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1.发明授权Agent delivery catheter having a radially expandable centering support member 有权药剂递送导管具有径向可扩张的居中支撑构件公开(公告)号：US08568355B2
公开(公告)日：2013-10-29
申请号：US13323122
申请日：2011-12-12
申请人： Sung Woo Min , Randolf von Oepen , Binh T. Nguyen , Kevin J. Ehrenreich , William E. Webler, Jr. , Rommel Lumauig , Gregory W. Chan , Lorcan J. Coffey , Travis R. Yribarren , Jesus Magana
发明人： Sung Woo Min , Randolf von Oepen , Binh T. Nguyen , Kevin J. Ehrenreich , William E. Webler, Jr. , Rommel Lumauig , Gregory W. Chan , Lorcan J. Coffey , Travis R. Yribarren , Jesus Magana
CPC分类号： A61M25/0155 , A61M25/0013 , A61M25/0068 , A61M25/008 , A61M25/0082 , A61M25/0084 , A61M25/04 , A61M25/0606 , A61M25/1002 , A61M25/1011 , A61M2025/0081 , A61M2025/0092 , A61M2025/0096 , A61M2025/0681 , A61M2025/1047
摘要： A catheter for delivering an agent to an injection site in a wall of a patient's body lumen, with an elongated shaft having a needle-through lumen slidably containing a needle therein, and an expandable member on the distal shaft section which has a collapsed configuration and a radially expanded configuration. In the radially expanded configuration, the expandable member supports the shaft in a position spaced away from the body lumen wall, and the needle slidably exits the needle-through lumen in the extended configuration through the port spaced away from the body lumen wall as a portion of the expandable member maintains the position of the port section of the shaft in the body lumen. The expandable member typically has an open-walled, helical, or lobed configuration providing a perfusion path along the expandable member.
摘要翻译： 一种导管，用于将药剂递送到患者体腔的壁中的注射部位，细长轴具有可滑动地包含针的针穿腔，以及具有折叠构型的远侧轴部上的可扩张构件，以及 径向扩张构型。 在径向展开的构造中，可扩张构件将轴支撑在远离体腔壁的位置上，并且针以延伸构型通过与体腔内壁间隔的端口可滑动地离开针穿腔，作为一部分 所述可扩张构件保持所述轴的所述端口部分在所述体腔中的位置。 可膨胀构件通常具有提供沿着可膨胀构件的灌注路径的开放壁，螺旋形或叶状结构。
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2.发明申请公开(公告)号：US20120143139A1
公开(公告)日：2012-06-07
申请号：US13323122
申请日：2011-12-12
申请人： Sung Woo Min , Randolf von Oepen , Binh T. Nguyen , Kevin J. Ehrenreich , William E. Webler, JR. , Rommel Lumauig , Gregory W. Chan , Lorcan J. Coffey , Travis R. Yribarren , Jesus Magana
发明人： Sung Woo Min , Randolf von Oepen , Binh T. Nguyen , Kevin J. Ehrenreich , William E. Webler, JR. , Rommel Lumauig , Gregory W. Chan , Lorcan J. Coffey , Travis R. Yribarren , Jesus Magana
IPC分类号： A61M25/04
CPC分类号： A61M25/0155 , A61M25/0013 , A61M25/0068 , A61M25/008 , A61M25/0082 , A61M25/0084 , A61M25/04 , A61M25/0606 , A61M25/1002 , A61M25/1011 , A61M2025/0081 , A61M2025/0092 , A61M2025/0096 , A61M2025/0681 , A61M2025/1047
摘要： A catheter for delivering an agent to an injection site in a wall of a patient's body lumen, with an elongated shaft having a needle-through lumen slidably containing a needle therein, and an expandable member on the distal shaft section which has a collapsed configuration and a radially expanded configuration. In the radially expanded configuration, the expandable member supports the shaft in a position spaced away from the body lumen wall, and the needle slidably exits the needle-through lumen in the extended configuration through the port spaced away from the body lumen wall as a portion of the expandable member maintains the position of the port section of the shaft in the body lumen. The expandable member typically has an open-walled, helical, or lobed configuration providing a perfusion path along the expandable member.
