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公开(公告)号：US10085968B2
公开(公告)日：2018-10-02
申请号：US14950834
申请日：2015-11-24
发明人： Liming Shao , John Emmerson Campbell , Michael Charles Hewitt , Una Campbell , Taleen G. Hanania
IPC分类号： C07D233/00 , C07D403/02 , C07D403/14 , C07D231/00 , C07D487/02 , C07D487/00 , C07D405/00 , C07D409/00 , C07D495/02 , A61K31/415 , A61K31/40 , C07D277/22 , A61K31/381 , C07D277/60 , C07D333/54 , C07D333/76 , C07D333/78 , C07D495/04 , C07D495/20 , A61K31/435 , A61K31/55 , A61K45/06
摘要： Provided herein are multicyclic compounds of formula (IVa), shown below, wherein R1, R2, R3, R4, R5, R6, R7, m, and n are defined herein elsewhere, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.
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公开(公告)号：US09351954B2
公开(公告)日：2016-05-31
申请号：US14205859
申请日：2014-03-12
发明人： Liming Shao , John Emmerson Campbell , Michael Charles Hewitt , Una Campbell , Taleen G. Hanania
IPC分类号： C07D495/02 , C07D233/00 , C07D403/02 , C07D403/14 , C07D231/00 , C07D487/00 , C07D487/02 , C07D405/00 , C07D409/00 , C07D411/00 , A61K31/415 , A61K31/40 , A61K31/48 , A61K31/381 , C07D277/60 , C07D333/54 , C07D333/76 , C07D333/78 , C07D495/04 , C07D495/20 , A61K31/435 , A61K31/55 , A61K45/06
CPC分类号： A61K31/381 , A61K31/435 , A61K31/55 , A61K45/06 , C07D277/60 , C07D333/54 , C07D333/76 , C07D333/78 , C07D495/04 , C07D495/20
摘要： Provided herein are multicyclic compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. For example, disclosed herein are compounds having formula (IIa) shown below, or a pharmaceutically acceptable salt or stereoisomer thereof, wherein the variables are defined herein. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.
摘要翻译： 本文提供多环化合物，其合成方法，包含该化合物的药物组合物及其使用方法。 例如，本文公开的是具有下面所示的式（IIa）的化合物或其药学上可接受的盐或立体异构体，其中变量在本文中定义。 本文提供的化合物可用于治疗，预防和/或治疗各种神经障碍，包括但不限于精神病和精神分裂症。
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公开(公告)号：US10894033B2
公开(公告)日：2021-01-19
申请号：US16791118
申请日：2020-02-14
发明人： Liming Shao , John Emmerson Campbell , Michael Charles Hewitt , Una Campbell , Taleen G. Hanania
IPC分类号： A61K31/381 , C07D277/60 , C07D333/54 , C07D333/76 , A61K45/06 , C07D495/04 , C07D495/20 , A61K31/435 , A61K31/55 , C07D333/78
摘要： Provided herein are multicyclic compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.
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公开(公告)号：US10562916B2
公开(公告)日：2020-02-18
申请号：US15787880
申请日：2017-10-19
IPC分类号： A61K31/498 , C07D241/40 , C07D498/06 , C07D401/06 , C07D471/04 , C07D471/14 , C07D487/04 , C07D491/056 , C07D498/14 , C07D519/00 , C07D403/06 , C07D401/14 , C07D405/14 , C07D409/06 , C07D409/14 , C07D413/06 , C07D417/06 , C07D498/04 , A61K31/4164 , A61K31/4178 , A61K31/4709 , A61K31/4985 , A61K31/506 , A61K31/517 , A61K31/5383 , C07D233/58 , C07D471/06
摘要： Provided herein are cyclic nucleotide phosphodiesterase inhibitors, and pharmaceutical compositions thereof, useful for the treatment of, for example, central nervous system and metabolic diseases and disorder.
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公开(公告)号：US10562878B2
公开(公告)日：2020-02-18
申请号：US15836261
申请日：2017-12-08
发明人： Liming Shao , Fengjiang Wang , Scott Christopher Malcolm , Michael Charles Hewitt , Larry R. Bush , Jianguo Ma , Mark A. Varney , Una Campbell , Sharon Rae Engel , Larry Wendell Hardy , Patrick Koch , John E. Campell
IPC分类号： C07D333/20 , C07C211/17 , C07C211/40 , C07C215/42 , C07C215/44 , C07C217/52 , C07C217/74 , C07C323/32 , C07D207/06 , C07D207/08 , C07D211/14 , C07D265/14 , C07D277/28 , C07D295/06 , C07D307/52 , C07D317/58 , C07D317/72 , C07D319/06 , C07D491/056 , C07C211/29 , C07D211/16
摘要： The invention relates to novel cyclohexylamine derivatives and their use in the treatment and/or prevention of central nervous system (CNS) disorders, such as depression, anxiety, schizophrenia and sleep disorder as well as methods for their synthesis. The invention also relates to pharmaceutical compositions containing the compounds of the invention, as well as methods of inhibiting reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine from the synaptic cleft and methods of modulating one or more monoamine transporter.
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![Substituted imidazo[1,2-a]pyridines as PDE-10 inhibitors](/abs-image/US/2020/02/25/US10570156B2/abs.jpg.150x150.jpg)
公开(公告)号：US10570156B2
公开(公告)日：2020-02-25
申请号：US15818044
申请日：2017-11-20
IPC分类号： A61K31/437 , C07D471/04 , C07D519/00 , A61K45/06 , C07D487/04 , A61K31/4375 , A61K31/4745 , A61K31/4985 , A61K31/519 , A61K31/5383
摘要： Provided herein are cyclic nucleotide phosphodiesterase inhibitors of Formula (I) of claim 1, and pharmaceutical compositions thereof, useful for the treatment of, for example, central nervous system and metabolic diseases and disorder.
