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1.发明授权Compounds and methods for immunotherapy and immunodiagnosis of prostate cancer 失效前列腺癌的免疫治疗和免疫诊断的化合物和方法
公开(公告)号：US6034218A
公开(公告)日：2000-03-07
申请号：US946026
申请日：1997-10-07
IPC分类号： A61K39/00 , C07K14/705 , C07K14/82 , C07K14/00
CPC分类号： C07K14/705 , C07K14/82 , A61K39/00
摘要： Compounds and methods for treating and diagnosing prostate cancer are provided. The inventive compounds include polypeptides containing at least a portion of a prostate protein. Vaccines and pharmaceutical compositions for immunotherapy of prostate cancer comprising such polypeptides or DNA molecules encoding such polypeptides are also provided. The inventive polypeptides may also be used to generate antibodies useful for the diagnosis and monitoring of prostate cancer. Nucleic acid sequences for preparing probes, primers, and polypeptides are also provided.
摘要翻译： 提供了治疗和诊断前列腺癌的化合物和方法。 本发明化合物包括含有至少一部分前列腺蛋白质的多肽。 还提供了包含这样的多肽或编码这种多肽的DNA分子的前列腺癌的免疫治疗用疫苗和药物组合物。 本发明的多肽也可用于产生可用于诊断和监测前列腺癌的抗体。 还提供了用于制备探针，引物和多肽的核酸序列。
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公开(公告)号：US07074898B2
公开(公告)日：2006-07-11
申请号：US10010940
申请日：2001-12-05
申请人： Jiangchun Xu , Davin C. Dillon , Jennifer L. Mitcham , Susan L. Harlocker , Yuqiu Jiang , Steven G. Reed , Michael D. Kalos , Gary R. Fanger , Marc W. Retter , John A. Stolk , Craig H. Day
发明人： Jiangchun Xu , Davin C. Dillon , Jennifer L. Mitcham , Susan L. Harlocker , Yuqiu Jiang , Steven G. Reed , Michael D. Kalos , Gary R. Fanger , Marc W. Retter , John A. Stolk , Craig H. Day
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K2039/5156 , A61K2039/53 , C07K14/4748 , C07K14/705 , C07K2319/00 , C12N9/6424 , C12N2760/16022 , C12N2760/16222
摘要： Compositions and methods for the therapy and diagnosis of cancer, such as prostate cancer, are disclosed. Compositions may comprise one or more prostate-specific proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a prostate-specific protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as prostate cancer. Diagnostic methods based on detecting a prostate-specific protein, or mRNA encoding such a protein, in a sample are also provided.
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公开(公告)号：US07048931B1
公开(公告)日：2006-05-23
申请号：US10129909
申请日：2000-11-09
申请人： Jiangchun Xu , Davin C. Dillon , Jennifer L. Mitcham , Susan L. Harlocker , Yuqiu Jiang , Steven G. Reed , Michael D. Kalos , Marc W. Retter , John A. Stolk , Craig H. Day , Yasir A. W. Skeiky , Aijun Wang
发明人： Jiangchun Xu , Davin C. Dillon , Jennifer L. Mitcham , Susan L. Harlocker , Yuqiu Jiang , Steven G. Reed , Michael D. Kalos , Marc W. Retter , John A. Stolk , Craig H. Day , Yasir A. W. Skeiky , Aijun Wang
CPC分类号： C07K14/4748 , A61K38/00 , C07H21/02 , C07K16/3069 , C07K2317/34 , C07K2317/80
摘要： Compositions and methods for the therapy and diagnosis of cancer, such as prostate cancer, are disclosed. Compositions may comprise one or more prostate-specific proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a prostate-specific protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as prostate cancer. Diagnostic methods based on detecting a prostate-specific protein, or mRNA encoding such a protein, in a sample are also provided.