摘要翻译： 一种导管，用于将药剂递送到患者体腔的壁中的注射部位，细长轴具有可滑动地包含针的针穿腔，以及具有折叠构型的远侧轴部上的可扩张构件，以及 径向扩张构型。 在径向展开的构造中，可扩张构件将轴支撑在远离体腔壁的位置上，并且针以延伸构型通过与体腔内壁间隔的端口可滑动地离开针穿腔，作为一部分 所述可扩张构件保持所述轴的所述端口部分在所述体腔中的位置。 可膨胀构件通常具有提供沿着可膨胀构件的灌注路径的开放壁，螺旋形或叶状结构。
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3.发明授权Agent delivery catheter having a radially expandable centering support members 有权药剂递送导管具有径向可扩张的居中支撑构件公开(公告)号：US08075519B2
公开(公告)日：2011-12-13
申请号：US12328390
申请日：2008-12-04
申请人： Sung Woo Min , Randolf von Oepen , Binh T. Nguyen , Kevin J. Ehrenreich , William E. Webler, Jr. , Rommel Lumauig , Gregory W. Chan , Lorcan J. Coffey , Travis R. Yribarren , Jesus Magana
发明人： Sung Woo Min , Randolf von Oepen , Binh T. Nguyen , Kevin J. Ehrenreich , William E. Webler, Jr. , Rommel Lumauig , Gregory W. Chan , Lorcan J. Coffey , Travis R. Yribarren , Jesus Magana
IPC分类号： A61M29/00
CPC分类号： A61M25/0155 , A61M25/0013 , A61M25/0068 , A61M25/008 , A61M25/0082 , A61M25/0084 , A61M25/04 , A61M25/0606 , A61M25/1002 , A61M25/1011 , A61M2025/0081 , A61M2025/0092 , A61M2025/0096 , A61M2025/0681 , A61M2025/1047
摘要： A catheter for delivering an agent to an injection site in a wall of a patient's body lumen, with an elongated shaft having a needle-through lumen slidably containing a needle therein, and an expandable member on the distal shaft section which has a collapsed configuration and a radially expanded configuration. In the radially expanded configuration, the expandable member supports the shaft in a position spaced away from the body lumen wall, and the needle slidably exits the needle-through lumen in the extended configuration through the port spaced away from the body lumen wall as a portion of the expandable member maintains the position of the port section of the shaft in the body lumen. The expandable member typically has an open-walled, helical, or lobed configuration providing a perfusion path along the expandable member.
摘要翻译： 一种导管，用于将药剂递送到患者体腔的壁中的注射部位，细长轴具有可滑动地包含针的针穿腔，以及具有折叠构型的远侧轴部上的可扩张构件，以及 径向扩张构型。 在径向展开的构造中，可扩张构件将轴支撑在远离体腔壁的位置上，并且针以延伸构型通过与体腔内壁间隔的端口可滑动地离开针穿腔，作为一部分 所述可扩张构件保持所述轴的所述端口部分在所述体腔中的位置。 可膨胀构件通常具有提供沿着可膨胀构件的灌注路径的开放壁，螺旋形或叶状结构。
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4.发明申请公开(公告)号：US20100145265A1
公开(公告)日：2010-06-10
申请号：US12328390
申请日：2008-12-04
申请人： Sung Woo Min , Randolf von Oepen , Binh T. Nguyen , Kevin J. Ehrenreich , William E. Webler, JR. , Rommel Lumauig , Gregory W. Chan , Lorcan J. Coffey , Travis R. Yribarren , Jesus Magana
发明人： Sung Woo Min , Randolf von Oepen , Binh T. Nguyen , Kevin J. Ehrenreich , William E. Webler, JR. , Rommel Lumauig , Gregory W. Chan , Lorcan J. Coffey , Travis R. Yribarren , Jesus Magana
IPC分类号： A61M25/092
CPC分类号： A61M25/0155 , A61M25/0013 , A61M25/0068 , A61M25/008 , A61M25/0082 , A61M25/0084 , A61M25/04 , A61M25/0606 , A61M25/1002 , A61M25/1011 , A61M2025/0081 , A61M2025/0092 , A61M2025/0096 , A61M2025/0681 , A61M2025/1047
摘要： A catheter for delivering an agent to an injection site in a wall of a patient's body lumen, with an elongated shaft having a needle-through lumen slidably containing a needle therein, and an expandable member on the distal shaft section which has a collapsed configuration and a radially expanded configuration. In the radially expanded configuration, the expandable member supports the shaft in a position spaced away from the body lumen wall, and the needle slidably exits the needle-through lumen in the extended configuration through the port spaced away from the body lumen wall as a portion of the expandable member maintains the position of the port section of the shaft in the body lumen. The expandable member typically has an open-walled, helical, or lobed configuration providing a perfusion path along the expandable member.
