of uses, including in diagnostic or therapeutic methods.
摘要翻译： 提供了可用作免疫原和肿瘤标记物的各种化合物。 本发明公开了与癌症的检测有关的方法。 乳糖系列1型链的延伸形式显示存在于各种癌组织中。 本发明还提供了由其制备的细胞系和单克隆抗体。 这样的抗体具有许多用途，包括诊断或治疗方法。
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4.发明授权Disialofucoganglioside immunogen and fucoganglioside monosialosyl Le.sup.a II 失效唾液中神经节苷脂免疫原和神经节苷脂单唾液酸Lea II
公开(公告)号：US5011920A
公开(公告)日：1991-04-30
申请号：US348688
申请日：1989-05-05
CPC分类号： C07H15/10 , C07K16/3046 , Y10S530/861
摘要： Disialosyl Le.sup.a (IV.sup.3 NeuAcIII.sup.6 NeuAcIII.sup.4 FucLc.sub.4), a novel human cancer-associated fucoganglioside that is highly immunogenic. Also, a hybridoma cell line (ATCC No. HB 8861) secreting a monoclonal IgG3 antibody (FH7) directed to disialosyl Le.sup.a. The disialosyl Le.sup.a antigen was detected in various cancer tissues and their cell lines but was absent in various normal tissues and blood cells. Sera of patients with various cancers, particularly early cases of colonic and gastric cancers, showed an elevated disialosyl Le.sup.a antigen level, which subsequently decreased after surgical tumor removal.
摘要翻译： 二唾液酸Lea（IV3NeuAcIII6NeuAcIII4FucLc4）是一种高度免疫原性的新型人类癌症相关的神经节苷脂。 此外，分泌针对二唾液酸Lea的单克隆IgG3抗体（FH7）的杂交瘤细胞系（ATCC No.BB8861）。 在各种癌组织及其细胞系中检测到二唾液酸Lea抗原，但在各种正常组织和血细胞中不存在。 各种癌症患者的血清，特别是结肠和胃癌的早期病例，显示出升高的二唾液酸Lea抗原水平，其随后手术切除肿瘤后降低。
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5.发明授权Naturally occurring gangliosides containing de-N-acetyl-sialic acid and their applications as modifiers of cell physiology 失效含有脱-N-乙酰唾液酸的天然存在的神经节苷脂及其作为细胞生理学改性剂的应用
公开(公告)号：US5272138A
公开(公告)日：1993-12-21
申请号：US467458
申请日：1990-01-19
申请人： Sen-itiroh Hakomori , Gustavo A. Nores , Nobuo Hanai , Taeko Dohi , Steven B. Levery , Mary Ellen K. Salyan , Hisao Nojiri
发明人： Sen-itiroh Hakomori , Gustavo A. Nores , Nobuo Hanai , Taeko Dohi , Steven B. Levery , Mary Ellen K. Salyan , Hisao Nojiri
IPC分类号： A61K31/70 , C07H15/10 , A61K31/725 , C07H5/06 , C07H13/06
摘要： A method for preparing de-N-acylated forms of an N-acyl sugar-containing glycosphingolipid and lyso forms of glycosphingolipid comprising hydrolyzing the glycosphingolipids under mild alkaline conditions such that the N-acyl group of the sugar moiety is preferentially hydrolyzed. Substantially pure gangliosides containing de-N-acetyl-sialic acid isolated from natural sources. A culture medium for stimulating growth of human and animal cells comprising: essential nutrients for cell growth, and a cell growth stimulatory amount of one or more gangliosides containing de-N-acetyl-sialic acid. A method for stimulating growth of human and animal cells cultured in vitro with a cell growth stimulatory amount of one or more gangliosides containing de-N-acetyl-sialic acid. A medicament and method for stimulating or inhibiting growth of human and animal cells by stimulating or inhibiting the production of growth stimulators selected from the group consisting of gangliosides containing de-N-acetyl-sialic acid, substances that promote synthesis of gangliosides containing de-N-acetyl-sialic acid and pharmaceutically acceptable salts thereof.
