公开(公告)号：US5713888A

公开(公告)日：1998-02-03

申请号：US461471

申请日：1995-06-05

申请人： Steven Neuenfeldt ,  James H. Brauker

发明人： Steven Neuenfeldt ,  James H. Brauker

IPC分类号： A61B5/00 ,  A61K9/22 ,  A61L27/38 ,  A61L27/56 ,  A61L29/00 ,  A61L29/08 ,  A61L29/14

CPC分类号： A61L27/56 ,  A61F2/022 ,  A61L27/38 ,  A61L27/3839 ,  A61L29/005 ,  A61L29/085 ,  A61L29/146 ,  A61B5/14532 ,  A61B5/413

摘要： An implant assembly for a host tissue is provided. The implant assembly comprises a pouch including wall means defining a chamber for holding a second member, the wall means including an outer vascularizing membrane having a conformation that results in growth of vascular structures by the host tissue close to an interface between the vascularizing membrane and host tissue. The assembly includes a second member that can be removably inserted in the chamber including an interior for receiving cells and wall means defining an immuno-isolating membrane that isolates the cells from the immune response of the host tissue.

摘要翻译： 提供了一种用于宿主组织的植入物组件。 所述植入物组件包括包含限定用于保持第二构件的室的壁装置的袋，所述壁装置包括外部血管化膜，所述外部血管膜具有导致血管结构由所述宿主组织在所述血管化膜和宿主之间的界面附近生长的构象 组织。 该组件包括可拆卸地插入腔室中的第二构件，包括用于接纳细胞的内部和限定免疫隔离膜的壁装置，所述隔离膜将细胞与宿主组织的免疫应答隔离。

公开(公告)号：US6060640A

公开(公告)日：2000-05-09

申请号：US446210

申请日：1995-05-19

申请人： Robin G. Pauley ,  Donna L. McLarty ,  Atul R. Khare ,  Shmuel Sternberg ,  Daniel R. Boggs ,  Steven Neuenfeldt ,  Mark Jones ,  James H. Brauker ,  Laura A. Martinson

发明人： Robin G. Pauley ,  Donna L. McLarty ,  Atul R. Khare ,  Shmuel Sternberg ,  Daniel R. Boggs ,  Steven Neuenfeldt ,  Mark Jones ,  James H. Brauker ,  Laura A. Martinson

IPC分类号： A61F2/02 ,  A61K9/00 ,  A61L27/38 ,  C12N5/08 ,  A61D7/00 ,  A61M31/00

CPC分类号： A61K9/0024 ,  A61F2/022 ,  A61L27/38

摘要： A permeable structure forms a chamber to hold living cells. The structure includes a first permeable region surrounding at least a portion of the chamber having a conformation that, when implanted in host tissue, substantially blocks penetration of host cells into the chamber while permitting solute transport. The structure also includes a second permeable region overlying the first permeable region having a conformation that, when implanted in host tissue, forms a permeable interface with host tissue that permits solute transport. A third permeable region is located between the first and second permeable regions. The third region comprises a solution of polymer material formed in place between the first and second permeable regions. The third permeable region bonds the first and second permeable regions together. The third permeable region also has a conformation that, when implanted in host tissue, permits solute transport between the first and second permeable regions. The third, formed-in-place region bonds the first and second permeable regions together, providing a robust, laminated structure that resists delamination during implantation caused by cellular infiltration into discontinuous spaces between the first and second regions. The third, formed-in-place region can also have a conformation providing an immunoisolation effect. Furthermore, the permeability of the third, formed-in-place membrane is sufficient high that it does not adversely effect the permeability value desired for the overall multiple layer membrane structure.

