-
公开(公告)号：US20100015211A1
公开(公告)日：2010-01-21
申请号：US11664962
申请日：2005-11-01
IPC分类号： A61K9/127 , A61K39/21 , A61K39/295 , A61K39/116 , A61K39/00 , A61P37/04 , A61P31/12 , A61P31/18
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/21 , A61K2039/5256 , A61K2039/53 , A61K2039/54 , A61K2039/545 , C12N2710/10343 , C12N2740/16122 , C12N2760/16134
摘要： The present invention relates to methods, polypeptides, and polynucleotides encoding immunogenic identical or analogous HIV polypeptides derived from the same or different strains within an HIV subtype and/or different subtypes. Uses of the polynucleotides and polypeptides in combination approaches for generating immune responses are also described. The combination approaches described herein induce broad and potent immune responses against diverse HIV strains from multiple strains within a given subtype and against diverse subtypes. Formulations of compositions for generating immune responses and methods of use for such compositions are also disclosed.
摘要翻译： 本发明涉及编码来自HIV亚型和/或不同亚型中的相同或不同菌株的免疫原性相同或类似的HIV多肽的方法，多肽和多核苷酸。 还描述了用于产生免疫应答的组合方法中多核苷酸和多肽的用途。 本文描述的组合方法诱导针对来自给定亚型中的多种菌株和针对不同亚型的多种HIV株的广泛和有效的免疫应答。 还公开了用于产生免疫应答的组合物的制剂和用于这种组合物的方法。
-
2.发明授权Fusion proteins comprising CD4 minimal modules and invasin polypeptides that are capable of binding to the HIV envelope and exposing cryptic neutraliziation epitopes 有权包含能够结合HIV包膜并暴露神经中和表位的CD4最小模块和侵袭素多肽的融合蛋白公开(公告)号：US08206720B2
公开(公告)日：2012-06-26
申请号：US11597340
申请日：2005-06-08
申请人： Vega Masignani , Maria Scarselli , Barbara Capecchi , Victoria Sharma , Susan W. Barnett , Indresh K. Srivastava , Rino Rappuoli
发明人： Vega Masignani , Maria Scarselli , Barbara Capecchi , Victoria Sharma , Susan W. Barnett , Indresh K. Srivastava , Rino Rappuoli
CPC分类号： C07K14/70514 , C07K2319/01
摘要： Fusion proteins comprising CD4 minimal modules that bind to HIV Env polypeptides in a non-CD4 backbone are described. Also described are complexes of these fusion proteins with Env as well as methods of diagnosis, treatment and prevention using the polynucleotides and polypeptides are also provided.
摘要翻译： 描述了包含在非CD4主链中结合HIV Env多肽的CD4最小模块的融合蛋白。 还描述了这些融合蛋白与Env的复合物以及使用多核苷酸和多肽的诊断，治疗和预防的方法。
-
公开(公告)号：US20110065146A1
公开(公告)日：2011-03-17
申请号：US12770905
申请日：2010-04-30
申请人： Susan W. Barnett , Jan zur Megede , Indresh Srivastava , Ying Lian , Karin Hartog , Hong Liu , Catherine Greer , Mark Selby , Christopher Walker
发明人： Susan W. Barnett , Jan zur Megede , Indresh Srivastava , Ying Lian , Karin Hartog , Hong Liu , Catherine Greer , Mark Selby , Christopher Walker
IPC分类号： C12P21/00
CPC分类号： C12N7/00 , A61K39/00 , A61K48/00 , A61K2039/5156 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , A61K2039/54 , C07K14/005 , C12N15/86 , C12N2740/16023 , C12N2740/16043 , C12N2740/16052 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322 , C12N2770/24222 , C12N2800/108 , C12N2840/20 , C12N2840/203
摘要： The present invention relates to the efficient expression of HIV polypeptides in a variety of cell types, including, but not limited to, mammalian, insect, and plant cells. Synthetic expression cassettes encoding the HIV Gag-containing polypeptides are described, as are uses of the expression cassettes in applications including DNA immunization, generation of packaging cell lines, and production of Env-, tat- or Gag-containing proteins. The invention provides methods of producing Virus-Like Particles (VLPs), as well as, uses of the VLPs including, but not limited to, vehicles for the presentation of antigens and stimulation of immune response in subjects to whom the VLPs are administered.
