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公开(公告)号：US20090326337A1
公开(公告)日：2009-12-31
申请号：US12375861
申请日：2007-07-31
CPC分类号： G01N27/04 , G01N15/1031 , G01N2015/0038 , G01R27/02 , G01R33/09 , G01R33/095 , G01R33/1269 , G11C11/161 , G11C11/18 , G11C13/0019
摘要： Disclosed herein is an apparatus for sensing characteristics of an object. In a preferred embodiment, the apparatus comprises an array, wherein the array comprises a plurality of nanoscale hybrid semiconductor/metal devices which are in proximity to an object, each hybrid semiconductor/metal device being configured to produce a voltage in response to a perturbation, wherein the produced voltage is indicative of a characteristic of the object. Any of a variety of nanoscale EXX sensors can be selected as the hybrid semiconductor/metal devices in the array. With such an array, ultra high resolution images of nanoscopic resolution can be generated of objects such as living cells, wherein the images are indicative of a variety of cell biologic processes.
摘要翻译： 本文公开了一种用于感测物体的特性的装置。 在优选实施例中，该装置包括阵列，其中阵列包括接近物体的多个纳米级混合半导体/金属器件，每个混合半导体/金属器件被配置为响应于扰动产生电压， 其中所产生的电压表示物体的特性。 可选择各种纳米级EXX传感器中的任何一种作为阵列中的混合半导体/金属器件。 利用这样的阵列，可以生成诸如活细胞的物体的纳米分辨率的超高分辨率图像，其中图像指示各种细胞生物过程。
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公开(公告)号：US08436436B2
公开(公告)日：2013-05-07
申请号：US12375861
申请日：2007-07-31
CPC分类号： G01N27/04 , G01N15/1031 , G01N2015/0038 , G01R27/02 , G01R33/09 , G01R33/095 , G01R33/1269 , G11C11/161 , G11C11/18 , G11C13/0019
摘要： Disclosed herein is an apparatus for sensing characteristics of an object. In a preferred embodiment, the apparatus comprises an array, wherein the array comprises a plurality of nanoscale hybrid semiconductor/metal devices which are in proximity to an object, each hybrid semiconductor/metal device being configured to produce a voltage in response to a perturbation, wherein the produced voltage is indicative of a characteristic of the object. Any of a variety of nanoscale EXX sensors can be selected as the hybrid semiconductor/metal devices in the array. With such an array, ultra high resolution images of nanoscopic resolution can be generated of objects such as living cells, wherein the images are indicative of a variety of cell biologic processes.
摘要翻译： 本文公开了一种用于感测物体的特性的装置。 在优选实施例中，该装置包括阵列，其中阵列包括接近物体的多个纳米级混合半导体/金属器件，每个混合半导体/金属器件被配置为响应于扰动产生电压， 其中所产生的电压表示物体的特性。 可选择各种纳米级EXX传感器中的任何一种作为阵列中的混合半导体/金属器件。 利用这样的阵列，可以生成诸如活细胞的物体的纳米分辨率的超高分辨率图像，其中图像指示各种细胞生物过程。
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3.发明申请Method and Apparatus for High Resolution Photon Detection Based on Extraordinary Optoconductance (EOC) Effects 有权基于特殊光电导（EOC）影响的高分辨率光子检测方法与装置公开(公告)号：US20110233382A1
公开(公告)日：2011-09-29
申请号：US12986621
申请日：2011-01-07
IPC分类号： H01L27/146 , H01L31/0224 , H01L29/02 , H01J40/14
CPC分类号： H01L27/14665 , B82Y15/00 , H01L27/1446 , H01L31/0304 , H01L31/09 , H01L31/108 , Y02E10/544
摘要： The inventors disclose a new high performance optical sensor, preferably of nanoscale dimensions, that functions at room temperature based on an extraordinary optoconductance (EOC) phenomenon, and preferably an inverse EOC (I-EOC) phenomenon, in a metal-semiconductor hybrid (MSH) structure having a semiconductor/metal interface. Such a design shows efficient photon sensing not exhibited by bare semiconductors. In experimentation with an exemplary embodiment, ultrahigh spatial resolution 4-point optoconductance measurements using Helium-Neon laser radiation reveal a strikingly large optoconductance property, an observed maximum measurement of 9460% EOC, for a 250 nm device. Such an exemplary EOC device also demonstrates specific detectivity higher than 5.06×1011 cm√Hz/W for 632 nm illumination and a high dynamic response of 40 dB making such sensors technologically competitive for a wide range of practical applications.
