公开(公告)号：US5245018A

公开(公告)日：1993-09-14

申请号：US783776

申请日：1991-10-29

申请人： Susumu Kondo ,  Sakae Okano ,  Makoto Azuma

发明人： Susumu Kondo ,  Sakae Okano ,  Makoto Azuma

IPC分类号： A61K51/00 ,  A61K51/08 ,  C07F13/00

CPC分类号： A61K51/08 ,  A61K2123/00

摘要： A process for preparing a radiopharmaceutical composition comprising a technetium 99m chelate complex, comprises the steps of:(1) mixing (a) HSCH.sub.2 CO--NHCH.sub.2 CO--NHCH.sub.2 CO--NHCH.sub.2 COOH (mercaptoacetylglycylglycylglycine, MAG3), (b) a watersoluble reducing agent, (c) a water-soluble stabilizing agent in an amount of not less than 70 mol per 1 mol of the water-soluble reducing agent and (d) a pertechnetate at a pH of about 8 to 11; and(2) heating the resultant mixture at a temperature of about 90 to 140.degree. C.Said process removes any troublesome labeling operation at the diagnostic site and relieve the practitioners from the exposure to radiation during the labeling operation.

公开(公告)号：US5352431A

公开(公告)日：1994-10-04

申请号：US119387

申请日：1993-09-13

申请人： Yuji Hashiguchi ,  Kumiko Iwai ,  Shigemi Seri ,  Susumu Kondo ,  Makoto Azuma

发明人： Yuji Hashiguchi ,  Kumiko Iwai ,  Shigemi Seri ,  Susumu Kondo ,  Makoto Azuma

IPC分类号： A61K49/00 ,  A61K49/04 ,  A61K49/08 ,  A61K49/12 ,  A61K51/00 ,  C08B37/08 ,  A61K31/715

CPC分类号： A61K49/085 ,  A61K49/04 ,  A61K49/126 ,  A61K49/128 ,  A61K51/04 ,  A61K51/065 ,  Y10S514/836 ,  Y10T436/24

摘要： There is disclosed an imaging agent for diagnosis comprising a compound composed of a polynuclear type compound of the formula I or II: ##STR1## wherein each X is a hydrogen atom or a bifunctional ligand, at least one of them are bifunctional ligand and m or n is an integer or 1 to 6, and at least one metal ion being coordinated with at least one bifunctional ligand moiety, said metal ion being selected from the group consisting of metal ions having the atomic number of 21-29, 31, 32, 37-39, 42-44, 49 and 56-83.

摘要翻译： 公开了一种用于诊断的成像剂，其包含由式I或II的多核型化合物组成的化合物：其中每个X为氢原子或双官能配体，至少 其中一个是双官能配体，m或n是整数或1-6，并且至少一个金属离子与至少一个双官能配体部分配位，所述金属离子选自具有原子序数的金属离子 21-29,31,32,37-39,42-44,49和56-83段。

公开(公告)号：US5271924A

公开(公告)日：1993-12-21

申请号：US952992

申请日：1992-09-29

申请人： Yuji Hashiguchi ,  Kumiko Iwai ,  Shigemi Seri ,  Susumu Kondo ,  Makoto Azuma

发明人： Yuji Hashiguchi ,  Kumiko Iwai ,  Shigemi Seri ,  Susumu Kondo ,  Makoto Azuma

IPC分类号： A61K49/00 ,  A61K49/04 ,  A61K49/08 ,  A61K49/12 ,  A61K51/00 ,  C08B37/08 ,  G01N24/08 ,  A61K31/715

CPC分类号： A61K49/085 ,  A61K49/04 ,  A61K49/126 ,  A61K49/128 ,  A61K51/04 ,  A61K51/065 ,  Y10S514/836 ,  Y10T436/24

摘要： There is disclosed an imaging agent for diagnosis comprising a compound composed of a polynuclear type compound of the formula I or II: ##STR1## wherein each X is a hydrogen atom or a bifunctional ligand, at least one of them are bifunctional ligand and m or n is an integer of 1 to 6, and at least one metal ion being coordinated with at least one bifunctional ligand moiety, said metal ion being selected from the group consisting of metal ions having the atomic number of 21-29, 31, 32, 37-39, 42-44, 49 and 56-83.

