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公开(公告)号：US09242005B1
公开(公告)日：2016-01-26
申请号：US11507860
申请日：2006-08-21
申请人： Syed Hossainy , Florian Niklas Ludwig , Stephen Pacetti , Paul Consigny , Fozan El-Nounou , Thierry Glauser , Jessica DesNoyer
发明人： Syed Hossainy , Florian Niklas Ludwig , Stephen Pacetti , Paul Consigny , Fozan El-Nounou , Thierry Glauser , Jessica DesNoyer
CPC分类号： A61K47/42 , A61K9/0019 , A61K9/1075 , A61K9/127 , A61K9/1273 , A61M5/178 , A61M25/104 , A61M31/00 , A61M2025/0087 , A61M2025/105 , A61M2025/1052
摘要： Pro-healing agent formulation compositions, methods and treatments for enhancing vascular healing are disclosed herein. In some embodiments, a pro-healing agent is encapsulated, suspended, disposed within or loaded into a biodegradable carrier for sustained-release delivery to a denuded or damaged endothelium treatment area in a blood vessel. In some applications, the pro-healing agent can accelerate re-endothelialization of a denuded vascular region. In some applications, the pro-healing agent can assist in the regaining of endothelium functionality. The formulation can be delivered by a delivery assembly such as an infusion catheter, a porous balloon catheter, a needle injection catheter, a double balloon catheter or the like.
摘要翻译： 本文公开了用于增强血管愈合的预愈合剂制剂组合物，方法和治疗。 在一些实施方案中，将前修复剂包封，悬浮，置于生物降解载体内或装载到可生物降解的载体中，以缓释递送至血管内的裸露或损伤的内皮治疗区域。 在一些应用中，预愈合剂可以加速裸露的血管区域的再内皮化。 在一些应用中，前修复剂可以帮助恢复内皮功能。 制剂可以通过输送组件例如输注导管，多孔气囊导管，针注射导管，双气囊导管等来递送。
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公开(公告)号：US20070202323A1
公开(公告)日：2007-08-30
申请号：US11365392
申请日：2006-02-28
CPC分类号： A61L31/16 , A61L31/10 , A61L2300/416 , A61L2300/422 , A61L2300/606 , Y10T428/265 , Y10T428/31855 , Y10T428/31935 , Y10T428/31938 , C08L29/04
摘要： A method of forming a surface layer that includes a hydroxyl polymer on a substrate coating on a medical device is provided.
摘要翻译： 提供了一种在医疗装置上的基底涂层上形成包含羟基聚合物的表面层的方法。
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3.发明申请Coatings for implantable devices comprising polymers of lactic acid and methods for fabricating the same 审中-公开用于包含乳酸聚合物的可植入装置的涂层及其制造方法公开(公告)号：US20050112170A1
公开(公告)日：2005-05-26
申请号：US10718976
申请日：2003-11-20
申请人： Syed Hossainy , Yiwen Tang , Eugene Michal , Thierry Glauser , Stephen Pacetti , Jessica DesNoyer
发明人： Syed Hossainy , Yiwen Tang , Eugene Michal , Thierry Glauser , Stephen Pacetti , Jessica DesNoyer
IPC分类号： A61F2/00 , A61F2/86 , A61L29/08 , A61L29/16 , A61L31/10 , A61L31/14 , A61L31/16 , A61L33/06 , A61M29/02
CPC分类号： A61L31/10 , A61F2/86 , A61F2250/0067 , A61L31/148 , A61L31/16 , A61L2300/416 , A61L2300/606 , C08L67/04
摘要： Coatings for an implantable medical device and a method of fabricating thereof are disclosed, the coatings comprising polymers of lactic acid.
摘要翻译： 公开了用于可植入医疗装置的涂层及其制造方法，所述涂层包含乳酸聚合物。
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4.发明申请Methods, Compositions and Devices for Treating Lesioned Sites Using Bioabsorbable Carriers 审中-公开用生物可吸收载体处理病变部位的方法，组成和装置公开(公告)号：US20100222872A1
公开(公告)日：2010-09-02
申请号：US12782656
申请日：2010-05-18
申请人： Lothar W. Kleiner , Syed Hossainy , Irina Astafieva , Stephen Pacetti , Thierry Glauser , Jessica Desnoyer , Florian N. Ludwig
发明人： Lothar W. Kleiner , Syed Hossainy , Irina Astafieva , Stephen Pacetti , Thierry Glauser , Jessica Desnoyer , Florian N. Ludwig
CPC分类号： A61K9/143 , A61K9/0019 , A61K9/1611 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/00 , C08L67/04
摘要： Methods and compositions for the sustained release of treatment agents to treat an occluded blood vessel and affected tissue and/or organs are disclosed. Porous or non-porous bioabsorbable glass, metal or ceramic bead, rod or fiber particles can be loaded with a treatment agent, and optionally an image-enhancing agent, and coated with a sustained-release coating for delivery to an occluded blood vessel and affected tissue and/or organs by a delivery device. Implantable medical devices manufactured with coatings including the particles or embedded within the medical device are additionally disclosed.