摘要翻译： 可渗透结构形成容纳活细胞的室。 所述结构包括围绕所述腔室的至少一部分的第一可渗透区域，其具有当植入宿主组织时基本上阻挡宿主细胞渗入所述腔室同时允许溶质运输的构象。 该结构还包括覆盖第一可渗透区域的第二可渗透区域，其具有当植入宿主组织中时形成允许溶质运输的宿主组织的可渗透界面的构象。 第三可渗透区域位于第一和第二可渗透区域之间。 第三区域包括在第一和第二可渗透区域之间形成的聚合物材料溶液。 第三可渗透区域将第一和第二可渗透区域结合在一起。 第三可渗透区域还具有当植入宿主组织时允许溶质在第一和第二可渗透区域之间传输的构象。 第三个就地区域将第一和第二可渗透区域结合在一起，提供坚固的层压结构，其抵抗由于细胞浸润到第一和第二区域之间的不连续空间而在植入过程中的分层。 第三个就地区域也可以具有提供免疫隔离作用的构象。 此外，第三成形膜的渗透性足够高，使得其不会对整个多层膜结构所期望的渗透性值产生不利影响。

公开(公告)号：US08444663B2

公开(公告)日：2013-05-21

申请号：US12357846

申请日：2009-01-22

申请人： Kevin L. Houser ,  Sarah A. Noschang ,  Steven Neuenfeldt ,  Craig N. Faller ,  Jeffrey J. Vaitekunas

发明人： Kevin L. Houser ,  Sarah A. Noschang ,  Steven Neuenfeldt ,  Craig N. Faller ,  Jeffrey J. Vaitekunas

IPC分类号： A61B17/32

CPC分类号： A61B17/320092 ,  A61B2017/00831 ,  A61B2017/2825

摘要： An ultrasonic-surgical-shears tissue pad has a tissue-pad body including a base material and at least one filler material. An alternate ultrasonic-surgical-shears tissue pad has a tissue-pad body having adjoining first and second regions, wherein the first region includes a first material and wherein the second region includes a second material. An ultrasonic surgical shears includes an ultrasonic surgical blade and a clamping arm which is operable to open and close toward the blade and which has a transversely and resiliently flexible distal tip. An alternate ultrasonic surgical shears includes an ultrasonic surgical blade, a clamping arm operable to open and close toward the blade, and a tissue pad attached to the clamping arm and having a clamping surface, wherein at least a portion of the tissue pad is resiliently flexible in a direction substantially perpendicular to the clamping surface.

摘要翻译： 超声外科剪切组织垫具有包括基材和至少一种填充材料的组织垫体。 替代的超声外科剪切组织垫具有具有邻接的第一和第二区域的组织垫体，其中第一区域包括第一材料，并且其中第二区域包括第二材料。 超声手术剪刀包括超声手术刀片和夹持臂，其可操作以朝向刀片打开和关闭，并且具有横向和弹性柔性的远侧末端。 替代的超声手术剪刀包括超声手术刀片，可操作以朝向刀片打开和关闭的夹持臂以及附接到夹持臂并具有夹紧表面的组织垫，其中组织垫的至少一部分具有弹性柔性 在大致垂直于夹紧表面的方向上。

公开(公告)号：US20070073325A1

公开(公告)日：2007-03-29

申请号：US11555889

申请日：2006-11-02

申请人： Foster Stulen ,  Steven Neuenfeldt ,  Kevin Houser

发明人： Foster Stulen ,  Steven Neuenfeldt ,  Kevin Houser

IPC分类号： A61B17/32

CPC分类号： A61B17/320068 ,  A61B2017/22018 ,  A61B2017/320072 ,  A61B2017/32008 ,  A61B2017/320089 ,  A61B2217/005

摘要： An ultrasonic surgical blade, and an instrument, having a gain step. The blade body has, in any half wave length of the ultrasonic-surgical-blade body, a first vibration antinode, a vibration node, a second vibration antinode, and a gain step. The gain step is located between the second vibration antinode and the first vibration antinode. The gain step is spaced apart from the vibration node by a gain-step distance greater than 5% of the distance between the second vibration antinode and the first vibration antinode. The instrument includes the blade, a handpiece having an ultrasonic transducer, and an ultrasonic transmission rod whose proximal end is operatively connected to the ultrasonic transducer and whose distal end activates the blade. In one option, the first vibration antinode is the distal tip, and the gain step is located between the vibration node and the distal tip, resulting in an increased active length of the blade.