摘要翻译： 本发明人公开了一种新的高性能光学传感器，优选纳米级尺寸，其在室温下基于金属 - 半导体混合物（MSH）中的非常光导（EOC）现象，优选反EOC（I-EOC）现象起作用 ）结构具有半导体/金属界面。 这样的设计显示出没有露出半导体的高效光子传感器。 在使用示例性实施例的实验中，使用氦 - 氖激光辐射的超高空间分辨率4点光电导测量显示了对于250nm器件的显着大的光导特性，观察到的最大测量值为9460％EOC。 这种示例性的EOC装置还显示出对于632nm照明高于5.06×1011cm / Hz / W的特定检测率和40dB的高动态响应，使得这种传感器在广泛的实际应用中技术上是有竞争力的。
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公开(公告)号：US08497459B2
公开(公告)日：2013-07-30
申请号：US12986621
申请日：2011-01-07
CPC分类号： H01L27/14665 , B82Y15/00 , H01L27/1446 , H01L31/0304 , H01L31/09 , H01L31/108 , Y02E10/544
摘要： The inventors disclose a new high performance optical sensor, preferably of nanoscale dimensions, that functions at room temperature based on an extraordinary optoconductance (EOC) phenomenon, and preferably an inverse EOC (I-EOC) phenomenon, in a metal-semiconductor hybrid (MSH) structure having a semiconductor/metal interface. Such a design shows efficient photon sensing not exhibited by bare semiconductors. In experimentation with an exemplary embodiment, ultrahigh spatial resolution 4-point optoconductance measurements using Helium-Neon laser radiation reveal a strikingly large optoconductance property, an observed maximum measurement of 9460% EOC, for a 250 nm device. Such an exemplary EOC device also demonstrates specific detectivity higher than 5.06×1011 cm√Hz/W for 632 nm illumination and a high dynamic response of 40 dB making such sensors technologically competitive for a wide range of practical applications.
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5.发明申请Ultrasonic Characterization of Internal Body Conditions Using Information Theoretic Signal Receivers 审中-公开使用信息理论信号接收机的内部身体条件的超声波表征公开(公告)号：US20070232909A1
公开(公告)日：2007-10-04
申请号：US11692706
申请日：2007-03-28
IPC分类号： A61B8/00
CPC分类号： A61K49/225 , A61B8/481 , A61K49/1809 , B82Y5/00
摘要： Disclosed herein is a technique for performing medical imaging on a region of interest (ROI) wherein information theoretic signal receivers are used to enhance the detection and monitoring of pathologies such as angiogenesis and muscular dystrophy. Examples of information theoretic signal receivers that can be used in the practice of the invention include Shannon entropy signal receivers, continuous limit Shannon entropy signal receivers, Renyi entropy signal receivers, specific heat analog signal receivers, and thermodynamic energy analog signal receivers. The contrast enhancement provided by contrast agents, either targeted contrast agents or bubble-based contrast agents, is enhanced through the use of such information theoretic signal receivers. Further still, the contrast agents can be heated to further enhance visualization with information theoretic signal receivers.
摘要翻译： 本文公开了一种用于在感兴趣区域（ROI）上进行医学成像的技术，其中使用信息理论信号接收器来增强诸如血管生成和肌营养不良症等病理学的检测和监测。 可用于本发明实践的信息理论信号接收机的例子包括香农熵信号接收机，连续极限香农熵信号接收机，仁义熵信号接收机，比热模拟信号接收机和热力学能量模拟信号接收机。 通过使用这种信息理论信号接收器，可以增强由造影剂，即目标对比剂或基于气泡的造影剂提供的对比度增强。 此外，还可以加热造影剂以进一步增强信息理论信号接收器的可视化。
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公开(公告)号：US20120128590A1
公开(公告)日：2012-05-24
申请号：US13109873
申请日：2011-05-17
CPC分类号： A61K9/1075 , A61K9/127 , A61K38/1767 , A61K47/546 , A61K47/62 , A61K47/6907 , A61K47/6911
摘要： Compositions which comprise emulsions of nanoparticles for delivery of membrane-integrating peptides are described. The nanoparticles comprise a liquid hydrophobic core coated with a lipid/surfactant layer which contains the membrane-integrating peptides. Methods to use such compositions are also described.
