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公开(公告)号：US20090297534A1
公开(公告)日：2009-12-03
申请号：US11988761
申请日：2006-07-13
申请人： Sudhir Paul , Yasuhiro Nishiyama , Carl V. Hanson , Marc Weksler
发明人： Sudhir Paul , Yasuhiro Nishiyama , Carl V. Hanson , Marc Weksler
IPC分类号： A61K39/395
CPC分类号： C12N9/0002 , C07K16/1063 , C07K16/18 , C07K2317/34
摘要： The present invention describes the composition of class and subclass selected pooled human immunoglobulins with catalytic activity, methods of preparation thereof, and therapeutic utility thereof.
摘要翻译： 本发明描述了具有催化活性的选择的合并的人免疫球蛋白的类别和亚类的组成，其制备方法及其治疗用途。
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公开(公告)号：US20120121633A1
公开(公告)日：2012-05-17
申请号：US13184530
申请日：2011-07-16
CPC分类号： C07K16/1063 , A61K39/12 , A61K39/21 , A61K2039/54 , A61K2039/543 , A61K2039/545 , A61K2039/55505 , A61K2039/55544 , A61K2039/55561 , A61K2039/55566 , A61K2039/6037 , A61K2039/6081 , C07K2317/21 , C07K2317/34 , C07K2317/76 , C12N2740/16071 , C12N2740/16122 , C12N2740/16134
摘要： Provided are immunogenic compositions based on the highly conserved, core CD4 binding site of the gp120 protein of the human immunodeficiency virus. One embodiment includes an antigenic conjugate of an electophilic derivative of HIV gp120 peptide 416-433, designated E-416-433, covalently linked to an immunogenic carrier protein. The compositions are effective in stimulating the production of HIV neutralizing antibodies in mammals. Provided also are related methods of immunization, methods of antibody production and antibodies obtained using the methods of the invention.
摘要翻译： 提供基于人免疫缺陷病毒的gp120蛋白的高度保守的核心CD4结合位点的免疫原性组合物。 一个实施方案包括与免疫原性载体蛋白共价连接的HIV gp120肽416-433的亲电子衍生物（命名为E-416-433）的抗原缀合物。 该组合物有效刺激哺乳动物中HIV抗体的产生。 还提供了相关免疫方法，抗体产生方法和使用本发明的方法获得的抗体。
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公开(公告)号：US20050142649A1
公开(公告)日：2005-06-30
申请号：US10930548
申请日：2004-08-31
申请人： Sudhir Paul , Yasuhiro Nishiyama
发明人： Sudhir Paul , Yasuhiro Nishiyama
IPC分类号： C07K16/10 , C07K16/32 , C12N9/00 , A61K39/395 , C07K14/47
CPC分类号： C12N9/0002 , A61K2039/505 , C07K16/1063 , C07K16/32 , C07K2319/00
摘要： Improved methods for the production, selection and inhibition of catalytic antibodies are disclosed.
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公开(公告)号：US09969797B2
公开(公告)日：2018-05-15
申请号：US12589440
申请日：2009-10-23
申请人： Sudhir Paul , Stephanie Planque , Yasuhiro Nishiyama , Eric L. Brown , Keri C. Smith , Hiroaki Taguchi
发明人： Sudhir Paul , Stephanie Planque , Yasuhiro Nishiyama , Eric L. Brown , Keri C. Smith , Hiroaki Taguchi
CPC分类号： C07K16/18 , A61K2039/505 , C07K16/1063 , C07K16/109 , C07K16/1271 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/622 , G01N33/6854
摘要： Disclosed are antibodies (immunoglobulins) and fragments thereof that hydrolyze or bind polypeptide antigens belonging to Staphyloccus aureus, hepatitis C virus, human immunodeficiency virus and Alzheimer's disease. Also disclosed are novel methods to improve the antigen reactivity of the immunoglobulins and to treat a pathophysiological condition using the immunoglobulins as therapeutics.
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5.发明申请公开(公告)号：US20100183614A1
公开(公告)日：2010-07-22
申请号：US12589440
申请日：2009-10-23
申请人： Sudhir Paul , Stephanie Planque , Yasuhiro Nishiyama , Eric L. Brown , Keri C. Smith , Hiroaki Taguchi
发明人： Sudhir Paul , Stephanie Planque , Yasuhiro Nishiyama , Eric L. Brown , Keri C. Smith , Hiroaki Taguchi
IPC分类号： A61K39/395 , C07K16/00 , C07K16/10 , C07K16/12 , A61P31/18 , A61P31/14 , A61P31/04 , A61P25/28 , C40B30/04
CPC分类号： C07K16/18 , A61K2039/505 , C07K16/1063 , C07K16/109 , C07K16/1271 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/622 , G01N33/6854
摘要： Disclosed are antibodies (immunoglobulins) and fragments thereof that hydrolyze or bind polypeptide antigens belonging to Staphyloccus aureus, hepatitis C virus, human immunodeficiency virus and Alzheimer's disease. Also disclosed are novel methods to improve the antigen reactivity of the immunoglobulins and to treat a pathophysiological condition using the immunoglobulins as therapeutics.