摘要翻译： 一种具有增益步长的超声手术刀和仪器。 刀片体在超声外科手术刀体的任何半波长中具有第一振动波腹，振动节点，第二振动波腹和增益步长。 增益步骤位于第二振动波腹与第一振动波腹之间。 增益步长与振动节点间的距离大于第二振动波腹与第一振动波腹之间距离的5％。 仪器包括刀片，具有超声波换能器的手持件和超声波传输杆，其近端可操作地连接到超声波换能器，其远端激活刀片。 在一个选择中，第一振动波腹是远端，并且增益步骤位于振动节点和远侧末端之间，导致叶片的有效长度增加。

公开(公告)号：US20060079876A1

公开(公告)日：2006-04-13

申请号：US11246330

申请日：2005-10-07

申请人： Kevin Houser ,  Mark Neurohr ,  Steven Neuenfeldt ,  Scott Barton

发明人： Kevin Houser ,  Mark Neurohr ,  Steven Neuenfeldt ,  Scott Barton

IPC分类号： A61B18/18

CPC分类号： A61B17/320092 ,  A61B17/2909 ,  A61B2017/00353 ,  A61B2017/00424 ,  A61B2017/2825 ,  A61B2017/2911 ,  Y10T29/49005 ,  Y10T29/49998

摘要： An ultrasonic clamp coagulator assembly that is configured to permit selective cutting, coagulation and clamping of tissue during surgical procedures. An elongated portion of the instrument can be configured for endoscopic applications and has an outside diameter of less than 6 mm. The construction includes a clamping mechanism, including a clamp arm pivotally mounted at the distal portion of the instrument, which is specifically configured to create a desired level of tissue clamping forces, exceeding 4 pounds when the trigger is fully closed. The clamping mechanism includes a two-piece pad design and pad material that enables the higher tissue clamping forces and a force-limiting mechanism that effectively smooths out abusive tissue forces. The assembly also features hand activation configured to provide an ergonomical grip and operation for the surgeon. Hand switches are placed in the range of the natural swing of the surgeon's thumb, whether gripping the surgical instrument right-handed or left handed.

摘要翻译： 超声波夹具凝固器组件，其构造成允许在外科手术期间选择性地切割，凝结和夹紧组织。 仪器的细长部分可以配置为内窥镜应用，外径小于6毫米。 该结构包括夹紧机构，其包括枢转地安装在仪器的远端部分处的夹紧臂，其特别构造成当触发器完全关闭时产生超过4磅的组织夹紧力。 夹紧机构包括两件式垫片设计和垫片材料，其能够实现较高的组织夹紧力，以及有效地平滑滥用组织力的力限制机构。 组件还具有手动激活，其被配置为为外科医生提供人体工程学的握持和操作。 手动开关放置在外科医生拇指的自然摆动的范围内，无论是右手还是左手握住手术器械。

公开(公告)号：US20100023044A1

公开(公告)日：2010-01-28

申请号：US12357846

申请日：2009-01-22

申请人： Kevin L. Houser ,  Sarah A. Noschang ,  Steven Neuenfeldt ,  Craig N. Faller ,  Jeffrey J. Vaitekunas

发明人： Kevin L. Houser ,  Sarah A. Noschang ,  Steven Neuenfeldt ,  Craig N. Faller ,  Jeffrey J. Vaitekunas

IPC分类号： A61B17/3201

CPC分类号： A61B17/320092 ,  A61B2017/00831 ,  A61B2017/2825

摘要： An ultrasonic-surgical-shears tissue pad has a tissue-pad body including a base material and at least one filler material. An alternate ultrasonic-surgical-shears tissue pad has a tissue-pad body having adjoining first and second regions, wherein the first region includes a first material and wherein the second region includes a second material. An ultrasonic surgical shears includes an ultrasonic surgical blade and a clamping arm which is operable to open and close toward the blade and which has a transversely and resiliently flexible distal tip. An alternate ultrasonic surgical shears includes an ultrasonic surgical blade, a clamping arm operable to open and close toward the blade, and a tissue pad attached to the clamping arm and having a clamping surface, wherein at least a portion of the tissue pad is resiliently flexible in a direction substantially perpendicular to the clamping surface.

