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    CATEGORIZED DOCUMENT BASES
    1.
    发明申请
    CATEGORIZED DOCUMENT BASES 审中-公开
    分类文件基础

    公开(公告)号：US20110167068A1

    公开(公告)日：2011-07-07

    申请号：US13051198

    申请日：2011-03-18

    申请人： Steven O. Kimbrough ,  Ian C. MacMillan ,  John P. Ranieri ,  James D. Thompson

    发明人： Steven O. Kimbrough ,  Ian C. MacMillan ,  John P. Ranieri ,  James D. Thompson

    IPC分类号： G06F17/30

    CPC分类号： G06F16/353

    摘要： A method of managing information comprises generating a categorized document base. Generating the document base comprises providing a pre-existing classification of things other than documents, providing a source collection of documents, and automatically assessing the documents using Information Retrieval techniques to assign at least some of the documents to one or more taxa of the classification. For each taxon in the classification one or more numerical scores are assigned, based at least in part on a composition, makeup or constitution of the documents assigned to the taxon of the categorized document base.

    摘要翻译： 管理信息的方法包括生成分类文档库。 生成文档基础包括提供除文档之外的事物的预先分类，提供文档的源集合，以及使用信息检索技术自动评估文档，以将至少一些文档分配给分类的一个或多个分类。 对于分类中的每个分类，至少部分地基于分配给分类文档基础的分类单的文档的构成，组成或构成来分配一个或多个数值分数。

    Categorized document bases
    2.
    发明授权
    Categorized document bases 有权
    分类文件库

    公开(公告)号：US07917519B2

    公开(公告)日：2011-03-29

    申请号：US11586306

    申请日：2006-10-25

    申请人： Steven O. Kimbrough ,  Ian C. MacMillan ,  John P. Ranieri ,  James D. Thompson

    发明人： Steven O. Kimbrough ,  Ian C. MacMillan ,  John P. Ranieri ,  James D. Thompson

    IPC分类号： G06F7/00 ,  G06F17/30

    CPC分类号： G06F17/30707

    摘要： A method of managing information comprises generating a categorized document base. Generating the document base comprises providing a pre-existing classification of things other than documents, providing a source collection of documents, and automatically assessing the documents using Information Retrieval techniques to assign at least some of the documents to one or more taxa of the classification. For each taxon in the classification one or more numerical scores are assigned, based at least in part on a composition, makeup or constitution of the documents assigned to the taxon of the categorized document base.

    摘要翻译： 管理信息的方法包括生成分类文档库。 生成文档基础包括提供除文档之外的事物的预先分类，提供文档的源集合，以及使用信息检索技术自动评估文档，以将至少一些文档分配给分类的一个或多个分类。 对于分类中的每个分类，至少部分地基于分配给分类文档基础的分类单的文档的构成，组成或构成来分配一个或多个数值分数。

    Bioartificial extracellular matrix containing hydrogel matrix derivatized with cell adhesive peptide fragment
    4.
    发明授权
    Bioartificial extracellular matrix containing hydrogel matrix derivatized with cell adhesive peptide fragment 有权
    生物人造细胞外基质含有细胞粘附肽片段衍生的水凝胶基质

    公开(公告)号：US6156572A

    公开(公告)日：2000-12-05

    申请号：US160654

    申请日：1998-09-25

    申请人： Ravi Bellamkonda ,  John P. Ranieri ,  Patrick Aebischer

    发明人： Ravi Bellamkonda ,  John P. Ranieri ,  Patrick Aebischer

    IPC分类号： A61L27/00 ,  A61K38/00 ,  A61L27/20 ,  A61L27/22 ,  A61L27/38 ,  A61L27/52 ,  A61L31/00 ,  A61L31/04 ,  C07K7/06 ,  C07K7/08 ,  C07K14/78 ,  C12N5/00 ,  C07K17/02 ,  C07K17/10 ,  C12N11/10

    CPC分类号： A61L27/3839 ,  A61L27/20 ,  A61L27/227 ,  A61L27/52 ,  A61L31/005 ,  A61L31/047 ,  C07K14/78 ,  A61K38/00 ,  A61L2430/32 ,  Y10S530/812 ,  Y10S530/813

    摘要： A bioartificial extracellular matrix for use in tissue regeneration or replacement is provided by derivatizing a three-dimensional hydrogel matrix with a cell adhesive extracellular matrix protein or cell adhesive peptide fragment of the protein. Preferably, derivatizing is by covalent immobilization of a cell adhesive peptide fragment having the amino acid sequence, ArgGlyAsp, TyrIleGlySerArg or IleLysValAlaVal. Cartilage or tendon can be regenerated by implanting a matrix containing an adhesive peptide fragment that favors chondrocyte invasion. The matrix can be pre-seeded with cells, and tissue can be reconstituted in vitro and then implanted. A cell-seeded matrix can be encapsulated in a semi-permeable membrane to form a bioartificial organ. An agarose hydrogel matrix having an agarose concentration of 0.5-1.25% (w/v) and an average pore radius between 120 nm and 290 nm is preferred. A nerve guidance channel for use in regenerating severed nerve is prepared containing a tubular semi-permeable membrane having openings adapted to receive ends of a severed nerve, and an inner lumen containing the hydrogel matrix having a bound cell adhesive peptide fragment through which the nerve can regenerate.