摘要翻译： 公开了水解或结合属于金黄色葡萄球菌，丙型肝炎病毒，人类免疫缺陷病毒和阿尔茨海默氏病的多肽抗原的抗体（免疫球蛋白）及其片段。 还公开了改善免疫球蛋白的抗原反应性并使用免疫球蛋白作为治疗剂治疗病理生理状况的新方法。
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6.发明申请公开(公告)号：US20090117115A1
公开(公告)日：2009-05-07
申请号：US11983592
申请日：2007-11-09
IPC分类号： A61K39/395 , C07K14/00 , G01N33/53 , A61P31/18
CPC分类号： C07K16/1063 , A61K2039/505 , C07K2317/34
摘要： Provided herein are dual epitope polypeptides and electrophilic analogs thereof having a superantigenic epitope and at least one other epitope effective to induce the production of antibodies with binary specificity for the epitopes on a polypeptide antigen. Also, provided are electrophilic analogs of polyclonal B cell stimulants or lipids, polysaccharides and lipopolysaccharides or nucleotides. In addition, provided herein are methods for increasing production of binary epitope specific antibodies recognizing B cell polypeptide antigens, for stimulating production of antibodies using one or more of the polypeptides or electrophilic analogs and for isolating binary epitope specific antibodies or fragments thereof. Further provided are the antibodies so produced and methods of treating HIV using the same.
摘要翻译： 本文提供了双表位多肽及其亲电子类似物，其具有超抗原表位和至少一个其他表位，其有效地诱导针对多肽抗原上的表位具有二元特异性的抗体的产生。 此外，提供多克隆B细胞兴奋剂或脂质的亲电子类似物，多糖和脂多糖或核苷酸。 此外，本文提供的是用于增加识别B细胞多肽抗原的二元表位特异性抗体的产生的方法，用于刺激使用一种或多种多肽或亲电子类似物产生抗体并分离二聚表位特异性抗体或其片段。 还提供了如此制备的抗体以及使用其制备HIV的方法。
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7.发明授权公开(公告)号：US06855804B2
公开(公告)日：2005-02-15
申请号：US10114716
申请日：2002-04-01
申请人： Sudhir Paul , Yasuhiro Nishiyama
发明人： Sudhir Paul , Yasuhiro Nishiyama
CPC分类号： C12N9/0002 , A61K2039/505 , C07K16/1063 , C07K16/32 , C07K2319/00
摘要： Improved methods for the production, selection and inhibition of catalytic antibodies are disclosed.
摘要翻译： 公开了用于生产，选择和抑制催化抗体的改进方法。
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8.发明授权Covalent attachment of ligands to nucleophilic proteins guided by non-covalent 有权配体对非共价引导的亲核蛋白的共价连接公开(公告)号：US09006388B2
公开(公告)日：2015-04-14
申请号：US10581296
申请日：2004-03-26
申请人： Sudhir Paul , Yasuhiro Nishiyama
发明人： Sudhir Paul , Yasuhiro Nishiyama
IPC分类号： A61K38/00 , C07K2/00 , C07K4/00 , C07K5/00 , C07K7/00 , C07K14/00 , C07K16/00 , C07K17/00 , A61K47/48 , C07K14/005 , C07K16/10 , A61K39/00
CPC分类号： A61K47/48238 , A61K47/62 , A61K2039/505 , A61K2039/60 , A61K2039/6093 , C07K14/005 , C07K16/1063 , C07K2317/34 , C07K2317/76 , C12N2740/16122
摘要： A covalently reactive ligand analogue (CAL) of formula (1): wherein, L1 . . . Lx . . . Lm are components defining a ligand determinant, Lx is a component unit of the ligand determinant selected from the group consisting of an amino acid residue, sugar residue, a fatty acid residue and a nucleotide, L′ is a functional group of Lx, Y″ is atom, covalent bond or linker, Y′ is an optional charged or neutral group Y is a covalently reactive electrophilic group that reacts specifically with a receptor that binds to said ligand determinant, and n is an integer from 1 to 1000 m is an integer from 1 to 30.
摘要翻译： 式（1）的共价反应性配体类似物（CAL）：其中，L1。 。 。 Lx。 。 。 Lm是定义配体决定簇的成分，Lx是选自氨基酸残基，糖残基，脂肪酸残基和核苷酸的配体决定簇的成分单元，L'是Lx，Y“的官能团， 是原子，共价键或接头，Y'是任选的带电荷或中性基团Y是与结合所述配位体决定簇的受体特异性反应的共价反应性亲电子基团，n是1至1000m的整数是整数 从1到30。
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公开(公告)号：US08980646B2
公开(公告)日：2015-03-17
申请号：US10581294
申请日：2004-03-26
申请人： Sudhir Paul , Yasuhiro Nishiyama
发明人： Sudhir Paul , Yasuhiro Nishiyama
CPC分类号： C07K16/2863 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/105 , A01K2267/01 , C07K16/1063 , C07K16/44 , C07K2317/21 , C07K2317/34 , C12Q1/37 , G01N33/6854 , G01N2333/901
摘要： Improved methods for the production, selection and inhibition of catalytic and covalent antibodies are disclosed.
摘要翻译： 公开了用于生产，选择和抑制催化和共价抗体的改进方法。
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10.发明申请公开(公告)号：US20110287031A1
公开(公告)日：2011-11-24
申请号：US12387020
申请日：2009-04-27
申请人： Sudhir Paul , Yasuhiro Nishiyama
发明人： Sudhir Paul , Yasuhiro Nishiyama
IPC分类号： A61K39/395 , C07K7/08 , C07K19/00 , A61K38/08 , C12N9/00 , C12N9/96 , C07F9/6561 , A61P35/00 , A61P35/02 , A61P19/02 , A61P11/06 , A61P27/02 , A61P19/04 , A61P37/04 , C07K7/06
CPC分类号： A61M25/0905 , A61M2025/09108
摘要： Improved methods for the production, selection and inhibition of catalytic antibodies are disclosed.
摘要翻译： 公开了生产，选择和抑制催化抗体的改进方法。
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