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公开(公告)号：US07927609B2
公开(公告)日：2011-04-19
申请号：US11927566
申请日：2007-10-29
申请人： Steven G. Reed , Yasir A. W. Skeiky , Davin C. Dillon , Antonio Campos-Neto , Raymond Houghton , Thomas S. Vedvick , Daniel R. Twardzik , Michael J. Lodes , Ronald C. Hendrickson
发明人： Steven G. Reed , Yasir A. W. Skeiky , Davin C. Dillon , Antonio Campos-Neto , Raymond Houghton , Thomas S. Vedvick , Daniel R. Twardzik , Michael J. Lodes , Ronald C. Hendrickson
CPC分类号： C07K14/35 , A61K38/00 , A61K39/00 , A61K2039/51 , C07K2319/00
摘要： Compounds and methods for inducing protective immunity against tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or more M. tuberculosis proteins and DNA molecules encoding such polypeptides. Such compounds may be formulated into vaccines and/or pharmaceutical compositions for immunization against M. tuberculosis infection, or may be used for the diagnosis of tuberculosis.
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公开(公告)号：US20090312244A1
公开(公告)日：2009-12-17
申请号：US11927566
申请日：2007-10-29
申请人： Steven G. Reed , Yasir A.W. Skeiky , Davin C. Dillon , Antonio Campos-Neto , Raymond Houghton , Thomas S. Vedvick , Daniel R. Twardzik , Michael J. Lodes , Ronald C. Hendrickson
发明人： Steven G. Reed , Yasir A.W. Skeiky , Davin C. Dillon , Antonio Campos-Neto , Raymond Houghton , Thomas S. Vedvick , Daniel R. Twardzik , Michael J. Lodes , Ronald C. Hendrickson
CPC分类号： C07K14/35 , A61K38/00 , A61K39/00 , A61K2039/51 , C07K2319/00
摘要： Compounds and methods for inducing protective immunity against tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or more M. tuberculosis proteins and DNA molecules encoding such polypeptides. Such compounds may be formulated into vaccines and/or pharmaceutical compositions for immunization against M. tuberculosis infection, or may be used for the diagnosis of tuberculosis.
摘要翻译： 公开了诱导针对结核病的保护性免疫的化合物和方法。 提供的化合物包括含有至少一种免疫原性部分的一种或多种结核分枝杆菌蛋白质和编码这种多肽的DNA分子的多肽。 这些化合物可以配制成针对结核分枝杆菌感染免疫的疫苗和/或药物组合物，或可用于诊断结核病。
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公开(公告)号：US06962710B2
公开(公告)日：2005-11-08
申请号：US10084843
申请日：2002-02-25
申请人： Steven G. Reed , Yasir A. W. Skeiky , Davin C. Dillon , Antonio Campos-Neto , Raymond Houghton , Thomas S. Vedvick , Daniel R. Twardzik , Michael J. Lodes , Ronald C. Hendrickson
发明人： Steven G. Reed , Yasir A. W. Skeiky , Davin C. Dillon , Antonio Campos-Neto , Raymond Houghton , Thomas S. Vedvick , Daniel R. Twardzik , Michael J. Lodes , Ronald C. Hendrickson
IPC分类号： G01N33/53 , A61K31/711 , A61K38/00 , A61K39/00 , A61K39/04 , A61K49/00 , A61P31/04 , A61P31/06 , A61P37/04 , C07K1/00 , C07K14/35 , C12N15/00 , A61K39/385 , C07H21/04 , C12N1/12
CPC分类号： C07K14/35 , A61K38/00 , A61K39/00 , A61K2039/51 , C07K2319/00
摘要： Compounds and methods for inducing protective immunity against tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or more M. tuberculosis proteins and DNA molecules encoding such polypeptides. Such compounds may be formulated into vaccines and/or pharmaceutical compositions for immunization against M. tuberculosis infection, or may be used for the diagnosis of tuberculosis.
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公开(公告)号：US06290969B1
公开(公告)日：2001-09-18
申请号：US08818112
申请日：1997-03-13
申请人： Steven G. Reed , Yasir A. W. Skeiky , Davin C. Dillon , Antonio Campos-Neto , Raymond Houghton , Thomas S. Vedvick , Daniel R. Twardzik
发明人： Steven G. Reed , Yasir A. W. Skeiky , Davin C. Dillon , Antonio Campos-Neto , Raymond Houghton , Thomas S. Vedvick , Daniel R. Twardzik
IPC分类号： A61K3904
CPC分类号： C07K14/35 , A61K38/00 , A61K39/00 , A61K2039/51 , C07K2319/00
摘要： Compounds and methods for inducing protective immunity against tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or more M. tuberculosis proteins and DNA molecules encoding such polypeptides. Such compounds may be formulated into vaccines and/or pharmaceutical compositions for immunization against M. tuberculosis infection, or may be used for the diagnosis of tuberculosis.