公开(公告)号：US5094950A

公开(公告)日：1992-03-10

申请号：US362370

申请日：1989-06-05

申请人： Susumu Kondo ,  Miki Kurami ,  Makoto Azuma

发明人： Susumu Kondo ,  Miki Kurami ,  Makoto Azuma

IPC分类号： A61K51/04 ,  A61K51/10 ,  C07C237/10 ,  C07C317/18 ,  C07C323/60 ,  C07D207/40 ,  C07D207/404 ,  C07D207/46

CPC分类号： C07D207/46 ,  A61K51/048 ,  A61K51/1093 ,  C07C237/10 ,  C07C317/18 ,  C07C323/60 ,  C07D207/404 ,  A61K2121/00 ,  A61K2123/00

摘要： A compound of the formula II: ##STR1## wherein n is an integer of 2 to 10, A' is a bivalent linking group formed by reacting both the reactive groups of a cross linking reagent, andB is a residue of a polypeptide compound, and physiologically acceptable salts thereof are disclosed. Such compound is useful as a non-radioactive carrier for radioactive metal elements.

公开(公告)号：US5422095A

公开(公告)日：1995-06-06

申请号：US222226

申请日：1994-04-04

申请人： Yuji Hashiguchi ,  Kumiko Iwai ,  Shigemi Seri ,  Susumu Kondo ,  Makoto Azuma

发明人： Yuji Hashiguchi ,  Kumiko Iwai ,  Shigemi Seri ,  Susumu Kondo ,  Makoto Azuma

IPC分类号： A61K49/00 ,  A61K49/04 ,  A61K49/08 ,  A61K49/12 ,  A61K51/00 ,  C08B37/08 ,  A61K51/04

CPC分类号： A61K49/085 ,  A61K49/04 ,  A61K49/126 ,  A61K49/128 ,  A61K51/04 ,  A61K51/065 ,  Y10S514/836 ,  Y10T436/24

摘要： There is disclosed an imaging agent for diagnosis comprising a compound composed of a polynuclear type compound of the formula I or II: ##STR1## wherein each X is a hydrogen atom or a bifunctional ligand, at least one of them are bifunctional ligand and m or n is an integer of 1 to 6, and at least one metal ion being coordinated with at least one bifunctional ligand moiety, said metal ion being selected from the group consisting of metal ions having the atomic number of 21-29, 31, 32, 37-39, 42-44, 49 and 56-83.

摘要翻译： 公开了一种用于诊断的成像剂，其包含由式I或II的多核型化合物组成的化合物：其中每个X为氢原子或双官能配体，至少 其中一个是双官能配体，m或n是1至6的整数，并且至少一个金属离子与至少一个双官能配体部分配位，所述金属离子选自具有原子序数的金属离子 21-29,31,32,37-39,42-44,49和56-83段。

公开(公告)号：US5271929A

公开(公告)日：1993-12-21

申请号：US910546

申请日：1992-07-08

申请人： Yuji Hashiguchi ,  Kumiko Iwai ,  Shigemi Seri ,  Susumu Kondo ,  Makoto Azuma

发明人： Yuji Hashiguchi ,  Kumiko Iwai ,  Shigemi Seri ,  Susumu Kondo ,  Makoto Azuma

IPC分类号： A61K49/00 ,  A61K49/08 ,  A61K49/12 ,  C07H15/04 ,  C08B33/08 ,  C08B37/00 ,  G01N24/08 ,  A61K31/715 ,  C07H23/00 ,  C08B35/08

CPC分类号： A61K49/12 ,  A61K49/085 ,  Y10S514/836 ,  Y10T436/24

摘要： There is disclosed a nuclear magnetic resonance imaging agent comprising a complex compound composed of (a) a dialdehyde-saccharide having a molecular weight of from 500 to 10,000, at least one of the constituent monosaccharides of which is oxidation-cleaved, (b) at least one complexing agent which is chemically coupled to an aldehyde group of the dialdehyde-saccharide and (c) a paramagnetic metal ion which is chemically coupled to the complexing agent.

公开(公告)号：US5250702A

公开(公告)日：1993-10-05

申请号：US691989

申请日：1991-04-26

申请人： Susumu Kondo ,  Miki Kurami ,  Makoto Azuma

发明人： Susumu Kondo ,  Miki Kurami ,  Makoto Azuma

IPC分类号： A61K51/04 ,  A61K51/10 ,  C07C237/10 ,  C07C317/18 ,  C07C323/60 ,  C07D207/40 ,  C07D207/404 ,  C07D207/46 ,  C07C103/50 ,  C07C403/12 ,  C07D401/12

CPC分类号： C07D207/46 ,  A61K51/048 ,  A61K51/1093 ,  C07C237/10 ,  C07C317/18 ,  C07C323/60 ,  C07D207/404 ,  A61K2121/00 ,  A61K2123/00

摘要： A compound of the formula II: ##STR1## wherein n is an integer of 2 to 10,A' is a bivalent linking group formed by reacting both the reactive groups of a cross linking reagent, andB is a residue of a polypeptide compound,and physiologically acceptable salts thereof are disclosed. Such compound is useful as a non-radioactive carrier for radioactive metal elements.