摘要翻译： 本发明涉及HIV多肽在各种细胞类型中的有效表达，包括但不限于哺乳动物，昆虫和植物细胞。 描述了编码含有HIV Gag的多肽的合成表达盒，以及包括DNA免疫，产生包装细胞系以及产生含有Env，tat或Gag的蛋白质的应用中的表达盒的用途。 本发明提供了生产病毒样颗粒（VLP）的方法，以及VLP的使用，包括但不限于用于呈递抗体的媒介物和在施用VLP的受试者中刺激免疫应答。
-
公开(公告)号：US07622125B2
公开(公告)日：2009-11-24
申请号：US11124602
申请日：2005-05-05
申请人： Jan zur Megede , Susan W. Barnett
发明人： Jan zur Megede , Susan W. Barnett
CPC分类号： C07K14/005 , A61K2039/53 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322 , C12N2770/36143
摘要： The present disclosure relates to vectors comprising polynucleotide sequences that encode HIV polypeptides. In particular, the disclosure relates polycistronic vector constructs comprising sequences that encode HIV polypeptides as a single polyprotein. Compositions comprising these vectors and sequences along with methods of using these vectors and sequences are also disclosed.
摘要翻译： 本公开涉及包含编码HIV多肽的多核苷酸序列的载体。 具体地，本公开涉及包含将HIV多肽编码为单个多蛋白的序列的多顺反子载体构建体。 还公开了包含这些载体和序列的组合以及使用这些载体和序列的方法。
-
公开(公告)号：US20080261271A1
公开(公告)日：2008-10-23
申请号：US12026619
申请日：2008-02-06
申请人： Susan W. Barnett , Jan zur Megede , Indresh Srivastava , Ying Lian , Karin Hartog , Hong Liu , Catherine Greer , Mark Selby , Christopher Walker
发明人： Susan W. Barnett , Jan zur Megede , Indresh Srivastava , Ying Lian , Karin Hartog , Hong Liu , Catherine Greer , Mark Selby , Christopher Walker
IPC分类号： C12N15/49
CPC分类号： C12N7/00 , A61K39/00 , A61K48/00 , A61K2039/5156 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , A61K2039/54 , C07K14/005 , C12N15/86 , C12N2740/16023 , C12N2740/16043 , C12N2740/16052 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322 , C12N2770/24222 , C12N2800/108 , C12N2840/20 , C12N2840/203
摘要： The present invention relates to the efficient expression of HIV polypeptides in a variety of cell types, including, but not limited to, mammalian, insect, and plant cells. Synthetic expression cassettes encoding the HIV Gag-containing polypeptides are described, as are uses of the expression cassettes in applications including DNA immunization, generation of packaging cell lines, and production of Env-, tat- or Gag-containing proteins. The invention provides methods of producing Virus-Like Particles (VLPs), as well as, uses of the VLPs including, but not limited to, vehicles for the presentation of antigens and stimulation of immune response in subjects to whom the VLPs are administered.
摘要翻译： 本发明涉及HIV多肽在各种细胞类型中的有效表达，包括但不限于哺乳动物，昆虫和植物细胞。 还描述了编码含有HIV Gag的多肽的合成表达盒，以及包括DNA免疫，产生包装细胞系以及产生含有Env-，tat-或Gag的蛋白质的应用中的表达盒的用途。 本发明提供了生产病毒样颗粒（VLP）的方法，以及VLP的使用，包括但不限于用于呈递抗体的媒介物和在施用VLP的受试者中刺激免疫应答。
-
公开(公告)号：US20110257377A1
公开(公告)日：2011-10-20
申请号：US12225655
申请日：2007-03-27
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , A61K2039/62 , A61K2039/64 , C12N2740/16122 , C12N2740/16134 , C12N2740/16322 , C12N2740/16334
摘要： Complexes of HIV Env and Tat proteins are advantageous as immunogens compared to Tat or Env alone, but they may dissociate when combined with a vaccine adjuvant. To avoid dissociation, complexes of Env and Tat are stabilized by the use of covalent cross linking. The extent of cross linking is important to the binding properties of the complexes, and so is controlled to avoid the loss of Env's ability to bind specifically to CD4 and Tat's ability to bind specifically to anti-Tat monoclonal antibodies.
摘要翻译： HIV环境和Tat蛋白的复合物作为免疫原与Tat或Env单独相比是有利的，但当与疫苗佐剂组合时它们可能解离。 为了避免解离，Env和Tat的复合物通过使用共价交联来稳定。 交联的程度对于复合物的结合特性是重要的，因此被控制以避免Env特异性结合CD4和Tat特异性结合抗Tat单克隆抗体的能力的丧失。
-
7.发明申请公开(公告)号：US20100183653A1
公开(公告)日：2010-07-22
申请号：US11597340
申请日：2005-06-08
申请人： Vega Masignani , Maria Scarselli , Barbara Capecchi , Victoria Sharma , Susan W. Barnett , Indresh K. Srivastava , Rino Rappuoli
发明人： Vega Masignani , Maria Scarselli , Barbara Capecchi , Victoria Sharma , Susan W. Barnett , Indresh K. Srivastava , Rino Rappuoli
IPC分类号： A61K39/02 , A61K39/21 , C12P21/06 , C12N5/10 , C12N1/21 , C12N1/19 , C12N15/63 , C07K14/24 , C07K16/00 , C07H21/04 , C07K14/155
CPC分类号： C07K14/70514 , C07K2319/01
摘要： Fusion proteins comprising CD4 minimal modules that bind to HIV Env polypeptides in a non-CD4 backbone are described. Also described are complexes of these fusion proteins with Env as well as methods of diagnosis, treatment and prevention using the polynucleotides and polypeptides are also provided.
