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    Multiple-layer, formed-in-place immunoisolation membrane structures for implantation of cells in host tissue
    2.
    发明授权
    Multiple-layer, formed-in-place immunoisolation membrane structures for implantation of cells in host tissue 失效
    用于在宿主组织中植入细胞的多层形成的免疫隔离膜结构

    公开(公告)号：US6060640A

    公开(公告)日：2000-05-09

    申请号：US446210

    申请日：1995-05-19

    Applicant: Robin G. Pauley ,  Donna L. McLarty ,  Atul R. Khare ,  Shmuel Sternberg ,  Daniel R. Boggs ,  Steven Neuenfeldt ,  Mark Jones ,  James H. Brauker ,  Laura A. Martinson

    Inventor： Robin G. Pauley ,  Donna L. McLarty ,  Atul R. Khare ,  Shmuel Sternberg ,  Daniel R. Boggs ,  Steven Neuenfeldt ,  Mark Jones ,  James H. Brauker ,  Laura A. Martinson

    IPC: A61F2/02 ,  A61K9/00 ,  A61L27/38 ,  C12N5/08 ,  A61D7/00 ,  A61M31/00

    CPC classification number: A61K9/0024 ,  A61F2/022 ,  A61L27/38

    Abstract: A permeable structure forms a chamber to hold living cells. The structure includes a first permeable region surrounding at least a portion of the chamber having a conformation that, when implanted in host tissue, substantially blocks penetration of host cells into the chamber while permitting solute transport. The structure also includes a second permeable region overlying the first permeable region having a conformation that, when implanted in host tissue, forms a permeable interface with host tissue that permits solute transport. A third permeable region is located between the first and second permeable regions. The third region comprises a solution of polymer material formed in place between the first and second permeable regions. The third permeable region bonds the first and second permeable regions together. The third permeable region also has a conformation that, when implanted in host tissue, permits solute transport between the first and second permeable regions. The third, formed-in-place region bonds the first and second permeable regions together, providing a robust, laminated structure that resists delamination during implantation caused by cellular infiltration into discontinuous spaces between the first and second regions. The third, formed-in-place region can also have a conformation providing an immunoisolation effect. Furthermore, the permeability of the third, formed-in-place membrane is sufficient high that it does not adversely effect the permeability value desired for the overall multiple layer membrane structure.

    Abstract translation: 可渗透结构形成容纳活细胞的室。 所述结构包括围绕所述腔室的至少一部分的第一可渗透区域，其具有当植入宿主组织时基本上阻挡宿主细胞渗入所述腔室同时允许溶质运输的构象。 该结构还包括覆盖第一可渗透区域的第二可渗透区域，其具有当植入宿主组织中时形成允许溶质运输的宿主组织的可渗透界面的构象。 第三可渗透区域位于第一和第二可渗透区域之间。 第三区域包括在第一和第二可渗透区域之间形成的聚合物材料溶液。 第三可渗透区域将第一和第二可渗透区域结合在一起。 第三可渗透区域还具有当植入宿主组织时允许溶质在第一和第二可渗透区域之间传输的构象。 第三个就地区域将第一和第二可渗透区域结合在一起，提供坚固的层压结构，其抵抗由于细胞浸润到第一和第二区域之间的不连续空间而在植入过程中的分层。 第三个就地区域也可以具有提供免疫隔离作用的构象。 此外，第三成形膜的渗透性足够高，使得其不会对整个多层膜结构所期望的渗透性值产生不利影响。

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