摘要翻译： 公开了用于持续释放治疗剂以治疗闭塞的血管和受影响的组织和/或器官的方法和组合物。 多孔或无孔生物可吸收玻璃，金属或陶瓷珠，棒或纤维颗粒可以加载处理剂和任选的图像增强剂，并涂覆有持续释放的涂层以递送至闭塞的血管并受影响 组织和/或器官。 另外公开了用包括颗粒的涂层制造的植入式医疗装置或嵌入在医疗装置内的植入式医疗装置。
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5.发明申请METHODS, COMPOSITIONS AND DEVICES FOR TREATING LESIONED SITES USING BIOABSORBABLE CARRIERS 审中-公开方法，组合物和使用生物可降解载体处理裂解位点的装置公开(公告)号：US20080051335A1
公开(公告)日：2008-02-28
申请号：US11614047
申请日：2006-12-20
申请人： Lothar Kleiner , Syed Hossainy , Irina Astafieva , Stephen Pacetti , Thierry Glauser , Jessica DesNoyer , Florian Ludwig
发明人： Lothar Kleiner , Syed Hossainy , Irina Astafieva , Stephen Pacetti , Thierry Glauser , Jessica DesNoyer , Florian Ludwig
CPC分类号： A61K9/143 , A61K9/0019 , A61K9/1611 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/00 , C08L67/04
摘要： Methods and compositions for the sustained release of treatment agents to treat an occluded blood vessel and affected tissue and/or organs are disclosed. Porous or non-porous bioabsorbable glass, metal or ceramic bead, rod or fiber particles can be loaded with a treatment agent, and optionally an image-enhancing agent, and coated with a sustained-release coating for delivery to an occluded blood vessel and affected tissue and/or organs by a delivery device. Implantable medical devices manufactured with coatings including the particles or embedded within the medical device are additionally disclosed.
摘要翻译： 公开了用于持续释放治疗剂以治疗闭塞的血管和受影响的组织和/或器官的方法和组合物。 多孔或无孔生物可吸收玻璃，金属或陶瓷珠，棒或纤维颗粒可以加载处理剂和任选的图像增强剂，并涂覆有持续释放的涂层以递送至闭塞的血管并受影响 组织和/或器官。 另外公开了用包括颗粒的涂层制造的植入式医疗装置或嵌入在医疗装置内的植入式医疗装置。
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6.发明申请Polymers containing poly(ester amides) and agents for use with medical articles and methods of fabricating the same 审中-公开含聚（酯酰胺）的聚合物和用于医疗制品的试剂及其制造方法公开(公告)号：US20050265960A1
公开(公告)日：2005-12-01
申请号：US10855294
申请日：2004-05-26
IPC分类号： A61L27/34 , A61L29/08 , A61L31/10 , C08G69/44 , A61K31/765
摘要： Polymers containing poly(ester amides) and agents for use with medical articles and methods of fabricating the same are disclosed. The medical article generally comprises an implantable substrate having a coating, and the coating contains a polymer comprising a polymeric product of a reaction comprising a polyol, a polycarboxylic acid, an amino acid and an agent.
摘要翻译： 公开了含有聚（酯酰胺）的聚合物和用于医疗制品的试剂及其制造方法。 医疗制品通常包括具有涂层的可植入基底，并且该涂层含有包含包含多元醇，多元羧酸，氨基酸和试剂的反应的聚合产物的聚合物。
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7.发明申请Methods, Compositions and Devices for Treating Lesioned Sites Using Bioabsorbable Carriers 审中-公开用生物可吸收载体处理病变部位的方法，组成和装置公开(公告)号：US20110027188A1
公开(公告)日：2011-02-03
申请号：US12901402
申请日：2010-10-08
申请人： Lothar W. Kleiner , Syed Hossainy , Irina Astafieva , Stephen Pacetti , Thierry Glauser , Jessica DesNoyer , Florian N. Ludwig
发明人： Lothar W. Kleiner , Syed Hossainy , Irina Astafieva , Stephen Pacetti , Thierry Glauser , Jessica DesNoyer , Florian N. Ludwig
CPC分类号： A61K9/143 , A61K9/0019 , A61K9/1611 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/00 , C08L67/04
摘要： An implantable medical device is disclosed having a plurality of smaller particles contained in a plurality of larger particles and configured to be released from the larger particles when the device is implanted in a patient. The smaller particles and the larger particles are made of bioabsorbable metal, glass or ceramic. A substance can be associated with the smaller particles. The larger particles can be embedded within at least a portion of the device.