    摘要翻译： 通过用蛋白质的细胞粘附细胞外基质蛋白或细胞粘附肽片段衍生三维水凝胶基质来提供用于组织再生或替代的生物人造细胞外基质。 优选地，衍生化是通过共价固定具有氨基酸序列ArgGlyAsp，TyrIleGlySerArg或IleLysValAlaVal的细胞粘附性肽片段。 可以通过植入含有有利于软骨细胞侵入的粘合肽片段的基质来再生软骨或肌腱。 基质可以用细胞预种子，组织可以在体外重建然后植入。 细胞接种的基质可以包封在半透膜中以形成生物人造器官。 具有琼脂糖浓度为0.5-1.25％（w / v）且平均孔半径在120nm与290nm之间的琼脂糖水凝胶基质是优选的。 制备用于再生切断的神经的神经引导通道，其包含具有适于接收切断的神经的端部的开口的管状半透膜，以及含有具有结合的细胞粘附肽片段的水凝胶基质的内腔，神经可穿过该片段 再生。

    Protein mixtures to induce therapeutic angiogenesis
    6.
    发明授权
    Protein mixtures to induce therapeutic angiogenesis 有权
    蛋白质混合物诱导治疗性血管发生

    公开(公告)号：US06211157B1

    公开(公告)日：2001-04-03

    申请号：US09173989

    申请日：1998-10-16

    申请人： James J. Benedict ,  John P. Ranieri ,  Marsha L. Whitney

    发明人： James J. Benedict ,  John P. Ranieri ,  Marsha L. Whitney

    IPC分类号： A61K3818

    CPC分类号： A61K38/1875

    摘要： An angiogenic factor comprising a mixture of proteins derived from bone. The angiogenic protein mixture is produced by a series of steps that allow the proteins to be kept in solution. The angiogenic mixture of bone proteins is produced by a multi-step process that includes at least one ultrafiltration step, an anion exchange chromatography step, a cation exchange chromatography step and a high performance liquid chromatography (HPLC) purification step.

    摘要翻译： 包含衍生自骨的蛋白质混合物的血管生成因子。 血管生成蛋白质混合物通过允许蛋白质保持在溶液中的一系列步骤产生。 通过包括至少一个超滤步骤，阴离子交换层析步骤，阳离子交换层析步骤和高效液相色谱（HPLC）纯化步骤的多步法生产骨蛋白的血管生成混合物。

    Soldering methods and compositions
    7.
    发明授权
    Soldering methods and compositions 失效
    焊接方法和组成

    公开(公告)号：US06340113B1

    公开(公告)日：2002-01-22

    申请号：US09226942

    申请日：1999-01-08

    申请人： Donald H. Avery ,  John P. Ranieri

    发明人： Donald H. Avery ,  John P. Ranieri

    IPC分类号： B23K3100

    CPC分类号： H05K3/3484 ,  B23K35/0244 ,  B23K35/025 ,  B23K2101/36 ,  H05K3/3463 ,  H05K2201/0215 ,  H05K2201/0218 ,  H05K2203/043

    摘要： Soldering methods and compositions are disclosed to provide electrical connections between surfaces with reduced likelihood of short circuits or solder-starved joints. Two component solder compositions are employed to preferably form “metallic foam” joints upon heating. In one embodiment, bimetallic particles are disclosed which fuse together rapidly reducing the likelihood of reflow-related solder joint faults. The methods and compositions of the present invention can also reduce the potential for thermal fatigue and other solder joint failures in electronic devices following fabrication because the porous solder joints relieve plastic constraints and lower the average tensile joint stress. In one preferred embodiment, solder compositions are employed which are composed of particles of a first metal coated with a second metal. Alternatively, the compositions can include particles of a first metal surrounded by a salt solution or suspension of a second metal. The metals are chosen such that their individual melting points are higher than the melting points of the alloy or alloys formed when they are combined. Upon heating of such coated particles, melting occurs at the interfaces between the core materials and their coatings. The liquid so formed causes various particles to fuse together in a porous metal foam that provides an electronic connection capable of withstanding thermal cycling with significantly lower failure rates. This soldering technique is particularly advantageous when applied to soldering of ball arrays and similar structures that facilitate mounting of chips to printed circuit boards, other chips or substrates, generally. The present invention can also be useful in reducing the total amount of lead and/or other toxic components present in solder compositions.