摘要翻译： 一种制备N-酰基糖型鞘糖脂的N-脱酰基形式的方法，其包括在温和碱性条件下水解糖鞘脂，使糖部分的N-酰基优先水解。 含有从天然来源分离的脱-N-乙酰唾液酸的纯粹神经节苷脂。 用于刺激人和动物细胞生长的培养基包括：用于细胞生长的必需营养物和含有脱-N-乙酰唾液酸的一种或多种神经节苷脂的细胞生长刺激量。 用于刺激体外培养的细胞生长刺激量的含有脱-N-乙酰唾液酸的一种或多种神经节苷脂的人和动物细胞生长的方法。 通过刺激或抑制选自包含脱-N-乙酰唾液酸的神经节苷脂的生长刺激剂的生成来刺激或抑制人和动物细胞生长的药物和方法，促进含有脱-N-乙酰唾液酸的神经节苷脂合成的物质 乙酰唾液酸及其药学上可接受的盐。
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公开(公告)号：US4851511A
公开(公告)日：1989-07-25
申请号：US824172
申请日：1986-01-30
CPC分类号： C07H15/10 , C07K16/3046 , Y10S424/804 , Y10S530/861
摘要： Disialosyl Le.sup.a (IV.sup.3 NeuAcIII.sup.6 NeuAcIII.sup.4 FucLc.sub.4), a novel human cancer-associated fucoganglioside that is highly immunogenic. Also, a hybridoma cell line (ATCC No. HB 8861)secreting a monoclonal IgG3 antibody (FH7) directed to disialosyl Le.sup.a. The disialosyl Le.sup.a antigen was detected in various cancer tissues and their cell lines but was absent in various normal tissues and blood cells. Sera of patients with various cancers, particularly early cases of colonic and gastric cancers, showed an elevated disialosyl Le.sup.a antigen level, which subsequently decreased after surgical tumor removal.
摘要翻译： 二唾液酸Lea（IV3NeuAcIII6NeuAcIII4FucLc4）是一种高度免疫原性的新型人类癌症相关的神经节苷脂。 此外，分泌针对二唾液酸Lea的单克隆IgG3抗体（FH7）的杂交瘤细胞系（ATCC No.BB8861）。 在各种癌组织及其细胞系中检测到二唾液酸Lea抗原，但在各种正常组织和血细胞中不存在。 各种癌症患者的血清，特别是结肠和胃癌的早期病例，显示出升高的二唾液酸Lea抗原水平，其随后手术切除肿瘤后降低。
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7.发明授权Monoclonal antibody NUH2 capable of inactivating motility of human sperm, antigen defined by said monoclonal antibody and methods of using said monoclonal antibody and antigen 失效单克隆抗体NUH2能够消除人类动物的动力，由单个抗体测定的抗原以及使用所述单克隆抗体和抗原的方法
公开(公告)号：US5227160A
公开(公告)日：1993-07-13
申请号：US219401
申请日：1988-07-15
申请人： Edward Nudelman , Tokio Kaizu , Ulla Mandel-Clausen , Steven B. Levery , Sen-itiroh Hakomori , Yoshiyuki Tsuji , Shinzo Isojima
发明人： Edward Nudelman , Tokio Kaizu , Ulla Mandel-Clausen , Steven B. Levery , Sen-itiroh Hakomori , Yoshiyuki Tsuji , Shinzo Isojima
IPC分类号： G01N33/558 , A61K35/52 , A61K38/00 , A61K39/00 , A61K39/395 , C07K14/435 , C07K16/00 , C07K16/18 , C12N5/10 , C12N15/02 , C12P21/08 , C12R1/91 , G01N33/577
CPC分类号： A61K35/52 , C07K16/18 , A61K38/00 , Y10S424/811 , Y10S514/843
摘要： Monoclonal antibody NUH2 produced by a hybridoma having ATCC deposit no. HB 9762. An isolated antigen capable of specifically binding to anti-human sperm antibodies including NUH2 and comprising at least an epitope having a sialyl I structure, and any analogues derived from said antigen. Methods of using the monoclonal antibody and antigen for contraception and treating infertility in human females.