摘要翻译： 公开了一种植入式医疗装置，其具有包含在多个较大颗粒中的多个较小颗粒，并且构造成当将该装置植入患者时从较大颗粒释放。 较小的颗粒和较大的颗粒由生物可吸收的金属，玻璃或陶瓷制成。 物质可以与较小的颗粒相关联。 较大的颗粒可以嵌入装置的至少一部分内。
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8.发明申请Methods, compositions and devices for treating lesioned sites using bioabsorbable carriers 审中-公开用生物可吸收载体处理损伤部位的方法，组合物和装置公开(公告)号：US20070258903A1
公开(公告)日：2007-11-08
申请号：US11416860
申请日：2006-05-02
申请人： Lothar Kleiner , Syed Hossainy , Irina Astafieva , Stephen Pacetti , Thierry Glauser , Jessica DesNoyer , Florian Ludwig
发明人： Lothar Kleiner , Syed Hossainy , Irina Astafieva , Stephen Pacetti , Thierry Glauser , Jessica DesNoyer , Florian Ludwig
CPC分类号： A61K9/0019 , A61K9/143 , A61K9/1611 , A61L31/148 , A61L31/16 , A61L2300/602
摘要： Methods and compositions for the sustained release of treatment agents to treat an occluded blood vessel and affected tissue and/or organs are disclosed. Porous or non-porous bioabsorbable glass, metal or ceramic bead, rod or fiber particles can be loaded with a treatment agent, and optionally an image-enhancing agent, and coated with a sustained-release coating for delivery to an occluded blood vessel and affected tissue and/or organs by a delivery device.
摘要翻译： 公开了用于持续释放治疗剂以治疗闭塞的血管和受影响的组织和/或器官的方法和组合物。 多孔或无孔生物可吸收玻璃，金属或陶瓷珠，棒或纤维颗粒可以加载处理剂和任选的图像增强剂，并涂覆有持续释放的涂层以递送至闭塞的血管并受影响 组织和/或器官。
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9.发明授权公开(公告)号：US08647680B2
公开(公告)日：2014-02-11
申请号：US12789002
申请日：2010-05-27
IPC分类号： A61K9/14 , A61K33/00 , A61K31/198 , A61P9/10 , A61M25/00
CPC分类号： A61K33/00 , A61K9/00 , A61K31/198 , A61K38/005 , A61K38/44 , A61L27/38 , A61L29/16 , A61L31/16 , A61L2300/40
摘要： Methods and compositions for inducing apoptosis of cells, such as macrophages, at a lesioned site of a body vessel are disclosed herein. Nitric oxide can be directly or indirectly delivered to a treatment site to increase macrophage apoptosis. Delivery can include site specific delivery of nitric oxide gas, nitric oxide in aqueous solution or a substance(s) which releases nitric oxide or causes nitric oxide to be generated from an endogenous source. Delivery can be achieved by a delivery system such as a catheter assembly, stent or other suitable device.
摘要翻译： 本文公开了在身体血管的损伤部位诱导细胞例如巨噬细胞凋亡的方法和组合物。 一氧化氮可以直接或间接地递送到治疗部位以增加巨噬细胞凋亡。 交付可以包括一氧化氮气体，一氧化氮在水溶液中的位置特异性递送或释放一氧化氮或从内源产生一氧化氮的物质。 可以通过诸如导管组件，支架或其它合适的装置之类的递送系统实现递送。
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10.发明授权公开(公告)号：US07744928B2
公开(公告)日：2010-06-29
申请号：US11404233
申请日：2006-04-14
IPC分类号： A61K33/00
CPC分类号： A61K33/00 , A61K9/00 , A61K31/198 , A61K38/005 , A61K38/44 , A61L27/38 , A61L29/16 , A61L31/16 , A61L2300/40
摘要： Methods and compositions for inducing apoptosis of cells, such as macrophages, at a lesioned site of a body vessel are disclosed herein. Nitric oxide can be directly or indirectly delivered to a treatment site to increase macrophage apoptosis. Delivery can include site specific delivery of nitric oxide gas, nitric oxide in aqueous solution or a substance(s) which releases nitric oxide or causes nitric oxide to be generated from an endogenous source. Delivery can be achieved by a delivery system such as a catheter assembly, stent or other suitable device.
摘要翻译： 本文公开了在身体损伤部位诱导细胞例如巨噬细胞凋亡的方法和组合物。 一氧化氮可以直接或间接地递送到治疗部位以增加巨噬细胞凋亡。 交付可以包括一氧化氮气体，一氧化氮在水溶液中的位置特异性递送或释放一氧化氮或从内源产生一氧化氮的物质。 可以通过诸如导管组件，支架或其他合适的装置之类的递送系统实现递送。
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