    摘要翻译： 公开了焊接方法和组合物以提供表面之间的电连接，减少了短路或焊接缺陷接头的可能性。 采用双组分焊料组合物在加热时优选形成“金属泡沫”接头。 在一个实施例中，公开了双重金属颗粒，其将熔合在一起迅速降低了回流焊接断裂的可能性。 本发明的方法和组合物还可以减少在制造后的电子器件中的热疲劳和其它焊接接头故障的可能性，因为多孔焊点缓解了塑性约束并降低了平均拉伸接头应力。 在一个优选实施例中，使用由涂覆有第二金属的第一金属的颗粒组成的焊料组合物。 或者，组合物可以包括由第二金属的盐溶液或悬浮液包围的第一金属的颗粒。 选择金属使得其各自的熔点高于当它们组合时形成的合金或合金的熔点。 在加热这种涂覆的颗粒时，在芯材和它们的涂层之间的界面处发生熔融。 如此形成的液体导致各种颗粒在多孔金属泡沫中熔合在一起，其提供能够承受热循环并且具有显着更低故障率的电子连接。 这种焊接技术在应用于有助于将芯片安装到印刷电路板，其它芯片或基板上的类似结构的焊球时是特别有利的。 本发明还可用于减少焊料组合物中存在的铅和/或其它有毒成分的总量。

    Nerve guidance channel containing bioartificial three-dimensional hydrogel extracellular matrix derivatized with cell adhesive peptide fragment
    9.
    发明授权
    Nerve guidance channel containing bioartificial three-dimensional hydrogel extracellular matrix derivatized with cell adhesive peptide fragment 失效
    神经引导通道含有用细胞粘附肽片段衍生的生物人造三维水凝胶细胞外基质

    公开(公告)号：US5834029A

    公开(公告)日：1998-11-10

    申请号：US280646

    申请日：1994-07-20

    申请人： Ravi Bellamkonda ,  John P. Ranieri ,  Patrick Aebischer

    发明人： Ravi Bellamkonda ,  John P. Ranieri ,  Patrick Aebischer

    IPC分类号： A61L27/00 ,  A61K38/00 ,  A61L27/20 ,  A61L27/22 ,  A61L27/38 ,  A61L27/52 ,  A61L31/00 ,  A61L31/04 ,  C07K7/06 ,  C07K7/08 ,  C07K14/78 ,  A61K35/30 ,  A61B17/08 ,  C12N5/00 ,  C12N11/10

    CPC分类号： A61L27/3839 ,  A61L27/20 ,  A61L27/227 ,  A61L27/52 ,  A61L31/005 ,  A61L31/047 ,  C07K14/78 ,  A61K38/00 ,  A61L2430/32 ,  Y10S530/812 ,  Y10S530/813

    摘要： A bioartificial three-dimensional hydrogel extracellular matrix derivatized with a cell adhesive peptide fragment is provided for use in tissue regeneration or replacement. The choice of adhesive peptide fragment depends on the desired target cell type. Cartilage or tendon can be regenerated by implanting a matrix containing adhesive peptide fragments that favor chondrocyte invasion. The matrix can be pre-seeded with cells, and tissue can be reconstituted in vitro and then implanted. A cell-seeded matrix can be encapsulated in a semi-permeable membrane to form a bioartificial organ. An agarose hydrogel matrix having an agarose concentration of 0.5-1.25% (w/v) and an average gel pore radius between 120 nm and 290 nm is preferred. The peptide fragment preferably contains the sequence, ArgGlyAsp or TyrIleGlySerArg or IleLysValAlaVal, and is covalently immobilized to the matrix. A nerve guidance channel for use in regenerating severed nerve is prepared containing a tubular semi-permeable membrane having openings adapted to receive the ends of a severed nerve, and an inner lumen containing the matrix having an adhesive peptide fragment through which the nerve can regenerate.

    摘要翻译： 提供用细胞粘附肽片段衍生的生物人造三维水凝胶细胞外基质用于组织再生或替代。 粘合肽片段的选择取决于所需的靶细胞类型。 可以通过植入含有有利于软骨细胞侵袭的粘合肽片段的基质来再生软骨或肌腱。 基质可以用细胞预种子，组织可以在体外重建然后植入。 细胞接种的基质可以包封在半透膜中以形成生物人造器官。 琼脂糖水凝胶基质的琼脂糖浓度为0.5-1.25％（w / v），平均凝胶孔半径在120nm和290nm之间是优选的。 肽片段优选含有序列ArgGlyAsp或TyrIleGlySerArg或IleLysValAlaVal，并且共价固定在基质上。 制备用于再生切断的神经的神经引导通道，其包含具有适于接收切断的神经的末端的开口的管状半透膜，以及含有所述基质的内腔，所述内腔具有粘合肽片段，神经可通过所述粘合肽片段再生。