摘要翻译： 超声外科剪切组织垫具有包括基材和至少一种填充材料的组织垫体。 替代的超声外科剪切组织垫具有具有邻接的第一和第二区域的组织垫体，其中第一区域包括第一材料，并且其中第二区域包括第二材料。 超声手术剪刀包括超声手术刀片和夹持臂，其可操作以朝向刀片打开和关闭，并且具有横向和弹性柔性的远侧末端。 替代的超声手术剪刀包括超声手术刀片，可操作以朝向刀片打开和关闭的夹持臂以及附接到夹持臂并具有夹紧表面的组织垫，其中组织垫的至少一部分具有弹性柔性 在大致垂直于夹紧表面的方向上。

公开(公告)号：US5545223A

公开(公告)日：1996-08-13

申请号：US413588

申请日：1995-03-30

申请人： Steven Neuenfeldt ,  James Brauker ,  Robert Clarke

发明人： Steven Neuenfeldt ,  James Brauker ,  Robert Clarke

IPC分类号： A61B5/00 ,  A61F2/02 ,  A61K9/22 ,  A61L27/38 ,  A61L27/56 ,  A61L29/00 ,  A61L29/14 ,  C12M3/06 ,  C12N5/00

CPC分类号： A61L29/146 ,  A61F2/022 ,  A61L27/38 ,  A61L27/56 ,  A61L29/005 ,  A61B5/14532 ,  Y10S623/902

摘要： A method and apparatus for implanting cells in a host is provided. In an embodiment, an implant assembly for a host tissue is provided comprising wall means defining a chamber for holding cells for implantation, the wall means including means for foxing a porous boundary between the host tissue and the implanted cells in the chamber, the pore size of the boundary being sufficient to isolate the implanted cells from the immune response of the host tissue, and port means for providing selective access to the chamber.

摘要翻译： 提供了一种用于在主机中植入细胞的方法和装置。 在一个实施例中，提供了一种用于宿主组织的植入物组件，其包括限定用于保持用于植入的细胞的室的壁装置，所述壁装置包括用于在宿主组织和腔室中的植入细胞之间激发多孔边界的装置， 的边界足以将植入的细胞与宿主组织的免疫应答隔离，以及用于提供对腔室的选择性接近的端口装置。

公开(公告)号：US20070173872A1

公开(公告)日：2007-07-26

申请号：US11337405

申请日：2006-01-23

申请人： Steven Neuenfeldt

发明人： Steven Neuenfeldt

IPC分类号： A61B17/32

CPC分类号： A61B17/320092 ,  A61B17/3201 ,  A61B18/1442 ,  A61B2017/00778 ,  A61B2017/2927 ,  A61B2017/320078 ,  A61B2017/320093 ,  A61B2017/320094 ,  A61B2017/320095 ,  A61B2018/1452 ,  A61B2018/1467

摘要： A first medical instrument is for cutting and coagulating patient tissue and includes a two-pronged end effector. The end effector has a first prong which includes a medical ultrasonic blade, has a second prong which includes an arm opposing the ultrasonic blade, and has a surgical knife. A second medical instrument is for a medical instrument for cutting and coagulating patient tissue and includes a two-pronged end effector. The end effector has a first prong which includes a first bipolar radio-frequency electrode, has a second prong which includes an arm opposing the electrodes, and has a surgical knife.