摘要翻译： 一种导管，用于将药剂递送到患者体腔的壁中的注射部位，细长轴具有可滑动地包含针的针穿腔，以及具有折叠构型的远侧轴部上的可扩张构件，以及 径向扩张构型。 在径向展开的构造中，可扩张构件将轴支撑在远离体腔壁的位置上，并且针以延伸构型通过与体腔内壁间隔的端口可滑动地离开针穿腔，作为一部分 所述可扩张构件保持所述轴的所述端口部分在所述体腔中的位置。 可膨胀构件通常具有提供沿着可膨胀构件的灌注路径的开放壁，螺旋形或叶状结构。
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5.发明申请SYSTEMS AND METHODS FOR CREATING ENLARGED MIGRATION CHANNELS FOR THERAPEUTIC AGENTS WITHIN THE ENDOTHELIUM 审中-公开用于在内皮细胞中产生治疗药物的扩增通道的系统和方法公开(公告)号：US20090270787A1
公开(公告)日：2009-10-29
申请号：US12108167
申请日：2008-04-23
申请人： Randolf von Oepen , Travis R. Yribarren , Kevin J. Ehrenreich , William E. Webler, JR. , Binh T. Nguyen , Mina Chow , Gregory W. Chan , Rachel Bright
发明人： Randolf von Oepen , Travis R. Yribarren , Kevin J. Ehrenreich , William E. Webler, JR. , Binh T. Nguyen , Mina Chow , Gregory W. Chan , Rachel Bright
IPC分类号： A61M25/00
CPC分类号： A61M25/10 , A61B18/1492 , A61B18/24 , A61B2017/22051 , A61B2018/00238 , A61B2018/2272 , A61M2025/0024 , A61M2025/105 , A61M2025/1086
摘要： A system for enlarging endothelium migration channels at a treatment site in a coronary vessel wall, to enable enhanced delivery of a therapeutic agent thereto. The system includes an enlarging agent, for enlarging endothelium migration channels at a treatment site in a coronary vessel wall. It also includes a delivery system, for delivering the enlarging agent to the treatment site, so that the enlarging agent will be delivered thereby to enlarge the endothelium migration channels at the treatment site, and for delivering the therapeutic agent to the delivery site. The therapeutic agent will thereby be delivered into the enlarged migration channels at the treatment site, to treat the treatment site with the therapeutic agent.
摘要翻译： 一种用于在冠状血管壁的治疗部位扩大内皮迁移通道的系统，以便能够增强治疗剂的递送。 该系统包括放大剂，用于在冠状血管壁的治疗部位扩大内皮迁移通道。 它还包括用于将放大剂递送到治疗部位的递送系统，以便扩大剂将被递送，从而扩大治疗部位的内皮迁移通道，并将治疗剂输送到递送部位。 因此，治疗剂将被输送到治疗部位的扩大的移植通道中，用治疗剂治疗治疗部位。
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公开(公告)号：US20090318855A1
公开(公告)日：2009-12-24
申请号：US12145212
申请日：2008-06-24
申请人： Kevin J. Ehrenreich , Kim-Lien Nguyen , Randolf von Oepen , Gregory W. Chan , William Earl Webler, Jr. , Travis R. Yribarren
发明人： Kevin J. Ehrenreich , Kim-Lien Nguyen , Randolf von Oepen , Gregory W. Chan , William Earl Webler, Jr. , Travis R. Yribarren
CPC分类号： A61M25/1011 , A61M25/007 , A61M25/0082 , A61M2025/0096 , A61M2025/105 , A61M2025/1052
摘要： This invention is generally related to therapeutic treatment of a coronary vessel wall, and more particularly, to systems and methods for improving uptake of therapeutic agents within the endothelium for enhanced delivery of therapeutic agents to a treatment site. A medical device is provided that is capable of reducing the pressure applied to a vessel wall and delivering a therapeutic agent into the vessel wall. Also, methods are described for using the device to facilitate delivery and uptake of a therapeutic agent into the vessel wall.
摘要翻译： 本发明通常涉及冠状血管壁的治疗处理，更具体地涉及用于改善内皮内治疗剂吸收的用于增强治疗剂递送至治疗部位的系统和方法。 提供了能够降低施加到血管壁并将治疗剂输送到血管壁中的压力的医疗装置。 此外，描述了使用该装置促进治疗剂递送和吸收到血管壁中的方法。
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7.发明申请RAPID-EXCHANGE RETRACTABLE SHEATH SELF-EXPANDING DELIVERY SYSTEM WITH INCOMPRESSIBLE INNER MEMBER AND FLEXIBLE DISTAL ASSEMBLY 有权快速可交换式自动膨胀系统，具有不可组织的内部会员和灵活的远程装配公开(公告)号：US20090157162A1
公开(公告)日：2009-06-18
申请号：US12253757
申请日：2008-10-17
CPC分类号： A61F2/95 , A61F2/966 , A61F2002/9517 , A61F2250/0098 , A61M25/0045 , A61M25/005 , A61M25/0051 , A61M25/0133
摘要： A delivery system for delivery of a medical device, the delivery system having an inner member having a proximal section, a distal section and a longitudinal axis therebetween, and an outer member disposed about the inner member, wherein the distal section of the inner member includes at least two wires wound about the inner member.
