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公开(公告)号：US09061001B2
公开(公告)日：2015-06-23
申请号：US12587955
申请日：2009-10-15
申请人： Sylvia van Drunen Littel-van den Hurk , Volker Gerdts , Andrew Potter , Lorne Babiuk , Robert Hancock , Scott Halperin , Jennifer Kovacs-Nolan , George Mutwiri , Song Lee , Mi-Na Kweon , Jason Kindrachuk , Melissa Elliott
发明人： Sylvia van Drunen Littel-van den Hurk , Volker Gerdts , Andrew Potter , Lorne Babiuk , Robert Hancock , Scott Halperin , Jennifer Kovacs-Nolan , George Mutwiri , Song Lee , Mi-Na Kweon , Jason Kindrachuk , Melissa Elliott
IPC分类号： A61K49/00 , A61K47/00 , A61K38/04 , A61K39/39 , A61K39/02 , A61K39/155 , C07K7/08 , A61K45/06 , A61K47/30 , A61K39/00
CPC分类号： A61K39/39 , A61K39/099 , A61K39/12 , A61K39/155 , A61K45/06 , A61K47/30 , A61K2039/55516 , A61K2039/55561 , A61K2039/6093 , C07K7/08 , C12N2760/18534
摘要： Methods and compositions for enhancing an immune response to a selected antigen are described. The methods are useful for the treatment and prevention of microbial infections, such as infections caused by bacteria, viruses, fungi and parasites. The methods and compositions include host defense peptides, polyphosphazenes and immunostimulatory sequences to enhance the immune response to a coadministered antigen.
摘要翻译： 描述了增强对所选抗原的免疫应答的方法和组合物。 该方法可用于治疗和预防微生物感染，例如由细菌，病毒，真菌和寄生虫引起的感染。 方法和组合物包括宿主防御肽，聚磷腈和免疫刺激序列，以增强对共同施用的抗原的免疫应答。
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公开(公告)号：US20100239611A1
公开(公告)日：2010-09-23
申请号：US12587955
申请日：2009-10-15
申请人： Sylvia van Drunen Littel-van den Hurk , Volker Gerdts , Andrew Potter , Lorne Babiuk , Robert Hancock , Scott Halperin , Jennifer Kovacs-Nolan , George Mutwiri , Song Lee , Mi-Na Kweon , Jason Kindrachuk , Melissa Elliot
发明人： Sylvia van Drunen Littel-van den Hurk , Volker Gerdts , Andrew Potter , Lorne Babiuk , Robert Hancock , Scott Halperin , Jennifer Kovacs-Nolan , George Mutwiri , Song Lee , Mi-Na Kweon , Jason Kindrachuk , Melissa Elliot
IPC分类号： A61K39/155 , A61K39/39 , C07K7/08 , A61K39/35 , A61K39/10 , A61P31/12 , A61P31/04 , A61P31/10 , A61P33/00
CPC分类号： A61K39/39 , A61K39/099 , A61K39/12 , A61K39/155 , A61K45/06 , A61K47/30 , A61K2039/55516 , A61K2039/55561 , A61K2039/6093 , C07K7/08 , C12N2760/18534
摘要： Methods and compositions for enhancing an immune response to a selected antigen are described. The methods are useful for the treatment and prevention of microbial infections, such as infections caused by bacteria, viruses, fungi and parasites. The methods and compositions include host defense peptides, polyphosphazenes and immunostimulatory sequences to enhance the immune response to a coadministered antigen.
摘要翻译： 描述了增强对所选抗原的免疫应答的方法和组合物。 该方法可用于治疗和预防微生物感染，例如由细菌，病毒，真菌和寄生虫引起的感染。 方法和组合物包括宿主防御肽，聚磷腈和免疫刺激序列，以增强对共同施用的抗原的免疫应答。
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公开(公告)号：US06946448B2
公开(公告)日：2005-09-20
申请号：US10155867
申请日：2002-05-23
CPC分类号： A61K39/00 , A61K39/12 , A61K39/245 , A61K2039/5252 , A61K2039/53 , A61K2039/54 , A61K2039/542 , A61K2039/55505 , A61K2039/57 , C12N2710/16734 , C12N2730/10134
摘要： Methods of nucleic acid immunization comprising the in utero delivery of nucleic acid molecules that encode one or more selected antigens to a vertebrate fetus are disclosed.
摘要翻译： 公开了包含将脊椎动物胎儿编码一种或多种选择的抗原的核酸分子的子宫内递送的核酸免疫方法。
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公开(公告)号：US20060008466A1
公开(公告)日：2006-01-12
申请号：US11127061
申请日：2005-05-10
申请人： Shokrollah Elahi , Volker Gerdts , Lorne Babiuk
发明人： Shokrollah Elahi , Volker Gerdts , Lorne Babiuk
CPC分类号： A61K38/1709 , C07K14/4723
摘要： Methods for the treatment and prevention of microbial infection, such as infections caused by bacteria, viruses, fungi and parasites are disclosed, as are adjuvants for use with vaccines against such microbes. The methods use porcine β-defensins, such as porcine β-defensin-1 and are particularly useful for treating or preventing infections caused by gram-negative bacteria, such as pertussis.
摘要翻译： 公开了用于治疗和预防微生物感染的方法，例如由细菌，病毒，真菌和寄生虫引起的感染，以及用于针对这种微生物的疫苗的佐剂。 该方法使用猪β-防御素，例如猪β-防御素-1，并且特别可用于治疗或预防革兰氏阴性细菌如百日咳引起的感染。
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