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公开(公告)号：US5698673A
公开(公告)日：1997-12-16
申请号：US434761
申请日：1995-05-04
CPC分类号： C07K7/06 , C07K5/0215 , C07K5/1019
摘要： Disclosed are peptides having anti-mellitin activity and having the formulae AC-IVILZZ-NH.sub.2, wherein Z is an amino acid. Also disclosed are compositions containing these peptides and methods of using them.
摘要翻译： 公开了具有抗梅毒素活性并具有式AC-IVILZZ-NH 2的肽，其中Z是氨基酸。 还公开了含有这些肽的组合物和使用它们的方法。
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公开(公告)号：US06391917B1
公开(公告)日：2002-05-21
申请号：US09838726
申请日：2001-04-19
申请人： Charles R. Petrie , Patricia A. McKernan , Emma E. Moore , John M. Ostresh , Jean-Philippe Meyer , Richard A. Houghten , Clemencia Pinilla
发明人： Charles R. Petrie , Patricia A. McKernan , Emma E. Moore , John M. Ostresh , Jean-Philippe Meyer , Richard A. Houghten , Clemencia Pinilla
IPC分类号： A61K3117
CPC分类号： C07C275/28 , C07D209/20 , Y10S514/878
摘要： Dialkyl urea compounds are described which act as calcitonin mimetics. These compounds are useful in the treatment of diseases which are associated with bone resorption. The calcitonin mimetics of the present invention are also useful in assays for the determination of calcitonin receptor activity.
摘要翻译： 描述了作为降钙素模拟物的二烷基脲化合物。 这些化合物可用于治疗与骨吸收相关的疾病。 本发明的降钙素模拟物也可用于测定降钙素受体活性的测定中。
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公开(公告)号：US06221913B1
公开(公告)日：2001-04-24
申请号：US09233893
申请日：1999-01-20
申请人： Charles R. Petrie , Patricia A. McKernan , Emma E. Moore , John M. Ostresh , Jean-Philippe Meyer , Richard A. Houghten , Clemencia Pinilla
发明人： Charles R. Petrie , Patricia A. McKernan , Emma E. Moore , John M. Ostresh , Jean-Philippe Meyer , Richard A. Houghten , Clemencia Pinilla
IPC分类号： A61K3117
CPC分类号： C07C275/28 , C07D209/20 , Y10S514/878
摘要： Dialkyl urea compounds are described which act as calcitonin mimetics. These compounds are useful in the treatment of diseases which are associated with bone resorption. The calcitonin mimetics of the present invention are also useful in assays for the determination of calcitonin receptor activity.
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4.发明授权Scanning synthetic peptide combinatorial libraries: oligopeptide mixture sets having a one predetermined residue at a single, predetermined position, methods of making and using the same 失效扫描合成肽组合文库：在单个预定位置具有一个预定残基的寡肽混合物组，制备和使用它们的方法
公开(公告)号：US5556762A
公开(公告)日：1996-09-17
申请号：US943709
申请日：1992-09-11
CPC分类号： C07K7/06 , B01J19/0046 , C07K1/047 , B01J2219/00297 , B01J2219/00461 , B01J2219/005 , B01J2219/00585 , B01J2219/0059 , B01J2219/00592 , B01J2219/00596 , B01J2219/00725 , C40B40/10 , C40B60/14
摘要： Synthetic peptide combinatorial libraries (sets) having a single, predetermined amino acid residue at a single, predetermined oligopeptide chain position and mixtures of amino acid residues at the other chain positions are disclosed, as are their processes of synthesis and use in determining the amino acid residue sequence of an oligopeptide ligand that binds to an acceptor molecule.