摘要翻译： 描述了包含用于递送膜整合肽的纳米颗粒的乳液的组合物。 纳米颗粒包含涂覆有含有膜整合肽的脂质/表面活性剂层的液体疏水核心。 还描述了使用这种组合物的方法。
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7.发明授权Nanoparticle delivery systems comprising a hydrophobic core and a lipid/surfactant layer comprising a membrane-lytic peptide 有权纳米颗粒递送系统包括疏水核心和包含膜溶解肽的脂质/表面活性剂层公开(公告)号：US07943168B2
公开(公告)日：2011-05-17
申请号：US12043063
申请日：2008-03-05
CPC分类号： A61K9/1075 , A61K9/127 , A61K38/1767 , A61K47/546 , A61K47/62 , A61K47/6907 , A61K47/6911
摘要： Compositions which comprise emulsions of nanoparticles for delivery of membrane-integrating peptides are described. The nanoparticles comprise a liquid hydrophobic core coated with a lipid/surfactant layer which contains the membrane-integrating peptides. Methods to use such compositions are also described.
摘要翻译： 描述了包含用于递送膜整合肽的纳米颗粒的乳液的组合物。 纳米颗粒包含涂覆有含有膜整合肽的脂质/表面活性剂层的液体疏水核心。 还描述了使用这种组合物的方法。
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公开(公告)号：US07566442B2
公开(公告)日：2009-07-28
申请号：US11971818
申请日：2008-01-09
申请人： Gregory M. Lanza , Samuel A. Wickline , Tom Harris
发明人： Gregory M. Lanza , Samuel A. Wickline , Tom Harris
CPC分类号： A61K49/223 , A61K47/6907 , A61K49/0002 , A61K49/1833 , B82Y5/00
摘要： Emulsions preferably of nanoparticles formed from high boiling liquid perfluorochemical substances, said particles coated with a lipid/surfactant coating are made specific to regions of activated endothelial cells by coupling said nanoparticles to a ligand specific for αvβ3 integrin, other than an antibody. The nanoparticles may further include biologically active agents, radionuclides, or other imaging agents.
摘要翻译： 优选由高沸点液体全氟化学物质形成的纳米颗粒，所述涂覆有脂质/表面活性剂涂层的颗粒通过将所述纳米颗粒与除抗体以外的α-角蛋白3整联蛋白特异性的配体结合而对活化内皮细胞的区域特异性。 纳米颗粒可以进一步包括生物活性剂，放射性核素或其它成像剂。
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公开(公告)号：US08617516B2
公开(公告)日：2013-12-31
申请号：US12910385
申请日：2010-10-22
CPC分类号： A61K9/5123 , A61K49/1806
摘要： The present invention provides a substantially non-lytic, non-cytotoxic anchor peptide that is capable of stably inserting into lipid membranes. In particular, the invention provides nanoparticles comprising stably inserted anchor peptides, which may be conjugated to a variety of different cargo complexes.
摘要翻译： 本发明提供了能够稳定地插入脂质膜中的基本上非裂解性的非细胞毒性锚定肽。 特别地，本发明提供包含稳定插入的锚定肽的纳米颗粒，其可以缀合到各种不同的货物配合物。
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公开(公告)号：US08496945B2
公开(公告)日：2013-07-30
申请号：US13109873
申请日：2011-05-17
CPC分类号： A61K9/1075 , A61K9/127 , A61K38/1767 , A61K47/546 , A61K47/62 , A61K47/6907 , A61K47/6911
摘要： Compositions which comprise emulsions of nanoparticles for delivery of membrane-integrating peptides are described. The nanoparticles comprise a liquid hydrophobic core coated with a lipid/surfactant layer which contains the membrane-integrating peptides. Methods to use such compositions are also described.
摘要翻译： 描述了包含用于递送膜整合肽的纳米颗粒的乳液的组合物。 纳米颗粒包含涂覆有含有膜整合肽的脂质/表面活性剂层的液体疏水核心。 还描述了使用这种组合物的方法。
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