公开(公告)号：US20240342347A1

公开(公告)日：2024-10-17

申请号：US18612034

申请日：2024-03-21

Applicant: Surmodics, Inc.

Inventor： Syed Hossainy

IPC: A61L33/00 ,  A61L29/08 ,  A61L29/16 ,  A61L33/06

CPC classification number: A61L33/0023 ,  A61L29/085 ,  A61L29/16 ,  A61L33/0064 ,  A61L33/062 ,  A61L2300/42

Abstract: Embodiments herein relate to biofouling resistant coatings for medical devices. In an embodiment, an anti-fouling coated medical device is included having a substrate and a coating disposed over the substrate. The coating can include a hydrogel, and a polyzwitterion. The polyzwitterion can include a bound portion and an unbound portion. In some embodiments the coating can further include a heparin compound. Other embodiments are also included herein.

公开(公告)号：US20240277906A1

公开(公告)日：2024-08-22

申请号：US18405604

申请日：2024-01-05

Applicant: Surmodics, Inc.

Inventor： David E. Babcock ,  Syed Hossainy

IPC: A61L29/08 ,  A61L29/14

CPC classification number: A61L29/085 ,  A61L29/145 ,  A61L2400/10 ,  A61L2420/06 ,  A61L2420/08

Abstract: Embodiments herein relate to lubricious coatings for medical devices. A coated medical device is included having a substrate and a lubricious coating disposed thereon. In some embodiments, the lubricious coating can include an outer protective layer including long polymer chains. The long polymer chains can include a bonded end and a mobile free end. In some embodiments, the lubricious coating can include a hydrogel layer and long polymer chains that are at least partially disposed within the lubricious coating. Other embodiments are also included herein.

公开(公告)号：US20240240098A1

公开(公告)日：2024-07-18

申请号：US18388652

申请日：2023-11-10

Applicant: Surmodics, Inc.

Inventor： Michael Militello ,  Syed Hossainy ,  David E. Babcock

IPC: C10M107/42 ,  A61L29/04 ,  A61L29/08 ,  C10M107/28 ,  C10M137/06 ,  C10M169/04 ,  C10N20/04 ,  C10N40/00 ,  C10N50/00

CPC classification number: C10M107/42 ,  A61L29/049 ,  A61L29/085 ,  C10M107/28 ,  C10M137/06 ,  C10M169/04 ,  A61L2400/10 ,  A61L2420/02 ,  C10M2209/0845 ,  C10M2217/0285 ,  C10M2223/042 ,  C10N2020/04 ,  C10N2040/50 ,  C10N2050/023

Abstract: Embodiments herein relate to polyacrylic acid containing lubricious coatings for medical devices. In an embodiment, a lubricious coated medical device is included having a substrate and a first layer disposed over the substrate. The first layer can include a photoreactive polyvinylpyrrolidone, a non-photoreactive polyvinylpyrrolidone, and a crosslinking compound. A second layer can be disposed over the first layer, the second layer can include a poly(acrylic acid), and a non-photoreactive polyvinylpyrrolidone. The non-photoreactive polyvinylpyrrolidone of the second layer forms a complex with the poly(acrylic acid) of the second layer. The non-photoreactive polyvinylpyrrolidone of the second layer has a concentration existing as a gradient through a thickness of the second layer with a lower concentration at an outer surface of the second layer than at an inner surface of the second layer. Other embodiments are also included herein.