摘要翻译： 用于输送医疗装置的输送系统，所述输送系统具有内部构件，所述内部构件具有近侧部分，远侧部分和其间的纵向轴线以及围绕所述内部构件设置的外部构件，其中所述内部构件的远端部分包括 至少两根缠绕在内部构件上的电线。
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8.发明授权Rapid-exchange retractable sheath self-expanding delivery system with incompressible inner member and flexible distal assembly 有权快速交换可伸缩护套自扩张输送系统，具有不可压缩内部构件和柔性远端组件公开(公告)号：US08114144B2
公开(公告)日：2012-02-14
申请号：US12253757
申请日：2008-10-17
IPC分类号： A61F2/06
CPC分类号： A61F2/95 , A61F2/966 , A61F2002/9517 , A61F2250/0098 , A61M25/0045 , A61M25/005 , A61M25/0051 , A61M25/0133
摘要： Delivery system for delivery of a medical device includes an inner member having a proximal section, a distal section and a longitudinal axis therebetween. The inner member has a first layer and a second layer wherein the first layer and the second layer are attached together at a first segment and a second segment. The second segment is spaced from the first segment along a length of the inner member and the first layer and the second layer are free of attachment between the first segment and the second segment. The inner member further includes at least two wires disposed along the length of the inner member between the first layer and the second layer. As disclosed, the at least two wires can include a first coil and a second coil moveable relative to each other between the first and second segments.
摘要翻译： 用于输送医疗装置的输送系统包括具有近端部分，远侧部分和其间的纵向轴线的内部构件。 内部构件具有第一层和第二层，其中第一层和第二层在第一段和第二段处连接在一起。 第二段沿着内部构件的长度与第一段间隔开，并且第一层和第二层在第一段和第二段之间没有附接。 内部构件还包括沿着内部构件的长度在第一层和第二层之间设置的至少两根线。 如所公开的，所述至少两根导线可以包括第一线圈和第二线圈，所述第一线圈和第二线圈可在第一和第二段之间相对于彼此移动。
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9.发明申请EXPANDABLE ENDOPROSTHESES, SYSTEMS, AND METHODS FOR TREATING A BIFURCATED LUMEN 有权可膨胀的内生物，系统和处理分离的水的方法公开(公告)号：US20110288622A1
公开(公告)日：2011-11-24
申请号：US12782399
申请日：2010-05-18
CPC分类号： A61F2/915 , A61F2/954 , A61F2002/065 , A61F2002/91525 , A61F2002/91558 , A61F2002/91575 , A61F2210/0076 , A61F2230/0054
摘要： An endoprosthesis for treating a bifurcated lumen. The distal end of the endoprosthesis can include at least two wings and at least two troughs so the endoprosthesis can adequately scaffold the ostium of a bifurcated lumen by at least partially straddling the carina of the lumen bifurcation. The distal end of the endoprosthesis can also be configured to have increased expandability to help allow conformity to the anatomy of a bifurcated lumen.
摘要翻译： 用于治疗分叉腔的内用假体。 内用假体的远端可以包括至少两个翼和至少两个槽，使得内假体可以通过至少部分地跨越管腔分叉的小孔来充分地支撑分叉腔的口。 内用假体的远端还可以被配置为具有增加的可扩展性，以帮助允许符合分叉腔的解剖结构。
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10.发明授权公开(公告)号：US08805492B2
公开(公告)日：2014-08-12
申请号：US12491957
申请日：2009-06-25
申请人： Gregory W. Chan
发明人： Gregory W. Chan
IPC分类号： A61N1/08
CPC分类号： A61M5/14276 , A61M2205/3523 , A61M2205/3561 , A61M2205/3584 , A61M2230/04 , A61M2230/08 , A61N1/375 , A61N1/3962 , A61N1/3968 , Y10T29/49002
摘要： A cardiac rhythm management (CRM) system includes an implantable medical device that delivers combined electrical and drug therapies. The implantable medical device includes a drug reservoir that is refillable after implantation. In one embodiment, the implantable medical device includes an implantable housing encapsulating a pulse generator circuit and a drug delivery device. In another embodiment, the implantable medical device includes an implantable pulse generator and an implantable drug delivery device fastened to each other.
摘要翻译： 心律管理（CRM）系统包括可植入医疗装置，其提供组合的电疗法和药物疗法。 可植入医疗装置包括在植入后可再填充的药物储存器。 在一个实施例中，可植入医疗装置包括封装脉冲发生器电路和药物输送装置的可植入壳体。 在另一个实施例中，可植入医疗装置包括可植入的脉冲发生器和彼此紧固的可植入药物输送装置。
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