摘要翻译： 公开了诱导针对结核病的保护性免疫的化合物和方法。 提供的化合物包括含有至少一种免疫原性部分的一种或多种结核分枝杆菌蛋白质和编码这种多肽的DNA分子的多肽。 这些化合物可以配制成针对结核分枝杆菌感染免疫的疫苗和/或药物组合物，或可用于诊断结核病。
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公开(公告)号：US07989605B2
公开(公告)日：2011-08-02
申请号：US11980320
申请日：2007-10-29
申请人： Steven G. Reed , Yasir A. W. Skeiky , Davin C. Dillon , Antonio Campos-Neto , Raymond Houghton , Thomas S. Vedvick , Daniel R. Twardzik
发明人： Steven G. Reed , Yasir A. W. Skeiky , Davin C. Dillon , Antonio Campos-Neto , Raymond Houghton , Thomas S. Vedvick , Daniel R. Twardzik
CPC分类号： C07K14/35 , A61K38/00 , A61K39/00 , A61K2039/51 , C07K2319/00
摘要： Compounds and methods for inducing protective immunity against tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or more M. tuberculosis proteins and DNA molecules encoding such polypeptides. Such compounds may be formulated into vaccines and/or pharmaceutical compositions for immunization against M. tuberculosis infection, or may be used for the diagnosis of tuberculosis.
摘要翻译： 公开了诱导针对结核病的保护性免疫的化合物和方法。 提供的化合物包括含有至少一种免疫原性部分的一种或多种结核分枝杆菌蛋白质和编码这种多肽的DNA分子的多肽。 这些化合物可以配制成针对结核分枝杆菌感染免疫的疫苗和/或药物组合物，或可用于诊断结核病。
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公开(公告)号：US20080199405A1
公开(公告)日：2008-08-21
申请号：US11801112
申请日：2007-05-07
申请人： Steven G. Reed , Yasir A.W. Skeiky , Davin C. Dillon , Antonio Campos-Neto , Raymond Houghton , Thomas S. Vedvick , Daniel R. Twardzik , Michael J. Lodes , Ronald C. Hendrickson
发明人： Steven G. Reed , Yasir A.W. Skeiky , Davin C. Dillon , Antonio Campos-Neto , Raymond Houghton , Thomas S. Vedvick , Daniel R. Twardzik , Michael J. Lodes , Ronald C. Hendrickson
IPC分类号： A61K39/00 , A61K31/70 , A61K49/00 , C07K14/00 , C12N1/00 , C12N15/00 , C12N5/06 , C12N15/11 , C12N1/20 , C12M1/34 , A61P43/00 , A61K38/00
CPC分类号： C07K14/35 , A61K38/00 , A61K39/00 , A61K2039/51 , C07K2319/00
摘要： Compounds and methods for inducing protective immunity against tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or more M. tuberculosis proteins and DNA molecules encoding such polypeptides. Such compounds may be formulated into vaccines and/or pharmaceutical compositions for immunization against M. tuberculosis infection, or may be used for the diagnosis of tuberculosis.
摘要翻译： 公开了诱导针对结核病的保护性免疫的化合物和方法。 提供的化合物包括含有至少一种免疫原性部分的一种或多种结核分枝杆菌蛋白质和编码这种多肽的DNA分子的多肽。 这些化合物可以配制成针对结核分枝杆菌感染免疫的疫苗和/或药物组合物，或可用于诊断结核病。
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公开(公告)号：US06338852B1
公开(公告)日：2002-01-15
申请号：US08818111
申请日：1997-03-13
申请人： Steven G. Reed , Yasir A. W. Skeiky , Davin C. Dillon , Antonio Campos-Neto , Raymond Houghton , Thomas S. Vedvick , Daniel R. Twardzik
发明人： Steven G. Reed , Yasir A. W. Skeiky , Davin C. Dillon , Antonio Campos-Neto , Raymond Houghton , Thomas S. Vedvick , Daniel R. Twardzik
IPC分类号： A61K3904
CPC分类号： G01N33/5695 , A61K39/00 , C07K14/35 , C12Q1/6883
摘要： Compounds and methods for diagnosing tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of one or more M. tuberculosis proteins, and DNA sequences encoding such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of M. tuberculosis infection in patients and biological samples. Antibodies directed against such polypeptides are also provided.
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