摘要翻译： 第一种医疗器械用于切割和凝固患者组织，并且包括双管齐下的末端执行器。 末端执行器具有包括医用超声波刀片的第一插脚，具有包括与超声波刀片相对的臂的第二插脚，并且具有手术刀。 第二医疗器械用于切割和凝固患者组织的医疗器械，并且包括双管齐下的末端执行器。 末端执行器具有包括第一双极射频电极的第一插脚，具有包括与电极相对的臂的第二插脚，并且具有手术刀。

公开(公告)号：US20060079877A1

公开(公告)日：2006-04-13

申请号：US11246384

申请日：2005-10-07

申请人： Kevin Houser ,  Steven Neuenfeldt ,  Mark Neurohr ,  Craig Faller

发明人： Kevin Houser ,  Steven Neuenfeldt ,  Mark Neurohr ,  Craig Faller

IPC分类号： A61B18/18

CPC分类号： A61B17/320092 ,  A61B17/2909 ,  A61B2017/00353 ,  A61B2017/00424 ,  A61B2017/2825 ,  A61B2017/2911 ,  A61B2017/320094 ,  A61B2017/320095 ,  Y10T29/49005 ,  Y10T29/49998

摘要： An ultrasonic clamp coagulator assembly that is configured to permit selective cutting, coagulation and clamping of tissue during surgical procedures. An elongated portion of the instrument can be configured for endoscopic applications and has an outside diameter of less than 6 mm. The construction includes a clamping mechanism, including a clamp arm pivotally mounted at the distal portion of the instrument, which is specifically configured to create a desired level of tissue clamping forces, exceeding 4 pounds when the trigger is fully closed. The clamping mechanism includes a two-piece pad design and pad material that enables the higher tissue clamping forces and a force-limiting mechanism that effectively smooths out abusive tissue forces. The assembly also features hand activation configured to provide an ergonomical grip and operation for the surgeon. Hand switches are placed in the range of the natural swing of the surgeon's thumb, whether gripping the surgical instrument right-handed or left handed.

摘要翻译： 超声波夹具凝固器组件，其构造成允许在外科手术期间选择性地切割，凝结和夹紧组织。 仪器的细长部分可以配置为内窥镜应用，外径小于6毫米。 该结构包括夹紧机构，其包括枢转地安装在仪器的远端部分处的夹紧臂，其特别构造成当触发器完全关闭时产生超过4磅的组织夹紧力。 夹紧机构包括两件式垫片设计和垫片材料，其能够实现较高的组织夹紧力，以及有效地平滑滥用组织力的力限制机构。 组件还具有手动激活，其被配置为为外科医生提供人体工程学的握持和操作。 手动开关放置在外科医生拇指的自然摆动的范围内，无论是右手还是左手握住手术器械。

公开(公告)号：US20060030848A1

公开(公告)日：2006-02-09

申请号：US11243585

申请日：2005-10-05

申请人： H. Craig ,  John Cummings ,  James Giordano ,  Kevin Houser ,  Steven Neuenfeldt ,  Richard Schwemberger ,  David Yates ,  Scott Wampler

发明人： H. Craig ,  John Cummings ,  James Giordano ,  Kevin Houser ,  Steven Neuenfeldt ,  Richard Schwemberger ,  David Yates ,  Scott Wampler

IPC分类号： A61B18/18

CPC分类号： A61B17/320092 ,  A61B2017/320078 ,  A61B2017/320093 ,  A61B2017/320094 ,  A61B2017/320095

摘要： An ultrasonic surgical clamp coagulator apparatus is configured to effect cutting, coagulation and clamping of tissue by cooperation of a clamping mechanism of the apparatus with an associated ultrasonic end-effector. The clamping mechanism includes a pivotal clamp arm, which cooperates with the end-effector for gripping tissue. The clamp arm is provided with a clamp tissue pad that has at least one raised portion to achieve the desired cutting and coagulation effect on the tissue.