摘要翻译： 公开了在单个预定寡肽链位置具有单个预定氨基酸残基并在其它链位置具有氨基酸残基混合物的合成肽组合文库（组），以及合成和用于确定氨基酸的方法 与受体分子结合的寡肽配体的残基序列。
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5.发明申请公开(公告)号：US20110183358A1
公开(公告)日：2011-07-28
申请号：US11886385
申请日：2006-03-17
申请人： John C. Reed , Richard A. Houghten , Adel Nefzi , John M. Ostresh , Kate Welsh , Clemencia Pinilla
发明人： John C. Reed , Richard A. Houghten , Adel Nefzi , John M. Ostresh , Kate Welsh , Clemencia Pinilla
IPC分类号： G01N33/53
CPC分类号： C07D207/09 , A61K38/00
摘要： The invention provides isolated agents having novel chemical structures and possessing superior activity as derepressors of IAP inhibited caspase. The invention further provides a method of derepressing an IAP-inhibited caspase. The invention further provides assay methods employing labeled compounds of the invention, especially fluorescent labeled compounds.
摘要翻译： 本发明提供了具有新化学结构并且作为IAP抑制剂抑制半胱天冬酶具有优异活性的分离剂。 本发明还提供了一种去抑制IAP抑制的半胱天冬酶的方法。 本发明还提供了使用本发明的标记化合物，特别是荧光标记的化合物的测定方法。
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公开(公告)号：US06255351B1
公开(公告)日：2001-07-03
申请号：US09410115
申请日：1999-09-30
申请人： Charles R. Petrie , Patricia A. McKernan , Emma E. Moore , John M. Ostresh , Jean-Philippe Meyer , Richard A. Houghten , Clemencia Pinilla
发明人： Charles R. Petrie , Patricia A. McKernan , Emma E. Moore , John M. Ostresh , Jean-Philippe Meyer , Richard A. Houghten , Clemencia Pinilla
IPC分类号： A61K3117
CPC分类号： C07C275/28 , C07D209/20 , Y10S514/878
摘要： Dialkyl urea compounds are described which act as calcitonin mimetics. These compounds are useful in the treatment of diseases which are associated with bone resorption. The calcitonin mimetics of the present invention are also useful in assays for the determination of calcitonin receptor activity.
摘要翻译： 描述了作为降钙素模拟物的二烷基脲化合物。 这些化合物可用于治疗与骨吸收相关的疾病。 本发明的降钙素模拟物也可用于测定降钙素受体活性的测定中。
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公开(公告)号：US20090214580A1
公开(公告)日：2009-08-27
申请号：US10587987
申请日：2005-02-02
申请人： Richard A. Houghten , Clemencia Pinilla , Roland Martin , Claus-Steffen Sturzebecher , Jacquline Shukaiak-Quant , Henry F. McFarland
发明人： Richard A. Houghten , Clemencia Pinilla , Roland Martin , Claus-Steffen Sturzebecher , Jacquline Shukaiak-Quant , Henry F. McFarland
CPC分类号： A61K38/08 , A61K38/10 , A61K2300/00
摘要： The present invention is related to complex peptide mixtures with immunomodulatory effects and methods for their use. The invention is further directed toward treatments of diseases through the modulation of the immune system with complex peptide mixtures. The invention is also directed to methods for improving the characteristics of complex peptide mixtures.
摘要翻译： 本发明涉及具有免疫调节作用的复合肽混合物及其使用方法。 本发明还涉及通过用复合肽混合物调节免疫系统来治疗疾病。 本发明还涉及用于改善复合肽混合物的特征的方法。
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8.发明申请公开(公告)号：US20090043099A1
公开(公告)日：2009-02-12
申请号：US11982317
申请日：2007-10-31
申请人： John C. Reed , Richard A. Houghten , Adel Nefzi , John M. Ostresh , Clemencia Pinilla , Kate Welsh
发明人： John C. Reed , Richard A. Houghten , Adel Nefzi , John M. Ostresh , Clemencia Pinilla , Kate Welsh
IPC分类号： C07D241/08 , C07C275/42 , C07D207/09
CPC分类号： C07D207/09 , C07C275/28 , C07D241/08
摘要： The invention provides isolated agents having novel chemical structures and possessing superior activity as derepressors of IAP inhibited caspase. The invention further provides a method of derepressing an IAP-inhibited caspase. The invention further provides assay methods employing labeled compounds of the invention, especially fluorescent labeled compounds.