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![Substituted pyrazolo[1,5-a]pyridines as PDE-10 inhibitors](/abs-image/US/2018/01/02/US09856274B2/abs.jpg.150x150.jpg)
公开(公告)号：US09856274B2
公开(公告)日：2018-01-02
申请号：US14884397
申请日：2015-10-15
IPC分类号： A61K31/4353 , C07D487/04 , C07D519/00 , A61K45/06 , C07D471/04 , A61K31/4375 , A61K31/4745 , A61K31/4985 , A61K31/519 , A61K31/5383
CPC分类号： C07D519/00 , A61K31/4375 , A61K31/4745 , A61K31/4985 , A61K31/519 , A61K31/5383 , A61K45/06 , C07D471/04 , C07D487/04
摘要： Provided herein are substituted pyrazolopyridine compounds, and pharmaceutical compositions thereof, useful for the treatment of, for example, central nervous system and metabolic diseases and disorder.
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公开(公告)号：US20180037590A1
公开(公告)日：2018-02-08
申请号：US15787880
申请日：2017-10-19
IPC分类号： C07D498/06 , A61K31/506 , A61K31/517 , A61K31/5383 , C07D233/58 , A61K31/4164 , A61K31/4178 , A61K31/4709 , A61K31/498 , A61K31/4985 , C07D498/04 , C07D409/14 , C07D413/06 , C07D417/06 , C07D401/14 , C07D405/14 , C07D409/06 , C07D519/00 , C07D498/14 , C07D491/056 , C07D487/04 , C07D471/14 , C07D471/04 , C07D403/06 , C07D471/06 , C07D401/06
CPC分类号： C07D498/06 , A61K31/4164 , A61K31/4178 , A61K31/4709 , A61K31/498 , A61K31/4985 , A61K31/506 , A61K31/517 , A61K31/5383 , C07D233/58 , C07D401/06 , C07D401/14 , C07D403/06 , C07D405/14 , C07D409/06 , C07D409/14 , C07D413/06 , C07D417/06 , C07D471/04 , C07D471/06 , C07D471/14 , C07D487/04 , C07D491/056 , C07D498/04 , C07D498/14 , C07D519/00
摘要： Provided herein are heteroaryl compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. In one embodiment, the compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as CNS disorders and metabolic disorders, including, but not limited to, e.g., neurological disorders, psychosis, schizophrenia, obesity, and diabetes.
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公开(公告)号：US09868718B2
公开(公告)日：2018-01-16
申请号：US14502532
申请日：2014-09-30
发明人： Liming Shao , Fengjiang Wang , Scott Christopher Malcolm , Michael Charles Hewitt , Larry R. Bush , Jianguo Ma , Mark A. Varney , Una Campbell , Sharon Rae Engel , Larry Wendell Hardy , Patrick Koch , John E. Campbell
IPC分类号： C07C13/28 , C07D333/20 , C07C211/17 , C07C211/29 , C07C211/40 , C07C215/42 , C07C215/44 , C07C217/52 , C07C217/74 , C07C323/32 , C07D207/06 , C07D207/08 , C07D211/14 , C07D265/14 , C07D277/28 , C07D295/06 , C07D307/52 , C07D317/58 , C07D317/72 , C07D319/06 , C07D491/056 , C07D211/16
CPC分类号： C07D333/20 , C07C211/17 , C07C211/29 , C07C211/40 , C07C215/42 , C07C215/44 , C07C217/52 , C07C217/74 , C07C323/32 , C07C2601/02 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07C2602/08 , C07D207/06 , C07D207/08 , C07D211/14 , C07D211/16 , C07D265/14 , C07D277/28 , C07D295/06 , C07D307/52 , C07D317/58 , C07D317/72 , C07D319/06 , C07D491/056
摘要： The invention relates to novel cyclohexylamine derivatives and their use in the treatment and/or prevention of central nervous system (CNS) disorders, such as depression, anxiety, schizophrenia and sleep disorder as well as methods for their synthesis. The invention also relates to pharmaceutical compositions containing the compounds of the invention, as well as methods of inhibiting reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine from the synaptic cleft and methods of modulating one or more monoamine transporter.
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公开(公告)号：US09834564B2
公开(公告)日：2017-12-05
申请号：US14627355
申请日：2015-02-20
IPC分类号： A61K31/4709 , C07D215/12 , C07D498/06 , C07D401/06 , C07D403/06 , C07D471/04 , C07D471/14 , C07D487/04 , C07D491/056 , C07D498/14 , C07D519/00 , C07D401/14 , C07D405/14 , C07D409/06 , C07D409/14 , C07D413/06 , C07D417/06 , C07D498/04 , A61K31/4164 , A61K31/4178 , A61K31/498 , A61K31/4985 , A61K31/506 , A61K31/517 , A61K31/5383 , C07D233/58 , C07D471/06
CPC分类号： C07D498/06 , A61K31/4164 , A61K31/4178 , A61K31/4709 , A61K31/498 , A61K31/4985 , A61K31/506 , A61K31/517 , A61K31/5383 , C07D233/58 , C07D401/06 , C07D401/14 , C07D403/06 , C07D405/14 , C07D409/06 , C07D409/14 , C07D413/06 , C07D417/06 , C07D471/04 , C07D471/06 , C07D471/14 , C07D487/04 , C07D491/056 , C07D498/04 , C07D498/14 , C07D519/00
摘要： Provided herein are Cyclic Nucleotide Phosphodiesterase inhibitors, and pharmaceutical compositions thereof, useful for the treatment of, for example, central nervous system and metabolic diseases and disorder.
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