摘要翻译： 描述了包含在非CD4主链中结合HIV Env多肽的CD4最小模块的融合蛋白。 还描述了这些融合蛋白与Env的复合物以及使用多核苷酸和多肽的诊断，治疗和预防的方法。
-
公开(公告)号：US20090238841A1
公开(公告)日：2009-09-24
申请号：US12364294
申请日：2009-02-02
申请人： John Donnelly , Susan W. Barnett , Derek O'Hagan
发明人： John Donnelly , Susan W. Barnett , Derek O'Hagan
IPC分类号： A61K39/21 , C12P21/02 , A61K31/713 , A61P31/18 , A61K31/711
CPC分类号： A61K39/21 , A61K39/12 , A61K48/0041 , A61K48/005 , A61K48/0083 , A61K2039/53 , A61K2039/545 , A61K2039/55566 , A61K2039/57 , A61K2039/6093 , C07K14/005 , C12N15/87 , C12N2740/16034 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222 , C12N2740/16234
摘要： Provided herein are HIV vaccines comprising HIV polypeptide-encoding DNA adsorbed to PLG and/or HIV proteins. Also provided are methods of using these vaccines to generate immune responses in a subject.
摘要翻译： 本文提供包含吸附于PLG和/或HIV蛋白质的编码HIV多肽的DNA的HIV疫苗。 还提供了使用这些疫苗在受试者中产生免疫应答的方法。
-
9.发明申请POLYNUCLEOTIDES ENCODING ANTIGENIC HIV TYPE B POLYPEPTIDES, POLYPEPTIDES, AND USES THEREOF 有权编码抗原型HIV多肽的多核苷酸，多肽及其用途公开(公告)号：US20090004733A1
公开(公告)日：2009-01-01
申请号：US12018413
申请日：2008-01-23
申请人： Jan zur Megede , Susan W. Barnett
发明人： Jan zur Megede , Susan W. Barnett
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/21 , A61K2039/53 , C12N15/86 , C12N2740/16022 , C12N2740/16043 , C12N2740/16052 , C12N2740/16134 , C12N2740/16222 , C12N2740/16234 , C12N2800/108 , C12N2830/42 , C12N2840/203
摘要： The present invention relates to polynucleotides encoding immunogenic HIV polypeptides. Uses of the polynucleotides in applications including immunization, generation of packaging cell lines, and production of HIV polypeptides are also described. Polynucleotides encoding antigenic HIV polypeptides are described, as are uses of these polynucleotides and polypeptide products therefrom, including formulations of immunogenic compositions and uses thereof.
摘要翻译： 本发明涉及编码免疫原性HIV多肽的多核苷酸。 还描述了在包括免疫，产生包装细胞系以及产生HIV多肽的应用中多核苷酸的用途。 描述了编码抗原性HIV多肽的多核苷酸，以及来自其的这些多核苷酸和多肽产物的用途，包括免疫原性组合物的制剂及其用途。
-
公开(公告)号：US20080300385A1
公开(公告)日：2008-12-04
申请号：US11729076
申请日：2007-03-27
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , A61K2039/62 , A61K2039/64 , C12N2740/16122 , C12N2740/16134 , C12N2740/16322 , C12N2740/16334
摘要： Complexes of HIV Env and Tat proteins are advantageous as immunogens compared to Tat or Env alone, but they may dissociate when combined with a vaccine adjuvant. To avoid dissociation, complexes of Env and Tat are stabilized by the use of covalent cross linking. The extent of cross linking is important to the binding properties of the complexes, and so is controlled to avoid the loss of Env's ability to bind specifically to CD4 and Tat's ability to bind specifically to anti-Tat monoclonal antibodies.
摘要翻译： HIV环境和Tat蛋白的复合物作为免疫原与Tat或Env单独相比是有利的，但当与疫苗佐剂组合时它们可能解离。 为了避免解离，Env和Tat的复合物通过使用共价交联来稳定。 交联的程度对于复合物的结合特性是重要的，因此被控制以避免Env特异性结合CD4和Tat特异性结合抗Tat单克隆抗体的能力的丧失。
-
-
-
-
-
-
-
-
-
搜索结果
27 条记录 (耗时 0.035 秒)