摘要翻译： 本发明提供了具有新化学结构并且作为IAP抑制剂抑制半胱天冬酶具有优异活性的分离剂。 本发明还提供了一种去抑制IAP抑制的半胱天冬酶的方法。 本发明还提供了使用本发明的标记化合物，特别是荧光标记的化合物的测定方法。
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公开(公告)号：US07217688B2
公开(公告)日：2007-05-15
申请号：US11186629
申请日：2005-07-19
申请人： John C. Reed , Richard A. Houghten , Adel Nefzi , John M. Ostresh , Clemencia Pinilla , Kate Welsh
发明人： John C. Reed , Richard A. Houghten , Adel Nefzi , John M. Ostresh , Clemencia Pinilla , Kate Welsh
IPC分类号： A01N37/18
CPC分类号： C07D207/09 , A61K38/00
摘要： The invention provides isolated agents having novel chemical structures and possessing superior activity as derepressors of IAP inhibited caspase. The invention further provides a method of derepressing an IAP-inhibited caspase. The invention further provides assay methods employing labeled compounds of the invention, especially fluorescent labeled compounds.
摘要翻译： 本发明提供了具有新化学结构并且作为IAP抑制剂抑制半胱天冬酶具有优异活性的分离剂。 本发明还提供了一种去抑制IAP抑制的半胱天冬酶的方法。 本发明还提供了使用本发明的标记化合物，特别是荧光标记的化合物的测定方法。
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10.发明授权
公开(公告)号：US5504190A
公开(公告)日：1996-04-02
申请号：US253854
申请日：1994-06-03
申请人： Richard A. Houghten , Julio H. Cuervo , Clemencia Pinilla , Jon R. Appel, Jr. , Silvie Blondelle
发明人： Richard A. Houghten , Julio H. Cuervo , Clemencia Pinilla , Jon R. Appel, Jr. , Silvie Blondelle
IPC分类号： A61K38/00 , B01J19/00 , C07K1/04 , C07K1/113 , C07K7/06 , C40B40/10 , C40B60/14 , G01N33/53 , A61K38/04 , C07K5/00 , C07K7/00 , C07K16/00
CPC分类号： C07K7/06 , B01J19/0046 , C07K1/047 , B01J2219/00297 , B01J2219/00461 , B01J2219/005 , B01J2219/00585 , B01J2219/0059 , B01J2219/00592 , B01J2219/00596 , B01J2219/00725 , C40B40/10 , C40B60/14
摘要： A process for the synthesis of a complex mixture pool of solid support-coupled monomeric repeating unit compounds such as amino acid derivatives is disclosed in which the mixture pool contains an equimolar representation of reacted monomeric repeating unit compounds coupled. Also disclosed is a process for the stepwise synthesis of a complex mixture of coupled or free, unsupported oligomers such as oligopeptides. A set of self-solubilizing, unsupported mixed oligopeptides having one or more predetermined amino acid residues at one or more of the same, predetermined positions in the oligopeptide chain in which the set contains equimolar amounts of a plurality of different amino acid residues, preferably at least six different residues, at one or more of the same predetermined positions of the oligopeptide chain is also disclosed, as are methods of making and using the same.
摘要翻译： 公开了一种用于合成固体支持偶联单体重复单元化合物如氨基酸衍生物的复合混合物池的方法，其中混合物池包含偶联反应的单体重复单元化合物的等摩尔表示。 还公开了逐步合成偶联或游离的，未负载的寡聚物如寡肽的复合混合物的方法。 在寡肽链中的一个或多个相同的预定位置上具有一个或多个预定氨基酸残基的一组自溶解的，未支撑的混合寡肽，其中该组含有等摩尔量的多个不同氨基酸残基，优选在 还公开了在寡肽链的一个或多个相同的预定位置处的至少六个不同的残基，以及制备和使用寡肽链的方法。
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