摘要翻译： 式II的化合物：其中n是2至10的整数，A'是通过使交联剂的反应性基团反应形成的二价连接基团，B是多肽化合物的残基 ，及其生理上可接受的盐。 这种化合物可用作放射性金属元素的非放射性载体。

公开(公告)号：US07060518B2

公开(公告)日：2006-06-13

申请号：US11240903

申请日：2005-09-30

申请人： Susumu Kondo ,  Matsuyuki Ogasawara ,  Ryuzo Iga ,  Yasuhiro Kondo ,  Yoshio Noguchi ,  Masahiro Yuda ,  Ken Tsuzuki ,  Satoshi Oku

发明人： Susumu Kondo ,  Matsuyuki Ogasawara ,  Ryuzo Iga ,  Yasuhiro Kondo ,  Yoshio Noguchi ,  Masahiro Yuda ,  Ken Tsuzuki ,  Satoshi Oku

IPC分类号： H01L21/00

CPC分类号： B82Y20/00 ,  G02F1/01708 ,  H01S5/0265 ,  H01S5/2226 ,  H01S5/227 ,  H01S5/3072

摘要： A semiconductor optical device includes a semiconductor substrate and a stacked body formed by at least a first cladding layer, an active region and a second cladding layer; wherein both sides of the stacked body are buried by a burying layer formed by a semi-insulating semiconductor crystal; the burying layer includes a first layer that is placed adjacent to both sides of the stacked body and a second layer that is placed adjacent to the first layer; the first layer includes Ru as a dopant; composition of the second layer is different from the composition of the first layer, or a dopant of the second layer is different from the dopant of the first layer. The device can also be configured such that the width of the active region is smaller than the width of the cladding layers of the stacked body; and a Ru-doped semi-insulating layer is provided in a space between the burying layer and the active region in both sides of the active region.

公开(公告)号：US20060030065A1

公开(公告)日：2006-02-09

申请号：US11240903

申请日：2005-09-30

申请人： Susumu Kondo ,  Matsuyuki Ogasawara ,  Ryuzo Iga ,  Yasuhiro Kondo ,  Yoshio Noguchi ,  Masahiro Yuda ,  Ken Tsuzuki ,  Satoshi Oku

发明人： Susumu Kondo ,  Matsuyuki Ogasawara ,  Ryuzo Iga ,  Yasuhiro Kondo ,  Yoshio Noguchi ,  Masahiro Yuda ,  Ken Tsuzuki ,  Satoshi Oku

IPC分类号： H01L21/00

CPC分类号： B82Y20/00 ,  G02F1/01708 ,  H01S5/0265 ,  H01S5/2226 ,  H01S5/227 ,  H01S5/3072

摘要： A semiconductor optical device includes a semiconductor substrate and a stacked body formed by at least a first cladding layer, an active region and a second cladding layer; wherein both sides of the stacked body are buried by a burying layer formed by a semi-insulating semiconductor crystal; the burying layer includes a first layer that is placed adjacent to both sides of the stacked body and a second layer that is placed adjacent to the first layer; the first layer includes Ru as a dopant; composition of the second layer is different from the composition of the first layer, or a dopant of the second layer is different from the dopant of the first layer. The device can also be configured such that the width of the active region is smaller than the width of the cladding layers of the stacked body; and a Ru-doped semi-insulating layer is provided in a space between the burying layer and the active region in both sides of the active region.

公开(公告)号：US5606342A

公开(公告)日：1997-02-25

申请号：US400014

申请日：1995-03-06

申请人： Masato Shoji ,  Hoko Hirai ,  Susumu Kondo ,  Akio Murayama

发明人： Masato Shoji ,  Hoko Hirai ,  Susumu Kondo ,  Akio Murayama

IPC分类号： G02F1/133 ,  G09G3/20 ,  G09G3/36

CPC分类号： G09G3/3622 ,  G09G2320/0209

摘要： In liquid crystal display system 10 which has a matrix arrangement of scanning electrode group 12 and data electrode group 13 and in which each electrode group is driven by a pulse like waveform, this is a liquid crystal display system in which a lower level region than the pulse wave peak value is formed in at least one of the rising or the falling portions of the pulse wave which drives at least one of the electrode groups.A liquid crystal display system with a uniform display with extremely little display non-uniformity can be obtained.

摘要翻译： 在具有扫描电极组12和数据电极组13的矩阵排列的液晶显示系统10中，其中每个电极组由像波形的脉冲驱动，这是一种液晶显示系统，其中比 脉冲波峰值形成在驱动至少一个电极组的脉波的上升或下降部分中的至少一个中。 可以获得具有非常小的显示不均匀性的均匀显示的液晶显示系统。