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8.发明授权Antibodies that bind novel carbohydrate ligands (myelorollins) that cause E-selectin dependent cell rolling, and uses thereof 失效结合导致E-选择素依赖性细胞翻滚的新型碳水化合物配体（髓磷脂）的抗体及其用途
公开(公告)号：US5876715A
公开(公告)日：1999-03-02
申请号：US635849
申请日：1996-04-22
IPC分类号： A61P29/00 , C07H3/06 , C07H15/10 , A61K39/395 , C07K16/00
摘要： The invention relates to antibodies that specifically bind a myelorollin comprising an unbranched polylactosamine comprising at least 10 monosaccharides and having terminal .alpha.2.fwdarw.3 sialylation and internal .alpha.1.fwdarw.3 fucosylation at various N-acetylglucosamine residues except the penultimate N-acetylglucosamine residue. The invention also relates to a method of using such antibodies to inhibit E-selectin-dependent rolling of a cell on another cell, wherein one of the cells expresses a myelorollin that binds the antibodies.
摘要翻译： 本发明涉及特异性结合髓鞘蛋白的抗体，其包含非分支的多聚乳糖胺，其包含至少10个单糖并且具有末端α2-> 3唾液酸化和内部α1→3岩藻糖基化，除了倒数第二个N-乙酰氨基葡萄糖残基之外的各种N-乙酰葡糖胺残基。 本发明还涉及使用这种抗体抑制细胞在另一个细胞上的E-选择蛋白依赖性滚动的方法，其中一个细胞表达结合抗体的髓鞘蛋白。
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9.发明授权Carbohydrate ligands (myelorollin) that cause E-selectin dependent cell rolling and adhesion under dynamic flow system 失效在动态流动系统下引起E-选择素依赖性细胞滚动和粘附的碳水化合物配体（髓磷脂）
公开(公告)号：US6133239A
公开(公告)日：2000-10-17
申请号：US688124
申请日：1996-07-29
摘要： An unbranched polylactosamine comprising at least 6 monosaccharides and having terminal .alpha.2.fwdarw.3 sialylation and internal .alpha.1.fwdarw.3 fucosylation at various N-acetylglucosamine residues except for solely at the penultimate N-acetylglucosamine residue.
摘要翻译： 包含至少6个单糖并且具有末端α2-> 3唾液酸化和不同N-乙酰葡糖胺残基的内部α1-> 3岩藻糖基化的非支化多聚乳糖胺，除了仅在倒数第二个N-乙酰氨基葡萄糖残基之外。
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10.发明授权Method for inhibition of cell motility by sphingosine-1-phosphate and its derivatives 失效抑制鞘氨醇-1-磷酸及其衍生物的细胞运动性的方法
公开(公告)号：US5877167A
公开(公告)日：1999-03-02
申请号：US797926
申请日：1997-02-12
CPC分类号： A61K31/6615 , A61K31/66 , A61K31/661 , C07F9/113 , C07F9/173
摘要： A method of inhibiting tumor cell chemotactic motility and/or chemoinvasion, a method of inhibiting phagokinetic activity of tumor cells and neutrophils, a method of inhibiting tumor cell metastasis and a method of inhibiting inflammation due to motility and invasion into blood vessel walls of neutrophils comprising contacting the cells or administering to a host in need of treatment an inhibitory amount of an agent selected from the group consisting of sphingosine-1-phosphate, derivatives of sphingosine-1-phosphate, and mimetics of the sphingosine-1-phosphate or of the derivatives, and pharmaceutically acceptable salts of the agent. A method of preparing sphingosine-1-phosphate and its derivatives is also described.
摘要翻译： 一种抑制肿瘤细胞趋化运动和/或化学侵蚀的方法，抑制肿瘤细胞和嗜中性粒细胞的吞噬作用的方法，抑制肿瘤细胞转移的方法以及抑制由于运动和侵入嗜中性粒细胞血管壁引起的炎症的方法，包括 使细胞接触或向需要治疗的宿主施用抑制量的选自鞘氨醇-1-磷酸，鞘氨醇-1-磷酸的衍生物和鞘氨醇-1-磷酸的模拟物的药剂，或 衍生物和药学上可接受的盐。 还描述了制备鞘氨醇-1-磷酸酯及其衍生物的方法。
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